Papers by Ana Luisa Pimentel
Journal of Affective Disorders, 2020
BACKGROUND Suicide rates vary substantially by sex. Suicides committed by males significantly out... more BACKGROUND Suicide rates vary substantially by sex. Suicides committed by males significantly outnumber female suicides. Disparities in community and social factors provide a partial explanation for this phenomenon. Thus, the evaluation of sex differences at a biological level might contribute to the elucidation of the factors involved in this imbalance. The aim of the present study was to evaluate sex-specific gene expression patterns in the suicidal brain. METHODS postmortem samples from the dorsolateral prefrontal cortex (DLPFC) of 75 Latino individuals were analyzed. We considered the following groups: i) male suicides (n = 38), ii) female suicides (n = 10), iii) male controls (n = 20), and iv) female controls (n = 7). Gene expression profiles were evaluated by microarrays. Differentially expressed genes among the groups were identified with a linear model. Similarities and differences in the gene sets between the sexes were identified. RESULTS Differentially expressed genes were identified between suicides and controls of each sex: 1,729 genes in females and 1,997 genes in males. Female-exclusive suicide genes were related to cell proliferation and immune response. Meanwhile, male-exclusive suicide genes were associated to DNA binding and ribonucleic protein complex. Sex-independent suicide genes showed enrichment in mitochondrial and vesicular functions. LIMITATIONS Relatively small sample size. Our diagnosis approach was limited to information found on coroner's records. The analysis was limited to a single brain area (DLPFC) and we used microarrays. CONCLUSION Previously unexplored sex differences in the brain gene expression of suicide completers were identified, providing valuable foundation for the evaluation of sex-specific factors in suicide.
European Neuropsychopharmacology, 2019
Expresar mi gratitud a Dios, quien con su bendición llena siempre mi vida y a toda mi familia por... more Expresar mi gratitud a Dios, quien con su bendición llena siempre mi vida y a toda mi familia por estar siempre presentes. Mi profundo agradecimiento a todas los ingenieros y personal que conforman la escuela de ingeniería automotriz, por darme la confianza, abrirme las puertas y permitirme realizar todo el proceso investigativo dentro de su establecimiento educativo. De igual manera mis agradecimientos a mis profesores en especial al Ing. Luis Buenaño, Ing. Bolívar Cuaical quienes con la enseñanza de sus valiosos conocimientos hicieron que pueda culminar este proyecto, gracias a cada una de ustedes por su paciencia, dedicación, apoyo incondicional y amistad. Cristian Joel Aldas Ruiz El más sincero agradecimiento a todos los docentes de la Escuela de Ingeniería Automotriz, por inculcarme los conocimientos necesarios para defenderme en el área laboral, por la paciencia y consejos brindados en todos estos años de carrera, gracias a ellos he logrado cumplir mi objetivo que es ser un Ingeniero Automotriz de calidad y ético. Agradezco a mis amigos que estuvieron ahí brindándome su apoyo para seguir adelante y no rendirme, en especial a mis Padres por su confianza y esfuerzo diario. A mi Tutor y Asesor por guiarme con su experiencia, sabiduría, para culminar con éxito esta etapa.
Journal of Dual Diagnosis
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Papers by Ana Luisa Pimentel