Papers by Aldemar Gonzalez
Revista Logos Ciencia & Tecnología
La endometritis se define como la inflamación del endometrio, y es considerada una de las princip... more La endometritis se define como la inflamación del endometrio, y es considerada una de las principales causas de sub e infertilidad en la yegua, que generan pérdidas económicas significativas, con una incidencia del 10 al 15 %. Existen diferentes etiologías, destacándose la mala conformación del perineo, útero abdominal, pérdida de la actividad miometrial, número de montas, factores moleculares y genéticos, y la presencia de bacterias y hongos. El presente artículo expone el caso de una yegua criolla colombiana de 15 años con historial de abortos y nula obtención de embriones, donde fueron realizados como métodos diagnósticos la evaluación del sistema genital externo e interno, ultrasonografía, citología, cultivo y biopsia endometrial; la cual reportó endometritis crónica de clasificación II B, asociada edema tipo 4, y estableciendo un pronóstico reservado para la reproducción, después de comprobarse la endometritis fúngica. El tratamiento consistió en la utilización de complejos vit...
Revista de Medicina Veterinaria
El objetivo del presente estudio fue conocer la asociación existente entre las medidas morfométri... more El objetivo del presente estudio fue conocer la asociación existente entre las medidas morfométricas, el engrasamiento corporal medido por ultrasonido, y la biometría testicular en caballos del Criadero Caballar Mancillas de la Policía Nacional, ubicado en el municipio de Facatativá, Cundinamarca. Se realizaron mediciones morfométricas en doce sementales adultos de seis razas, entre los cinco y los catorce años. Dichos ejemplares estaban en entrenamiento y en un programa reproductivo, y en un buen estado de bienestar físico, mental y reproductivo. Las medidas analizadas fueron la altura a la cruz (AL), el perímetro torácico (PTm), la longitud corporal (LCm), la circunferencia del cuello (CCmU), relación entre la circunferencia del cuello y la alzada (PCCA), relación entre circunferencia torácica y altura (PPTmA), el peso en bascula real (PBR), pliegue cutáneo (PCmm), la condición corporal (CC), el espesor del pliegue cutáneo (EPC), el espesor de la grasa en la cadera (EGC), el espes...
Abstract Text: Copy number variants (CNV) are an important source of genetic and phenotypic infor... more Abstract Text: Copy number variants (CNV) are an important source of genetic and phenotypic information. They have been associated with diseases and production traits in cattle. In this work, the objective is to identify CNVs and CNV regions (CNVR) in five Autochtonous Spanish beef cattle breeds accounting 366 individuals in trios genotyped with BovineHD Beadchip. From those, we extracted the corresponding subset relative to 50K SNP array. After detection and quality filtering been applied, we identified 3,965 CNVRs in the HD array and 201 with the 50K. The total length of CNVRs covered 8.6% and 1.2% of the autosomal cattle genome, respectively. Was found segregating CNV present in more than one breed varying from 33 to 268 for the HD information and from 0 and 10 for the 50K. The interest and applicability of these results needs further investigation. Keywords: beef cattle genomic copy number variants single nucleotide polymorphism
MOESM6 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 6: Figure S6 Manhattan plots of the results along the autosomal genome obtained w... more Additional file 6: Figure S6 Manhattan plots of the results along the autosomal genome obtained with the H12 procedure.
MOESM8 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 8: Figure S8. Manhattan plots of the results along the autosomal genome obtained ... more Additional file 8: Figure S8. Manhattan plots of the results along the autosomal genome obtained with the nSL procedure.
MOESM7 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 7: Figure S7. Manhattan plots of the results along the autosomal genome obtained ... more Additional file 7: Figure S7. Manhattan plots of the results along the autosomal genome obtained with the iHS procedure.
MOESM11 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 11: Figure S11. Manhattan plots of the results along the autosomal genome obtaine... more Additional file 11: Figure S11. Manhattan plots of the results along the autosomal genome obtained with the VarLD procedure.
MOESM5 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 5: Figure S5. Manhattan plots of the results along the autosomal genome obtained ... more Additional file 5: Figure S5. Manhattan plots of the results along the autosomal genome obtained with the XP-CLR procedure.
MOESM2 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 2: Figure S2. Manhattan plots of the results along the autosomal genome obtained ... more Additional file 2: Figure S2. Manhattan plots of the results along the autosomal genome obtained with the Fu and Li procedure.
MOESM10 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 10: Figure S10. Manhattan plots of the results along the autosomal genome obtaine... more Additional file 10: Figure S10. Manhattan plots of the results along the autosomal genome obtained with the XP-EHH procedure.
MOESM1 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 1: Figure S1. Manhattan plots of the results along the autosomal genome obtained ... more Additional file 1: Figure S1. Manhattan plots of the results along the autosomal genome obtained with the Tajima procedure.
MOESM9 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 9: Figure S9. Manhattan plots of the results along the autosomal genome obtained ... more Additional file 9: Figure S9. Manhattan plots of the results along the autosomal genome obtained with the F ST procedure.
MOESM3 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 3: Figure S3. Manhattan plots of the results along the autosomal genome obtained ... more Additional file 3: Figure S3. Manhattan plots of the results along the autosomal genome obtained with the Fay and Wu procedure.
MOESM4 of On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
Additional file 4: Figure S4. Manhattan plots of the results along the autosomal genome obtained ... more Additional file 4: Figure S4. Manhattan plots of the results along the autosomal genome obtained with the SelEstim procedure.
Revista Mexicana de Ciencias Pecuarias
Agricultural production seeks to obtain high quality, safe products for human consumption-a great... more Agricultural production seeks to obtain high quality, safe products for human consumption-a great concern for the dairy chain. The present investigation seeks to identify the correlation between the compositional and sanitary quality of raw milk (SCC/mL). The investigation was carried out in three districts of the Department of Nariño, Colombia. For this purpose, sampling and information collection was executed throughout the years 2016 and 2017. To determine the relationship between composition and sanitary quality, an analysis was made of the principal components of the milk, and a design of mixed models was creating using selected variables. The analysis showed that there is a relationship between the compositional variables, and the mixed model indicated that there is a significant relationship between the somatic cell count and the milk quality of the region. It was concluded that a somatic cell count above 500,000 CFU/mL has negative effects on protein, casein, and milk production.
Frontiers in Genetics
Mapping Recombination Rate from the LD Phase Mouresan et al. differences in the enriched gene ont... more Mapping Recombination Rate from the LD Phase Mouresan et al. differences in the enriched gene ontology (GO) terms between the genes located in the genomic regions with estimates of the recombination rate over (or below) the 95 th (or 5 th ) percentile throughout the autosomal genome.
Bayesian analysis of parent-specific transmission ratio distortion in seven Spanish beef cattle breeds
Animal Genetics, 2016
Transmission ratio distortion (TRD) is the departure from the expected Mendelian ratio in offspri... more Transmission ratio distortion (TRD) is the departure from the expected Mendelian ratio in offspring, a poorly investigated biological phenomenon in livestock species. Given the current availability of specific parametric methods for the analysis of segregation data, this study focused on the screening of TRD in 602 402 single nucleotide polymorphisms covering all autosomal chromosomes in seven Spanish beef cattle breeds. On average, 0.13% (n = 786) and 0.01% (n = 29) of genetic markers evidenced sire- or dam-specific TRD respectively. There were no single nucleotide polymorphisms accounting for both sire- and dam-specific TRD at the same time, and only one marker (rs43147474) accounted for (sire-specific) TRD in all seven breeds. It must be noted that rs43147474 is located in the fourth intronic region of the GTP-binding protein 10 gene, and this locus has been previously linked to the maintenance of mitochondria and nucleolar architectures. Alternatively, other candidate genes surround this hot-spot for sire-specific TRD in the cattle genome, and they are related to embryonic and postnatal lethality as well as prostate cancer, among others. This research characterized the distribution of TRD in the bovine genome, highlighting heterogeneous results when comparing across breeds.
The BovineHD 770K BeadChip was used on 116 sire/dam/offspring triplets from five Spanish local be... more The BovineHD 770K BeadChip was used on 116 sire/dam/offspring triplets from five Spanish local beef cattle breeds (Asturiana de los Valles, Avileña-Negra Ibérica, Bruna dels Pirineus, Pirenaica and Retinta). The parents were chosen to be as unrelated as possible. We calculated the molecular coancestry for every pair of individuals (within and between populations). From them, Reynolds, Nei’s minimum and standard distances and average FST were calculated for each subset of markers at every Mb along the autosomal chromosomes. The results of the total genetic diversity showed an average FST value of 0.049 (0.015). However, the FST vary enormously across genomic regions, showed remarkable differences with respect to the average estimate. In particular, regions of the chromosomes 2, 5, 6, 11, 13 and 18 showed a global FST greater than 0.15. In these regions a total of 77 genes were identified.
High-density SNP genotyping was used to describe the genetic variability and relationships among ... more High-density SNP genotyping was used to describe the genetic variability and relationships among five Spanish beef cattle breeds (Asturiana de los Valles, Avileña – Negra Ibérica, Bruna dels Pirineus, Pirenaica and Retinta). A total of 239 samples were genotyped with the BovineHD (778 K) Beadchip, which proved its suitability for the study of these breeds. Genetic diversity, measured as the expected heterozygosity, was around 0.31, similar to other European cattle breeds. The degree of genetic differentiation was little to moderate, as the F ST estimates ranged from 0.024 to 0.065. PCA analysis was able to distinguish five separated clusters corresponding to each breed. The clusters were confirmed through an analysis for ancestries which also showed admixture among some breeds. This contributes background information to explore the feasibility of genomic selection in Spanish beef breeds.
Evaluation of the use of a Meta-population for Genomic Selection in Spanish Beef Cattle Breeds EF Mouresan1, S. Munilla1, 2, C. Diaz3, A. González Rodríguez1, J. Piedrafita4
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Papers by Aldemar Gonzalez