Papers by Giuliana Scarpati
1 anesthesia and intensive care, University of salerno, salerno, italy; 2 Department of neuroscie... more 1 anesthesia and intensive care, University of salerno, salerno, italy; 2 Department of neurosciences, reproductive and odonto-stomatological sciences, University Hospital Federico ii, naples, italy; 3 anesthesia and intensive care, cardarelli Hospital, naples, italy *corresponding author: edoardo De robertis, Department of neurosciences, reproductive and odonto-stomatological sciences, University Hospital Federico ii, naples, italy. e-mail: [email protected] a B s t r a c t acute and chronic liver diseases may escalate to hepatic encephalopathy (He) and multiple organ failure, requiring admission and organ support in intensive care Unit (icU). Hepatic dysfunction in icU is a broad and complex topic; unfortunately, up to now, the understanding of its underlying pathophysiology is far from complete. He and cirrhotic cardiomyopathy (CCM) need timely diagnostic and therapeutic measures aiming at the identification and elimination of causative factors, to improve patients' prognosis. through this short review, we tried to answer the most asked questions about clinical features of He and ccM at the icU stage. (Cite this article as: scarpati g, De robertis e, esposito c, Piazza o. Hepatic encephalopathy and cirrhotic cardiomyopathy in intensive care Unit. Minerva anestesiol 2018;84:970-9.
Neurology International, 2010
The complex picture of inflammation and coagulation alterations comes to life in acute stroke pha... more The complex picture of inflammation and coagulation alterations comes to life in acute stroke phases. Increasing evidence points to a strong interaction and extensive crosstalk between the inflammation and coagulation systems: the interest towards this relationship has increased since recent experimental research showed that the early administration of antithrombin III (ATIII) decreases the volume of ischemia in mice and might be neuroprotective, playing an antiinflammatory role.
European Journal of Anaesthesiology, 2007
European Journal of Anaesthesiology, 2010
Translational Research means different things to different people, but it seems crucial to almost... more Translational Research means different things to different people, but it seems crucial to almost everyone. This discipline, although defined differently in academia, regulatory institutions, and industry, shares the fundamental vision of Translational Medicine, which efficiently and effectively translates basic scientific findings relevant to human disease into knowledge that benefits patients. In the present perspective, we collected commentaries and descriptions about Translational Medicine to stimulate discussion and better understand what Translational Medicine is.
International journal of general …, Jan 1, 2010
ObjectivesRestoration of circulation is crucial in the surgical patient management. Colloids and ... more ObjectivesRestoration of circulation is crucial in the surgical patient management. Colloids and crystalloids are widely used for blood volume therapy. We reviewed recent trials to evaluate efficacy and safety of hydroxyethyl starch (HES) 130/0.4 during surgery.Material and methodsA subjective, not systematic, review of literature was performed. Papers were searched to answer questions about efficacy of HES, its impact on coagulation and inflammation and its effects on pulmonary mechanics and renal function.ConclusionsHES 130/0.4 is effective for volume therapy and is less expensive than human albumin. Its effects on coagulation and renal function are manageable; it may ameliorate pulmonary permeability and reduce inflammation.
Translational Medicine @ UniSa - ISSN 2239-9747, Oct 1, 2012
Purpose: To develop a clinically relevant
porcine model for the study of hepatic metabolism of ... more Purpose: To develop a clinically relevant
porcine model for the study of hepatic metabolism of drugs
by means of hepatic vein catheterization.
Materials and Methods: review of literature and
elaboration of a hypothesis, design of an experimental
method.
Results: recent clinical studies were conducted by
withdrawing cirrhotic patients’ blood from right hepatic vein
during hepatic vein pressure gradient measurements. Basing
on our personal clinical experience and evaluation of
research needs, an experimental model is proposed.
Conclusions: contemporary measurement of peripheral
and hepatic concentration of drugs by peripheral vein and
hepatic vein catheterization can be used to create a reliable
and reproducible porcine model to study liver metabolism of
drugs in vivo.
Abstract-Arginine vasopressin (AVP) and its synthetic, long-acting analog terlipressin (TP) are p... more Abstract-Arginine vasopressin (AVP) and its synthetic, long-acting analog terlipressin (TP) are potent alternative vasoconstrictors in the treatment of septic patients with catecholamine-refractive vasodilatatory shock. Recent clinical data suggest that early administration of AVP analogues may be advantageous compared to a last resort therapy. However, it is still unknown whether vasopressin and terlipressin are equally effective for hemodynamic support in shock.
Background Metabolic management of brain-death organ donors includes correction of the hormonal p... more Background Metabolic management of brain-death organ donors includes correction of the hormonal perturbations that occur after cerebral death and impair circulatory function. Vasopressin is a hormone secreted by the posterior pituitary gland, which contributes to maintain systemic blood pressure by regulating urine secretion and small arteriole tonus. During brain death, the pituitary gland is damaged and hormone secretion rapidly ceases.
Nosocomial infection, in particular pneumonia, is an important risk factor for hospital mortality... more Nosocomial infection, in particular pneumonia, is an important risk factor for hospital mortality and morbidity. Acinetobacter baumannii is a common multi-resistant microorganism responsible of Ventilator Associated Pneumonia (VAP). Currently Colistin is a rescue therapy for this pathogen. The purpose of this study is to compare the outcome of VAP caused by Acinetobacter baumannii and VAP by other microorganisms in critical patients. Comorbidity, prognostic scores, mortality and eradication frequency did not turn out significantly different between the two study groups. Colistin safety was tested.
Books by Giuliana Scarpati
Translational medicine is the base of biomedicine that promotes the value of investments and actu... more Translational medicine is the base of biomedicine that promotes the value of investments and actualize the very revolution in modern science. Translational Research means different things to different people, but it seems crucial to almost everyone. This discipline, although defined differently in academia, regulatory institutions, and industry, shares the fundamental vision of Translational Medicine, which efficiently and effectively translates basic scientific findings relevant to human disease into knowledge that benefits patients. This book brings together descriptions about Translational Medicine to better understand what Translational Medicine is. It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation. The authors explore the dynamic interactions and key challenges.
Book Reviews by Giuliana Scarpati
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Papers by Giuliana Scarpati
porcine model for the study of hepatic metabolism of drugs
by means of hepatic vein catheterization.
Materials and Methods: review of literature and
elaboration of a hypothesis, design of an experimental
method.
Results: recent clinical studies were conducted by
withdrawing cirrhotic patients’ blood from right hepatic vein
during hepatic vein pressure gradient measurements. Basing
on our personal clinical experience and evaluation of
research needs, an experimental model is proposed.
Conclusions: contemporary measurement of peripheral
and hepatic concentration of drugs by peripheral vein and
hepatic vein catheterization can be used to create a reliable
and reproducible porcine model to study liver metabolism of
drugs in vivo.
Books by Giuliana Scarpati
Book Reviews by Giuliana Scarpati
porcine model for the study of hepatic metabolism of drugs
by means of hepatic vein catheterization.
Materials and Methods: review of literature and
elaboration of a hypothesis, design of an experimental
method.
Results: recent clinical studies were conducted by
withdrawing cirrhotic patients’ blood from right hepatic vein
during hepatic vein pressure gradient measurements. Basing
on our personal clinical experience and evaluation of
research needs, an experimental model is proposed.
Conclusions: contemporary measurement of peripheral
and hepatic concentration of drugs by peripheral vein and
hepatic vein catheterization can be used to create a reliable
and reproducible porcine model to study liver metabolism of
drugs in vivo.