Papers by Nisrine Khoubila
Clinical Lymphoma Myeloma and Leukemia
Clinical Lymphoma Myeloma and Leukemia
Clinical Lymphoma Myeloma and Leukemia
Clinical Lymphoma Myeloma and Leukemia
Sang Thrombose Vaisseaux, Sep 1, 2021
Case Reports in Oncological Medicine, 2020
According to the World Health Organization, medulloepithelioma belongs to the embryonal neoplasm ... more According to the World Health Organization, medulloepithelioma belongs to the embryonal neoplasm entity. It is a very rare, highly malignant tumor typically affecting infants and young children. Usually, the tumor arises in the eye or in the central nervous system; a peripheral location has been rarely reported without an established treatment. The recognition and separation of this neoplasm from other differential tumors are mandatory for better understanding of its biology and determination of optimal treatment. This paper reports a case of an ectopic intrapelvic medulloepithelioma with liver metastasis in a 3-year-old girl.
Pediatric Blood & Cancer
In low‐ and middle‐income countries, therapeutic options for advanced, refractory, or relapsing m... more In low‐ and middle‐income countries, therapeutic options for advanced, refractory, or relapsing malignancies are limited due to local constraints such as cost of drugs, distance from oncology centers, and lack of availability of new anticancer drugs. Metronomics, which combines metronomic chemotherapy (MC) and drug repositioning, allows for the provision of new therapeutic options for patients in this setting.
Clinical Lymphoma Myeloma and Leukemia
Clinical Lymphoma Myeloma and Leukemia
Clinical Lymphoma Myeloma and Leukemia
Clinical Lymphoma Myeloma and Leukemia
Aim: To assess the impact of oral health on the quality of life in children with acute leukemia.M... more Aim: To assess the impact of oral health on the quality of life in children with acute leukemia.Methods: Forty children (age 11 to 14 years) with acute leukemia from the Pediatric Oncology and Hematology Departments of the 20th August Hospital Casablanca and the Pediatrics Department P3 at Abderrahim Harouchi Hospital Casablanca, Morocco were surveyed. Data was collected via an administered questionnaire. The questionnaire is a translated version of the Child-Oral Impacts of Daily Performance Questionnaire in Arabic (validated in Morocco).Results: The most commonly reported problems were: dental tartar, teeth position abnomalities, tooth decay, dental sensitivity and oral ulcerations. The overall prevalence of oral problems impacting upon daily activities (eating, speaking, cleaning teeth, relaxing, sleeping, smiling, showing teeth, studying and being in touch with other children) over the last 3 months was 52.5%. The most frequently affected daily activity was eating difficulties (...
Clinical Lymphoma Myeloma and Leukemia
Pan African Medical Journal, 2014
L'ONA n'est pas une maladie spécifique, mais c'est l'aboutissement de diverses conditions patholo... more L'ONA n'est pas une maladie spécifique, mais c'est l'aboutissement de diverses conditions pathologiques dont la plupart altère la circulation sanguine. Elle peut compliquer toutes les maladies systémiques et auto-immunes essentiellement le lupus érythémateux systémique. Sa survenue au cours de l'artérite de Takayasu a été exceptionnellement rapportée. Nous rapportons l'observation d'une femme âgée de 69 ans, et suivie pour artérite de Takayasu qui se présentait pour des douleurs de la hanche gauche. Un scanner de la hanche gauche avait confirmé le diagnostic d'une ostéonecrose aseptique de la tête fémorale gauche stade 3.
Cytogenetic abnormalities are frequently reported in the literature describing the presence of ch... more Cytogenetic abnormalities are frequently reported in the literature describing the presence of chromosomal rearrangements in important cases of acute myeloid leukemia (AML); the rate can reach 50–60% of cases of AML. Cytogenetic abnormalities represent an important prognosis factor, their analysis is crucial for AML; cytogenetic study permits to classify prognostic groups and indicate the treatment strategy and helps to improve the outcome of these patients and to increase their chances of cure. Hundreds of uncommon chromosomal aberrations from AML exist. This chapter summarizes chromosomal abnormalities that are common and classifies AML according to the World Health Organization (WHO) classifications from 2008 to 2016; we will discuss briefly gene mutations detected in normal karyotype (NK) AML by cuttingedge next-generation sequencing technology, like FLT3-ITD, nucleophosmin (NPM1), CCAAT/enhancer-binding protein alpha (CEBPA), and other additional mutations.
Cytogenetics - Classical and Molecular Strategies for Analysing Heredity Material, 2021
Genetic defects play a major role in pathogenesis of the most of haematological malignancies, inc... more Genetic defects play a major role in pathogenesis of the most of haematological malignancies, including cytogenetic abnormalities, gene mutations, and abnormal gene expression. Our knowledge about the genetics of haematological disorders has been dramatically improved during the past decade, due to revolution of sequencing technologies which have played a crucial role. In this chapter, we describe the techniques commonly employed for elucidating chromosomal aberrations, prognostic impact of recurrent chromosomal abnormalities, and recently updated risk stratification systems. We will summarise the chromosomal abnormalities recently identified on many of haematological diseases such acute myeloid leukaemia, acute lymphoid leukaemia, myelodysplasic syndrome, multiple myeloma, meyloproliferative disease and clarify their impacts on clinical phenotype and prognosis, as well as their role in the pathogenesis of these diseases. The aim of this chapter is to provide a brief overview of the...
Clinical Case Reports, 2020
In this paper, we report a life‐threatening condition and relate our experience in managing a hem... more In this paper, we report a life‐threatening condition and relate our experience in managing a hemophilia B patient who required three surgical procedures, highlighting the difficulties we encountered in our setting and propose some tangible.
Acute Myeloblastic Leukaemia (AML) is a malignant haemopathy characterized by infiltration and ac... more Acute Myeloblastic Leukaemia (AML) is a malignant haemopathy characterized by infiltration and accumulation in the bone marrow by myeloblastic-type blast cells causing medullary insufficiency. At the global level, the search for improved AML treatment is a long-standing concern.PurposeTo evaluate a new protocol AML MA 2003 its therapeutic results and tolerance in de novo AML patients.MethodsIt was a prospective and descriptive unicentre study carried out from January 2003 to December 2010. It included adults of 20 to 60 years with a diagnosis of de novo AML except a promyelocytic leukemia and without treatment by hydroxyurea.ResultsA total of 962 AMLs were diagnosed, 438 met the inclusion criteria, 48.4% women and 51.6% men with a median age of 39.8 years. 36.1% received hydroxyurea in pre-induction. 96.3% patients were induced, 76 (18%) died. A total of 178 (40.6%) of the 438 evaluable patients reached the maintenance phase. The overall survival of all patients was 32.4% at 5 years...
Myelodysplasia syndromes (MDS) are defined by a heterogeneous group of myeloid malignancies chara... more Myelodysplasia syndromes (MDS) are defined by a heterogeneous group of myeloid malignancies characterized by peripheral blood cytopenia and dishematopoiesis and frequently progress to acute myeloid leukemia. Conventional karyotype has a crucial role in myelodysplastic syndrome (MDS) and is one of items of the International Prognostic Scoring System (IPSS) for patient risk stratification and treatment selection. Approximately 50–60% of cases of MDS present chromosomal abnormalities, like the deletions of chromosome 5q and 7q, trisomy 8, and complex karyotypes. New genomic technologies have been developted, like single-nucleotide polymorphism array and next-generation sequencing. They can identify the heterozygous deletions wich result in haplo-insufficient gene expression (e.g., CSNK1A1, DDX41 on chromosome 5, CUX1, LUC7L2, EZH2 on chromosome 7) involved in the pathogenesis of myelodysplasia syndromes. Genetic abnormalities are multiple, the most recurrent one are involved in the RNA...
Introduction: AML is the most common form of acute leukemia in adults, accounting for 25% of leuk... more Introduction: AML is the most common form of acute leukemia in adults, accounting for 25% of leukemias in this population in the Western world. The characteristics of AML in the elder patients are different from those in young patients characterized by a high prevalence of poor prognosis cytogenetic abnormalities. All these factors make AML in patients older than 60 years to be an particular entity wich management is very difficult in developing countries. Data on this group of AML patients are rare in our context and the Morocco national AML-MA 2011 protocol wich is use for the treatement of AML is limited for patients aged less than 60 years. The aim of our study was to describe the epidemiological, clinical, biological characteristics of AML patients aged over 60 in the departement and to highlight the dificulties wich occurred in their management. Patients and method: A retrospective study was conducted from 1 January 2003 to 1 January 2016 including, all cases of AML patients o...
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Papers by Nisrine Khoubila