Papers by Alain-claude Roudot
Archives of Environmental and Occupational Health
In recent years more attention has been given to chemical exposure in hairdressers. This increasi... more In recent years more attention has been given to chemical exposure in hairdressers. This increasing interest is largely due to the various respiratory and skin symptoms observed in hairdressers. According to these symptoms, hairdressers are in contact with various sources of exposure. Particularly in France, little information is available to assess professional exposure of hairdressers. In order to gather information to assess exposure in hairdressers, eleven hairdressing salons were visited. All the salons were located in Brest city (France). Preferentially small hairdressing salons were visited. Observations were performed to obtain salon characteristics and to record workers' practices. Calculations revealed that in the worst case scenario, dermal professional exposure reaches 14.68 and 13.67 mg/kg/day for hair coloring and highlighting mixtures, respectively. Inhalation exposure represents 14.2 and 18.1 mg/kg/day for hair coloring and highlighting mixtures, respectively. Th...
Malaysian Journal of Nutrition
Molluscan Shellfish Safety, 2013
ABSTRACT In order to ensure food safety in Europe, the level of okadaic acid (OA) equivalents in ... more ABSTRACT In order to ensure food safety in Europe, the level of okadaic acid (OA) equivalents in live bivalve molluscs must not exceed 160 μg/kg of raw meat (Regulation 853/2004/EC). Therefore, sampling plans must be set up to monitor production areas, knowing that mussels be used as an indicator species (Regulation 854/2004/EC). During a contamination event, there is a high variability of contamination between mussels. For this reason, determining an appropriate sampling plan is difficult and must be made on a scientific basis. However, there has never been a probabilistic evaluation of the impact that sample size and the number of samples taken, have on the analytical results and the corresponding decision for the public safety of a specific lot of shellfish. In this paper we achieve this aim by the application of scientific method to contamination data already available in scientific publications. Variance data recorded in scientific publications are used to predict variance as a function of OA concentration. A lognormal distribution fits the observed OA distributions among individual mussels. A computer model is used to predict the probability of acceptance for a given sampling plan. By OC (Operating Characteristic) curves, the performance of several sampling plan designs is evaluated to demonstrate how to manipulate sample size, and number of samples analysed to reduce misclassification of production areas. According to these OC curves, a best fit sampling plan is proposed, which consists of taking two samples of 30–40 mussels each.
International Journal of Environmental Health Research, 2011
Shellfish consumption can be a major pathway of exposure to pollutants for humans. It is fundamen... more Shellfish consumption can be a major pathway of exposure to pollutants for humans. It is fundamental to know if people eat enough shellfish to cause health problems, firstly in high consumers as recreational shellfish harvesters. The objectives of this study were to investigate the types of shellfish eaten, number of meals, portion size, sources of shellfish and shellfish consumption rates
Food and Chemical Toxicology, 2014
Bisphenol A (BPA) is used in a wide variety of products and objects for consumers use (digital me... more Bisphenol A (BPA) is used in a wide variety of products and objects for consumers use (digital media such as CD's and DVD's, sport equipment, food and beverage containers, medical equipment). Here, we demonstrate the ubiquitous presence of this contaminant in foods with a background level of contamination of less than 5 μg/kg in 85% of the 1498 analysed samples. High levels of contamination (up to 400 μg/kg) were found in some foods of animal origin. We used a probabilistic approach to calculate dietary exposure from French individual consumption data for infants under 36 months, children and adolescents from 3 to 17 years, adults over 18 years and pregnant women. The estimated average dietary exposure ranged from 0.12 to 0.14 μg/kg body weight per day (bw/d) for infants, from 0.05 to 0.06 μg/kg bw/d for children and adolescents, from 0.038 to 0.040 μg/kg bw/d for adults and from 0.05 to 0.06 μg/kg bw/d for pregnant women. The main sources of exposure were canned foods (50% of the total exposure), products of animal origin (20%) and 30% as a background level. Based on the toxicological values set by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) for pregnant women, the risk was non negligible. Thus, we simulated scenarios to study the influence of cans and/or food of animal origin on the BPA-related risk for this specific population.
Journal of Applied Toxicology, 2011
The objective of this study was to evaluate the developmental toxic potential of di-n-propyl phth... more The objective of this study was to evaluate the developmental toxic potential of di-n-propyl phthalate (DnPP) in rats. Pregnant Sprague-Dawley rats were given DnPP at doses of 0 (olive oil), 0.5, 1 and 1.5 g kg -1 per day, by gavage, on gestation days 6-20. Benchmark doses were calculated for the effects of DnPP on fetal weight and anogenital distance of the male fetuses. Maternal body weight gain was significantly reduced at 1.5 g kg -1 per day, over gestation days 6-9. DnPP-treated dams also showed a statistically significant increase in liver weight and a mild but statistically significant peroxisomal enzyme induction at 1 or 1.5 g kg -1 per day. Male and female fetal body weights were significantly reduced at 1.5 g kg -1 per day. There was a statistically significant decrease in the anogenital distance of the male fetuses at 1 and 1.5 g kg -1 per day, and three males (of 75) showed malpositioned testis at the high dose. The mean percentage of fetuses per litter with cervical and thoracic rudimentary ribs was significantly increased at 1 and 1.5 g kg -1 per day. Delayed ossification was seen at 1 g kg -1 per day (phalanges) and 1.5 g kg -1 per day (hyoid, sternebrae, and phalanges). No treatment-related effects on prenatal viability or on fetal external or visceral malformations or variations were observed at any dose. Thus, there was no evidence of teratogenicity up to the high dose of 1.5 g kg -1 per day. The no-observed-adverse-effect level (NOAEL) for developmental toxicity was 0.5 g kg -1 per day.
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Papers by Alain-claude Roudot