Papers by Francisco Merlano
Journal of Nuclear Cardiology, 2005
Objective: To assess the effects combined therapy of inhibitor ACE, perindopril (P) and metabolic... more Objective: To assess the effects combined therapy of inhibitor ACE, perindopril (P) and metabolic anti-ischaemic agent, trimetazidine MR (T) on the parameters of myocardial ischaemia and on dynamic of left ventricular (LV) remodelling in hypertensive patients (pts ). Design and Methods: We studied 36 pts with BP Ն160/100 mm Hg (22 male and 14 female, average age 51.4 Ϯ3.7years) and with LV hypertrophy and silent myocardial ischaemia estimated by changes in wall motion score index ( WMSI ) at rest and at peak of the dobutamine stress-echocardiography (SE). The pts were randomized into two groups by 18 in each: I-was administered P (4-8 mg o.d.) and T (35 mg t.d.); II -P in same dose and placebo. Echocardiography and SE were performed at basiline and after 6 mounts of treatment. Results: BP fell less than 140/90 mm Hg in all groups. LV hypertrophy regression was observed in I and II groups by 83.3% and 77.8% accordingly. The WMSI was substantially improved at rest and at peak of the SE in the responders to regression and more pronounced in I group compared with II group: I-from 1.44Ϯ0.02 to 1.29Ϯ.01 at rest and from 1.72Ϯ0.02 to 1.52Ϯ0.01 at peak of SE (pϽ0.001, for each) II-from 1.41Ϯ0.03 to 1.31Ϯ0.02 at rest and from 1.69Ϯ0.04 to 1.58Ϯ0.03 at peak of SE (pϽ0.05). Simultaneously with LV hypertrophy regression and reduction of myocardial ischaemia parameters there was observed the improvement of diastolic function more expressed in I group compare with II group: peak of velocity of early and late filling ratio (E/A) was increased in I-from 0.95Ϯ0.03 to 1.26Ϯ0.02 (pϽ0.001); in II-from 0.94Ϯ0.02 to 1.16Ϯ0.03 (pϽ0.05); the isovolumetric relaxation time was decreased in all groups: I -from 137.5Ϯ5.03 to 103.1Ϯ3.08 msec (pϽ0.002); II-from 136.1Ϯ5.10 to 118.1Ϯ4.08 msec pϽ0.05). Conclusion: Despite identical fall of BP and LV hypertrophy regression the combined therapy with P and T produces more pronounced reduction of myocardial ischaemia and restoration of LV function compare with monotherapy of P in hypertensive pts.
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Papers by Francisco Merlano