Papers by sireesha malladi
We have designed and synthesized a series of novel amide derivatives of 1,3,4-oxadiazole-isoxazol... more We have designed and synthesized a series of novel amide derivatives of 1,3,4-oxadiazole-isoxazol-pyridine-benzimidazole (10a-j), and their structures are characterized by 1HNMR, 13CNMR and mass spectral data. The preliminary anticancer applications of these compounds are screened towards four types of human cancer cell lines including PC3 (prostate), A549 (lung), MCF-7 (breast) and DU-145 (prostate). The assay results revealed that many of the target compounds displayed remarkable anticancer activity. Among them, the compounds 10f, 10g, 10h and 10j are found to be more potent than rest of the compounds. In particularly, one compound 10f displayed most promising anticancer activity.
While trace amounts of fluorine are essential for life, its excessive intake leads to a disease k... more While trace amounts of fluorine are essential for life, its excessive intake leads to a disease known as fluorosis. It is a predominant ailment in majority of the countries inclusive of India. It is caused also by drinking fluoride containing water. Retention of fluorine in bones and teeth occurs through F−–(OH−) exchange on their inorganic component known as hydroxylapatite. Endeavour of the present study is to design a column using activated alumina as an adsorbent for continuous defluoridation of water for domestic purpose. As a part of it, operational defluoridation capacity of aluminawas determined by variation of different factors (amount of alumina, time, temperature, added salts). A family of four members was taken as a model. The initial and final fluoride concentrations were taken as 2.0 and 0.7 ppm, respectively. Dimension of the unit (adsorbent bed diameter and height) was determined.
viXra, 2019
Caralluma is a genus used as traditional medicine. Caralluma lasiantha is medicinally important d... more Caralluma is a genus used as traditional medicine. Caralluma lasiantha is medicinally important due to existence of pregnane glycosides, which may possess various biological activities. This article thoroughly reviewed about the usage of C. lasiantha in traditional medicinal system, phytochemicals present in it, profile identification studies, anti-hyperglycemic effect, antibacterial, antifungal, cytotoxic and antioxidant activities.
Lecture Notes on Multidisciplinary Industrial Engineering, 2019
While trace amounts of fluorine are essential for life, its excessive intake leads to a disease k... more While trace amounts of fluorine are essential for life, its excessive intake leads to a disease known as fluorosis. It is a predominant ailment in majority of the countries inclusive of India. It is caused also by drinking fluoride containing water. Retention of fluorine in bones and teeth occurs through F −-(OH −) exchange on their inorganic component known as hydroxylapatite. Endeavour of the present study is to design a column using activated alumina as an adsorbent for continuous defluoridation of water for domestic purpose. As a part of it, operational defluoridation capacity of alumina was determined by variation of different factors (amount of alumina, time, temperature, added salts). A family of four members was taken as a model. The initial and final fluoride concentrations were taken as 2.0 and 0.7 ppm, respectively. Dimension of the unit (adsorbent bed diameter and height) was determined. Keywords Design • Domestic defluoridizing unit • Fluorosis 13.1 Introduction Human beings and animals suffer from fluorosis due to extended acquaintance with fluoride containing water, air or food. India stands in the top listed countries which are challenged with fluorosis problem in view of obligatory consumption of water having high quantities of fluoride (1-48 ppm) [1]. In India, Andhra Pradesh State is one among the many affected belts by endemic fluoride [2]. As per Indian standards,
International Journal of Research in Pharmaceutical Sciences, 2018
Caralluma is one of the prominent genus out of 200 genera and 2500 species of Asclepiadaceae fami... more Caralluma is one of the prominent genus out of 200 genera and 2500 species of Asclepiadaceae family. Caralluma genus belongs to Asclepiadaceae and is widely distributed in Asia countries, Africa, Arabian Peninsula, Canary Islands and Southeast Europe. In folkloric medicine, as well as in Unani and Ayurvedic systems of medicine, the plants of Caralluma are being used for the treatment of diabetic patients and rheumatism. Tribals consider some of them as food during famines and also as a part of the traditional medicinal system. In India and Pakistan, Caralluma species have been used as emergency foods for the last few centuries. As allopathic medicines possess toxic nature and side effects, the use of plant-based medicine is becoming popular. This lead to a sudden enhancement in the production of herbal drugs. At present Caralluma is gaining much importance from researchers because it possesses array immunostimulating activities due to presence flavonoids and saponins and pregnane gl...
international journal of chemical sciences, 2017
Stigmasterol, a phytosteroid was isolated for the first time from C. lasiantha using n-hexane as ... more Stigmasterol, a phytosteroid was isolated for the first time from C. lasiantha using n-hexane as a solvent. Stigmasterol was characterized on the basis of physical, chemical and spectral data (IR, 1H NMR, 13C NMR, 1HNMR, DEPT-45, 90 & 135, and MS) analysis as well as by comparing them to their literature data. A sequence of steps was adopted like saponification, fractional crystallization and gradient elution column chromatography to isolate stigmasterol because some phytosterols possess identical physical properties which makes it difficult to isolate the constituents.
Asian Journal of Pharmaceutics, 2018
In history, medicinal plants were proven as a source of active compounds with therapeutic applica... more In history, medicinal plants were proven as a source of active compounds with therapeutic applications, and at present, they are an important collection for the discovery of novel drug leads. Caralluma is a genus used as traditional medicine. The present article thoroughly reviewed about the classification of Caralluma into subgenera, number of its species, its distribution in different parts of the world, and pharmacological activities exhibited by different species of Caralluma.
Asian Journal of Pharmaceutics, 2018
Aim: The objective of the current study is to develop a colorimetric method for the determination... more Aim: The objective of the current study is to develop a colorimetric method for the determination of mianserin, an antidepressant drug. Materials and Methods: Fast Sulphon Black F, an acidic dye was used to develop a soluble colored ion-pair complex. The complex was extracted into an organic solvent and absorbance was measured. Results: Reaction conditions were optimized to obtain a sensitive and stable chromophore (λmax 554 nm) in dichloromethane. Good linearity was observed for the calibration curve plotted in the studied concentration range (4–14 μg/mL) with regression analysis (r > 0.9997). High percentage recovery values (98.25–101.40) show that the method is accurate. Reproducibility of the method is evident from lower relative standard deviation (<2%) for both intra- and inter-day precision studies. Conclusions: The proposed method is validated as per the existing ICH guidelines. This method is simple as it does not require any pre-treatment process.
viXra, 2019
The kinetics of Ru(III) catalysed and uncatalysed oxidation of DL-alanine by N-bromosuccinimide (... more The kinetics of Ru(III) catalysed and uncatalysed oxidation of DL-alanine by N-bromosuccinimide (NBS) was studied in aqueous acetic acid and in the presence of perchloric acid and Hg (II). In both Ru(III) catalysed and uncatalysed oxidations, the kinetic orders were: first order in NBS, fractional order in substrate. The rate of the reaction decreased with the increase in perchloric acid concentration and addition of halide ions. The reactions were of fractional order with respect to Ru (III). Addition of Os(VIII) had no effect on the rate of oxidation of DL-alanine by NBS. The presence of catalysis with Ru (III) and the absence of catalysis with Os(VIII) in NBS oxidations was traced to different factors. A factor other than complexation could be a more powerful oxidant species like Ru (V) which accelerates the NBS oxidations. The effect of temperature was also investigated. By varying the solvent composition it was found that the reaction rate decreased with the decrease in dielect...
Results in Chemistry, 2021
Oriental Journal of Chemistry
A simple spectrophotometric method was developed to determine riociguat in bulk and tablet formul... more A simple spectrophotometric method was developed to determine riociguat in bulk and tablet formulation. The present method lies on the oxidation of MBTH by Fe +3 ions in acidic medium to form active coupling species and followed by its coupling with riociguat to form the chromophore having lmax 660 nm. Validated the proposed method as per the existing guidelines of ICH. Good linearity (r~ 0.999) was observed for calibration curve in the studied concentration range (6.25-37.50 μg mL-1). Reproducibility, accuracy and precision of the method were confirmed from low values of % RSD.
Oriental Journal of Chemistry
Phytochemical screening of Caralluma lasiantha was carried out and one C 21 pregnane steroid was ... more Phytochemical screening of Caralluma lasiantha was carried out and one C 21 pregnane steroid was isolated from chloroform extract. Based on spectroscopic studies (IR, 1 H NMR, 13 C NMR and ESI-MS) the isolated compound is 3b,14b-dihydroxy-14b-pregn-5-en-20-one which was earlier isolated from other species.
E-Journal of Chemistry, 2012
Some 4-thiazolidinone derivatives6(a-l)have been prepared bearing s-triazine moiety by the conden... more Some 4-thiazolidinone derivatives6(a-l)have been prepared bearing s-triazine moiety by the condensation of Schiff bases from bis-2,4 (4′-methyl-phenylamino)-s-triazine-6-ylaminobenzoyl substituted benzylhydrazone5(a-l)with thioglycolic acid. The structures of synthesized compound have been characterized by IR, 1HNMR spectral studies. The synthesized compounds6(a-l)has been screened for antibacterial activity.
Oriental Journal of Chemistry
A simple method is described to determine the amount of gemigliptin in bulk and tablet formulatio... more A simple method is described to determine the amount of gemigliptin in bulk and tablet formulation by visible spectrophotometry. Basis of the proposed method is the reaction of the primary amine present on gemigliptin with ninhydrin in alkaline pH (alkaline borate buffer) medium to produce a purple color (Ruhemann's purple) which has maximum absorption at 558 nm. The method was validated as per the current ICH guidelines. The obtained regression equation (y = 0.0148x+0.0011) in the range of 5-30 μg mL-1 has a good correlation coefficient (> 0.999). As the method does not require any separation, it is rapid and simple. The recovery levels of the drug were in the range of 99.73-99.96. This method is a green method as it no organic solvents were employed.
The kinetics of Ru(III) catalysed and uncatalysed oxidation of DL-alanine by N-bromosuccinimide (... more The kinetics of Ru(III) catalysed and uncatalysed oxidation of DL-alanine by N-bromosuccinimide (NBS) was studied in aqueous acetic acid and in the presence of perchloric acid and Hg (II). In both Ru(III) catalysed and uncatalysed oxidations, the kinetic orders were: first order in NBS, fractional order in substrate. The rate of the reaction decreased with the increase in perchloric acid concentration and addition of halide ions. The reactions were of fractional order with respect to Ru (III). Addition of Os(VIII) had no effect on the rate of oxidation of DL-alanine by NBS. The presence of catalysis with Ru (III) and the absence of catalysis with Os(VIII) in NBS oxidations was traced to different factors. A factor other than complexation could be a more powerful oxidant species like Ru (V) which accelerates the NBS oxidations. The effect of temperature was also investigated. By varying the solvent composition it was found that the reaction rate decreased with the decrease in dielectric constant of the solvent. All kinetic features were explained by postulating suitable mechanisms and rate laws.
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Papers by sireesha malladi