Papers by Ana Luiza Castro do Amaral
Em 1908, foi inaugurada a "Colonia Correccional (sic) do Porto das Palmas", considerado... more Em 1908, foi inaugurada a "Colonia Correccional (sic) do Porto das Palmas", considerado o primeiro presidio de seguranca maxima do Estado de Sao Paulo. A instituicao penal, inicialmente, tinha como missao abrigar sujeitos que eram considerados ameacas a sociedade, esses homens, eram condenados pelo Decreto no 145, de 1893, vulgarmente conhecida como Lei contra vadios, vagabundos e capoeiras. O objetivo do presente trabalho e realizar um estudo sobre o texto psicanalitico O estranho, desenvolvido por Freud, a nova categoria de sujeitos considerados marginais, surgida a partir do decreto no 145.
Experimental …, 2009
The abuse of pharmaceutical drugs and the inadequate ingestion of nutrients constitute external f... more The abuse of pharmaceutical drugs and the inadequate ingestion of nutrients constitute external factors that can alter brain development, both individually and in combination. We used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the combined effects of the antipyretic/analgesic/ anti-inflammatory drug dipyrone and malnutrition (M) in the developing rat brain. Suckling malnourished rats (M; n = 69) and well nourished controls (W; n = 76) received dipyrone (300 mg/kg/day) or saline per gavage for 7 consecutive days during the 2nd, 3rd, or 4th postnatal week. At 35-45 days, CSD was recorded at 2 points in the parietal region. In both groups, dipyrone increased CSD propagation velocities compared to respective saline controls (P b 0.05). This effect was intensified when dipyrone application during the 4th postnatal week intensified the increase compared to the 2nd and 3rd weeks. In saline-treated groups, the velocities (mean ± s.d., in mm/min) were 3.70 ± 0.11, 3.77 ± 0.16, and 3.78± 0.13 (W) and 4.13 ± 0.10, 4.16 ± 0.10, and 4.14 ± 0.09 (M), for animals treated in the 2nd, 3rd and 4th postnatal weeks. In dipyrone-treated groups, the respective values were 3.99± 0.14, 4.03± 0.16, and 4.30± 0.19 (W) and 4.47 ± 0.17, 4.70 ± 0.31, and 5.01 ± 0.28 (M). Results support the hypothesis that dipyrone has a CSD-facilitating effect, which is more intense at a late brain developmental stage and is facilitated by malnutrition. This may help explain the developmental brain excitability changes that are associated with pharmacological and nutritional factors.
Experimental …, 2009
The abuse of pharmaceutical drugs and the inadequate ingestion of nutrients constitute external f... more The abuse of pharmaceutical drugs and the inadequate ingestion of nutrients constitute external factors that can alter brain development, both individually and in combination. We used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the combined effects of the antipyretic/analgesic/ anti-inflammatory drug dipyrone and malnutrition (M) in the developing rat brain. Suckling malnourished rats (M; n = 69) and well nourished controls (W; n = 76) received dipyrone (300 mg/kg/day) or saline per gavage for 7 consecutive days during the 2nd, 3rd, or 4th postnatal week. At 35-45 days, CSD was recorded at 2 points in the parietal region. In both groups, dipyrone increased CSD propagation velocities compared to respective saline controls (P b 0.05). This effect was intensified when dipyrone application during the 4th postnatal week intensified the increase compared to the 2nd and 3rd weeks. In saline-treated groups, the velocities (mean ± s.d., in mm/min) were 3.70 ± 0.11, 3.77 ± 0.16, and 3.78± 0.13 (W) and 4.13 ± 0.10, 4.16 ± 0.10, and 4.14 ± 0.09 (M), for animals treated in the 2nd, 3rd and 4th postnatal weeks. In dipyrone-treated groups, the respective values were 3.99± 0.14, 4.03± 0.16, and 4.30± 0.19 (W) and 4.47 ± 0.17, 4.70 ± 0.31, and 5.01 ± 0.28 (M). Results support the hypothesis that dipyrone has a CSD-facilitating effect, which is more intense at a late brain developmental stage and is facilitated by malnutrition. This may help explain the developmental brain excitability changes that are associated with pharmacological and nutritional factors.
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Papers by Ana Luiza Castro do Amaral