Papers by Abdulmumeen Hamid
Ife Journal of Science
The preliminary phytochemical investigation of n-hexane, ethyl acetate and methanol extracts of T... more The preliminary phytochemical investigation of n-hexane, ethyl acetate and methanol extracts of Thaumatococcus daniellii leaves revealed the presence of fats and oils, terpenoids, flavonoids, steroids and glycosides. The antimicrobial tests against some strains of bacteria and fungi showed inhibitions at moderate to high concentrations. Methanol extract of the plant exhibited low 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with IC of 615.14 µg/ml. Gas chromatography-mass spectrometry (GC-MS) 50 characterization of n-hexane, ethylacetate and methanol extracts of T. daniellii leaves identified , thirteen and fifteen compounds, with tetracontane (28.76%) and L-ascorbic acid (15.07%); hexadecanoic acid (21.62%) and γ-sitosterol (11.06%); and naphthalene-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-,[1R(1.alpha.,7.beta.,8a.alpha.] (26.90%) and hexadecanoic acid (12.60%) being the major compounds respectively. The GC-MS analysis revealed various peaks of bioactive compounds of which the antioxidant and antimicrobial activities of the plant have been attributed to the prominent compounds in synergy with all the other compounds present in smaller quantities in the extracts.
And Antifungal Properties
Pharmacological investigation of Asystasia calyciana for its antibacterial
Journal of Ethnopharmacology, 2012
The phytochemical screening of Grewia pubescens leaf extracts showed the presence of alkaloids, s... more The phytochemical screening of Grewia pubescens leaf extracts showed the presence of alkaloids, steroids, terpenoids, flavonoids, saponins, anthraquinones, tannins, glycosides and fats and oils. Hexane, ethyl acetate and methanol extracts of the plant were...
The Preliminary phytoconstituent analysis of the hexane, ethylacetate and methanol extracts of Sm... more The Preliminary phytoconstituent analysis of the hexane, ethylacetate and methanol extracts of Smilax kraussiana leaves revealed the presence of glycosides, flavonoids and anthraquinones. The three extracts were evaluated invitro to determine inhibition of human pathogenic microorganisms made up of six bacteria and six fungi. The extracts inhibited the growth of the twelve test organisms significantly. Hexane and methanol extracts showed higher inhibition on Staphylococcus aureus and Bacillus subtilis (gram positive) than ethylacetate extract at concentrations between 25 and 200mg/mL, while all extracts possess lower antibacterial properties on Escherichia coli, Pseudomonas aeruginosa, Klebsiellae pneumonae and Salmonellae typhii (gram negative).However, hexane, ethylacetate and methanol extracts of Smilax kraussiana leaves exhibited higher antifungal activities on Candida albicans, Aspergillus niger, Rhizopus stolon, Penicillum notatum, Tricophyton rubrum and Epidermophyton floccos...
Research Journal of Agriculture and Biological Sciences, 2010
Hydrodistilled leaves of Clausena anisata yielded 0.55% (v/w) of essential oil. Analyses of the o... more Hydrodistilled leaves of Clausena anisata yielded 0.55% (v/w) of essential oil. Analyses of the oil by GC and GC/MS revealed that the oil was characterized by the abundance of phenylpropanoids, with anethole (31.1%) as the most abundant compound. Other principal constituents of the oil were trans-β- ocimene (20.0%), β-elemene (10.5%), estragole (6.9%), α-pinene (6.7%) and γ-cadinene (5.4%). Key word: Phenylpropanoids, anethole, estragole, trans-β-ocimene, β-elemene
Advances in Applied Science Research, 2011
The preliminary phytochemical studies of Baleria opaca (whole plant) extracts revealed the presen... more The preliminary phytochemical studies of Baleria opaca (whole plant) extracts revealed the presence of saponins, tannins, glycosides, alkaloids and anthraquinones, but absence of reducing sugars and flavonoids. Hexane, ethylacetate and methanol successive extracts of Baleria opaca effectively inhibited the growth of six test bacteria and six test fungi at different concentrations. The Methanol extract exhibited higher antibacterial properties than both hexane and ethylacetate extracts on Staphylococcus aureus and Bacillus subtilis (gram positive), Escherichia coli, Pseudomonas aeruginosa, Salmonellae typhii and Klebsiellae pneumonae (gram negative). All the extracts also exhibited significant antifungal properties on Candida albicans, Aspergillus niger, Rhizopus stolon, penicillum notatum, Tricophyton rubrum and Epidermophyton floccosum at concentrations between 25 and 200 mg/ml.
COVID-19: Critical discussion on the applications and implications of chemicals in sanitizers and disinfectants
EXCLI Journal, 2020
Advances in Environmental Biology, 2010
The uses of Brysocarpus coccineus stem in traditional African medicine have led to the antibacter... more The uses of Brysocarpus coccineus stem in traditional African medicine have led to the antibacterial and antifungal activities of the hexane, ethylacetate and methanol stem extracts of the plant evaluation using six pathogenic bacteria and six fungi. The extracts inhibited the 12 test organisms to different degrees. Hexane, ethylacetate and methanol successive extracts of Brysocarpus coccineus stem effectively inhibited the growth of Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa at concentrations between 12.5 and 200mg/ml, while the extracts showed lower inhibition on Staphylococcus aureus, Salmonellae typhii and Klebsiellae pneumonae. The sensitivity of test bacteria was concentration dependent, activity being higher at higher concentrations of the three extracts. Ethylacetate and methanol exhibited higher antifungal properties on Rhizopus stolon and Epidermophyton floccosum, while hexane also inhibited the growth of Rhizopus stolon, Epidermophyton floccosum, Trico...
Bush burning has been a detriment to the environment and health of mankind. It involves the produ... more Bush burning has been a detriment to the environment and health of mankind. It involves the production of air pollutants, such as carbon monoxide, hydrocarbons, hydrogen sulphide, nitrogen oxides, sulphur oxides, ozone and other oxidants. Particulate pollutants like dust, fume, mist and smoke are also obtained from bush burning. The sources and effects of these pollutants were treated in this study. The effects and problems of bush burning on man and his environment were also reported. Other health and environmental hazards reported in this study were acid rain, the green house effect, depletion of ozone layer and deforestation. Further, the quantification, control and monitoring techniques of these pollutants were reported in this review.
Nigerian Journal of Chemical Research, 2018
Antioxidant and anti-inflammatory activity of the extracts of Funtunmiaafricana(Benth.) stapfleav... more Antioxidant and anti-inflammatory activity of the extracts of Funtunmiaafricana(Benth.) stapfleaves were investigated in this study. The leaf part of Funtunmiaafricanawere dried, weighed, and exhaustively extracted with n-hexane and chloroform. GC-MS analysis of the extracts was carried out to know the number of compounds present in the extract as well as their molecular formula. These extracts of the plant were evaluated for antioxidant and anti-inflammatory activity using peroxide scavenging, lipoxidase and membrane stabilization. Hexane extract showed antioxidant activity with IC 50 of 194.09 μg/mL. Hexane and chloroform extracts also showed pronounced anti-inflammatory activity. The GC-MS analysis of the plant extracts showed the presence of twenty-eight compounds in chloroform extract, with terpenoids, fatty acids and unsaturated hydrocarbons as its principal components, while seven compounds were revealed in hexane extract of the plant, and its most abundant compound is 1,2-Be...
Advances in Environmental Biology, 2010
Pulverized leaf of vitex agnus-castus on hydrodistillation, afforded oil in the yield of 0.8%v/w.... more Pulverized leaf of vitex agnus-castus on hydrodistillation, afforded oil in the yield of 0.8%v/w. GC, GC/MS analyses of the oil revealed the abundance of hydrocarbon and oxygenated monoterpenes (53.2 and 24.5% respectively). The major constituents of the oil were; β-pinene (20.0%), viridiflorol (9.8%), α-pinene (9.1%), cisocimene (8.4%), 1,8-cineole (6.7%), β-farnesene (5.4%), terpinen-4-ol (4.2%), α-terpineol (4.1%) and β-phellandrene (4.1%).
In Pursuit of New Anti-malarial Candidates: Novel Synthesized and Characterized Pyrano-benzodioxepin Analogs Attenuated Plasmodium berghei Replication in Malaria-infected Mice
Heliyon
Advances in Applied Science Research, 2011
The hexane, ethylacetate and methanol extracts obtained from the whole plant of Asystasia gangeti... more The hexane, ethylacetate and methanol extracts obtained from the whole plant of Asystasia gangetica were evaluated invitro to determine inhibition of human pathogenic microorganisms made up of six bacteria and six fungi. The crude extracts inhibited the growth of twelve test organisms to different degrees. All the bacteria strains were sensitive to all the extracts at concentration ranging from 50 to 200mg/mL using the agar diffusion pour plate method. The inhibition of these test organisms were concentration dependent, activity being higher at higher concentrations of all the three extracts. The extracts showed higher antifungal properties on Candida albicans, Penicillum notatum, Tricophyton rubrum and Epidermophyton floccosum with activity comparable to that of the reference drug, Tioconazole. Preliminary phytochemical investigation of the extracts revealed the presence of saponins, reducing sugar, steroids, glycosides, flavonoids and anthraquinones.
Pulverized leaves of Aspilia africana afforded oil in the yield of 0.08% v/w. GC, GC/MS analyses ... more Pulverized leaves of Aspilia africana afforded oil in the yield of 0.08% v/w. GC, GC/MS analyses of the oil revealed the abundance of sesquiterpenes (57.5%), with �-cubebene (31.1%) as the major component. Copaene (7.0%) and �-caryophyllene (4.8%) existed in appreciable quantities. Predominant monoterpenes were: �-pinene (6.7%), �-thujene (5.1%) and car-3-ene (5.0%).
The phytochemical investigation of Asystasia calyciana (whole plant) extracts revealed the presen... more The phytochemical investigation of Asystasia calyciana (whole plant) extracts revealed the presence of saponins, tannins, steroids, glycosides, flavonoids and anthraquinones. The hexane, ethylacetate and methanol extracts of Asystasia calyciana were evaluated invitro to determine inhibition of human pathogenic microorganisms made up of six bacteria and six fungi. The plant metabolites inhibited the growth of twelve test organisms at different concentrations between 12.5 and 200mg/ml using agar diffusion plate method. The hexane extract exhibited higher antibacterial properties than both ethylacetate and methanol extracts of the plant. The hexane and ethylacetate extracts revealed higher antifungal properties than the methanol extract of A. calyciana, with activity of hexane and ethylacetate extracts comparable to that of the reference drug (tioconazole) against Candida albicans, Rhizopus stolon, Pneumonae notatum, Tricophyton rubrum and Epidermophyton floccosum and Candida albicans ...
Triterpenoids from the Aerial Parts of Smilax kraussiana as Antitumor Agents
Smilax kraussiana Meisn. (Synonym Smilax korthalsii A. DC.) is an ornamental plant. It is an ever... more Smilax kraussiana Meisn. (Synonym Smilax korthalsii A. DC.) is an ornamental plant. It is an evergreen shrub with climbing branches, stapler tendrils, and thorny flowers [1–9]. It is commonly known as West African sarsaparilla. Traditionally it is known as Odufat by the Ibibios, Uruk–ekwong by the Efiks, Jiabanammuo by the Ibos, Kurangawofi by the Hausas, and Ekanamagbo/Egun-igbao by the Yoruba of Nigeria. Preliminary work on the root of the plant revealed that it contained saponins, tannins, simple sugars, cardiac glycosides, and flavonoids [10]. The plant is used in the treatment of tumors, infertility, inflammatory rheumatism, gout, kidney problems, gonorrhea and syphilis, fever, malaria, and skin diseases [1, 4, 5, 11–13]. Some of the therapeutic properties of the plant have been established by various researchers. The acute toxicity potential of the plant and its antiplasmodial, antipyretic, anti-inflammatory, contraceptive, as well as analgesic activities, have been reported [...
Hormones
Preparation and Processing of Religious and Cultural Foods
Medicinal Chemistry Research, Dec 26, 2017
The original version of this article unfortunately contained a mistake. The first sentence under ... more The original version of this article unfortunately contained a mistake. The first sentence under the sub-heading "Cell culture and MTT assay for cell viability" is incorrect. The corrected sentence is given below, "Three human cancer cell lines namely K562 (Leukemia), WRL68 (hepatic) and MCF-7 (breast) obtained from National Centre for Cell Science (NCCS), Pune, India were cultured and maintained at CSIR-CIMAP, Lucknow. The cell lines were cultured in DMEM/Ham's F-12 medium containing 10% heatinactivated FBS, 5 mg/mL of penicillin, 10 mg/mL of neomycin, and 5 mg/mL streptomycin."
Uploads
Papers by Abdulmumeen Hamid