Anca Buzoianu

University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Clinical Pharmacology, Faculty Member

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Professor Anca Buzoianu, M.D., PhD - senior clinical pharmacologist, senior paediatrician, President of the Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.Interests in research: pharmacogenetics of the anticoagulants, drugs used in dermatology, anti epileptic drugs. Pharmacology of the microbiota, neurosciences and psychiatric pharmacology.
Address: Cluj-Napoca, Judetul Cluj, Romania

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Increased Chemerin and Decreased OMENTIN-1 Levels in Morbidly Obese Patients Are Correlated with Insulin Resistance, Oxidative Stress and Chronic Inflammation

Clujul Medical, 2014

Background and aim. Morbid obesity represents a proinflammatory and prooxidative state associated... more Background and aim. Morbid obesity represents a proinflammatory and prooxidative state associated with dysregulation of adipokines. We aimed to evaluate the circulating levels of chemerin and omentin-1 in morbidly obese (MO) patients and to investigate the relationship between these two adipokines and between each of them and anthropometric, metabolic, oxidative stress and chronic inflammatory parameters. Material and methods. 32 MO patients and 20 controls were investigated in this study. Anthropometric, metabolism parameters, inflammatory markers, oxidative stress indicators as well as chemerin and omentin-1 were measured. Results. Serum levels of chemerin were increased while omentin-1 levels were decreased in MO patients when compared with controls. Chemerin correlated positively with insulin, HOMA-IR, LDL cholesterol and negatively with total antioxidant response. Omentin-1 correlated negatively with tumor necrosis factor alpha and total cholesterol. In a multiple linear stepwise regression analysis we learnt that only p<0.001), total cholesterol (β=0.42, p<0.001) and triglycerides (β=0.31, p<0.05) remained significantly associated with chemerin changes. Using the same analysis we noticed that total cholesterol (β=-0.71, p<0.001), fasting glucose (β=-0.40, p<0.05) and body mass index (BMI) (β=-0.38, p<0.05) were considered to be significant predictors for omentin-1 changes. Conclusions. Chemerin and omentin-1 synthesis was dysregulated in MO patients. Chemerin might play a role in insulin resistance and oxidative stress. Chemerin changes seemed to be predicted mainly by insulin resistance. Omentin-1 levels were inversely associated 2 between 18.5 and 24.9 kg/m . All controls were clinically and biochemically free from any disease and under no medication.

Anca Buzoianu

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