Papers by Susan Harrison Uy
Disease models & mechanisms, 2012
Progenitor cells in the cerebral cortex undergo dynamic cellular and molecular changes during dev... more Progenitor cells in the cerebral cortex undergo dynamic cellular and molecular changes during development. Sall1 is a putative transcription factor that is highly expressed in progenitor cells during development. In humans, the autosomal dominant developmental disorder Townes-Brocks syndrome (TBS) is associated with mutations of the SALL1 gene. TBS is characterized by renal, anal, limb and auditory abnormalities. Although neural deficits have not been recognized as a diagnostic characteristic of the disease, ~10% of patients exhibit neural or behavioral abnormalities. We demonstrate that, in addition to being expressed in peripheral organs, Sall1 is robustly expressed in progenitor cells of the central nervous system in mice. Both classical- and conditional-knockout mouse studies indicate that the cerebral cortex is particularly sensitive to loss of Sall1. In the absence of Sall1, both the surface area and depth of the cerebral cortex were decreased at embryonic day 18.5 (E18.5). Th...
The Journal of Comparative Neurology, 2008
Sall3 is a zinc finger containing putative transcription factor and a member of the Sall gene fam... more Sall3 is a zinc finger containing putative transcription factor and a member of the Sall gene family.
Abstract Seventy-eight cattle samples from three Creole Caribbean islands and one Brazilian breed... more Abstract Seventy-eight cattle samples from three Creole Caribbean islands and one Brazilian breed were analyzed for sequence variation in the hypervariable segment of the mitochondrial DNA control region. Seventy-three samples displayed Bos taurus haplotypes, and five samples exhibited haplotypes that were of Bos indicus ancestry. Phylogenetic analysis revealed that all sampled B. taurus sequences fell into two distinct clusters with separate African and European origins.
Disease models & …, Jan 1, 2012
Cerebral Cortex, Jan 1, 2008
The Journal of …, Jan 1, 2008
Sall3 is a zinc finger containing putative transcription factor and a member of the Sall gene fam... more Sall3 is a zinc finger containing putative transcription factor and a member of the Sall gene family.
Cold Spring Harbor …, Jan 1, 2012
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Papers by Susan Harrison Uy