Jacek Debiec
Jacek Debiec is a Psychiatrist, Neuroscientist, and a Philosopher. His clinical and research interests include trauma, anxiety, and attachment. He co-authored "The Self: From Soul to Brain" and "The Emotional Brain Revisited".
Address: Ann Arbor, United States
Address: Ann Arbor, United States
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Papers by Jacek Debiec
viewed as irrational.
of brain anatomy. In an effort to explain emotions in
the brain, he proposed the existence of a complex set of
circuits. Some of the connections proposed were purely
speculative because the techniques available at the time
were not capable of revealing the detailed connectivity of
the brain. The Papez circuit, as it came to be called, was
one of the first examples of a network or systems-level
explanation of a complex mental function. His speculations
about brain wiring, when evaluated with modern
techniques, have turned out to be amazingly accurate.
Although his theory of the emotional functions of the circuit
turned out to not be correct, it was of great heuristic
value and led to much research. All subsequent
approaches to the emotional brain build upon the Papez
circuit theory.
Anthony P. King1, Erika Bocknek2, Lindsay Hamilton1, Katherine Rosenblum1, Julia Seng3, Jacek Debiec1, Maria Muzik1
1Psychiatry, University of Michigan, Ann Arbor, MI,2Education, Wayne State University, Detroit, MI,3Nursing School, University of Michigan, Ann Arbor, MI
70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry, Volume: 77
Background: The DRD4 VNTR has been associated with child behavior problems in gene x maternal insensitivity interactions in European and American cohorts of preschoolers; with 7-repeat allele associated with greater problems. We attempted to replicate and expand these findings by examining trajectories from early mother-infant dyadic interactions (7 mos) in a longitudinal cohort.
Methods: We are collecting a longitudinal cohort of mother-infant dyads (268 families recruited to date) with psychological and/or behavioral assessments at 6wks, 4mo, 7mo, 12mo, 15mo, 18mo, and 36mo. A latent variable “Negative Infant Temperament” was constructed from maternal report (IBQ) and behavioral coding (Distress, Negative Affect in Still Face paradigm at 7 mo), Achenbach CBCL was assessed at 18 mo. Maternal and infant genotype on DRD4 was obtained using PCR. A 65 family sample with complete DRD4 genotype, Infant Temperament, and 18 mo CBCL was used.
Results: Infants carrying 7- or 2-repeat DRD4 allele who had mothers meeting criteria for postpartum depression had greater behavior problems (CBCL) at 18 mo, but not non-carriers (interaction F=4.4,p<.05; beta=.305,p=.013). DRD4xMaternal depression was also associated with Infant Negative Temperament (beta=.365,p<.005), which mediated the effect on 18 mo CBCL (Sobel=3.31, p<.001)
Conclusions: These initial analyses replicate DRD4 x maternal state interaction in an independent cohort. The interaction effect on CBCL was seen at 18 mos, and was mediated by infant (7 mo) measure of negative temperament. Data collection is ongoing in this longitudinal cohort.
But some past experiences can keep haunting you for years. Life-threatening events – things like getting mugged or escaping from a fire – can be impossible to forget, even if you make every possible effort. Recent developments in the Supreme Court nomination hearings and the associated #WhyIDidntReport action on social media have rattled the public and raised questions about the nature, role and impact of these kinds of traumatic memories.