Papers by Jose Luis Neyro
Seminars in Interventional Radiology, 2006
Embolization is a remarkably versatile procedure used in nearly all vascular and nonvascular syst... more Embolization is a remarkably versatile procedure used in nearly all vascular and nonvascular systems to treat a wide range of pathology. The published literature is rich with studies demonstrating the enormous therapeutic potential offered by embolization procedures, and the possibilities continue to expand with the advent of new embolization agents and techniques. Unfortunately, with this variety and innovation comes a wide spectrum of potential complications, not always easy to classify and summarize, associated with embolization. This article reviews the procedures and associated complications of arterial and venous embolization procedures, organized by vascular distribution.
Fertility and Sterility, 1981
Two sisters, ages 18 and 25, presented with primary amenorrhea and underwent clinical, hormonal, ... more Two sisters, ages 18 and 25, presented with primary amenorrhea and underwent clinical, hormonal, cytogenetic, and pathologic evaluation. Both were of normal stature and lacking of somatic stigmata. Both patients had normal 46,XX karyotype on peripheral blood. Streak gonads were seen in both patients and a rather scanty number of primordial follicles was found in one patient. FSH, LH, and urinary estrogens were consistent with streak gonad syndrome. Autosomal recessive inheritance has been suggested in familial aggregates with XX gonadal dysgenesis.
Maturitas, 2009
To assess the prevalence of metabolic syndrome (MS) in women after menopause in different Brazili... more To assess the prevalence of metabolic syndrome (MS) in women after menopause in different Brazilian states using National Cholesterol Education Program (NCEP-ATP III) and International Diabetes Federation (IDF) definitions. Design: A cross multicenter study was realized in the states of Sao Paulo and Minas Gerais Brazil, which included 250 and 215 women respectively, totaling 465 participants. Menopause was diagnosed by clinical history of amenorrhea more than a year and FSH ≥ 30 mIU/mL levels. The MS was defined by at least 3 of NCEP-ATP III (2001) and IDF (2005) definitions. The study was approved by the Ethics in Research Committee. Results: The average age of women was 54.7±6.1 years, the age of menopause was 47.1±4.7 years and the time elapsed after the menopause of 7.3±6.3 years. The HDL-cholesterol levels was 51.7±13.4 mg/dL, fasting glycemia levels was 159.5±36.8 mg/dL, triglycerides levels was 102.5±36.8 mg/dL, abdominal waist circumference was 92, 1 9.3 cm, systolic blood pressure (BP) 129.8±19 mmHg and diastolic BP 79.6 11.6 mmHg. NCEP-ATPIII and IDF definitions had characterized MS in 24.3% (n = 113) and 27.74% (n = 129) of women, respectively, without any statistical significance. Conclusion: There was high prevalence of metabolic syndrome in Brazilian women after menopause. Meanwhile IDF diagnosed 16 women more than the NCEP definition. The morbidity and mortality from cardiovascular disease justify attention to diagnosis and treatment of MS.
The Journal of reproductive medicine, 1986
Nine phenotypic female patients with XY karyotype were evaluated through a clinical, cytogenetic,... more Nine phenotypic female patients with XY karyotype were evaluated through a clinical, cytogenetic, hormonal, endoscopic and histologic diagnostic protocol. Seven patients complained of primary amenorrhea and two patients of abnormal puberal development. The final diagnosis was XY gonadal dysgenesis (n = 5) and testicular feminization syndrome (n = 4). Two patients were less than 155 cm tall, and the remainder were over 155. Minor somatic anomalies were found in two patients with XY gonadal dysgenesis. Patient with testicular feminization syndrome had FSH and LH within the normal range, and patients with XY gonadal dysgenesis had elevated FSH and LH levels. Gonadoblastomas were found in two patients with XY gonadal dysgenesis (one patient with XO/XX/XY mosaicism). Laparoscopy and gonadal biopsy might be useful in some patients to avoid confusion between XY gonadal dysgenesis and testicular feminization syndrome. Early diagnosis of XY gonadal dysgenesis is always desirable, and bilater...
Progresos de Obstetricia y Ginecología, 1999
Progresos de Obstetricia y Ginecología, 1970
Human Reproduction, 1991
Twenty-nine infertile women with polycystic ovary disease which was resistant to therapy with clo... more Twenty-nine infertile women with polycystic ovary disease which was resistant to therapy with clomiphene citrate underwent a combined treatment for follicle recruitment consisting of pure FSH during the first days of the cycle and HMG during the last days of the follicular phase. Sixty cycles were stimulated of which 83% were ovulatory. Eighteen pregnancies were achieved (36% of cycles, 62% of patients). The multiple pregnancy rate was 39%. Twelve cycles (20%) showed the ovarian hyperstimulation syndrome (OHS) although seven of these resulted in full term deliveries. There were no miscarriages among the patients studied.
International journal of fertility and women's medicine
To assess the relationship between the concentrations of total immunoreactive alpha-inhibin in hu... more To assess the relationship between the concentrations of total immunoreactive alpha-inhibin in human seminal plasma, sperm quality, and in vitro fertilization (IVF) rates. Medical school hospital. Prospective study. 72 consecutive couples undergoing IVF with husband's sperm in which at least 4 oocytes were obtained. Alpha-inhibin determination by means of enzyme-linked immunosorbent assay, sperm analysis for density and motility, IVF rates. Total immunoreactive alpha-inhibin levels were not correlated with IVF rates. Nor were there any differences in fertilization rates in the different groups. Lower inhibin levels were found in oligozoospermic cases. Lower sperm counts were found in cases with inhibin values below the median value, and also with respect to various other cutoffs. No correlation was found between inhibin levels and any of the sperm variables measured. Total immunoreactive alpha-inhibin is not a prognostic factor in IVF cycles. However, an association was found be...
Zentralblatt für Gynäkologie, 1991
Between January 1980 and December 1990, 107 ovarian carcinoma patients in clinical complete remis... more Between January 1980 and December 1990, 107 ovarian carcinoma patients in clinical complete remission were submitted to a second-look laparotomy at our department. Borderline carcinomas were excluded from the study. Second-look laparotomy was negative in 78.5% of the cases (84 patients). During the follow-up period after the second-look-laparotomy (mean 59 months, range 6 to 120), a recurrence of the tumour was diagnosed in 7 patients (8.4% false-negative rate). This took place after a mean time of 39 months following the previous negative second-look (range 8 to 108). Three of the recurrences were localized in the pelvis, two in the upper abdomen and two in the paraaortic and supraclavicular lymph nodes, respectively. All patients with a recurrence belonged to the group having received adjuvant chemotherapy for one year after initial surgery. At the present time we lack any means to anticipate which patients with a negative second-look will eventually show a recurrence of their tum...
Journal of Obstetrics and Gynaecology, 1992
... cycles J. L. Neyro, G. Barrenetxea, M. J. Barbazan, M. M. Centeno, F. Montoya and F. J. Rodri... more ... cycles J. L. Neyro, G. Barrenetxea, M. J. Barbazan, M. M. Centeno, F. Montoya and F. J. Rodriguez-Escudero Human Reproduction Unit, Department of Obstetrics and ... John Hunter was the first to docu-ment an artificial insemination in 1799, for a husband with hypospadias. ...
Journal of Obstetrics and Gynaecology, 1993
As well as being essential for musculoskeletal health, vitamin D is involved in numerous other ph... more As well as being essential for musculoskeletal health, vitamin D is involved in numerous other physiological processes. Poor vitamin D status is linked to a wide range of diseases, including cardiovascular disease, autoimmune conditions, pulmonary disorders and upper respiratory tract infections. While optimal target concentrations of serum 25-hydroxyvitamin D (25(OH)D) for health maintenance or therapeutic purposes are still the subject of debate, there is reasonable agreement that serum 25(OH)D levels <50 nmol/L (20 ng/mL) constitute vitamin D deficiency and that severe deficiency states (serum 25(OH)D levels <25-30 nmol/L ≈ 10-12 ng/ mL) should be avoided. Main strategies to maintain or improve vitamin D status are food supplementation and therapeutic use of medicinal forms of vitamin D. In this review, we examine evidence that implicates vitamin D deficiency in diverse conditions in the clinical settings of endocrinology, rheumatology, pneumology and reproductive health. Cholecalciferol (vitamin D 3) is the most frequently used vitamin D supplement worldwide, though calcifediol (25-hydroxyvitamin D 3) has recently become more widely available. Calcifediol is one step closer than cholecalciferol in the metabolic pathway to biologically active vitamin D. Pharmacokinetic differences between these vitamin D metabolites confer putative advantages for calcifediol in certain clinical situations. The clinical use of calcifediol is explored more closely through case studies, which illustrate its adjunctive role in the treatment of several vitamin D deficiency-related skeletal and extraskeletal diseases.
Interest is growing in the knowledge of the mechanisms of action of vitamin D in very different a... more Interest is growing in the knowledge of the mechanisms of action of vitamin D in very different areas of pathology. In recent years, very different actions of vitamin D have been discovered. Far from being a simple vitamin, it is a hormonal complex that acts in very different parts of the body equipped with hormonal receptors for vitamin D. It controls more than 900 different genes ma king it. It represents up to 3% of the total human genome. There is a deficit in levels of 25 (OH)D in populations around the world, including young couples affected by fertility problems. In the field of infertility, it has shown beneficial actions on the e volution of polycystic ovary syndrome. It is capable of decreasing the growth of uterine fibroids and correlates well with anti-Mullerian hormone. It has also been shown to improve oocyte quality and the embryo implantation rate in assisted reproduction: Its adeq uate levels in pregnancy reduce the risk of gestational diabetes and improve perinatal outcomes: The objective of this manuscript is to review the most important aspects that relate to the endocrine system. of vitamin D with fertility and pregnancy .
Climacteric, 2015
Climacteric is considered a natural phase in a woman's aging process and is defined as the period... more Climacteric is considered a natural phase in a woman's aging process and is defined as the period starting from the decline in ovarian activity until the end of ovarian function. Natural menopause is defined as the permanent cessation of menstrual periods, after 12 months of amenorrhoea without any other pathological or physiological cause. It is characterised by a decrease in ovarian function with a consequent reduction in oestrogen levels. This condition, which involves
Climacteric, 2013
Osteoporosis is responsible for fragility fractures, which are associated with decreased physical... more Osteoporosis is responsible for fragility fractures, which are associated with decreased physical and social function. The GINERISK study was a cross-sectional epidemiological study conducted in 4157 Spanish postmenopausal women initially diagnosed with osteoporosis according to WHO criteria within the last 2 years. The aim of the study was to explore the impact of osteoporosis on health-related quality of life (HRQoL). Menopause-specific and generic HRQoL were assessed, respectively, with the specific Cervantes Scale and the generic SF-12v2 Health Survey. The impact of osteoporosis on HRQoL was ultimately evaluated in 3328 (80.1%) women who had measurements for both bone mineral densitometry (BMD) and HRQoL. Menopause-specific or generic HRQoL, respectively, were worse in women with current osteoporosis and prior osteoporotic bone fracture (BF) in comparison with current osteoporosis without BF or whose T-score had increased above -2.5 on the BMD after receiving osteoporosis drug therapy. Impaired HRQoL was found both in Spanish postmenopausal female populations and the Spanish general female population. Women with osteoporosis with BF had physical and mental summary component scores in the 20th and 30th percentiles, respectively, of the Spanish general population. Higher risk for cardiovascular death was also associated with greater HRQoL impairment. The use of selective estrogen receptor modulators in women with a BMD T-score ≤ -2.5 was associated with lower impact of osteoporosis on HRQoL, particularly in the domains of physical health and sexuality. The HRQoL analysis results in this study demonstrated a loss of quality of life in postmenopausal women with osteoporosis and confirmed that this loss is greater in women with prior osteoporotic fracture.
Journal of Bone and Mineral Research
Vitamin D plays a major role in bone health and probably also in multiple extraskeletal acute and... more Vitamin D plays a major role in bone health and probably also in multiple extraskeletal acute and chronic diseases. Although supplementation with calcifediol, a vitamin D metabolite, has demonstrated efficacy and safety in short-term clinical trials, its effects after long-term monthly administration have been studied less extensively. This report describes the results of a 1-year, phase III-IV, double-blind, randomized, controlled, parallel, multicenter superiority clinical trial to assess the efficacy and safety of monthly calcifediol 0.266 mg versus cholecalciferol 25,000 IU (0.625 mg) in postmenopausal women with vitamin D deficiency (25(OH)D < 20 ng/ mL). A total of 303 women were randomized and 298 evaluated. Patients were randomized 1:1:1 to calcifediol 0.266 mg/month for 12 months (Group A1), calcifediol 0.266 mg/month for 4 months followed by placebo for 8 months (Group A2), and cholecalciferol 25,000 IU/month (0.625 mg/month) for 12 months (Group B). By month 4, stable 25(OH)D levels were documented with both This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Ginecología y obstetricia de México, Jun 12, 2020
Opciones anticonceptivas para las adolescentes Resumen De forma global los datos muestran que la ... more Opciones anticonceptivas para las adolescentes Resumen De forma global los datos muestran que la mayoría de las mujeres en etapa reproductiva, incluidas las adolescentes, desean métodos modernos de planificación familiar. Muchas de estas mujeres no tienen acceso a la anticoncepción por diferentes causas, lo que se ve reflejado en tasas de fertilidad altas. Puesto que el embarazo durante la adolescencia se considera un problema de salud pública, diferentes instancias han manifestado su interés en establecer directrices específicas para este grupo etario. Esta revisión abarca todos los métodos anticonceptivos, incluida la anticoncepción reversible de larga duración, en particular idónea para las adolescentes. Es importante señalar que prácticamente no existen contraindicaciones para su implementación en este grupo etario.
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Papers by Jose Luis Neyro