Papers by Mohammadreza Peyman
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International Journal of Diabetes in Developing Countries, 2015
European Geriatric Medicine, 2014
The Breast Journal, 2015
Here, we present a case of tonic pupil associated with occult breast cancer as a paraneoplastic n... more Here, we present a case of tonic pupil associated with occult breast cancer as a paraneoplastic neuro-ophthalmology syndrome. A 45-year-old woman developed progressive photophobia and blurred vision due to unilateral Adie's tonic pupil. Magnetic resonance image of her brain and neurological examination (including deep tendon reflexes) were normal at first visit. Follow-up examinations performed by ophthalmologist every 6 month without any change in her condition. After 2 years, patient discovered a mass in her breast which identified to be malignant after diagnostic procedures. Despite surgical and medical treatment for cancer, no change in the ocular condition was happened.
International journal of ophthalmology, 2012
To determine the risk factors of clinically significant macular edema (CSME) in patients with non... more To determine the risk factors of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR) in a multi-ethnics Malaysian population. We performed a case control study in which 150 patients with bilateral NPDR and CSME in either eye were compared to 150 patients with bilateral NPDR and no CSME in both eyes. CSME and NPDR were graded according to Early Treatment of Diabetic Retinopathy Study criteria. Student's t-test, odds ratio and multiple logistic regression analysis were performed to analyze the duration of diabetes, body mass index (BMI), blood pressure(BP), total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TG), fasting blood glucose (FBG), HbA1c, full blood count, serum creatinine and proteinuria between the two groups. Both groups were matched in terms of age, gender and ethnicity. Duration of diabetes, total serum cholesterol, serum LDL, FBG, HbA1c and serum creatinine were sign...
BMJ case reports, 2010
Iris mammillations are dark brown, smooth, mound- or dome-shaped protuberances that are typically... more Iris mammillations are dark brown, smooth, mound- or dome-shaped protuberances that are typically found on the anterior iris surface and are presumed to be congenital in origin. This congenital anomaly is usually unilateral and can be hereditary or sporadic. Lisch nodules in neurofibromatosis, tapioca melanoma of the iris, inflammatory iris granulomata and Cogan-Reese syndrome should be considered in the differential diagnosis. In this case report, the authors present a case of a bilateral iris mammillations in two siblings with congenital adrenal hyperplasia (CAH). To our knowledge, this is the first case where bilateral iris mammilations have been found to be associated with a systemic condition. Iris mammillations can be considered as one of the clinical signs in CAH in view of the pathogenesis discussed. Detailed ocular examination in CAH may reveal an increased incidence.
International journal of ophthalmology, 2011
To investigate the fundus findings of patients infected with human immunodeficiency virus (HIV) i... more To investigate the fundus findings of patients infected with human immunodeficiency virus (HIV) in correlation to Highly Active Antiretroviral Therapy (HAART) and CD4 count. Two hundred and two patients of the three major races (Chinese, Malay and Indian) in Malaysia were recruited in this population-based cross-sectional study. This consisted of confirmed HIV sero-positive patients with HAART treatment (n=95) or without HAART therapy (n=107) from December 2007 to March 2008. They were further classified into the HIV infected group, AIDS related complex (ARC) group and AIDS group. Each group was then subdivided according to their CD4 count. Clinical fundus findings were recorded. Sixty six patients (32.7%) showed presence of fundus manifestation, majority of which was HIV microangiopathy (89%) and the rest being Cytomegalovirus (CMV) retinitis (11%). The most common fundus lesion was cotton wool spot (34%). There was a higher incidence of fundus manifestation in the non HAART group ...
European journal of ophthalmology
To find a method of calculating intraocular lens (IOL) power that may be independent of preoperat... more To find a method of calculating intraocular lens (IOL) power that may be independent of preoperative data in eyes that have previously undergone myopic laser in situ keratomileusis (LASIK). In 148 eyes of 75 patients, before and 6 months after LASIK, IOL power was calculated with SRK/T formula utilizing the spherical equivalent as the desired target refraction. Assuming that LASIK does not alter the crystalline lens refractive properties, IOL calculation error (CER) was estimated with this formula: CER = [pre-LASIK IOL power]/[post-LASIK IOL power]. Then the authors used postoperative biometry and Orbscan II corneal topography data in multiple regression models to find the best variables to predict the CER. Predicted amount of error which is calculated independent of preoperative data could be used to correct the post-LASIK calculated IOL: [corrected post-LASIK IOL power] = CER x [post-LASIK IOL power]. A regression model with these predictors was found: axial length in millimeters ...
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
To evaluate the effect of corneal flap hinge position on dry eye after laser in situ keratomileus... more To evaluate the effect of corneal flap hinge position on dry eye after laser in situ keratomileusis (LASIK). In a prospective double-masked randomized controlled clinical trial, 212 consecutive eyes of 106 myopic patients underwent LASIK; in each patient, one eye was randomly assigned to the superior hinge and the other eye to the nasal hinge procedure. The patients were examined pre-operatively and 1 week, 1 month, 3 months and 6 months after surgery for visual acuity, fluorescein tear film breakup time and Schirmer's baseline tear secretion test; a subjective evaluation of dry eye symptoms was accomplished by the Ocular Surface Disease Index (OSDI) questionnaire at the 1-month, 3-month and 6-month postoperative visits. Tear film breakup time was not significantly different with the nasal or superior hinge flap technique at the preoperative, 1-week, 1-month, 3-month and 6-month visits (p > 0.05 for all comparisons between two groups). No significant difference between the tw...
Ophthalmology, 2010
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Journal of Ophthalmology, 2014
Background. Our study aimed to investigate an association between ocular pseudoexfoliation (PXF) ... more Background. Our study aimed to investigate an association between ocular pseudoexfoliation (PXF) and sensorineural hearing loss (SNHL) and to compare them with age and sex matched controls without pseudoexfoliation. Method. This was a case-control study of 123 patients which included 68 cases with PXF (at least one eye) and 55 controls without pseudoexfoliation. Pure-tone audiometry (PTA) was done for these patients at sound frequencies taken as important for speech comprehension, that is, 250 Hertz (Hz), 500 Hz, 1000 Hz, and 2000 Hz. Results. There were 41 patients with pseudoexfoliation syndrome (PXE) and 27 with pseudoexfoliative glaucoma (PXEG). The majority of patients with hearing loss (60%; = 51) were PXF patients and the remaining 40% ( = 34) were controls. Below average hearing thresholds were significantly higher in the pseudoexfoliation group compared to the control group ( = 0.01; odds ratio (OR), 3.00; 95% confidence interval (CI), 1.25-7.19). However, there was no significant difference in the mean hearing threshold levels between the three groups (PXE, PXEG, and controls) in either ear (ANOVA, right ear: = 0.46 and left ear = 0.36). Conclusion. Our study found an association between PXF and SNHL, confirming that PXF can involve organs in the body other than the eye.
Advanced biomedical research, 2012
This study performed to assess the safety of cataract extraction with phacoemulsification and int... more This study performed to assess the safety of cataract extraction with phacoemulsification and intraocular lens (IOL) implantation in patients with high axial length compared with patients with normal axial length. A total of 866 eyes were enrolled in this study; all subjects underwent phacoemulsification and IOL implantation for treatment of cataract. Seven hundred and nine eyes fell in the normal group with axial lengths ranging between 21 and 24.5 mm, and 157 eyes were considered myopic with axial length equal or greater than 26 mm. The two groups were compared regarding intraoperative surgical complications, such as vitreous loss, posterior capsular rupture, nucleolus drop, and undesirable implantation of IOL in the anterior chamber. Age was a risk factor in both groups, with each year increase of age, the chance of incidence of intraoperative complications increased 1.04-folds (P = 0.03). And with 1 mm increase in axial length, the incidence of complications raised 1.22-folds (P...
To determine whether angiotensin II (AT II) levels in aqueous humor are related to diabetes melli... more To determine whether angiotensin II (AT II) levels in aqueous humor are related to diabetes mellitus and to evaluate the effect of captopril on this level. We also evaluated the correlation between severity of macular edema and captopril use. Methods: In a case-control study, aqueous humor samples were obtained at the onset of cataract surgery from 58 eyes of 58 patients, of whom 37 were diabetic. From these latter subjects, 16 had taken captopril (captopril group) for at least six months and 21 had not taken any angiotensin converting enzyme inhibitor (non-captopril group). AT II level was assessed by radioimmunoassay. Severity of macular edema was evaluated by clinical examination after surgery. Results: The aqueous level of AT II was significantly higher in diabetic patients (31.0±7.3 pg/ml) compared to non-diabetics (6.28±2.8 pg/ml) (Mann Whitney U test, P<0.0001). In diabetic patients, aqueous concentration of AT II in the captopril group (16.3±6.5 µg/ml) was significantly lower than the non-captopril group (75.73±9.36 µg/ml) (Mann Whitney U test, P<0.0003). The severity of macular edema was significantly less in the captopril group compared to the non-captopril group: 68.75% of the captopril group vs 33.3% of the non-captopril group had no macular edema (P<0.005). Conclusion: These findings suggest that the aqueous level of AT II is higher in diabetic eyes and is correlated with the severity of diabetic macular edema. Considering the possible role of AT II in the pathogenesis of diabetic macular edema, modulation of the ocular renin-angiotensin system may become an important target for its treatment.
Optometry and Vision Science, 2015
To report a rare case of nasal chondroma presenting as hypertelorism. We report a case of a 16-ye... more To report a rare case of nasal chondroma presenting as hypertelorism. We report a case of a 16-year-old boy with a large calcified mass arising from the posterior nasal cavity presenting as hypertelorism. Surgical excision was done, and the histopathological examination revealed a chondroma. The hypertelorism resolved postoperatively. Nasal chondroma may also present innocuously as hypertelorism as in this case.
To determine whether angiotensin II (AT II) levels in aqueous humor are related to diabetes melli... more To determine whether angiotensin II (AT II) levels in aqueous humor are related to diabetes mellitus and to evaluate the effect of captopril on this level. We also evaluated the correlation between severity of macular edema and captopril use. Methods: In a case-control study, aqueous humor samples were obtained at the onset of cataract surgery from 58 eyes of 58 patients, of whom 37 were diabetic. From these latter subjects, 16 had taken captopril (captopril group) for at least six months and 21 had not taken any angiotensin converting enzyme inhibitor (non-captopril group). AT II level was assessed by radioimmunoassay. Severity of macular edema was evaluated by clinical examination after surgery. Results: The aqueous level of AT II was significantly higher in diabetic patients (31.0±7.3 pg/ml) compared to non-diabetics (6.28±2.8 pg/ml) (Mann Whitney U test, P<0.0001). In diabetic patients, aqueous concentration of AT II in the captopril group (16.3±6.5 µg/ml) was significantly lower than the non-captopril group (75.73±9.36 µg/ml) (Mann Whitney U test, P<0.0003). The severity of macular edema was significantly less in the captopril group compared to the non-captopril group: 68.75% of the captopril group vs 33.3% of the non-captopril group had no macular edema (P<0.005). Conclusion: These findings suggest that the aqueous level of AT II is higher in diabetic eyes and is correlated with the severity of diabetic macular edema. Considering the possible role of AT II in the pathogenesis of diabetic macular edema, modulation of the ocular renin-angiotensin system may become an important target for its treatment.
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Papers by Mohammadreza Peyman