Anne Des Rieux

UCLouvain (University of Louvain), LDRI Louvain Drug Research Institute, Faculty Member

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Nader Ale Ebrahim نادر آل ابراهیم

Alzahra University

Prof. Dr. Md. Abdul Wazed

Chittagong University of Engineering & Technology (CUET)

Mahanim Hanid

Universiti Malaya

Linda MacDonald Glenn

University of California, Santa Cruz

José Luis Ponz Tienda

Universidad de los Andes (Colombia)

Peixin Dong

Hokkaido University

Revista Ingenieria Industrial

Universidad del Bio-bio

Carlos Luna Criado

Universidad Autónoma de Nuevo León

Ana Beloqui

UCLouvain (University of Louvain)

David Brayden

University College Dublin

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Apical papilla implantation promotes functional recovery after rat spinal cord injury

Surface Modification of Lipid-Based Nanoparticles

ACS Nano

There is a growing interest in the development of lipid-based nanocarriers for multiple purposes,... more There is a growing interest in the development of lipid-based nanocarriers for multiple purposes, including the recent increase of these nanocarriers as vaccine components during the COVID-19 pandemic. The number of studies that involve the surface modification of nanocarriers to improve their performance (increase the delivery of a therapeutic to its target site with less off-site accumulation) is enormous. The present review aims to provide an overview of various methods associated with lipid nanoparticle grafting, including techniques used to separate grafted nanoparticles from unbound ligands or to characterize grafted nanoparticles. We also provide a critical perspective on the usefulness and true impact of these modifications on overcoming different biological barriers, with our prediction on what to expect in the near future in this field.

Paclitaxel-loaded micelles enhance the vascular permeability and retention of nanomedicines in tumors

3rd Conference on “Innovation in Drug Delivery: Advances in Local Drug Delivery, 2013

Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells

International Journal of Pharmaceutics, 2022

Impairment of oligodendrocyte progenitor cell (OPC) differentiation into oligodendrocytes and chr... more Impairment of oligodendrocyte progenitor cell (OPC) differentiation into oligodendrocytes and chronic inflammation are key determinants of poor remyelination observed in diseases such as multiple sclerosis. For many promyelinating molecules, the therapeutic potential is hindered by poor solubility or limited access to the targeted cells. A promising approach to improve the delivery of those molecules to OPC is to encapsulate them in functionalized Lipid Nanocapsules (LNC). We aimed to develop the first OPC-targeting LNC, by grafting an anti-PDGFRα antibody on the surface of the LNC using several strategies and evaluating the interaction with PDGFRα via ELISA. We found that only site-selective click-chemistry grafting maintained anti-PDGFRα/PDGFRα association, which was confirmed in vitro on primary rat OPC. In conclusion, we demonstrated that it was possible to produce anti-PDGFRα functionalized LNC, we confirmed the antibody's ability to recognize its receptor after grafting and we optimized techniques to characterize antibody functionalized LNC.

Anne Des Rieux

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