We demonstrate that abundant quantities of short-lived β unstable ions can be trapped in a novel ... more We demonstrate that abundant quantities of short-lived β unstable ions can be trapped in a novel transparent Paul trap and that their decay products can directly be detected in coincidence. Low energy 6 He + (807 ms half-life) ions were extracted from the SPIRAL source at GANIL, then decelerated, cooled and bunched by means of the buffer gas cooling technique. More than 10 8 ions have been stored over a measuring period of six days and about 10 5 decay coincidences between the beta particles and the 6 Li ++ recoiling ions have been recorded. The technique can be extended to other short-lived species, opening new possibilities for trap assisted decay experiments.
Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms, 2008
The LPCTrap is a device whose central element is a transparent Paul trap for the efficient trappi... more The LPCTrap is a device whose central element is a transparent Paul trap for the efficient trapping of low energy radioactive ions produced by the SPIRAL facility at GANIL. The installation comprises a linear RFQ cooler and buncher for the beam preparation, and a decay chamber where the Paul trap is located. The system has been tested with ions having mass-to-charge ratios ranging from 4 to 40. The first run with radioactive 6 He + ions has demonstrated the overall performance of the system. In this contribution we describe the current status of the device, we present in particular the results of a numerical study carried out to determine the properties of the ion cloud inside the trap and provide updated values for the overall efficiency of the system.
We prove that a finite-dimensional Banach space X has numerical index 0 if and only if it is the ... more We prove that a finite-dimensional Banach space X has numerical index 0 if and only if it is the direct sum of a real space X 0 and nonzero complex spaces X 1 , . . . , Xn in such a way that the equality x 0 + e iq 1 ρ x 1 + · · · + e iqnρ xn = x 0 + · · · + xn holds for suitable positive integers q 1 , . . . , qn, and every ρ ∈ R and every x j ∈ X j (j = 0, 1, . . . , n). If the dimension of X is two, then the above result gives X = C, whereas dim(X) = 3 implies that X is an absolute sum of R and C. We also give an example showing that, in general, the number of complex spaces cannot be reduced to one.
The application of traps to precision measurements of the β-ν angular correlation coefficient a i... more The application of traps to precision measurements of the β-ν angular correlation coefficient a in nuclear β-decay is pursued by several laboratories world wide. Various nuclear transitions are addressed and different trap devices are used. At GANIL, a novel transparent Paul trap (LPCTrap) has been built downstream from the SPIRAL source to determine a in the pure Gamow-Teller decay of 6He. This transition is driven by the axial-vector interaction. The forbidden tensor interaction may be observed through a precise measurement of a. The LPCTrap consists of an RFQ-Buncher, a transparent Paul trap, and the detection system. It is currently the only facility that uses a Paul trap with a novel geometry to perform high-precision nuclear physics experiments. All the elements have been tested and meet the requirements. In this contribution we give a short status report of the project underlining the highlights achieved so far.
American cutaneous leishmaniasis (ACL) has been characterized as a zoonotic disease. However, per... more American cutaneous leishmaniasis (ACL) has been characterized as a zoonotic disease. However, peridomestic and domestic transmission have been recorded in at least nine countries in Central and South America. The present study was undertaken to identify the etiologic agent of a peridomestic epidemic of ACL in the Department of Tolima, Colombia. Leishmania isolates were obtained during the diagnosis of 56 patients with ACL who consulted the local leishmaniasis control program in three municipalities in Tolima. Species were identified using monoclonal antibodies and isoenzyme electrophoresis. A total of 53 (94.6%) of 56 isolates were identified as Leishmania (Viannia) guyanensis. Three isolates (5.4%) were identified as L. (V.) panamensis. Leishmania (V.) guyanensis is the probable etiologic agent of the largest epidemic of cutaneous leishmaniasis recorded in Colombia. This species has not previously been reported outside the Amazon and southeastern regions of Colombia, and has not been described in the peridomestic setting or linked with an epidemic.
Journal of Physics G-nuclear and Particle Physics, 2011
We have measured the β-ν angular correlation in the β decay of 6He+ ions using a transparent Paul... more We have measured the β-ν angular correlation in the β decay of 6He+ ions using a transparent Paul trap. The 6He+ ions, produced at GANIL, were first cooled and bunched before being injected in the LPCTrap setup. The angular correlation was inferred from the time of flight of recoil nuclei detected in coincidence with the β particles. The detection system gives access to the full β decay kinematics, providing means to check the data reliability and to reject a large fraction of background. We find aβν = -0.3335(73)stat(75)syst, in agreement with the standard model prediction for a pure Gamow-Teller transition.
Human embryonic stem cells (hESCs) have the potential to differentiate to diverse cell types. Thi... more Human embryonic stem cells (hESCs) have the potential to differentiate to diverse cell types. This ability endows hESCs with promise for the development of novel therapeutics, as well as promise for the development of a rigorous genetic system to probe human gene function. However, in spite of the impending utility of hESCs for clinical and basic applications, little is known about their fundamental properties. Recent reports have documented transcriptional profiles of mouse embryonic stem cells (mESCs), adult stem cells and a single hESC line, H9. To date, however, the transcriptional profiles of independently-derived hESC lines have not been compared. In order to examine the similarities and differences in multiple hESC lines, we compared gene expression profiles of the HSF-1, HSF-6 and H9 lines. We found that the majority of genes examined were expressed in all three cell lines. However, we also observed that each line possessed a unique expression signature; the expression of many genes was limited to just one or two hESC lines. We suggest that the observed differences in gene expression between independently-derived hESC lines may reflect inherent differences in the initial culture of each line and/or the underlying genetics of the embryos from which the lines were derived.
Presentamos el caso de un paciente masculino de 37 años, con el antecedente de que hace un año co... more Presentamos el caso de un paciente masculino de 37 años, con el antecedente de que hace un año comenzó con lesiones cutáneas constituidas por habones asociadas a deposiciones diarreicas, signos que desaparecieron sin tratamiento. Posteriormente, en las áreas donde hubo ronchas, aparecieron otras lesiones y el cuadro dermatológico fue adquiriendo gran polimorfismo. Se observó, vesículas, ampollas, excoriaciones y costras de forma bilateral y simétrica en tronco y raíces de extremidades. Se hizo el diagnóstico clínico e histológico (coloración de hematoxilina y eosina) de dermatitis herpetiforme, instituyéndose tratamiento a base de Dapsone y dieta libre de gluten, con lo que se logró el control del cuadro cutáneo. Sin embargo, persistieron los cuadros diarreicos, aunque de forma ocasional. El paciente interrumpió la terapéutica y reaparecieron las lesiones. Al reiniciar la terapéutica con sulfona, llamó la atención que aparecieron nuevos elementos ampollares más grandes en miembros inferiores, dejando amplias áreas denudadas. Se decidió hospitalizar al paciente para estudiarlo nuevamente. El estudio histológico por inmunofluerescencia directa (IFD) demostró la presencia de depósitos lineales de IgA a nivel de la unión dermoepidérmica. Se comprobó que el cuadro diarreico crónico fue causado por un síndrome de mala absorción secundario a giardiasis. Se arribó a la conclusión diagnóstica de que el paciente no era portador de dermatitis herpetiforme, sino de dermatosis IgA lineal del adulto. Consideramos que es de vital importancia la realización de la inmunofluorescencia directa de la piel sana perilesional, para el diagnóstico correcto de las enfermedades ampollares autoinmunes. Este es el primer caso de dermatosis IgA lineal del adulto que se publica en nuestro país (Cuba) y aunque la enfermedad es sumamente rara, pudiesen existir otros casos.
We demonstrate that abundant quantities of short-lived β unstable ions can be trapped in a novel ... more We demonstrate that abundant quantities of short-lived β unstable ions can be trapped in a novel transparent Paul trap and that their decay products can directly be detected in coincidence. Low energy 6 He + (807 ms half-life) ions were extracted from the SPIRAL source at GANIL, then decelerated, cooled and bunched by means of the buffer gas cooling technique. More than 10 8 ions have been stored over a measuring period of six days and about 10 5 decay coincidences between the beta particles and the 6 Li ++ recoiling ions have been recorded. The technique can be extended to other short-lived species, opening new possibilities for trap assisted decay experiments.
Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms, 2008
The LPCTrap is a device whose central element is a transparent Paul trap for the efficient trappi... more The LPCTrap is a device whose central element is a transparent Paul trap for the efficient trapping of low energy radioactive ions produced by the SPIRAL facility at GANIL. The installation comprises a linear RFQ cooler and buncher for the beam preparation, and a decay chamber where the Paul trap is located. The system has been tested with ions having mass-to-charge ratios ranging from 4 to 40. The first run with radioactive 6 He + ions has demonstrated the overall performance of the system. In this contribution we describe the current status of the device, we present in particular the results of a numerical study carried out to determine the properties of the ion cloud inside the trap and provide updated values for the overall efficiency of the system.
We prove that a finite-dimensional Banach space X has numerical index 0 if and only if it is the ... more We prove that a finite-dimensional Banach space X has numerical index 0 if and only if it is the direct sum of a real space X 0 and nonzero complex spaces X 1 , . . . , Xn in such a way that the equality x 0 + e iq 1 ρ x 1 + · · · + e iqnρ xn = x 0 + · · · + xn holds for suitable positive integers q 1 , . . . , qn, and every ρ ∈ R and every x j ∈ X j (j = 0, 1, . . . , n). If the dimension of X is two, then the above result gives X = C, whereas dim(X) = 3 implies that X is an absolute sum of R and C. We also give an example showing that, in general, the number of complex spaces cannot be reduced to one.
The application of traps to precision measurements of the β-ν angular correlation coefficient a i... more The application of traps to precision measurements of the β-ν angular correlation coefficient a in nuclear β-decay is pursued by several laboratories world wide. Various nuclear transitions are addressed and different trap devices are used. At GANIL, a novel transparent Paul trap (LPCTrap) has been built downstream from the SPIRAL source to determine a in the pure Gamow-Teller decay of 6He. This transition is driven by the axial-vector interaction. The forbidden tensor interaction may be observed through a precise measurement of a. The LPCTrap consists of an RFQ-Buncher, a transparent Paul trap, and the detection system. It is currently the only facility that uses a Paul trap with a novel geometry to perform high-precision nuclear physics experiments. All the elements have been tested and meet the requirements. In this contribution we give a short status report of the project underlining the highlights achieved so far.
American cutaneous leishmaniasis (ACL) has been characterized as a zoonotic disease. However, per... more American cutaneous leishmaniasis (ACL) has been characterized as a zoonotic disease. However, peridomestic and domestic transmission have been recorded in at least nine countries in Central and South America. The present study was undertaken to identify the etiologic agent of a peridomestic epidemic of ACL in the Department of Tolima, Colombia. Leishmania isolates were obtained during the diagnosis of 56 patients with ACL who consulted the local leishmaniasis control program in three municipalities in Tolima. Species were identified using monoclonal antibodies and isoenzyme electrophoresis. A total of 53 (94.6%) of 56 isolates were identified as Leishmania (Viannia) guyanensis. Three isolates (5.4%) were identified as L. (V.) panamensis. Leishmania (V.) guyanensis is the probable etiologic agent of the largest epidemic of cutaneous leishmaniasis recorded in Colombia. This species has not previously been reported outside the Amazon and southeastern regions of Colombia, and has not been described in the peridomestic setting or linked with an epidemic.
Journal of Physics G-nuclear and Particle Physics, 2011
We have measured the β-ν angular correlation in the β decay of 6He+ ions using a transparent Paul... more We have measured the β-ν angular correlation in the β decay of 6He+ ions using a transparent Paul trap. The 6He+ ions, produced at GANIL, were first cooled and bunched before being injected in the LPCTrap setup. The angular correlation was inferred from the time of flight of recoil nuclei detected in coincidence with the β particles. The detection system gives access to the full β decay kinematics, providing means to check the data reliability and to reject a large fraction of background. We find aβν = -0.3335(73)stat(75)syst, in agreement with the standard model prediction for a pure Gamow-Teller transition.
Human embryonic stem cells (hESCs) have the potential to differentiate to diverse cell types. Thi... more Human embryonic stem cells (hESCs) have the potential to differentiate to diverse cell types. This ability endows hESCs with promise for the development of novel therapeutics, as well as promise for the development of a rigorous genetic system to probe human gene function. However, in spite of the impending utility of hESCs for clinical and basic applications, little is known about their fundamental properties. Recent reports have documented transcriptional profiles of mouse embryonic stem cells (mESCs), adult stem cells and a single hESC line, H9. To date, however, the transcriptional profiles of independently-derived hESC lines have not been compared. In order to examine the similarities and differences in multiple hESC lines, we compared gene expression profiles of the HSF-1, HSF-6 and H9 lines. We found that the majority of genes examined were expressed in all three cell lines. However, we also observed that each line possessed a unique expression signature; the expression of many genes was limited to just one or two hESC lines. We suggest that the observed differences in gene expression between independently-derived hESC lines may reflect inherent differences in the initial culture of each line and/or the underlying genetics of the embryos from which the lines were derived.
Presentamos el caso de un paciente masculino de 37 años, con el antecedente de que hace un año co... more Presentamos el caso de un paciente masculino de 37 años, con el antecedente de que hace un año comenzó con lesiones cutáneas constituidas por habones asociadas a deposiciones diarreicas, signos que desaparecieron sin tratamiento. Posteriormente, en las áreas donde hubo ronchas, aparecieron otras lesiones y el cuadro dermatológico fue adquiriendo gran polimorfismo. Se observó, vesículas, ampollas, excoriaciones y costras de forma bilateral y simétrica en tronco y raíces de extremidades. Se hizo el diagnóstico clínico e histológico (coloración de hematoxilina y eosina) de dermatitis herpetiforme, instituyéndose tratamiento a base de Dapsone y dieta libre de gluten, con lo que se logró el control del cuadro cutáneo. Sin embargo, persistieron los cuadros diarreicos, aunque de forma ocasional. El paciente interrumpió la terapéutica y reaparecieron las lesiones. Al reiniciar la terapéutica con sulfona, llamó la atención que aparecieron nuevos elementos ampollares más grandes en miembros inferiores, dejando amplias áreas denudadas. Se decidió hospitalizar al paciente para estudiarlo nuevamente. El estudio histológico por inmunofluerescencia directa (IFD) demostró la presencia de depósitos lineales de IgA a nivel de la unión dermoepidérmica. Se comprobó que el cuadro diarreico crónico fue causado por un síndrome de mala absorción secundario a giardiasis. Se arribó a la conclusión diagnóstica de que el paciente no era portador de dermatitis herpetiforme, sino de dermatosis IgA lineal del adulto. Consideramos que es de vital importancia la realización de la inmunofluorescencia directa de la piel sana perilesional, para el diagnóstico correcto de las enfermedades ampollares autoinmunes. Este es el primer caso de dermatosis IgA lineal del adulto que se publica en nuestro país (Cuba) y aunque la enfermedad es sumamente rara, pudiesen existir otros casos.
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