Papers by Maria Kobayashi
Fuel and Energy Abstracts, 2011
A measurement of the Z/γ⁎Z/γ⁎ transverse momentum (pTZ) distribution in proton–proton collisions ... more A measurement of the Z/γ⁎Z/γ⁎ transverse momentum (pTZ) distribution in proton–proton collisions at s=7 TeV is presented using Z/γ⁎→e+e−Z/γ⁎→e+e− and Z/γ⁎→μ+μ−Z/γ⁎→μ+μ− decays collected with the ATLAS detector in data sets with integrated luminosities of 35 pb−1 and 40 pb−1, respectively. The normalized differential cross sections are measured separately for electron and muon decay channels as well as for their combination up to pTZ of 350 GeV for invariant dilepton masses 66 GeV<mℓℓ<116 GeV66 GeV<mℓℓ<116 GeV. The measurement is compared to predictions of perturbative QCD and various event generators. The prediction of resummed QCD combined with fixed order perturbative QCD is found to be in good agreement with the data.
Brazilian Journal of Medical and Biological Research, 2005
The pharmacokinetics of propranolol may be altered by hypothermic cardiopulmonary bypass (CPB), r... more The pharmacokinetics of propranolol may be altered by hypothermic cardiopulmonary bypass (CPB), resulting in unpredictable postoperative hemodynamic responses to usual doses. The objective of the present study was to investigate the pharmacokinetics of propranolol in patients undergoing coronary artery bypass grafting (CABG) by CPB under moderate hypothermia. We evaluated 11 patients, 4 women and 7 men (mean age 57 ± 8 years, mean weight 75.4 ± 11.9 kg and mean body surface area 1.83 ± 0.19 m 2 ), receiving propranolol before surgery (80-240 mg a day) and postoperatively (10 mg a day). Plasma propranolol levels were measured before and after CPB by highperformance liquid chromatography. Pharmacokinetic Solutions 2.0 software was used to estimate the pharmacokinetic parameters after administration of the drug pre-and postoperatively. There was an increase of biological half-life from 4.5 (95% CI = 3.9-6.9) to 10.6 h (95% CI = 8.2-14.7; P < 0.01) and an increase in volume of distribution from 4.9 (95% CI = 3.2-14.3) to 8.3 l/kg (95% CI = 6.5-32.1; P < 0.05), while total clearance remained unchanged 9.2 (95% CI = 7.7-24.6) vs 10.7 ml min -1 kg -1 (95% CI = 7.7-26.6; NS) after surgery. In conclusion, increases in drug distribution could be explained in part by hemodilution during CPB. On the other hand, the increase of biological half-life can be attributed to changes in hepatic metabolism induced by CPB under moderate hypothermia. These alterations in the pharmacokinetics of propranolol after CABG with hypothermic CPB might induce a greater myocardial depression in response to propranolol than would be expected with an equivalent dose during the postoperative period.
European Physical Journal C, 2011
Molecular Genetics and Metabolism, 2001
We summarize the diagnosis, outcome, and molecular studies of five Mediterranean patients with ci... more We summarize the diagnosis, outcome, and molecular studies of five Mediterranean patients with citrullinemia: four neonatal classical forms and one subacute form, who also suffers from Down syndrome and presented with severe hepatic encephalopathy at age 7. Mutational analysis revealed three alleles with a common mutation and five new mutations: two Moroccan siblings are homozygous for G390R, the subacute form is compound heterozygous for G390R/G117D (new mutation), and the two other neonatal forms are compound heterozygous for four new mutations: V69A/E270Q and T119I(R108L)/?.
Analytica Chimica Acta, 1995
... gels and grafted layers using the quartz crystal microbalance technique Maria I. Ivanchenko a... more ... gels and grafted layers using the quartz crystal microbalance technique Maria I. Ivanchenko a, Hiroo Kobayashi a, Eduard A. Kulik b, Natalia B. Dobrova b ... was isolated from the other by a plastic cylinder attached to the surface of the crystal by a silicon sealant (Shin-Etsu Kagaku ...
Journal of High Energy Physics, 2010
First measurements of the W -> lnu and Z/gamma* -> ll (l = e, mu) production cross sections in pr... more First measurements of the W -> lnu and Z/gamma* -> ll (l = e, mu) production cross sections in proton-proton collisions at sqrt(s) = 7 TeV are presented using data recorded by the ATLAS experiment at the LHC. The results are based on 2250 W -> lnu and 179 Z/gamma* -> ll candidate events selected from a data set corresponding to an integrated luminosity of approximately 320 nb-1. The measured total W and Z/gamma*-boson production cross sections times the respective leptonic branching ratios for the combined electron and muon channels are $\stotW$ * BR(W -> lnu) = 9.96 +- 0.23(stat) +- 0.50(syst) +- 1.10(lumi) nb and $\stotZg$ * BR(Z/gamma* -> ll) = 0.82 +- 0.06(stat) +- 0.05(syst) +- 0.09(lumi) nb (within the invariant mass window 66 < m_ll < 116 GeV). The W/Z cross-section ratio is measured to be 11.7 +- 0.9(stat) +- 0.4(syst). In addition, measurements of the W+ and W- production cross sections and of the lepton charge asymmetry are reported. Theoretical predictions based on NNLO QCD calculations are found to agree with the measurements.
Hypertension Research, 2003
Since the discovery that adrenomedullin gene expression is 20- to 40-fold higher in endothelial c... more Since the discovery that adrenomedullin gene expression is 20- to 40-fold higher in endothelial cells than even in the adrenal medulla, this peptide has been regarded as an important secretory product of the vascular endothelium, together with nitric oxide, eicosanoids, endothelin-1, and other vasoactive metabolites. Cerebral endothelial cells secrete an exceptionally large amount of adrenomedullin, and the adrenomedullin concentration is about 50% higher in the cerebral circulation than in the peripheral vasculature. The adrenomedullin production of cerebral endothelial cells is induced by astrocyte-derived factors. Adrenomedullin causes vasodilation in the cerebral circulation, may participate in the maintenance of the resting cerebral blood flow, and may be protective against ischemic brain injury. Recent data from our laboratory indicate that adrenomedullin, as an endothelium-derived autocrine/paracrine hormone, plays an important role in the regulation of specific blood-brain barrier properties. Adrenomedullin is suggested to be one of the physiological links between astrocyte-derived factors, cyclic adenosine 3&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;5&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;-monophosphate (cAMP), and the induction and maintenance of the blood-brain barrier. Moreover, the role of adrenomedullin in the differentiation and proliferation of endothelial cells and in angiogenesis suggests a more complex function for adrenomedullin in the cerebral circulation and in the development of the blood-brain barrier.
Interactions, 2011
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentu... more Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √ s = 7 TeV pp collisions
Journal of High Energy Physics, 2010
First measurements of the W → ℓν and Z/γ * → ℓℓ (ℓ = e, μ) production cross sections in proton-pr... more First measurements of the W → ℓν and Z/γ * → ℓℓ (ℓ = e, μ) production cross sections in proton-proton collisions at \( \sqrt {s} = 7\;{\text{TeV}} \) are presented using data recorded by the ATLAS experiment at the LHC. The results are based on 2250 W → ℓν and 179 Z/γ * → ℓℓ candidate events selected from a data set corresponding to an integrated luminosity of approximately 320 nb. The measured total W and Z/γ ∗-boson production cross sections times the respective leptonic branching ratios for the combined electron and muon channels are \( \sigma_W^{\text{tot}} \) . BR(W → ℓν) = 9.96 ± 0.23(stat) ± 0.50(syst) ± 1.10(lumi) nb and \( \sigma_{{{Z} \left/ {\gamma } \right.}}^{\text{tot}} \) BR(Z/γ ∗ → ℓℓ) = 0.82 ± 0.06 (stat) ± 0.05 (syst) ± 0.09(lumi) nb (within the invariant mass window 66 m ℓℓ 116GeV). The W/Z cross-section ratio is measured to be 11.7 ± 0.9(stat) ± 0.4(syst). In addition, measurements of the W + and W − production cross sections and of the lepton charge asymmetry are reported. Theoretical predictions based on NNLO QCD calculations are found to agree with the measurements.
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Papers by Maria Kobayashi