Papers by Claude Jaquiéry
Eminektomie nach Myrhaug
Der MKG-Chirurg, Aug 16, 2016
ZusammenfassungHintergrundRezidivierende Unterkieferluxationen rufen bei Betroffenen einen hohen ... more ZusammenfassungHintergrundRezidivierende Unterkieferluxationen rufen bei Betroffenen einen hohen Leidensdruck hervor. Nach Ausschöpfung aller konservativen Maßnahmen werden daher oft weitergehende Therapien notwendig. Eine operative Therapieoption ist die Eminektomie nach Myrhaug.Material und MethodeNeben der Darstellung möglicher Therapieoptionen, auch im historischen Kontext, zeigt dieser Beitrag die retrospektiven Ergebnisse der bis zu 2,5 Jahren postoperativen Nachkontrollen einer Fallserie von 8 Patienten, bei denen eine ein- oder beidseitige Eminektomie durchgeführt wurde.ErgebnisseAlle Patienten profitierten von der Eminektomie, die jeweils komplikationslos durchgeführt werden konnte. Es traten keine Reluxationen auf. Zudem waren die funktionellen und ästhetischen Ergebnisse vollumfänglich zufriedenstellend.SchlussfolgerungenBei rezidivierenden Unterkieferluxationen ist die Eminektomie eine wirksame Therapieoption mit geringer Morbidität und wenigen Komplikationen. Eine präoperative Computertomographie zum Ausschluss einer Pneumatisation der Eminentia articularis wird empfohlen. Der Eingriff kann ein- oder beidseitig erfolgen.AbstractBackgroundRecurrent mandibular dislocation generates a considerable degree of suffering for affected patients. After exhausting all conservative treatment options, further surgical strategies are often necessary. Eminectomy according to Myrhaug is a surgical option to treat recurrent mandibular dislocationMaterial and methodsIn addition to the presentation of possible therapy options, also in a historical context, this article represents the retrospective results of 8 patients who underwent unilateral or bilateral eminectomy including a postoperative follow-up of 2.5 years.ResultsAll patients in this case series benefited from eminectomy, which in each case could be carried out with no complications. During the follow-up period no recurrences occurred. In addition, the functional and aesthetic results were considered to be entirely satisfactory.ConclusionsEminectomy according to Myrhaug is an effective option to treat recurrent mandibular dislocation with a low morbidity and a low complication rate. A preoperative computed tomography imaging is recommended to exclude pneumatization of the articular eminence. The method can be recommended for both bilateral and unilateral cases.
Journal of Clinical Medicine, Apr 19, 2023
This study aimed to evaluate the availability and use of dental and maxillofacial emergency algor... more This study aimed to evaluate the availability and use of dental and maxillofacial emergency algorithms in Swiss hospitals. A survey was performed among physicians at Swiss emergency departments (ED) and participants of the "36th Annual Meeting of the Society for Oral and Cranio-Maxillofacial Surgery". Eighty-nine EDs in Switzerland were questioned about the availability and use of electronic algorithms in their hospitals. Eighty-one (91%) participated in the study. In 75 (93%) of the EDs, electronic algorithms are used, mainly "medStandards". Six have no available algorithms. Fifty-two (64%) use algorithms daily. Eight (10%) Swiss EDs have maxillofacial and dental algorithms, and 73 (90%) have no access to or do not know about them. For dental algorithms, 28 (38%) of the respondents would like to have access, and 16 (22%) do not desire access. For maxillofacial algorithms, 23 (32%) want to have access and 21 (29%) do not want it. Most (74%) of the participating maxillofacial surgeons did not know about the existence of ED algorithms regarding their specialty. Our study shows that the existence of specific algorithms is often not known. Furthermore, there is a demand for dental and maxillofacial algorithms in Swiss EDs.
Analgesic benefit of metamizole and ibuprofen vs. either medication alone: a randomized clinical trial
Minerva Anestesiologica, Jun 1, 2022
BACKGROUND Postoperative pain relief remains a key problem after surgery. Multimodal pain therapy... more BACKGROUND Postoperative pain relief remains a key problem after surgery. Multimodal pain therapy has proven beneficial in alleviating pain to a certain extent. However, when combining non-opioids, the focus has been on NSAIDs and paracetamol, but effects of combined use are only moderate. Metamizole could be a potent adjunct, due to its preclusion in several countries, data on its combined use are sparse, despite its common use in many countries. The aim of this study was to examine whether the combination of metamizole and ibuprofen is superior in relieving postoperative pain to either drug alone. METHODS For this randomized, placebo-controlled, cross-over study, 35 patients undergoing bilateral lower third molar extraction were randomized. Each patient received three applications of 1000mg metamizole + 400mg ibuprofen for surgery on one side and either 1000mg metamizole + placebo or 400mg ibuprofen + placebo on the other side. Pain ratings, rescue-medication (tramadol), and sleep were assessed for 18 hours. RESULTS The combined treatment of metamizole and ibuprofen showed lower mean pain scores over 12 hours than ibuprofen (2.4±1.3 vs 3.8±1.6; P=0.005)). Further, combined treatment showed lower mean pain scores over 6 hours than ibuprofen (2.0±1.2 vs. 3.1±1.6; P=0.022) or metamizole alone (2.0±1.2 vs. 3.3±1.7; P=0.015). Consumption of rescue medication was lowest in the combination-group (25% vs. 46%-metamizole; 50%-ibuprofen). The trial was stopped prematurely as the COVID-pandemic halted elective surgeries. CONCLUSIONS Combined use enables superior pain control compared to ibuprofen after molar extraction and tends to be superior to metamizole alone. The premature study-termination may overestimate this effect.
Non-surgical treatment of mandibular fractures—survey of 28 patients
International Journal of Oral and Maxillofacial Surgery, Mar 1, 2004
Between January 1996 and January 2001 28 patients (nine females, nineteen males) with 35 fracture... more Between January 1996 and January 2001 28 patients (nine females, nineteen males) with 35 fractures were treated by observation and soft diet only. Patients with isolated high condylar neck fractures were not included. The mean age at time of trauma was 35.6 years (5/80). Only patients with normal occlusion and radiologically undisplaced fractures were included. The follow-up time was 15 weeks on average (8/33). The patients did not undergo any active treatment. They just received the instruction to reduce mouth opening and to take a soft diet for 4 weeks. During the first 2 weeks after the trauma the patients were seen twice a week. Follow-up X-rays were performed after 4 and after 8 to 12 weeks. As a preemptive therapy antibiotics (amoxicillin plus clavulanic acid 2 x 1g/day) were given for 5 days. Spontaneous healing of all fractures was observed. In two patients a tooth had to be removed out of the fracture line. One patient complained about an occlusal problem after 1 week. In his case intermaxillary fixation was installed for 2 weeks. For forensic reasons the patients have to be fully informed about possible complications before indicating this type of management. Patient selection is crucial and requires a highly experienced surgeon. Patient inconvenience due to frequent consultations must be taken into consideration. This type of treatment can be recommended only in selected cases.
Differentialtherapeutische Überlegungen zur Schädelbasisrekonstruktion mit freien Lappen
Handchirurgie Mikrochirurgie Plastische Chirurgie, May 18, 2005
Imstrumente, Materialien und Geräte SPI - Ein modernes Implantatsystem für die Praxis
Frontiers in Bioengineering and Biotechnology, 2022
Background: Devitalized bone matrix (DBM) is currently the gold standard alternative to autologou... more Background: Devitalized bone matrix (DBM) is currently the gold standard alternative to autologous bone grafting in maxillofacial surgery. However, it fully relies on its osteoconductive properties and therefore requires defects with healthy bone surrounding. Fractionated human adipose tissue, when differentiated into hypertrophic cartilage in vitro, was proven reproducibly osteogenic in vivo, by recapitulating endochondral ossification (ECO). Both types of bone substitutes were thus compared in an orthotopic, preclinical mandibular defect model in rat.Methods: Human adipose tissue samples were collected and cultured in vitro to generate disks of hypertrophic cartilage. After hypertrophic induction, eight samples from two donors were implanted into a mandible defect in rats, in parallel to Bio-Oss® DBM granules. After 12 weeks, the mandible samples were harvested and evaluated by Micro-CT and histology.Results: Micro-CT demonstrated reproducible ECO and complete restoration of the m...
調整可能な組成と機能の生体材料としての人工細胞外マトリックス【Powered by NICT】
Advanced Functional Materials, 2017
Journal of Cranio-Maxillofacial Surgery, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Bisphosphonate und Kiefernekrose
Bei der Osteoporoseprophylaxe und der Behandlung von ossaren Metastasen bei Tumorerkrankungen spi... more Bei der Osteoporoseprophylaxe und der Behandlung von ossaren Metastasen bei Tumorerkrankungen spielen Bisphosphonate eine nicht mehr wegzudenkende Rolle. Leider haufen sich in den letzten Jahren die Berichte uber spontane Nekrosen im Kieferbereich. Solche Nekrosen konnen zum Teil durch zahnarztliche Massnahmen ausgelost werden. Worauf ist also bei der Behandlung von Risikopatienten zu achten?
Manufacturing of Human Tissues as off‐the‐Shelf Grafts Programmed to Induce Regeneration
Advanced Materials, 2021
Design criteria for tissue‐engineered materials in regenerative medicine include robust biologica... more Design criteria for tissue‐engineered materials in regenerative medicine include robust biological effectiveness, off‐the‐shelf availability, and scalable manufacturing under standardized conditions. For bone repair, existing strategies rely on primary autologous cells, associated with unpredictable performance, limited availability and complex logistic. Here, a conceptual shift based on the manufacturing of devitalized human hypertrophic cartilage (HyC), as cell‐free material inducing bone formation by recapitulating the developmental process of endochondral ossification, is reported. The strategy relies on a customized human mesenchymal line expressing bone morphogenetic protein‐2 (BMP‐2), critically required for robust chondrogenesis and concomitant extracellular matrix (ECM) enrichment. Following apoptosis‐driven devitalization, lyophilization, and storage, the resulting off‐the‐shelf cartilage tissue exhibits unprecedented osteoinductive properties, unmatched by synthetic delivery of BMP‐2 or by living engineered grafts. Scalability and pre‐clinical efficacy are demonstrated by bioreactor‐based production and subsequent orthotopic assessment. The findings exemplify the broader paradigm of programming human cell lines as biological factory units to engineer customized ECMs, designed to activate specific regenerative processes.
International Journal of Molecular Sciences, 2020
Most bones of the human body form and heal through endochondral ossification, whereby hypertrophi... more Most bones of the human body form and heal through endochondral ossification, whereby hypertrophic cartilage (HyC) is formed and subsequently remodeled into bone. We previously demonstrated that HyC can be engineered from human mesenchymal stromal cells (hMSC), and subsequently devitalized by apoptosis induction. The resulting extracellular matrix (ECM) tissue retained osteoinductive properties, leading to ectopic bone formation. In this study, we aimed at engineering and devitalizing upscaled quantities of HyC ECM within a perfusion bioreactor, followed by in vivo assessment in an orthotopic bone repair model. We hypothesized that the devitalized HyC ECM would outperform a clinical product currently used for bone reconstructive surgery. Human MSC were genetically engineered with a gene cassette enabling apoptosis induction upon addition of an adjuvant. Engineered hMSC were seeded, differentiated, and devitalized within a perfusion bioreactor. The resulting HyC ECM was subsequently ...
European Cells and Materials, 2018
Several growth factors (GFs) are expressed as tendons heal, but it remains unknown whether their ... more Several growth factors (GFs) are expressed as tendons heal, but it remains unknown whether their combined application enhances the healing process. This matter was addressed by applying a combination of basic fibroblast growth factor (bFGF), bone morphogenetic protein 12 (BMP-12) and transforming growth factor beta 1 (TGFβ 1 ) in a rat Achilles tendon transection model. GFs were applied in one of the three following ways: i) direct application of all three factors at the time of surgery; ii) sequential, tiered percutaneous injection of individual factors immediately after surgery, 48 h and 96 h later; iii) load of all three factors onto a collagen sponge implanted at the time of surgery. After 1, 2, 4 and 8 weeks, healing was assessed based on tendon length and thickness, mechanical strength, stiffness and histology. Best results were achieved when GFs were loaded onto a collagen sponge -with a rapid increase in mechanical strength (load to failure, 71.2 N vs. 7.7 N in controls), consistent tendon length over time (9.9 mm vs. 16.2 mm in controls) and faster tendon remodelling, as measured by histology -followed by tiered injection therapy over 96 h. In conclusion, implantation of a GF-loaded collagen sponge could provide a promising treatment, especially in high-performance athletes and revision cases prone to re-rupture. For conservative treatment, tiered percutaneous GF application could be an option for improving clinical outcome.
Ober- und Unterkieferrekonstruktion mit präfabrizierten mikrovaskulären Fibulatransplantaten und osseointegrierten Implantaten – eine prospektive Studie
Handchirurgie · Mikrochirurgie · Plastische Chirurgie, 2005
Advanced Functional Materials, 2017
Engineered and decellularized extracellular matrices (ECM) are receiving increasing interest in r... more Engineered and decellularized extracellular matrices (ECM) are receiving increasing interest in regenerative medicine as materials capable to induce cell growth/differentiation and tissue repair by physiological presentation of embedded cues. However, ECM production/decellularization processes and control over their composition remain primary challenges. This study reports engineering of ECM materials with customized properties, based on genetic manipulation of immortalized and death‐inducible human mesenchymal stromal cells (hMSC), cultured within 3D porous scaffolds under perfusion flow. The strategy allows for robust ECM deposition and subsequent decellularization by deliberate cell‐apoptosis induction. As compared to standard production and freeze/thaw treatment, this grants superior preservation of ECM, leading to enhanced bone formation upon implantation in calvarial defects. Tunability of ECM composition and function is exemplified by modification of the cell line to overexpr...
Developments in X-Ray Tomography X, 2016
Micro computed tomography (μCT) is well established in virtually all fields of biomedical researc... more Micro computed tomography (μCT) is well established in virtually all fields of biomedical research, allowing for the non-destructive volumetric visualization of tissue morphology. A variety of specimens can be investigated, ranging from soft to hard tissue to engineered structures like scaffolds. Similarly, the size of the objects of interest ranges from a fraction of a millimeter to several tens of centimeters. While synchrotron radiation-based μCT still offers unrivaled data quality, the ever-improving technology of cathodic tube-based machines offers a valuable and more accessible alternative. The Biomaterials Science Center of the University of Basel operates a nanotom R m (phoenix|x-ray, GE Sensing & Inspection Technologies GmbH, Wunstorf, Germany), with a 180 kV source and a minimal spot size of about 0.9 µm. Through the adjustable focus-specimen and focus-detector distances, the effective pixel size can be adjusted from below 500 nm to about 80 µm. On the high-resolution side, it is for example possible to visualize the tubular network in sub-millimeter thin dentin specimens. It is then possible to locally extract parameters such as tubule diameter, density, or alignment, giving information on cell movements during tooth formation. On the other side, with a horizontal shift of the 3,072 pixels × 2,400 pixels detector, specimens up to 35 cm in diameter can be scanned. It is possible, for example, to scan an entire human knee, albeit with inferior resolution. Lab source μCT machines are thus a powerful and flexible tool for the advancement of biomedical research, and a valuable and more accessible alternative to synchrotron radiation facilities.
Cellular / tissue engineering - Bone and cartilage tissue engineering for facial reconstructive surgery
Der Risikopatient in der Oralchirurgie
Imstrumente, Materialien und Geräte SPI - Ein modernes Implantatsystem für die Praxis
Kieferrekonstruktion unter Verwendung von präformierten Fibulatransplantaten mit osseointegrierten dentalen Implantaten
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Papers by Claude Jaquiéry