Escherichia coli Escherichia coli Escherichia coli Escherichia coli infection, a negative prognos... more Escherichia coli Escherichia coli Escherichia coli Escherichia coli infection, a negative prognostic factor on infection, a negative prognostic factor on infection, a negative prognostic factor on infection, a negative prognostic factor on the evolution of patients with surgical diseases the evolution of patients with surgical diseases the evolution of patients with surgical diseases the evolution of patients with surgical diseases
Journal of Laparoendoscopic & Advanced Surgical Techniques, 1997
We describe the combined use of laparoscopic and endoscopie techniques in a case of acute primary... more We describe the combined use of laparoscopic and endoscopie techniques in a case of acute primary gastric volvulus. Once the diagnosis is confirmed with a water-soluble upper gastrointestinal series, prompt intervention is required. With an atraumatic bowel grasper the stomach is reoriented with the greater curvature in its normal anatomic position. Two transabdominal wall sutures are placed along the greater curvature to fix it to anterior abdominal wall. Upper endoscopy is then performed. Once confident that the gastric mucosa is viable, a 20F "pull-type" gastrostomy tube is placed endoscopically, guided by the external illumination and probing by the laparoscope. The gastrostomy tube now acts as an anterior anchor for the stomach allowing repositioning of the gastropexy sutures if necessary. Endoscopy confirms the placement of a broad, properly aligned gastropexy. Classically, gastric volvulus has been treated by laparotomy. Both endoscopie and laparoscopic techniques have been individually reported in the treatment of acute and chronic gastric volvulus, however, each has as its limitations. By combining the procedures we were able to better assess both the intra-abdominal and the intraluminal status of the stomach and its position before, during, and after fixation to the anterior abdominal wall. The postoperative stay seen with the combined technique was less than has been reported in patients treated by open surgery or by either the endoscopie or laparoscopic methods alone. The combined laparoscopic and endoscopie approach to acute gastric volvulus provides the benefit of a minimally invasive approach, to a better anterior gastropexy. This procedure should be considered when confronted with patients with acute primary, gastric volvulus.
BackgroundWhile Primary Care Physicians (PCPs) play a key role in cancer detection, they can find... more BackgroundWhile Primary Care Physicians (PCPs) play a key role in cancer detection, they can find cancer diagnosis challenging, and some patients have considerable delays between presentation and onward referral.AimThis study explores European PCPs’ experiences and views on cases where they considered that they had been slow to think of, or act on, a possible cancer diagnosis.Design & settingA multicentre European qualitative study, based on an online survey with open-ended questions asking PCPs for their narratives about cases when they had missed a diagnosis of cancer.MethodUsing maximum variation sampling, PCPs in 23 European countries were asked to describe what happened in a case where they were slow to think of a cancer diagnosis, and for their views on why it happened. Thematic analysis was used to analyse the data.ResultsA total of 158 PCPs completed the questionnaire. The main themes were: where patients’ descriptions did not suggest cancer; when distracting factors reduced...
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and the second most fr... more Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and the second most frequent cause of cancer-related death worldwide. The aim of this review is to identify whether phytotherapy has an effect over the treatment of HCC or if it is suitable as a combination with chemotherapy. A systematic review was performed in order to offer current information over the use of phytotherapy in HCC. We conducted an electronic search of articles published in English in peer reviewed journals between 2012-2022. After keywords were associated, 302 articles were found. After the exclusion of articles which did not meet the inclusion criteria, there were 77 articles eligible for abstract evaluation. The following were discarded: two case report, one systematic review, 36 in vitro studies and nine studies which discussed other pathologies or with no regard to phytotherapy. The remaining articles encompassed 27 in vivo studies of phytotherapy in hepatocellular carcinoma and two rand...
International Journal of Molecular Sciences, Feb 9, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Journal of Gastrointestinal and Liver Diseases, Dec 16, 2022
Background & Aims: Gastric cancer is one of the most common malignancies, with an aggressive evol... more Background & Aims: Gastric cancer is one of the most common malignancies, with an aggressive evolution and a poor long-term prognosis. No screening program is available in Europe for this pathology; therefore, the delay from the appearance of the first symptom until the initiation of treatment might influence the prognosis of gastric cancer patients. We aimed to investigate the impact on the prognosis of the delay in the presentation and diagnosis in patients with gastric adenocarcinoma. Methods: Our study is a retrospective, single-center, observational cohort study, based on patients diagnosed with gastric adenocarcinoma and operated in our institution between 2013 and 2021. We have defined patient delay as the time from the onset of symptoms to the first encounter with a health care provider and diagnosis delay as the time from the first consultation with a health care provider to the establishment of the final diagnosis. Results: A total of 671 patients were included in our study. The survival rate at 5 years was 55% for the patients operated with curative intent and 7.4% for the patients operated with palliative intent. Patient delay and diagnosis delay were not correlated with the overall survival. A lower survival was observed for patients admitted through transfer (p<0.001) or the emergency department (p<0.001). No statistically significant relationship was identified between patient delay or diagnosis delay and the age, gender or area of origin of patients. Patients that experienced melena or hematemesis had a shorter patient delay, with a highly significant statistical relationship (p<0.01). Patients that experienced nausea, epigastric pain, palpable epigastric tumor mass or anorexia also had a highly significant statistical relationship between the symptoms and the patient delay interval. Conclusions: The overall survival is not influenced by the patient delay or diagnosis delay. An earlier presentation was correlated with some specific exhibited symptoms: upper gastro-intestinal bleeding, abdominal pain, palpable epigastric tumor, nausea.
Despite recent scientific advances in diagnosis and treatment of human infections, bacterial infe... more Despite recent scientific advances in diagnosis and treatment of human infections, bacterial infections continue to affect human health. The rate of morbidity and mortality caused by staphylococcal infections remains high and continues to be a threat to public health worldwide. Staphylococcal infections affect the population at risk regardless the level of country development. The highest risk categories include people with immunodeficiency, those with prolonged antibiotic treatment and repeated hospitalizations, patients with implanted medical devices or undergoing medical invasive procedures. The objective of this study was to analyse the influence of staphylococcal infection diagnosed during hospitalization on the evolution of patients admitted during two consecutive years, in surgical and intensive care wards in IRGH (Regional Institute of Gastroenterology and Hepatology) Cluj-Napoca, Romania, having as main diagnosis of hospitalization surgical digestive diseases along with oth...
Aloe vera (Aloe barbadensis Miller) is widely spread around the world and it is used in the food ... more Aloe vera (Aloe barbadensis Miller) is widely spread around the world and it is used in the food and cosmetic industry and traditional medicine due to its high content in bioactive compounds. Thus, this article investigated the phenolic compounds of Romanian Aloe vera gel and its antioxidant capacity. The gel was extracted using 4 different solvents: methanol, ethanol, water, and acetone. Total phenolics were measured by the Folin-Ciocalteu method, total flavonoids by aluminium chloride reaction, and the antioxidant capacity by DPPH radical-scavenging activity. The profile of the phenolic compound was determined using Fourier transform infrared spectroscopy and Liquid Chromatography-Diode Array Detection–Electro-Spray Ionization Mass Spectrometry. The methanolic extract had a significantly higher antioxidant activity, followed by ethanolic, water, and acetone extracts. The methanolic extract had also the highest total polyphenol content, while ethanolic extract had the highest tota...
Aloe, the largest genus in the Asphodelaceae family, comprises 548 species, with A. vera, A. arbo... more Aloe, the largest genus in the Asphodelaceae family, comprises 548 species, with A. vera, A. arborescens and A. ferox being among the most widely studied species. Aloe species originated in arid climates and cover various habitats, from sea level up to 2700 m, and from desert to closed-canopy forests. For human health, Aloe species are the richest natural sources. The biological activity of Aloe sp. constituents covers a wide spectrum. Most of the indications come from traditional, folkloric use and several have been verified by in vitro or in vivo studies. Emodin, the main phenolic component, has showed anti-neoplastic, anti-inflammatory, anti-angiogenic and toxicological potential for use in pharmacology. Polysaccharides, with acemannan being the most important, are present in high abundance in Aloe gels. Acemannan has been reported to have applications in oral, metabolic and cardiovascular diseases, oncology, dentistry and wound healing. The effectiveness of Aloe sp. constituents...
Hepatocellular carcinoma is the most common liver malignancy and is among the top five most commo... more Hepatocellular carcinoma is the most common liver malignancy and is among the top five most common cancers. Despite the progress of surgery and chemotherapy, the results are often disappointing, in part due to chemoresistance. This type of tumor has special characteristics that allow the improvement of diagnostic and treatment techniques used in clinical practice, by combining nanotechnology. This article presents a brief review of the literature focused on nano-conditioned diagnostic methods, targeted therapy, and therapeutic implications for the pathology of hepatocellular carcinoma. Within each subdomain, several modern technologies with significant impact were highlighted: serological, imaging, or histopathological diagnosis; intraoperative detection; carrier-type nano-conditioned therapy, thermal ablation, and gene therapy. The prospects offered by nanomedicine will strengthen the hope of more efficient diagnoses and therapies in the future.
Background and Aims: Several computed tomographic (CT) imaging features have been proposed to des... more Background and Aims: Several computed tomographic (CT) imaging features have been proposed to describe the infection of postoperative abdominal fluid collections; however, these features are vague, and there is a significant overlap between infected and non-infected collections. We assessed the role of textural parameters as additional diagnostic tools for distinguishing between infected and non-infected peritoneal collections in patients operated for gastric cancer. Methods: From 527 patients operated for gastric cancer, we retrospectively selected 82 cases with intraperitoneal collections who underwent CT exams. The fluid component was analyzed through a novel method (texture analysis); different patterns of pixel intensity and distribution were extracted and processed through a dedicated software (MaZda). A univariate analysis comparing the parameters of texture analysis between the two groups was performed. Afterwards, a multivariate analysis was performed for the univariate sta...
Sexually transmitted infections (STIs) are among the most common infections in Romania. Infection... more Sexually transmitted infections (STIs) are among the most common infections in Romania. Infection with Ureaplasma urelyticum is one of the major causes of STIs and can cause serious complications. Although tetracycline is the drug commonly used to treat infections caused by U. urealyticum, several studies indicate the emergence and rapid development of strains resistant to these antibiotics in the United States or Europe. Tetracycline resistance in bacteria is encoded by a number of different genetic determinants but in mycoplasmas the only tetracycline resistance determinant that has been reported is the tetM gene. Tetracycline resistance among Ureaplasma spp. is associated with the presence of the horizontally acquired tetM resistance gene. Our study on bacterial DNA aimed to determine the presence of tetracycline-resistant U. urealyticum strains, by identifying the presence of the tetM gene. We used first void urine samples from 622 STI-suspected subjects. DNA was extracted, puri...
BACKGROUND Microsatellites are short repeated DNA sequences normally found in the human genome. F... more BACKGROUND Microsatellites are short repeated DNA sequences normally found in the human genome. Following specific mutations, microsatellites can vary in the number of repeats thus making the DNA unstable. Microsatellite instability (MSI) is responsible for approximately 20% of rectal cancers, while the remaining 80% are caused by chromosomal instability. One of the following genes, MLH1, MLH2, MLH 6, and PMS2, is inactivated, leading to MSI colorectal cancers. AIM This study aimed to analyze the expression of some MMR system genes presenting mutations in mucinous rectal cancer and their correlations with clinical data. METHODS A retrospective study was performed on patients with rectal mucinous adenocarcinoma who underwent surgery between January 2000 and January 2017. We collected a total of 42 patients and analyzed the demographic data, histopathological results and MMR system genes mentioned above. RESULTS Almost 93% of the cases analyzed had MSI-H and only 7% were MSI-L. For ML...
Introduction: Quality of life is a difficult concept to understand and therefore difficult to eva... more Introduction: Quality of life is a difficult concept to understand and therefore difficult to evaluate. From the general definition to the individuality of the person, there are factors that positively or negatively influence quality of life. Aim: The aim is to identify the factors that influence the quality of life of primary caregivers of patients with progressive life-threatening illnesses. Methodology: PUBMED was searched to retrieve the relevant literature for our research questions used the following keywords: "Quality of life and caregiver or caretaker and palliative care or life threatening disease." Only quantitative studies containing randomized trials were included using at least one caregiver's quality-of-life tool, not older than 10 years, written in English, and with subjects older than 18 years, who considered they were involved in the active care of a palliative patient. Results: A number of 687 articles were identified from which only 38 were analyzed in detail regarding the impact of different interventions over the quality-of-life of the caregiver. The factors that influence the quality-of-life can be distributed into four areas: social, psycho-emotional, financial, and physical. The disruption of daily routine, non-existential financial resources, multiple responsibilities and psychological tension are reduce the caregiver's quality-of-life. Family involvment, knowledge about disease and treatment, abilities to communicate patient and the team and optimistic atitude improve caregiver's quality-of-life. Conclusions: The quality of life of the caregiver be improved by social, and relaxation techniques, reduction of insecurity or anxiety. Furthermore, the caregiver's quality of increases through and adequate communication diagnosis, a proper conducted treatment and education over the care maneuvers.
Hemoroidopexia cu stapler circular (operaţia Longo) este o tehnică destul de rar aplicată în ţara... more Hemoroidopexia cu stapler circular (operaţia Longo) este o tehnică destul de rar aplicată în ţara noastră, poate şi datorită faptului că reprezintă o abordare radical diferită de hemoroidectomie, la care se adaugă un cost crescut şi necesitatea unei instruiri specifice. Prezentăm rezultatele noastre pe termen lung cu tehnica standard. Datele a 35 de pacienţi cu hemoroizi simptomatici de gradul II şi III la care s-a efetuat hemoroidopexia în intervalul 01 ianuarie 2012-04 decembrie 2020 au fost colectate retrospectiv. Sex ratio masculin: feminin a fost de 3: 4 şi vârsta medie 45 (28-60) de ani. La controalele postoperatorii s-a efectuat de regulă tuşeul rectal şi s-a evaluat recidiva hemoroidală sau prolapsul. Timpul operator mediu a fost de 42 (30-70) min. Necesarul de analgezice administrate parenteral în primele 24 de ore au fost în medie de 1,52 doze. Spitalizarea medie postoperatorie a fost de 1,55 (1-2) zile. Un singur pacient a avut nevoie de reintervenţie pentru o hemoragie pe linia de staplare, doi pacienţi au avut o tromboză a unui pachet hemoroidal intern şi la un pacient s-a diagnosticat un prolaps la controlul efectuat la 3 luni. Nu s-a înregistrat nici un hematom, stenoză anastomotică, durere anală persistentă sau incontinenţă anală. Un pacient a menţionat un disconfort legat de prezenţa agrafelor de sutură. Pacienţii au fost urmăriţi timp de 6 (1-9) ani. Rata de satisfacţie a fost de 94%. Hemoroidopexia cu stapler circular este o metodă sigură, puţin dureroasă şi cu o durată redusă de internare post
INTRODUCTION Duplicated gallbladder is a seldom surgical finding that frequently eludes detection... more INTRODUCTION Duplicated gallbladder is a seldom surgical finding that frequently eludes detection on routine preoperative imaging and in some circumstances it might be even overlooked during surgery. Identification of this anomaly and its various types is important in order prevent post operative complications and recurrent symptoms after cholecystectomy. PRESENTATION OF CASE We present a female patient with biliary simptomatology who had previous cholecystectomy. Preoperatory imaging (MRCP) suspects a duplicated gallbladder which was confirmed intraoperatory and cholecystectomy was performed. The postoperative recovery was uneventful. DISCUSSION There are a very small number of reported cases with laparoscopic cholecystectomy for overlooked gallbladder duplication. Preoperative diagnosis holds a major contribution in planning surgery and preventing potential biliary injuries or re-operation if accessory gallbladder has been overlooked during initial surgery. CONCLUSION Accessory ga...
Escherichia coli Escherichia coli Escherichia coli Escherichia coli infection, a negative prognos... more Escherichia coli Escherichia coli Escherichia coli Escherichia coli infection, a negative prognostic factor on infection, a negative prognostic factor on infection, a negative prognostic factor on infection, a negative prognostic factor on the evolution of patients with surgical diseases the evolution of patients with surgical diseases the evolution of patients with surgical diseases the evolution of patients with surgical diseases
Journal of Laparoendoscopic & Advanced Surgical Techniques, 1997
We describe the combined use of laparoscopic and endoscopie techniques in a case of acute primary... more We describe the combined use of laparoscopic and endoscopie techniques in a case of acute primary gastric volvulus. Once the diagnosis is confirmed with a water-soluble upper gastrointestinal series, prompt intervention is required. With an atraumatic bowel grasper the stomach is reoriented with the greater curvature in its normal anatomic position. Two transabdominal wall sutures are placed along the greater curvature to fix it to anterior abdominal wall. Upper endoscopy is then performed. Once confident that the gastric mucosa is viable, a 20F "pull-type" gastrostomy tube is placed endoscopically, guided by the external illumination and probing by the laparoscope. The gastrostomy tube now acts as an anterior anchor for the stomach allowing repositioning of the gastropexy sutures if necessary. Endoscopy confirms the placement of a broad, properly aligned gastropexy. Classically, gastric volvulus has been treated by laparotomy. Both endoscopie and laparoscopic techniques have been individually reported in the treatment of acute and chronic gastric volvulus, however, each has as its limitations. By combining the procedures we were able to better assess both the intra-abdominal and the intraluminal status of the stomach and its position before, during, and after fixation to the anterior abdominal wall. The postoperative stay seen with the combined technique was less than has been reported in patients treated by open surgery or by either the endoscopie or laparoscopic methods alone. The combined laparoscopic and endoscopie approach to acute gastric volvulus provides the benefit of a minimally invasive approach, to a better anterior gastropexy. This procedure should be considered when confronted with patients with acute primary, gastric volvulus.
BackgroundWhile Primary Care Physicians (PCPs) play a key role in cancer detection, they can find... more BackgroundWhile Primary Care Physicians (PCPs) play a key role in cancer detection, they can find cancer diagnosis challenging, and some patients have considerable delays between presentation and onward referral.AimThis study explores European PCPs’ experiences and views on cases where they considered that they had been slow to think of, or act on, a possible cancer diagnosis.Design & settingA multicentre European qualitative study, based on an online survey with open-ended questions asking PCPs for their narratives about cases when they had missed a diagnosis of cancer.MethodUsing maximum variation sampling, PCPs in 23 European countries were asked to describe what happened in a case where they were slow to think of a cancer diagnosis, and for their views on why it happened. Thematic analysis was used to analyse the data.ResultsA total of 158 PCPs completed the questionnaire. The main themes were: where patients’ descriptions did not suggest cancer; when distracting factors reduced...
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and the second most fr... more Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and the second most frequent cause of cancer-related death worldwide. The aim of this review is to identify whether phytotherapy has an effect over the treatment of HCC or if it is suitable as a combination with chemotherapy. A systematic review was performed in order to offer current information over the use of phytotherapy in HCC. We conducted an electronic search of articles published in English in peer reviewed journals between 2012-2022. After keywords were associated, 302 articles were found. After the exclusion of articles which did not meet the inclusion criteria, there were 77 articles eligible for abstract evaluation. The following were discarded: two case report, one systematic review, 36 in vitro studies and nine studies which discussed other pathologies or with no regard to phytotherapy. The remaining articles encompassed 27 in vivo studies of phytotherapy in hepatocellular carcinoma and two rand...
International Journal of Molecular Sciences, Feb 9, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Journal of Gastrointestinal and Liver Diseases, Dec 16, 2022
Background & Aims: Gastric cancer is one of the most common malignancies, with an aggressive evol... more Background & Aims: Gastric cancer is one of the most common malignancies, with an aggressive evolution and a poor long-term prognosis. No screening program is available in Europe for this pathology; therefore, the delay from the appearance of the first symptom until the initiation of treatment might influence the prognosis of gastric cancer patients. We aimed to investigate the impact on the prognosis of the delay in the presentation and diagnosis in patients with gastric adenocarcinoma. Methods: Our study is a retrospective, single-center, observational cohort study, based on patients diagnosed with gastric adenocarcinoma and operated in our institution between 2013 and 2021. We have defined patient delay as the time from the onset of symptoms to the first encounter with a health care provider and diagnosis delay as the time from the first consultation with a health care provider to the establishment of the final diagnosis. Results: A total of 671 patients were included in our study. The survival rate at 5 years was 55% for the patients operated with curative intent and 7.4% for the patients operated with palliative intent. Patient delay and diagnosis delay were not correlated with the overall survival. A lower survival was observed for patients admitted through transfer (p<0.001) or the emergency department (p<0.001). No statistically significant relationship was identified between patient delay or diagnosis delay and the age, gender or area of origin of patients. Patients that experienced melena or hematemesis had a shorter patient delay, with a highly significant statistical relationship (p<0.01). Patients that experienced nausea, epigastric pain, palpable epigastric tumor mass or anorexia also had a highly significant statistical relationship between the symptoms and the patient delay interval. Conclusions: The overall survival is not influenced by the patient delay or diagnosis delay. An earlier presentation was correlated with some specific exhibited symptoms: upper gastro-intestinal bleeding, abdominal pain, palpable epigastric tumor, nausea.
Despite recent scientific advances in diagnosis and treatment of human infections, bacterial infe... more Despite recent scientific advances in diagnosis and treatment of human infections, bacterial infections continue to affect human health. The rate of morbidity and mortality caused by staphylococcal infections remains high and continues to be a threat to public health worldwide. Staphylococcal infections affect the population at risk regardless the level of country development. The highest risk categories include people with immunodeficiency, those with prolonged antibiotic treatment and repeated hospitalizations, patients with implanted medical devices or undergoing medical invasive procedures. The objective of this study was to analyse the influence of staphylococcal infection diagnosed during hospitalization on the evolution of patients admitted during two consecutive years, in surgical and intensive care wards in IRGH (Regional Institute of Gastroenterology and Hepatology) Cluj-Napoca, Romania, having as main diagnosis of hospitalization surgical digestive diseases along with oth...
Aloe vera (Aloe barbadensis Miller) is widely spread around the world and it is used in the food ... more Aloe vera (Aloe barbadensis Miller) is widely spread around the world and it is used in the food and cosmetic industry and traditional medicine due to its high content in bioactive compounds. Thus, this article investigated the phenolic compounds of Romanian Aloe vera gel and its antioxidant capacity. The gel was extracted using 4 different solvents: methanol, ethanol, water, and acetone. Total phenolics were measured by the Folin-Ciocalteu method, total flavonoids by aluminium chloride reaction, and the antioxidant capacity by DPPH radical-scavenging activity. The profile of the phenolic compound was determined using Fourier transform infrared spectroscopy and Liquid Chromatography-Diode Array Detection–Electro-Spray Ionization Mass Spectrometry. The methanolic extract had a significantly higher antioxidant activity, followed by ethanolic, water, and acetone extracts. The methanolic extract had also the highest total polyphenol content, while ethanolic extract had the highest tota...
Aloe, the largest genus in the Asphodelaceae family, comprises 548 species, with A. vera, A. arbo... more Aloe, the largest genus in the Asphodelaceae family, comprises 548 species, with A. vera, A. arborescens and A. ferox being among the most widely studied species. Aloe species originated in arid climates and cover various habitats, from sea level up to 2700 m, and from desert to closed-canopy forests. For human health, Aloe species are the richest natural sources. The biological activity of Aloe sp. constituents covers a wide spectrum. Most of the indications come from traditional, folkloric use and several have been verified by in vitro or in vivo studies. Emodin, the main phenolic component, has showed anti-neoplastic, anti-inflammatory, anti-angiogenic and toxicological potential for use in pharmacology. Polysaccharides, with acemannan being the most important, are present in high abundance in Aloe gels. Acemannan has been reported to have applications in oral, metabolic and cardiovascular diseases, oncology, dentistry and wound healing. The effectiveness of Aloe sp. constituents...
Hepatocellular carcinoma is the most common liver malignancy and is among the top five most commo... more Hepatocellular carcinoma is the most common liver malignancy and is among the top five most common cancers. Despite the progress of surgery and chemotherapy, the results are often disappointing, in part due to chemoresistance. This type of tumor has special characteristics that allow the improvement of diagnostic and treatment techniques used in clinical practice, by combining nanotechnology. This article presents a brief review of the literature focused on nano-conditioned diagnostic methods, targeted therapy, and therapeutic implications for the pathology of hepatocellular carcinoma. Within each subdomain, several modern technologies with significant impact were highlighted: serological, imaging, or histopathological diagnosis; intraoperative detection; carrier-type nano-conditioned therapy, thermal ablation, and gene therapy. The prospects offered by nanomedicine will strengthen the hope of more efficient diagnoses and therapies in the future.
Background and Aims: Several computed tomographic (CT) imaging features have been proposed to des... more Background and Aims: Several computed tomographic (CT) imaging features have been proposed to describe the infection of postoperative abdominal fluid collections; however, these features are vague, and there is a significant overlap between infected and non-infected collections. We assessed the role of textural parameters as additional diagnostic tools for distinguishing between infected and non-infected peritoneal collections in patients operated for gastric cancer. Methods: From 527 patients operated for gastric cancer, we retrospectively selected 82 cases with intraperitoneal collections who underwent CT exams. The fluid component was analyzed through a novel method (texture analysis); different patterns of pixel intensity and distribution were extracted and processed through a dedicated software (MaZda). A univariate analysis comparing the parameters of texture analysis between the two groups was performed. Afterwards, a multivariate analysis was performed for the univariate sta...
Sexually transmitted infections (STIs) are among the most common infections in Romania. Infection... more Sexually transmitted infections (STIs) are among the most common infections in Romania. Infection with Ureaplasma urelyticum is one of the major causes of STIs and can cause serious complications. Although tetracycline is the drug commonly used to treat infections caused by U. urealyticum, several studies indicate the emergence and rapid development of strains resistant to these antibiotics in the United States or Europe. Tetracycline resistance in bacteria is encoded by a number of different genetic determinants but in mycoplasmas the only tetracycline resistance determinant that has been reported is the tetM gene. Tetracycline resistance among Ureaplasma spp. is associated with the presence of the horizontally acquired tetM resistance gene. Our study on bacterial DNA aimed to determine the presence of tetracycline-resistant U. urealyticum strains, by identifying the presence of the tetM gene. We used first void urine samples from 622 STI-suspected subjects. DNA was extracted, puri...
BACKGROUND Microsatellites are short repeated DNA sequences normally found in the human genome. F... more BACKGROUND Microsatellites are short repeated DNA sequences normally found in the human genome. Following specific mutations, microsatellites can vary in the number of repeats thus making the DNA unstable. Microsatellite instability (MSI) is responsible for approximately 20% of rectal cancers, while the remaining 80% are caused by chromosomal instability. One of the following genes, MLH1, MLH2, MLH 6, and PMS2, is inactivated, leading to MSI colorectal cancers. AIM This study aimed to analyze the expression of some MMR system genes presenting mutations in mucinous rectal cancer and their correlations with clinical data. METHODS A retrospective study was performed on patients with rectal mucinous adenocarcinoma who underwent surgery between January 2000 and January 2017. We collected a total of 42 patients and analyzed the demographic data, histopathological results and MMR system genes mentioned above. RESULTS Almost 93% of the cases analyzed had MSI-H and only 7% were MSI-L. For ML...
Introduction: Quality of life is a difficult concept to understand and therefore difficult to eva... more Introduction: Quality of life is a difficult concept to understand and therefore difficult to evaluate. From the general definition to the individuality of the person, there are factors that positively or negatively influence quality of life. Aim: The aim is to identify the factors that influence the quality of life of primary caregivers of patients with progressive life-threatening illnesses. Methodology: PUBMED was searched to retrieve the relevant literature for our research questions used the following keywords: "Quality of life and caregiver or caretaker and palliative care or life threatening disease." Only quantitative studies containing randomized trials were included using at least one caregiver's quality-of-life tool, not older than 10 years, written in English, and with subjects older than 18 years, who considered they were involved in the active care of a palliative patient. Results: A number of 687 articles were identified from which only 38 were analyzed in detail regarding the impact of different interventions over the quality-of-life of the caregiver. The factors that influence the quality-of-life can be distributed into four areas: social, psycho-emotional, financial, and physical. The disruption of daily routine, non-existential financial resources, multiple responsibilities and psychological tension are reduce the caregiver's quality-of-life. Family involvment, knowledge about disease and treatment, abilities to communicate patient and the team and optimistic atitude improve caregiver's quality-of-life. Conclusions: The quality of life of the caregiver be improved by social, and relaxation techniques, reduction of insecurity or anxiety. Furthermore, the caregiver's quality of increases through and adequate communication diagnosis, a proper conducted treatment and education over the care maneuvers.
Hemoroidopexia cu stapler circular (operaţia Longo) este o tehnică destul de rar aplicată în ţara... more Hemoroidopexia cu stapler circular (operaţia Longo) este o tehnică destul de rar aplicată în ţara noastră, poate şi datorită faptului că reprezintă o abordare radical diferită de hemoroidectomie, la care se adaugă un cost crescut şi necesitatea unei instruiri specifice. Prezentăm rezultatele noastre pe termen lung cu tehnica standard. Datele a 35 de pacienţi cu hemoroizi simptomatici de gradul II şi III la care s-a efetuat hemoroidopexia în intervalul 01 ianuarie 2012-04 decembrie 2020 au fost colectate retrospectiv. Sex ratio masculin: feminin a fost de 3: 4 şi vârsta medie 45 (28-60) de ani. La controalele postoperatorii s-a efectuat de regulă tuşeul rectal şi s-a evaluat recidiva hemoroidală sau prolapsul. Timpul operator mediu a fost de 42 (30-70) min. Necesarul de analgezice administrate parenteral în primele 24 de ore au fost în medie de 1,52 doze. Spitalizarea medie postoperatorie a fost de 1,55 (1-2) zile. Un singur pacient a avut nevoie de reintervenţie pentru o hemoragie pe linia de staplare, doi pacienţi au avut o tromboză a unui pachet hemoroidal intern şi la un pacient s-a diagnosticat un prolaps la controlul efectuat la 3 luni. Nu s-a înregistrat nici un hematom, stenoză anastomotică, durere anală persistentă sau incontinenţă anală. Un pacient a menţionat un disconfort legat de prezenţa agrafelor de sutură. Pacienţii au fost urmăriţi timp de 6 (1-9) ani. Rata de satisfacţie a fost de 94%. Hemoroidopexia cu stapler circular este o metodă sigură, puţin dureroasă şi cu o durată redusă de internare post
INTRODUCTION Duplicated gallbladder is a seldom surgical finding that frequently eludes detection... more INTRODUCTION Duplicated gallbladder is a seldom surgical finding that frequently eludes detection on routine preoperative imaging and in some circumstances it might be even overlooked during surgery. Identification of this anomaly and its various types is important in order prevent post operative complications and recurrent symptoms after cholecystectomy. PRESENTATION OF CASE We present a female patient with biliary simptomatology who had previous cholecystectomy. Preoperatory imaging (MRCP) suspects a duplicated gallbladder which was confirmed intraoperatory and cholecystectomy was performed. The postoperative recovery was uneventful. DISCUSSION There are a very small number of reported cases with laparoscopic cholecystectomy for overlooked gallbladder duplication. Preoperative diagnosis holds a major contribution in planning surgery and preventing potential biliary injuries or re-operation if accessory gallbladder has been overlooked during initial surgery. CONCLUSION Accessory ga...
Uploads
Papers by Aida Puia