Papers by Avijit Kumar Awasthi
Journal of Public Health Policy, 2020
During the early months of the 2020 COVID-19 crisis, critical services in India for tuberculosis ... more During the early months of the 2020 COVID-19 crisis, critical services in India for tuberculosis (TB) have been disrupted. India has one of the highest burdens of TB and requires continuity of critical TB care. Here, we highlight important points and approaches that can be used to guide navigation of the combined COVID-19 and TB crisis in India.
Emergence of multidrug resistance among the major bacterial and fungal pathogens is big a burden ... more Emergence of multidrug resistance among the major bacterial and fungal pathogens is big a burden for health care workers. Therefore, there is a need to find out new alternate antimicrobial agents. Herbal therapy from plants offers an effective approach to treat such microbial infections. In this context, the present study was undertaken to investigate the antimicrobial potential of Vanda cristata plant. The dried root was extracted in different solvents, and their antimicrobial was determined against several drug resistant bacterial and fungal pathogens. Among the various solvent tested, ethyl acetate and acetone extracts showed highest activities against all the tested bacterial and fungal pathogens with minimum inhibitory concentration (MIC) values ranging from 3.12-50.00 mg/mL and from 12.5-100.00 μg/mL respectively. The acetone extract was quite less active as compared to ethyl acetate extract against fungal strains. Thus, the current investigation leads to fresh sources of new ...
Mycopathologia, 2011
The availability and aggressive use of chemotherapeutic and immunosuppressive agents as well as b... more The availability and aggressive use of chemotherapeutic and immunosuppressive agents as well as broad-spectrum antibacterial agents have created a large population of patients who are at increased risk of acquiring infections with fungal organisms, especially Candida species. Present work was undertaken to study the epidemiology and microbiology of candidemia and Candida colonization in hospitalized children. A total of 323 suspected cases of septicemia were enrolled, of which blood culture from 7.4% subjects was positive for Candida species. In total, 57.3% subjects were colonized by Candida species at least at one of the tested sites. Of 337 isolates, 24.3, 71.5, 2.9, 0.59, and 0.59% were Candida albicans, Candida tropicalis, Candida krusei, Candida kefyr, and Candida lusitaniae, respectively. Antifungal susceptibility results show that fluconazole, itraconazole, and amphotericin B resistance is prevalent in 18.2, 2.4, and 3.6% of C. albicans isolates, and 21.1, 4.6, and 0.04% of C. tropicalis isolates, respectively. In a large number of cases, source of blood infection was patient's own colonizers, as shown by genetic matching. It was also noted that some strain types are circulating within the ward. High prevalence of non-albicans candidemia with high resistance to fluconazole is prevalent in North Indian hospitalized children.
The availability and aggressive use of chemotherapeutic and immunosuppressive agents as well as b... more The availability and aggressive use of chemotherapeutic and immunosuppressive agents as well as broad-spectrum antibacterial agents have created a large population of patients who are at increased risk of acquiring infections with fungal organisms, especially Candida species. Present work was undertaken to study the epidemiology and microbiology of candidemia and Candida colonization in hospitalized children. A total of 323 suspected cases of septicemia were enrolled, of which blood culture from 7.4% subjects was positive for Candida species. In total, 57.3% subjects were colonized by Candida species at least at one of the tested sites. Of 337 isolates, 24.3, 71.5, 2.9, 0.59, and 0.59% were Candida albicans, Candida tropicalis, Candida krusei, Candida kefyr, and Candida lusitaniae, respectively. Antifungal susceptibility results show that fluconazole, itraconazole, and amphotericin B resistance is prevalent in 18.2, 2.4, and 3.6% of C. albicans isolates, and 21.1, 4.6, and 0.04% of C. tropicalis isolates, respectively. In a large number of cases, source of blood infection was patient's own colonizers, as shown by genetic matching. It was also noted that some strain types are circulating within the ward. High prevalence of non-albicans candidemia with high resistance to fluconazole is prevalent in North Indian hospitalized children.
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Papers by Avijit Kumar Awasthi