Papers by TANIA RODRIGUES
Can. J. Physiol. Pharmacol. , 2019
Imbalance in ventricular repolarization parameters are related to increased risk of severe
arrhyt... more Imbalance in ventricular repolarization parameters are related to increased risk of severe
arrhythmia and sudden cardiac death. There is limited research regarding markers to detect
patients at risk in this early stage. We aimed to assess the influence of grade I left ventricular
diastolic dysfunction on repolarization parameters in asymptomatic patients. Ambulatory patients
with grade I left ventricular diastolic dysfunction were studied and compared with a control
group. We assessed: the QT dispersion circadian variation, heart rate variability in the time and
frequency domains and dynamics of QT using a 12-lead Holter. In the diastolic dysfunction
group 8 (30%) patients had QT dispersion >80 ms. One (3.8%) patient presented premature
ventricular complex > 10/h. The comparison between the two groups showed that the difference
between the standard deviation of normal-to-normal intervals and low frequency power in both
groups was statistically significant. We therefore conclude that increased parameters of
ventricular repolarization and depressed heart rate variability reflect an imbalance in autonomic
responses in patients with grade I left ventricular diastolic dysfunction without cardiovascular
symptoms enabling the identification of patients that are at a higher risk for cardiovascular
events.
Un ive r sida de de Br a sília pa r a obt e n çã o do Tít ulo de D ou t or e m Ciências da Saúde ... more Un ive r sida de de Br a sília pa r a obt e n çã o do Tít ulo de D ou t or e m Ciências da Saúde Orientador: Prof. Dr. Francisco de Assis da Rocha Neves Brasília 2006
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Papers by TANIA RODRIGUES
arrhythmia and sudden cardiac death. There is limited research regarding markers to detect
patients at risk in this early stage. We aimed to assess the influence of grade I left ventricular
diastolic dysfunction on repolarization parameters in asymptomatic patients. Ambulatory patients
with grade I left ventricular diastolic dysfunction were studied and compared with a control
group. We assessed: the QT dispersion circadian variation, heart rate variability in the time and
frequency domains and dynamics of QT using a 12-lead Holter. In the diastolic dysfunction
group 8 (30%) patients had QT dispersion >80 ms. One (3.8%) patient presented premature
ventricular complex > 10/h. The comparison between the two groups showed that the difference
between the standard deviation of normal-to-normal intervals and low frequency power in both
groups was statistically significant. We therefore conclude that increased parameters of
ventricular repolarization and depressed heart rate variability reflect an imbalance in autonomic
responses in patients with grade I left ventricular diastolic dysfunction without cardiovascular
symptoms enabling the identification of patients that are at a higher risk for cardiovascular
events.
arrhythmia and sudden cardiac death. There is limited research regarding markers to detect
patients at risk in this early stage. We aimed to assess the influence of grade I left ventricular
diastolic dysfunction on repolarization parameters in asymptomatic patients. Ambulatory patients
with grade I left ventricular diastolic dysfunction were studied and compared with a control
group. We assessed: the QT dispersion circadian variation, heart rate variability in the time and
frequency domains and dynamics of QT using a 12-lead Holter. In the diastolic dysfunction
group 8 (30%) patients had QT dispersion >80 ms. One (3.8%) patient presented premature
ventricular complex > 10/h. The comparison between the two groups showed that the difference
between the standard deviation of normal-to-normal intervals and low frequency power in both
groups was statistically significant. We therefore conclude that increased parameters of
ventricular repolarization and depressed heart rate variability reflect an imbalance in autonomic
responses in patients with grade I left ventricular diastolic dysfunction without cardiovascular
symptoms enabling the identification of patients that are at a higher risk for cardiovascular
events.