Ana Beloqui
Address: Université catholique de Louvain
Faculte de pharmacie et sciences biomedicales
LDRI-Advanced Drug Delivery and Biomaterials
Avenue Mounier, 73 UCL B1 73.12
1200 Brussels
Belgium
Faculte de pharmacie et sciences biomedicales
LDRI-Advanced Drug Delivery and Biomaterials
Avenue Mounier, 73 UCL B1 73.12
1200 Brussels
Belgium
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Articles by Ana Beloqui
study, the tissue distribution of three lipid formulations based on Nanostructured Lipid Carriers (NLCs)
after intravenous administration to rats was evaluated. NLCs were prepared by a high pressure homogenization
method and varied in terms of particle size, surface charge, and surfactant content. The 99mTc
radiolabeled NLCs were intravenously administered to rats, and radioactivity levels in blood and tissues
were measured. Cmax, AUC0–24, and MRT0–24 were obtained from the radioactivity level versus time profiles.
The radiolabeled nanocarriers exhibited a long circulation time since radioactivity was detected in
blood even 24 h post-injection. No differences on the MRT values in blood among the NLCs were
observed, in spite of the different particle size and surface charge. The highest radioactivity levels were
measured in the kidney, followed by the bone marrow, the liver, and the spleen. In the kidney, there was
a higher accumulation of the positive nanoparticles, and in the liver, uptake of negative nanoparticles was
higher than positive ones. NLCs with the largest particle size showed a higher uptake in the lung and
lower accumulation in liver and bone marrow, in comparison with the smaller ones.
Papers by Ana Beloqui
study, the tissue distribution of three lipid formulations based on Nanostructured Lipid Carriers (NLCs)
after intravenous administration to rats was evaluated. NLCs were prepared by a high pressure homogenization
method and varied in terms of particle size, surface charge, and surfactant content. The 99mTc
radiolabeled NLCs were intravenously administered to rats, and radioactivity levels in blood and tissues
were measured. Cmax, AUC0–24, and MRT0–24 were obtained from the radioactivity level versus time profiles.
The radiolabeled nanocarriers exhibited a long circulation time since radioactivity was detected in
blood even 24 h post-injection. No differences on the MRT values in blood among the NLCs were
observed, in spite of the different particle size and surface charge. The highest radioactivity levels were
measured in the kidney, followed by the bone marrow, the liver, and the spleen. In the kidney, there was
a higher accumulation of the positive nanoparticles, and in the liver, uptake of negative nanoparticles was
higher than positive ones. NLCs with the largest particle size showed a higher uptake in the lung and
lower accumulation in liver and bone marrow, in comparison with the smaller ones.