Papers by Rodrigo Alberto Vieira Browne
Background: Aerobic exercise is recommended for glycemic and weight control in type 2 diabetes (T... more Background: Aerobic exercise is recommended for glycemic and weight control in type 2 diabetes (T2D), but exercise intensity that increase post-exercise fat oxidation has not been established yet. It is expected that high-intensity exercise induce higher absolute oxidations and rates of oxidation of CHO (during) and fat (after) in normoglycemic, but in hyperglycemic it is unclear. Aim: To compare the effects of exercise intensity on CHO and fat oxidation during and after exercise in individuals with T2D. Methods: Eleven persons with T2D, randomly underwent three experimental sessions 72 hours apart: 1) 20 minute of high-intensity exercise (120% of lactate threshold (LT) – 120%LT), 2) 20 minute of moderate intensity exercise (80% of LT – 80%LT), and 3) 20 minute of control session (CON) – no exercise was performed and the individuals remained seated during the whole time. Percentages of CHO and fat contribution and CHO and fat oxidation rate (mg/min) were analyzed during and after sessions. Results: The rate of CHO oxidation during exercise was significantly higher during 120%LT in relation to 80%LT and CON (18.2 ± 5.6 vs. 9.5 ± 2.7 vs. 1.1 ± 0.4 mg • min −1), the absolute rate of fat oxidation was significantly higher in 120%LT compared to 80%LT and CON during exercise (13.5 ± 3.3, 9.5 ± 2.2, and 0.7 ± 0.2 mg • min −1 , respectively, p < 0.05). During the post-exercise oxygen consumption recovery period, only the 120%LT had higher fat oxidation (94.5% vs. 68.1%, p < 0.05), when compared to CON. Both exercise sessions equally elicited a lowered glycaemia during the post-exercise period, but CHO oxidation was lower after 120%LT than CON (0.1 ± 0.2 vs. 0.9 ± 0.5 mg • min −1 , p < 0.05). Conclusions: Higher intensity elicited an elevated CHO oxidation rate during exercise and a higher percentage of fat utilization during the post-exercise recovery period compared to moderate-intensity exercise and control sessions. Relevance for patients: High-intensity aerobic exercise, even of short duration, may benefit individuals with T2D on the substrate oxidation related to the body fat. Exercise can be an important tool for the prevention and management of T2D due to its effects on carbohydrate and fat metabolism, reduction of body fat, and control of blood glucose.
Objetivo: Verificar o efeito agudo do exercício aeróbio vigoroso sobre o controle inibitório em a... more Objetivo: Verificar o efeito agudo do exercício aeróbio vigoroso sobre o controle inibitório em adolescentes. Métodos: Estudo controlado e randomizado com delineamento cruzado. Vinte púberes foram submetidos a duas sessões de 30 minutos: 1) sessão exercício aeróbio feito entre 65-75% da frequência cardíaca de reserva, com cinco minutos para aquecimento, 20 minutos na intensi-dade alvo e cinco minutos de volta à calma; e 2) sessão controle assistindo a desenho animado. Previamente e após as sessões, o teste de Stroop computadorizado (Testinpacs ®) foi aplicado para avaliar o controle inibitório. O tempo de reação (ms) e os erros cometidos (n) foram registrados. Resultados: O tempo de reação da sessão controle não apresentou diferença significativa. Por outro lado, o tempo de reação da sessão exercício diminuiu após a intervenção (p<0,001). Os erros cometidos na sessão exercício foram menores do que na sessão controle (p=0,011). Adicionalmente, houve associação positiva do tempo de reação () da sessão exercício com a idade (r 2 =0,404; p=0,003). Conclusões: O exercício aeróbio vigoroso parece promover melhoria aguda no controle inibitório em adolescentes. O efeito do exercício sobre o desempenho do controle inibitório foi associado à idade e demonstrou ser reduzido em faixas etárias mais altas.
Objective: To assess the acute effect of vigorous aerobic exercise on the inhibitory control in a... more Objective: To assess the acute effect of vigorous aerobic exercise on the inhibitory control in adolescents. Methods: Controlled, randomized study with crossover design. Twenty pubertal individuals underwent two 30-minute sessions: (1) aerobic exercise session performed between 65% and 75% of heart rate reserve, divided into 5 min of warm-up, 20 min at the target intensity and 5 min of cool down; and (2) control session watching a cartoon. Before and after the sessions, the computerized Stroop test-Testinpacs TM was applied to evaluate the inhibitory control. Reaction time (ms) and errors (n) were recorded. Results: The control session reaction time showed no significant difference. On the other hand, the reaction time of the exercise session decreased after the intervention (p<0.001). The number of errors made at the exercise session were lower than in the control session (p=0.011). Additionally, there was a positive association between reaction time () of the exercise session and age (r 2 =0.404, p=0.003). Conclusions: Vigorous aerobic exercise seems to promote acute improvement in the inhibitory control in adolescents. The effect of exercise on the inhibitory control performance was associated with age, showing that it was reduced at older age ranges.
The aim of this study was to analyze the acute responses of bradykinin, insulin, and glycemia to ... more The aim of this study was to analyze the acute responses of bradykinin, insulin, and glycemia to exercise performed above and below lactate threshold (LT) in individuals with type 2 diabetes mellitus (T2D). Eleven participants with a diagnosis of T2D randomly underwent three experimental sessions 72 h apart: 1) 20 min of exercise performed at 120% of LT (120%LT), 2) 20 min of exercise performed at 80% of LT (80%LT), and 3) 20 min of control session. Blood glucose was analyzed before, during, and at 45 min post-exercise. Bradykinin and insulin were analyzed before and at 45 min post-exercise. Both exercise sessions elicited a parallel decrease in glucose level during exercise (Pp0.002), with a greater decrease being observed for 120%LT (P=0.005). Glucose decreased 22.7 mg/dL (95%CI=10.3 to 35, P=0.001) at the 45 min post-exercise recovery period for 80%LT and decreased 31.2 mg/dL (95%CI=18.1 to 44.4, Po0.001) for 120%LT (P=0.004). Insulin decreased at post-exercise for 80%LT (P=0.001) and control (Pp0.035). Bradykinin increased at 45 min post-exercise only for 80%LT (P=0.013), but was unrelated to the decrease in glucose (r=–0.16, P=0.642). In conclusion, exercise performed above and below LT reduced glycemia independently of insulin, but exercise above LT was more effective in individuals with T2D. However, these changes were unrelated to the increase in circulating bradykinin.
The purpose of this study was to verify and compare the effect of 10 min of aerobic exercise perf... more The purpose of this study was to verify and compare the effect of 10 min of aerobic exercise performed above and below lactate threshold (LT) on executive control in children. Nine children (10.3 ± 0.5 yrs) underwent three sessions in randomized order: (a) 110%LT: 10 min of aerobic exercise at 110%LT; (b) 90%LT:10 min of aerobic exercise at 90%LT; and (c) control (CON): seated resting. The inhibitory control, declarative memory, cognitive flexibility, and logical reasoning were accessed over the post-session recovery by the Flanker task, free recall memory, trail making test, and tangram puzzle, respectively. Flanker task performance [performance = reaction time (ms) / correct responses (%)] was significantly better after 110%LT when compared with CON (1950.6 ± 1099.6 vs. 2827.4 ± 1385.1 ms; P=0.028). There was no significant difference among conditions in free recall memory, trail making test, and tangram puzzle (P>0.05). The findings indicate that 10 min of aerobic exercise above LT can acutely improve the inhibitory control in children.
Motriz: Revista de Educação Física, 2015
In order to investigate the validity of critical velocity (CV) as a noninvasive method to estimat... more In order to investigate the validity of critical velocity (CV) as a noninvasive method to estimate the lactate minimum velocity (LMV), 25 youth runners underwent the following tests: 1) 3,000m running; 2) 1,600m running; 3) LMV test. The intensity of lactate minimum was defined as the velocity corresponding to the lowest blood lactate concentration during the LMV test. The CV was determined using the linear model, defined by the inclination of the regression line between distance and duration in the running tests of 1,600 and 3,000m. There was no significant difference (p=0.3055) between LMV and CV. In addition, both protocols presented a good agreement based on the small difference between means and the narrow levels of agreement, as well as a standard error of estimation classified as ideal. In conclusion, CV, as identified in this study, may be an alternative for noninvasive identification of LMV.
Pensar a Prática, 2014
O artigo objetiva verificar a prevalência de fatores de risco cardiovascular em crianças. Duzenta... more O artigo objetiva verificar a prevalência de fatores de risco cardiovascular em crianças. Duzentas e doze crianças de escola pública e privada foram submetidas à avaliação do índice de massa corporal (IMC), pressão arterial (PA), nível de atividade física (NAF) e consumo máximo de oxigênio (VO 2 max). Não foram evidenciadas diferenças significativas nas variáveis quando comparadas entre quartis separados pelo NAF. Contudo, quando comparadas entre escola pública e particular, crianças da escola privada apresentaram maiores valores de IMC e PA, menor VO 2 max, bem como apresentaram maior prevalência de excesso de peso e PA elevada. Crianças da escola privada apresentam maior prevalência de fatores de risco cardiovascular quando comparado as da rede pública. Palavras-chave: Obesidade. Hipertensão. Atividade motora. Consumo de Oxigênio.
Motriz: Revista de Educação Física, 2015
In order to investigate the validity of critical velocity (CV) as a noninvasive method to estimat... more In order to investigate the validity of critical velocity (CV) as a noninvasive method to estimate the lactate minimum velocity (LMV), 25 youth runners underwent the following tests: 1) 3,000m running; 2) 1,600m running; 3) LMV test. The intensity of lactate minimum was defined as the velocity corresponding to the lowest blood lactate concentration during the LMV test. The CV was determined using the linear model, defined by the inclination of the regression line between distance and duration in the running tests of 1,600 and 3,000m. There was no significant difference (p=0.3055) between LMV and CV. In addition, both protocols presented a good agreement based on the small difference between means and the narrow levels of agreement, as well as a standard error of estimation classified as ideal. In conclusion, CV, as identified in this study, may be an alternative for noninvasive identification of LMV.
Revista Brasileira de Educação Física e Esporte, 2014
This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg 9... more This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg 9 -BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 diabetes (T2D) and 10 without type 2 diabetes (ND) underwent three sessions: 1) maximal incremental test on cycle ergometer to determine lactate threshold (LT); 2) 20-min of constant-load exercise on cycle ergometer, at 90% LT and; 3) control session. BP and oxygen uptake were measured at rest and at 15, 30 and 45 min post-exercise. Venous blood samples were collected at 15 and 45 minutes of the recovery period for further analysis of PKA, BK and DesArg 9 -BK. Nitrite plus nitrate (NOx) was analyzed at 15 minutes post exercise. The ND group presented post-exercise hypotension (PEH) of systolic blood pressure and mean arterial pressure on the 90% LT session but T2D group did not. Plasma NOx...
World journal of diabetes, Jan 15, 2014
The literature has shown the efficiency of exercise in the control of type 2 diabetes (T2D), bein... more The literature has shown the efficiency of exercise in the control of type 2 diabetes (T2D), being suggested as one of the best kinds of non-pharmacological treatments for its population. Thus, the scientific production related to this phenomenon has growing exponentially. However, despite its advances, still there is a lack of studies that have carried out a review on the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in individuals with T2D, not to mention that in a related way, these themes have been very little studied today. Therefore, the aim of this study was to organize and analyze the current scientific production about the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in T2D individuals. For such, a research with the following keywords was performed: -exercise; diabetes and post-exercise hypotension; diabetes and excess ...
Motriz: Revista de Educação Física, 2013
The purposes of this study were to analyze and compare the effects of exercise performed in diffe... more The purposes of this study were to analyze and compare the effects of exercise performed in different intensities, above and below lactate threshold (LT) on post-exercise blood pressure (BP) and nitric oxide (NO) responses in individuals with type 2 diabetes (T2D). For this, 11 T2D underwent the following experimental sessions: 1) control session; 2) 20-min of moderate cycling (80% LT); and 3) 20-min of high intensity cycling (120%LT) on a cycle ergometer. Plasma NO and BP measurements were carried out at rest and at 15 and 45 min of post-experimental sessions. When compared to rest, only the exercise session performed at 120%LT elicited an increase of NO (from 7.2 to 9.5 μM, p<0.05), as well as a decrease in BP (from 126.6±7.9 to 118.7±3.9 mmHg, p<0.05) during the postexercise period. In conclusion, the results suggest that NO release and post-exercise BP decrease are intensitydependent for individuals with T2D.
Cadernos de Terapia Ocupacional da UFSCar, 2013
A obesidade e a hipertensão arterial são tidas como fatores de risco para doenças cardiovasculare... more A obesidade e a hipertensão arterial são tidas como fatores de risco para doenças cardiovasculares e a sua prevalência parece diferir de acordo com a atividade profissional. Desse modo, o objetivo do presente estudo foi estimar a prevalência de fatores de risco cardiovascular em funcionários de uma mineradora e verificar os fatores associados à pressão arterial (PA) elevada. Para tanto, 197 voluntários (61,4% homens) com idade entre 20 e 60 anos, todos funcionários de uma empresa de mineração, foram avaliados quanto ao índice de massa corporal e PA. O excesso de peso (sobrepeso + obesidade) e os valores pressóricos elevados (pré-hipertenso + hipertenso) foram observados em 76,1% e 46,1% da amostra, respectivamente, sendo a prevalência de pré-hipertensos maior (p <0,05) nos homens. A probabilidade de ter PA elevada foi maior no sexo masculino (11%), e naqueles com idade superior a 40 anos (13%) e com excesso de peso (13%). Em conclusão, uma parcela expressiva dos mineradores encontra-se em risco para o desenvolvimento de doenças cardiovasculares. Ademais, as medidas contra a hipertensão arterial devem ser direcionadas especialmente aos funcionários do sexo masculino e aqueles com idade superior a 40 anos, sendo a prevenção e o controle do excesso de peso as principais medidas terapêuticas a ser adotadas.
PLoS ONE, 2013
This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg 9... more This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg 9 -BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 diabetes (T2D) and 10 without type 2 diabetes (ND) underwent three sessions: 1) maximal incremental test on cycle ergometer to determine lactate threshold (LT); 2) 20-min of constant-load exercise on cycle ergometer, at 90% LT and; 3) control session. BP and oxygen uptake were measured at rest and at 15, 30 and 45 min post-exercise. Venous blood samples were collected at 15 and 45 minutes of the recovery period for further analysis of PKA, BK and DesArg 9 -BK. Nitrite plus nitrate (NOx) was analyzed at 15 minutes post exercise. The ND group presented post-exercise hypotension (PEH) of systolic blood pressure and mean arterial pressure on the 90% LT session but T2D group did not. Plasma NOx increased ~24.4% for ND and ~13.8% for T2D group 15min after the exercise session. Additionally, only ND individuals showed increases in PKA and BK in response to exercise and only T2D group showed increased DesArg 9 -BK production. It was concluded that T2D individuals presented lower PKA, BK and NOx release as well as higher DesArg 9 -BK production and reduced PEH in relation to ND participants after a single exercise session. Citation: Simões HG, Asano RY, Sales MM, Browne RAV, Arsa G, et al. (2013) Type 2 Diabetes Elicits Lower Nitric Oxide, Bradykinin Concentration and Kallikrein Activity Together with Higher DesArg 9 -BK and Reduced Post-Exercise Hypotension Compared to Non-Diabetic Condition. PLoS ONE 8(11): e80348.
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Papers by Rodrigo Alberto Vieira Browne