Papers by martina marušić
Journal of Clinical Medicine
Almost two years after remdesivir was approved and extensively used in numerous clinical studies ... more Almost two years after remdesivir was approved and extensively used in numerous clinical studies for the treatment of COVID-19 patients, there is still no clear recommendation for the time and phase of the disease of remdesivir administration. This retrospective observational study included adults (≥18 years) with severe COVID-19, radiologically confirmed pneumonia, a need for supplemental oxygen and an interval from symptom onset to enrolment of 10 days or less. All patients were treated with remdesivir for 5 to 10 days, or with clinical improvement within that period. The primary goal was the outcome in patients treated with remdesivir during the early stage of the disease considering the different disease severity. The median time from symptom onset to treatment was 8.4 days (3–10). Clinical improvements and good outcomes were observed in 104 of 137 patients (75.9%); 33 (24.1%) of 137 patients died. Subgroup analyses showed that the mortality rate was significantly lower in moder...
SZO definira zdravlje kao stanje potpunog fizičkog, mentalnog i društvenog blagostanja, a ne samo... more SZO definira zdravlje kao stanje potpunog fizičkog, mentalnog i društvenog blagostanja, a ne samo odsustva bolesti ili slabosti. Kvaliteta života definirana je kao percepcija pojedinaca o njihovom položaju u životu u kontekstu kulture i vrijednosnih sustava u kojima žive, te u odnosu na njihove vlastite ciljeve. Posttraumatski stresni poremećaj (PTSP) psihijatrijski je poremećaj koji se može razviti u osoba aktivno ili pasivno izloženih životno ugrožavajućim iskustvima, a karakteriziraju ga simptomi poput ponovnog i trajnog prisjećanja na traumatski događaj, praćeno pretjeranom pobudljivošću i izbjegavanjem, te obamrlost. Premda je PTSP prvenstveno povezan sa mentalnim zdravljem, ne može se isključiti utjecaj tog poremećaja na fizičko zdravlje. Dosadašnja istraživanja pokazuju narušenu kvalitetu života u oboljelih od ovog poremećaja, uz česte poteškoće u psihosocijalnom funkcioniranju. Glavni cilj ovog istraživanja bio je utvrditi povezanost kvalitete života i težine simptoma PTSP-a...
Antibiotics
Background/Objectives: Prophylactic antibiotics (PAB) are being still widely used for treatment o... more Background/Objectives: Prophylactic antibiotics (PAB) are being still widely used for treatment of acute pancreatitis (AP) despite trials showing no firm evidence of efficacy. We aimed to evaluate effects of PAB for AP in a meta-analysis and the need for further research by trial sequential analysis (TSA). Methods: Medline, Scopus and Web of Science were searched for randomized clinical trials. Primary outcomes were all infections and mortality. Secondary outcomes comprised infected pancreatic necrosis (IPN), specific infections, organ failure, surgical interventions, and length of hospital stay. Results: Twenty-one trials with 1383 pts were included. PAB were received by 703 pts, while 680 were controls. Mortality was similar with RR 0.85 (95% CI 0.66–1.10). Infections were significantly reduced (RR 0.60; 95% CI 0.49–0.74), mainly due to decreased risk of sepsis (RR 0.43; 95% CI 0.25–0.73) and urinary tract infections (RR 0.46; 95% CI 0.25–0.86). No significant reduction for IPN wa...
Sveučilište u Rijeci. Medicinski fakultet. Katedra za psihijatriju i psihološku medicinu., Jul 12, 2019
Baza podataka je organizirana i uređena cjelina međusobno povezanih podataka spremljenih bez nepo... more Baza podataka je organizirana i uređena cjelina međusobno povezanih podataka spremljenih bez nepotrebne redundancije. Razlikujemo tri vrste baza pod
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Papers by martina marušić