Papers by Johan Mattelaer
European Urology, 1996
In a multicenter study, 905 patients with newly diagnosed advanced prostate cancer treated with f... more In a multicenter study, 905 patients with newly diagnosed advanced prostate cancer treated with flutamide were followed for safety and side effects. Flutamide was administered in monotherapy (75 patients (8%)) or as part of total androgen blockade (TAB groups): the latter group had orchiectomy (196 patients (22%)) or an LHRH (634 patients (70%)). The incidence of gastrointestinal complaints such as loss of appetite, vomiting/nausea and diarrhea (+/- 15%) was similar in the TAB and the monotherapy groups. Eighteen patients (2%) were withdrawn because of severe diarrhea. Hot flushes was the most frequently reported adverse event in TAB groups (40% of patients), leading to withdrawal in 4 patients (0.4%). Breast tenderness occurred most frequently in the monotherapy group (49%) and was reported as severe in 7% of the patients. Only 0.8% of the patients were withdrawn because of liver function changes. No unexpected potentially dangerous adverse events were reported. Flutamide alone or in combination therapy appears to be safe and well tolerated.
Janus; revue internationale de l'histoire des sciences, de la médecine, de la pharmacie, et de la technique, 1973
Acta urologica Belgica, 1998
The optimal treatment of ureteric lithiasis continues to be a point of discussion, as there are d... more The optimal treatment of ureteric lithiasis continues to be a point of discussion, as there are different treatment modalities. Conservative treatment, EWSL, ureteroscopy (URS), percutaneous litholapaxy, and (laparoscopic) ureterolithotomy, all have there place in the treatment of ureteric lithiasis. In order to evaluate if ureteroscopy is a valuable alternative to ESWL in the treatment of ureteric lithiasis, an analysis of all the ureteroscopies performed in our institution was made and these results were compared with results (both ESWL and URS) described in literature. During the period 1990 till 1997, 292 patients underwent in our institution in total 354 ureteroscopies for ureteric lithiasis. In all procedures a rigid 9 Fr. ureteroscope was used, together with laser lithotripsy or pneumatic lithotripsy as fragmentation device. Overall success rate in our series was 90.1%, with distal and middle ureteric stone location being more favorable (94% and 95%) than proximal location (7...
Acta urologica Belgica, 1997
To study the prognostic value of the prostate-specific antigen (PSA) response and its relationshi... more To study the prognostic value of the prostate-specific antigen (PSA) response and its relationship with other initial prognostic factors during the treatment of advanced prostatic carcinoma with total androgen blockade. Five hundred forty-six patients with advanced loco-regional (M0) or distant metastatic (M1) prostatic carcinoma treated with flutamide combined with either orchiectomy or LHRH analogues were included in this analysis. Initial patients characteristics and the PSA response were evaluated in relation to progression-free survival using a univariate and multivariate (Cox regression) analysis. The following prognostic factors were indicative of a decrease in progression-free survival: the absence of PSA normalization (< 4 ng/ml) after 3 or 6 months, M1 stage, high G grade, ECOG performance status > 1, presence of pain and absence of dysuria. In M1 patients the combination of PSA normalization after 3 or 6 months with initial G grade and ECOG performance status had th...
Acta urologica Belgica, 1997
Prognosis of patients who have been treated by radical prostatectomy, because of prostatic carcin... more Prognosis of patients who have been treated by radical prostatectomy, because of prostatic carcinoma, is dependent on a number of factors. In this study we try to determine these factors, their relationship with each other, their relationship with progression of disease and the prognostic value of this relationship. "Progression" (or relapse) of disease is defined as clinical evidence of local or general recurrence and/or isolated elevation of postoperative PSA level more than 0.2 ng/ml (Hybritech) at two consecutive outpatient visits. In our institution, 62 radical retropubic prostatectomies were performed over a period of 66 months. Without any exclusion, these patients were included in the analysis (with respect to "progression"), which consisted of bi- and multivariate analyses, Kaplan-Meier estimations and multivariate survival analyses using the "Cox proportional hazards model". Median follow-up time was 32 months. "Progression" was seen...
Acta urologica Belgica, 1973
Tijdschrift voor gastro-enterologie, 1968
Acta urologica Belgica, 1988
Acta urologica Belgica, 1990
Fournier's gangrene, or synergistic gangrene of the male external genitalia is a rapidly spre... more Fournier's gangrene, or synergistic gangrene of the male external genitalia is a rapidly spreading necrotising infection of the penis and scrotum. Although not so frequent in our civilized world it is by no means rare. In early days it was characterised by a high mortality. Aggressive surgical debridement, broad spectrum antibiotics and plastic reconstructive technics have all contributed to a better survival of the patients.
Acta urologica Belgica, 1991
Endopyelotomy is a recently developed endo-urological technique which gets to be standardised and... more Endopyelotomy is a recently developed endo-urological technique which gets to be standardised and gradually may replace the open pyeloplasty. Our technique is described and the early results are presented.
Verhandlungsbericht der Deutschen Gesellschaft für Urologie, 1977
Die meisten Antibiotika sind unwirksam bei der Behandlung einer bakteriellen Prostatitis. weil si... more Die meisten Antibiotika sind unwirksam bei der Behandlung einer bakteriellen Prostatitis. weil sie nur schwer in das Prostatagewebe penetrieren.
Urologia Internationalis, 1968
Zusammenfassung Das Zusammengehen von Stressinkontinenz und Prolapsus uteri ist häufig. Auf 861 F... more Zusammenfassung Das Zusammengehen von Stressinkontinenz und Prolapsus uteri ist häufig. Auf 861 Fälle von Prolapsus uteri fanden die Verfasser bei 339 Patientinnen eine Stressinkontinenz (39,3&amp;amp;amp;amp;percnt;). Dies erfordert eine kombinierte Behandlung dieser beiden Beschwerden. Die Wiederherstellung des cervicourethralen Winkels ist das Wesentliche bei der Behandlung. Mit der Kombination einer Vaginaltechnik (Marion- oder Kennedy-Operation) und der suprapubischen Zervikozystopexie nach Marshall, Marchetti, Krantz,
Acta urologica Belgica, 1982
Canadian Journal of Urology, Apr 1, 2016
The Lancet, 2002
We did a randomised phase III trial comparing external irradiation alone and external irradiation... more We did a randomised phase III trial comparing external irradiation alone and external irradiation combined with an analogue of luteinising-hormone releasing hormone (LHRH) to investigate the added value of long-term androgen suppression in locally advanced prostate cancer. Between 1987 and 1995, 415 patients were randomly assigned radiotherapy alone or radiotherapy plus immediate androgen suppression. Eligible patients had T1-2 tumours of WHO grade 3 or T3-4 N0-1 M0 tumours; the median age of participants was 71 years (range 51-80). In both treatment groups, 50 Gy radiation was delivered to the pelvis over 5 weeks, and 20 Gy over 2 weeks as a prostatic boost. Goserelin (3.6 mg subcutaneously every 4 weeks) was started on the first day of irradiation and continued for 3 years; cyproterone acetate (150 mg orally) was given for 1 month starting 1 week before the first goserelin injection. The primary endpoint was clinical disease-free survival. Analyses were by intention to treat. 412 patients had evaluable data, with median follow-up of 66 months (range 1-126). 5-year clinical disease-free survival was 40% (95% CI 32-48) in the radiotherapy-alone group and 74% (67-81) in the combined-treatment group (p=0.0001). 5-year overall survival was 62% (52-72) and 78% (72-84), respectively (p=0.0002) and 5-year specific survival 79% (72-86) and 94% (90-98). Immediate androgen suppression with an LHRH analogue given during and for 3 years after external irradiation improves disease-free and overall survival of patients with locally advanced prostate cancer.
The Aging Male, 2005
When we look to Africa today, there is a lot of pessimism. There is more hunger, more poverty, le... more When we look to Africa today, there is a lot of pessimism. There is more hunger, more poverty, less education and more corruption than 40 years ago. Two generations in the Western countries are equal to three generations in Africa, where life is shortened by early marriage, early childbirth and early death. Today, already more than 70% of the population lives in urban areas. A growing city becomes dirtier, uglier and more dangerous as a consequence of lack of planning and money, poor health and crime. But in spite of the fact of poverty, AIDS and low economic development, the population in Africa is still increasing. The average life expectancy at birth for men in Africa is 49 years (worldwide 63), but will increase to 60 years by 2050. The major problem for Africa is that the Western countries became rich before they became old, whereas the African countries will become old before they are rich!
From 1870 to 1914, Belgium - at that time one of the leading financial and industrial powers - fi... more From 1870 to 1914, Belgium - at that time one of the leading financial and industrial powers - financed, built and operated hundreds of kilometers of railways and tramways across the five continents. King Leopold II was the driving force behind these undertakings. In China, for instance, a railway between Beijing and Hankou and a tramway network in Tianjin were constructed. 'A Belgian Passage to China (1870-1930)' puts these two projects in the spotlight with a strong focus on the personal histories of some of the Belgian citizens involved in these large-scale projects. François Nuyens left Ghent in 1905 for Tianjin, where he built a power station and constructed a tram network. In a well-documented diary, Nuyens writes down his impressions of his stay in China between 1905 and 1908. Around the same time the Ghent born brothers Philippe and Adolphe Spruyt, both doctors, travelled to China to take care of the medical service at the railway construction sites between Beijing and Hankou. Both Philippe and Adolphe were avid collectors of Chinese antiquities, which are currently preserved in various Belgian musea. The brothers' lively correspondence and their more than 1,200 stereoscopic photographs on glass plate offer a unique glimpse of everyday life in China in the early twentieth century
Practical Aspects of Urinary Incontinence, 1986
The purpose of transurethral teflon injection to cure urinary stress incontinence in women is to ... more The purpose of transurethral teflon injection to cure urinary stress incontinence in women is to increase the urethral resistance to urine outflow. Although Gersuny injected glycerine around the perineal urethra to treat incontinent males it was Politano [1] who proposed teflon to treat incontinence in men after transurethral resection of the prostate and extended the technique to treat women patients. Heer [2] injected teflon into the wall of the urethra to increase its length and resistance but the technique of transurethral and periurethral injection of teflon paste was really developed in Western Europe by Sparwasser and Lampante [3,4] in 1978 with the fabrication of specialised instrumentation by Wolf-Knittlingen and Storz-Tuttlingen. Marketing by these manufacturers certainly diffused this new technique to most urological departments but was also responsable for a subjective overevaluation!
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Papers by Johan Mattelaer