Papers by Carolina Campanella
Frontiers in Psychiatry, Aug 25, 2017
with exposure to neutral and Iraq combat-related slides and sound before and after treatment. Nin... more with exposure to neutral and Iraq combat-related slides and sound before and after treatment. Nine patients in the MBSR group and 8 in the PCGT group completed all study procedures. results: Post-traumatic stress disorder patients treated with MBSR (but not PCGT) had an improvement in PTSD symptoms measured with the CAPS that persisted for 6 months after treatment. MBSR also resulted in an increase in mindfulness measured with the FFMQ. MBSR-treated patients had increased anterior cingulate and inferior parietal lobule and decreased insula and precuneus function in response to traumatic reminders compared to the PCGT group. conclusion: This study shows that MBSR is a safe and effective treatment for PTSD. Furthermore, MBSR treatment is associated with changes in brain regions that have been implicated in PTSD and are involved in extinction of fear responses to traumatic memories as well as regulation of the stress response.
Environmental health perspectives, Oct 26, 2020
Sleep, Apr 1, 2018
high extroversion group (p=.033). Sleep amount did not differ overall between groups (p>.5). Inte... more high extroversion group (p=.033). Sleep amount did not differ overall between groups (p>.5). Interestingly, sleep amount was not significantly related to performance in the low extroversion group (p>.05), and performance did not significantly differ between groups with sufficient sleep (>7 h;p>.5). Conclusion: Contrary to prior research, introverts did not outperform extroverts when sleep deficient; instead, extroverts performed significantly better than introverts and both personality types when rested. This effect was observed under conditions of acute sleep deficit (<7 h) rather than sleep deprivation. We theorize extroverts were more engaged in this learning task than previously studied psychomotor vigilance tasks, allowing them to compensate for resource depletion when sleep time is insufficient.
Schizophrenia Research, Jul 1, 2012
Medial temporal lobe (MTL) structures play a central role in episodic memory. Prior studies sugge... more Medial temporal lobe (MTL) structures play a central role in episodic memory. Prior studies suggest that individuals with schizophrenia have deficits in episodic memory as well as structural abnormalities of the medial temporal lobe (MTL). While correlations have been reported between MTL volume loss and episodic memory deficits in such individuals, it is not clear whether such correlations reflect the influence of the disease state or of underlying genetic influences that might contribute to risk. We used high resolution magnetic resonance imaging and probabilistic algorithms for image analysis to determine whether MTL structure, episodic memory performance and the relationship between the two differed among groups of 47 healthy control subjects, 50 control siblings, 39 schizophrenia subjects, and 33 siblings of schizophrenia subjects. High-dimensional large deformation brain mapping was used to obtain volume measures of the hippocampus. Cortical distance mapping was used to obtain volume and thickness measures of the parahippocampal gyrus (PHG) and its substructures: the entorhinal cortex (ERC), the perirhinal cortex (PRC), and the parahippocampal cortex (PHC). Neuropsychological data was used to establish an episodic memory domain score for each subject. Both schizophrenia subjects and their siblings displayed abnormalities in episodic memory performance. Siblings of individuals with schizophrenia, and to a lesser extent, individuals with schizophrenia themselves, displayed abnormalities in measures of MTL structure (volume loss or
Memory, May 25, 2016
Autobiographical memory (AM) is a critically important form of memory for life events that underg... more Autobiographical memory (AM) is a critically important form of memory for life events that undergoes substantial developmental changes from childhood to adulthood. Relatively little is known regarding the functional neural correlates of AM retrieval in children as assessed with fMRI, and how they may differ from adults. We investigated this question with 14 children ages 8-11 years and 14 adults ages 19-30 years, contrasting AM retrieval with semantic memory (SM) retrieval. During scanning, participants were cued by verbal prompts to retrieve previously selected recent AMs or to verify semantic properties of words. As predicted, both groups showed AM retrieval-related increased activation in regions implicated in prior studies, including bilateral hippocampus, and prefrontal, posterior cingulate, and parietal cortices. Adults showed greater activation in the hippocampal/parahippocampal region as well as prefrontal and parietal cortex, relative to children; age-related differences were most prominent in the first 8 sec versus the second 8 sec of AM retrieval and when AM retrieval was contrasted with semantic retrieval. This study is the first to characterise similarities and differences during AM retrieval in children and adults using fMRI.
Chronobiology International, Mar 23, 2023
John Wiley & Sons, Inc. eBooks, Feb 12, 2016
Journal of Affective Disorders Reports
Buildings, Mar 11, 2019
The living lab approach to building science research provides the ability to accurately monitor o... more The living lab approach to building science research provides the ability to accurately monitor occupants and their environment and use the resulting data to evaluate the impact that various components of the built environment have on human comfort, health, and well-being. A hypothesized benefit of the living lab approach is the ability to simulate the real indoor environment in an experimentally controlled setting over relatively long periods of time, overcoming a significant hurdle encountered in many chamber-type experimental designs that rarely reflect typical indoor environments. Here, we present indoor environmental quality measurements from a network of sensors as well as building system design and operational data demonstrating the ability of a living lab to realistically simulate a wide range of environmental conditions in an office setting by varying air temperature, lighting, façade control, and sound masking in a series of three human subject experiments. The temporal variability of thermal and lighting conditions was assessed on an hourly basis and demonstrated the significant impact of façade design and control on desk-level measurements of both factors. Additional factors, such as desk layout and building system design (e.g., luminaires, speaker system), also contributed significantly to spatial variability in air temperature, lighting, and sound masking exposures, and this variability was reduced in latter experiments by optimizing desk layout and building system design. While ecologically valid experimental conditions are possible with a living lab, a compromise between realism and consistency in participant experience must often be found by, for example, using an atypical desk layout to reduce spatial variability in natural light exposure. Based on the experiences from these three studies, experimental design and environmental monitoring considerations for future office-based living lab experiments are explored.
Sleep, Apr 1, 2018
high extroversion group (p=.033). Sleep amount did not differ overall between groups (p>.5). Inte... more high extroversion group (p=.033). Sleep amount did not differ overall between groups (p>.5). Interestingly, sleep amount was not significantly related to performance in the low extroversion group (p>.05), and performance did not significantly differ between groups with sufficient sleep (>7 h;p>.5). Conclusion: Contrary to prior research, introverts did not outperform extroverts when sleep deficient; instead, extroverts performed significantly better than introverts and both personality types when rested. This effect was observed under conditions of acute sleep deficit (<7 h) rather than sleep deprivation. We theorize extroverts were more engaged in this learning task than previously studied psychomotor vigilance tasks, allowing them to compensate for resource depletion when sleep time is insufficient.
Sleep
Introduction Sleep inertia is a temporary period of reduced alertness and impaired physical and c... more Introduction Sleep inertia is a temporary period of reduced alertness and impaired physical and cognitive performance that immediately follows waking. Sleep inertia can have devastating consequences necessitating an intervention to successfully mitigate symptoms. Previous work has demonstrated modest benefits for individual environmental interventions which manipulate either lighting, sound, or temperature. The current study sought to expand on previous work and measure the impact of a multimodal intervention that collectively manipulated light, sound, and ambient temperature on vigilance, mood, and sleepiness. Methods 37 adults (M=27.13 years, 19 F) who self-reported taking longer than 30 minutes to wake up for 60% of their work week slept in the lab for four nights. They were woken up each morning with either a traditional alarm sound or the multimodal intervention (two control nights and two intervention nights, counterbalanced across participants). Feelings of sleep inertia were...
Memory, 2016
Autobiographical memory (AM) is a critically important form of memory for life events that underg... more Autobiographical memory (AM) is a critically important form of memory for life events that undergoes substantial developmental changes from childhood to adulthood. Relatively little is known regarding the functional neural correlates of AM retrieval in children as assessed with fMRI, and how they may differ from adults. We investigated this question with 14 children ages 8-11 years and 14 adults ages 19-30 years, contrasting AM retrieval with semantic memory (SM) retrieval. During scanning, participants were cued by verbal prompts to retrieve previously selected recent AMs or to verify semantic properties of words. As predicted, both groups showed AM retrieval-related increased activation in regions implicated in prior studies, including bilateral hippocampus, and prefrontal, posterior cingulate, and parietal cortices. Adults showed greater activation in the hippocampal/parahippocampal region as well as prefrontal and parietal cortex, relative to children; age-related differences were most prominent in the first 8 sec versus the second 8 sec of AM retrieval and when AM retrieval was contrasted with semantic retrieval. This study is the first to characterise similarities and differences during AM retrieval in children and adults using fMRI.
Schizophrenia Research, 2012
Medial temporal lobe (MTL) structures play a central role in episodic memory. Prior studies sugge... more Medial temporal lobe (MTL) structures play a central role in episodic memory. Prior studies suggest that individuals with schizophrenia have deficits in episodic memory as well as structural abnormalities of the medial temporal lobe (MTL). While correlations have been reported between MTL volume loss and episodic memory deficits in such individuals, it is not clear whether such correlations reflect the influence of the disease state or of underlying genetic influences that might contribute to risk. We used high resolution magnetic resonance imaging and probabilistic algorithms for image analysis to determine whether MTL structure, episodic memory performance and the relationship between the two differed among groups of 47 healthy control subjects, 50 control siblings, 39 schizophrenia subjects, and 33 siblings of schizophrenia subjects. High-dimensional large deformation brain mapping was used to obtain volume measures of the hippocampus. Cortical distance mapping was used to obtain volume and thickness measures of the parahippocampal gyrus (PHG) and its substructures: the entorhinal cortex (ERC), the perirhinal cortex (PRC), and the parahippocampal cortex (PHC). Neuropsychological data was used to establish an episodic memory domain score for each subject. Both schizophrenia subjects and their siblings displayed abnormalities in episodic memory performance. Siblings of individuals with schizophrenia, and to a lesser extent, individuals with schizophrenia themselves, displayed abnormalities in measures of MTL structure (volume loss or cortical thinning) as compared to control groups. Further, we observed correlations between structural measures and memory performance in both schizophrenia subjects and their siblings, but not in their respective control groups. These findings suggest that disease-specific genetic factors present in both patients and their relatives may be responsible for correlated abnormalities of MTL structure and memory impairment. The observed attenuated effect of such factors on MTL structure in individuals with schizophrenia may be due to non-genetic influences related to the development and progression of the disease on global brain structure and cognitive processing.
The British Journal of Psychiatry, 2010
BackgroundThe relatives of individuals with schizophrenia exhibit deficits of overall frontal lob... more BackgroundThe relatives of individuals with schizophrenia exhibit deficits of overall frontal lobe volume, consistent with a genetic contribution to these deficits.AimsTo quantify the structure of gyral-defined subregions of prefrontal cortex in individuals with schizophrenia and their siblings.MethodGrey matter volume, cortical thickness, and surface area of the superior, middle and inferior frontal gyri were measured in participants with schizophrenia and their unaffected (non-psychotic) siblings (n = 26 pairs), and controls and their siblings (n = 40 pairs).ResultsGrey matter volume was reduced in the middle and inferior frontal gyri of individuals with schizophrenia, relative to controls. However, only inferior frontal gyrus volume was also reduced in the unaffected siblings of those with schizophrenia, yielding a volume intermediate between their affected siblings and controls.ConclusionsThe structure of subregions of the prefrontal cortex may be differentially influenced by ge...
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Papers by Carolina Campanella