Carolyn Gotay

University of British Columbia, Population & Public Health, Faculty Member

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Faris Lami

André Faro

Universidade Federal de Sergipe

Dayane Gabriele Alves Silveira

Universidade de Brasília - UnB

Alejandra Contreras

Instituto Nacional de Salud Pública México

Teresita Gonzalez de Cosio

Universidad Iberoamericana - Mexico

Nataliya Foigt

Institute of Gerontology, UKRAINE

Isaac A Adedeji

University of Ibadan Nigeria

olatunji adetokunboh

Stellenbosch University

Adnan Kisa

Kristiania University College

Khalid Altirkawi

University of Sharjah

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Papers by Carolyn Gotay

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

by Nader Jahanmehr, Nataliya Foigt, Farshad Pourmalek, Carolyn Gotay, Walter Mendoza, and Ismael Campos-Nonato

Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to... more Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context.

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A qualitative focus group study to identify the needs of survivors of stage II and III colorectal cancer

Psycho-Oncology, 2015

Prior survivorship research has largely focused on issues faced by survivors of childhood tumors,... more Prior survivorship research has largely focused on issues faced by survivors of childhood tumors, breast cancers, or hematologic malignancies. Relatively little is known about the needs of other prevalent survivor groups. Our aim was to identify the specific concerns of colorectal cancer (CRC) survivors in the key domains of physical functioning, psychological wellbeing, and social relationships. We conducted focus groups with stage II and III CRC survivors who had completed their primary active anti-cancer treatments. Patients were asked to describe how their diagnosis and treatment impacted their lives, to outline deficiencies in the care that they received, and to suggest ways of addressing any unmet needs. A content analysis was subsequently conducted to identify major themes. Thirty CRC survivors participated in six focus groups. Individuals reported some degree of dissatisfaction with the amount and type of diagnostic and treatment information they received at their initial clinic visit. Distress from toxicities, such as peripheral neuropathy, was also common among the survivors. Similarly, the majority faced challenges adjusting to their lives and daily activities, especially in caring for their colostomy. Having survived CRC, many survivors expressed an interest in advocacy and health promotion of CRC. CRC survivors face many barriers after their cancer treatment. Issues with colostomy are unique to this survivor group. Interventions to improve CRC survivorship care should also incorporate opportunities for patient advocacy. Copyright © 2015 John Wiley &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; Sons, Ltd.

Body mass index trajectories from ages 1 to 20: Results from two nationally representative canadian longitudinal cohorts

by Chris Richardson and Carolyn Gotay

Obesity, 2015

In this study, unique body mass index (BMI) trajectories from ages 1 to 20 years were identified;... more In this study, unique body mass index (BMI) trajectories from ages 1 to 20 years were identified; each trajectory according to socio demographic and family characteristics was described. Participants came from two national population surveys (n = 7,253; n = 901) and were aged 1-6 years at baseline. Children were surveyed biennially over eight waves up to 14-20 years of age. BMI trajectories by sex and survey cohort were identified by group-based trajectory modeling. After crossvalidating trajectories between survey cohorts, the characteristics of trajectory membership were assessed by multinomial regression. Four BMI trajectories were found: low, decreasing, medium, and high. The decreasing trajectory was characterized by an overweight or obese childhood followed by a normal-weight adolescence. The low, medium, and high trajectories were characterized by growth curves culminating, by age 20, to BMI 22.6, 29.3, and 34.9 kg/m(2) , respectively, for males and 20.6, 24.5, and 32.0 kg/m(2) , respectively, for females. Factors associated with the high trajectory included ethnicity and paternal education (female only), large for gestational age, rural area residence, and maternal smoking. The identification and validation of four major trajectories reflect the heterogeneity in patterns of BMI development from 1 to 20 years.

The Complementary Nature of Patient-Reported Outcomes (PROs) and Adverse Event Reporting in Cooperative Group Oncology Clinical Trials: A Pooled Analysis (NCCTG N0591)

Journal of pain and symptom management, Jan 29, 2015

Clinical trials utilize clinician-graded adverse events (AEs) and patient-reported outcomes (PROs... more Clinical trials utilize clinician-graded adverse events (AEs) and patient-reported outcomes (PROs) to describe symptoms. To examine the agreement between PROs and AEs in the clinical trial setting. Patient-level data were pooled from seven North Central Cancer Treatment Group, two Southwest Oncology Group and three Radiation Therapy Oncology Group lung studies that included both PROs and AE data. Ten-point changes (on a 0-100 scale) in PRO scores were considered clinically significant differences (CSDs). PRO score changes were compared to AE grade (Gr) categories (2+ yes vs. no and 3+ yes vs. no) using Wilcoxon rank- sum or two-sample t-tests between Gr categories. Incidence rates and concordance of CSD in PRO scores and AE grade categories were compiled. Spearman correlations were computed between PRO scores and AE severity. PROs completed by patients (N=1013) were the Uniscale, Lung Cancer Symptom Scale (LCSS), Functional Assessment of Cancer Therapy-Lung (FACT-L), Symptom Distres...

The Global Burden of Cancer 2013

JAMA Oncology, 2015

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The Effectiveness of Exercise Interventions for Improving Health-Related Quality of Life From Diagnosis Through Active Cancer Treatment

Oncology Nursing Forum, 2014

To evaluate the effectiveness of exercise interventions on overall health-related quality of life... more To evaluate the effectiveness of exercise interventions on overall health-related quality of life (HRQOL) and its domains among adults scheduled to, or actively undergoing, cancer treatment. 11 electronic databases were searched through November 2011. In addition, the authors searched PubMed&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s related article feature, trial registries, and reference lists of included trials and related reviews. 56 trials with 4,826 participants met the inclusion criteria. At 12 weeks, people exposed to exercise interventions had greater improvement in overall HRQOL, physical functioning, role functioning, social functioning, and fatigue. Improvement in HRQOL was associated with moderate-to-vigorous intensity exercise interventions. Exercise can be a useful tool for managing HRQOL and HRQOL domains for people scheduled to, or actively undergoing, cancer treatment. More methodologically rigorous trials are needed to examine the attributes of exercise programs most effective for improving HRQOL. Evidence from this review supports the incorporation of exercise programs of moderate-to-vigorous intensity for the management of HRQOL among people scheduled to, or actively undergoing, cancer treatment into clinical guidelines through the Oncology Nursing Society&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s Putting Evidence Into Practice resources.

Are exercise programs effective for improving health-related quality of life among cancer survivors? A systematic review and meta-analysis

Oncology nursing forum, 2014

To evaluate the effectiveness of exercise interventions on overall health-related quality of life... more To evaluate the effectiveness of exercise interventions on overall health-related quality of life (HRQOL) and its domains among cancer survivors who have completed primary treatment. 11 electronic databases were searched from inception (dates varied) to October 2011. The authors also identified eligible trials through a search of additional sources. 40 trials with 3,694 participants met the inclusion criteria. At 12 weeks, cancer survivors exposed to exercise interventions had greater positive improvement in overall HRQOL (standardized mean difference [SMD] 0.48; 95% confidence interval [CI] [0.16, 0.81]), emotional well-being (SMD 0.33; 95% CI [0.05, 0.61]), and social functioning (SMD 0.45; 95% CI [0.02, 0.87]); and had a significant reduction in anxiety (SMD -0.26; 95% CI [-0.44, -0.07]) and fatigue (SMD -0.82; 95% CI [-1.5, -0.14]). Exercise programs have a beneficial effect on HRQOL and most of its domains and can be integrated into the management plans for cancer survivors who...

Asbestos in Canada: time to change our legacy

Canadian Medical Association Journal, 2015

Hawaii's comprehensive cancer control program

Hawaii medical journal, 2005

Knowledge, attitudes, and behaviours towards cancer screening in indigenous populations: a systematic review

The Lancet Oncology, 2014

Cancer mortality among indigenous peoples is increasing, but these populations commonly under use... more Cancer mortality among indigenous peoples is increasing, but these populations commonly under use cancer-screening services. This systematic review explores knowledge, attitudes, and behaviours towards cancer screening among indigenous peoples worldwide. Searches of major bibliographic databases identifi ed primary studies published in English up to March, 2014; of 33 eligible studies, three were cohort studies, 27 cross-sectional, and three case-control. Knowledge of and participation in screening was greater for breast cancer than for other cancers. Indigenous peoples tended to have less knowledge, less favourable attitudes, and a higher propensity to refuse screening than non-indigenous populations. The most common factors aff ecting knowledge, attitudes, and behaviours towards cancer screening included access to screening, knowledge about cancer and screening, educational attainment, perceived necessity of screening, and age. Greater understanding of knowledge, attitudes, and behaviours towards cancer screening in diverse indigenous cultures is needed so that culturally appropriate cancer prevention programmes can be provided.

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Adaptation and Quality of Life among Long-Term Cervical Cancer Survivors in the Military Health Care System

Military Medicine, 2008

This study assessed quality of life in long-term cervical cancer survivors eligible for health ca... more This study assessed quality of life in long-term cervical cancer survivors eligible for health care in the military health system. TRICARE beneficiaries who were diagnosed as having cervical cancer in 1980 to 2000 completed self-administered questionnaires including standardized measures of quality of life, distress, and sexuality. Forty-one women (72% of those who received questionnaire packets) provided questionnaire data. More than 2,500 questionnaires were undeliverable, with no forwarding address. Data indicated that quality of life, cervical cancer-related stress, and intimacy concerns were comparable to population normative values. Survivors received more cancer screenings than the general population. Nearly one-half of respondents reported no effect of cancer on their sexual relationships, whereas approximately one-half said that cancer had a negative impact. Although cervical cancer survivors overall reported a high quality of life, many experienced significant decrements in sexual functioning. The Automated Central Tumor Registry presents challenges and potential for conducting this kind of research.

CVD prevention in 2014: Advances in the prevention of cardiovascular disease

Nature Reviews Cardiology, 2014

Patient-Reported Outcomes

International Journal of Gynecological Cancer, 2011

Examining the relationship between personality and affect-related attributes and adolescents' intentions to try smoking using the Substance Use Risk Profile Scale

by Jasmina Memetovic and Carolyn Gotay

Addictive Behaviors, 2016

Assessments of adolescents&amp;amp;amp;amp;amp;amp;amp;amp;#39; smoking intentions indicate t... more Assessments of adolescents&amp;amp;amp;amp;amp;amp;amp;amp;#39; smoking intentions indicate that many are susceptible to smoking initiation because they do not have resolute intentions to abstain from trying smoking in the future. Although researchers have developed personality and affect-related risk factor profiles to understand risk for the initiation of substance use and abuse (e.g., alcohol), few have examined the extent to which these risk factors are related to the tobacco use intentions of adolescents who have yet to try tobacco smoking. The objective of this study was to examine the relationships between personality and affect-related risk factors measured by the Substance Use Risk Profile Scale (SURPS) and smoking intentions in a sample of adolescents who have not experimented with tobacco smoking. Data is based on responses from 1352 participants in the British Columbia Adolescent Substance Use Survey (56% female, 76% in Grade 8) who had never tried smoking tobacco. Of these 1352 participants, 29% (n=338) were classified as not having resolute intentions to not try smoking. Generalized estimating equations were used to examine the relationship between each SURPS dimension (Anxiety Sensitivity, Hopelessness, Impulsivity and Sensation Seeking) and the intention to try cigarettes in the future. Hopelessness (AOR 1.06, 95% CI [1.03, 1.10], p&amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), Impulsivity (AOR 1.07 [1.03, 1.11], p&amp;amp;amp;amp;amp;amp;amp;amp;lt;.001) and Sensation Seeking (AOR 1.05 95% CI [1.02, 1.09], p&amp;amp;amp;amp;amp;amp;amp;amp;lt;.01) had independent statistically significant associations with having an intention to try smoking. These findings may be used to inform a prevention-oriented framework to reduce susceptibility to tobacco smoking.

Initial impact of tailored web-based messages about cigarette smoke and breast cancer risk on boys’ and girls’ risk perceptions and information seeking: Randomized controlled trial

by Jasmina Memetovic, Joan Bottorff, and Carolyn Gotay

Journal of Medical Internet Research (JMIR): Research Protocols, 2013

Background: Recent evidence indicates a causal link between both active smoking and secondhand sm... more

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Differential item functioning (DIF) in the EORTC QLQ-C30: a comparison of baseline, on-treatment and off-treatment data

by Marianne Hjermstad, J. Blazeby, Carolyn Gotay, Ali Montazeri, Kyriaki Mystakidou, and Morten Petersen

Quality of Life Research, 2009

Introduction Differential item functioning (DIF) analyses can be used to explore translation, cul... more Introduction Differential item functioning (DIF) analyses can be used to explore translation, cultural, gender or other differences in the performance of quality of life (QoL) instruments. These analyses are commonly performed using ''baseline'' or pretreatment data. We previously reported DIF analyses to examine the pattern of item responses for translations of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 QoL instrument, using only data collected prior to cancer treatment. We now compare the consistency of these results with similar analyses of on-treatment and offtreatment assessments and explore whether item relationships differ from those at baseline.

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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

by Farshad Pourmalek, Maziar Moradi-Lakeh, and Carolyn Gotay

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The Prognostic Significance of Patient-Reported Outcomes In Cancer Clinical Trials

Journal of Clinical …, Jan 1, 2008

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Assessment of Quality of Life In a Multicultural Cancer Patient Population

…, Jan 1, 2002

Quality of life (QOL) is increasingly assessed in cancer patients. In this article, the authors e... more Quality of life (QOL) is increasingly assessed in cancer patients. In this article, the authors examined the psychometric performance of a commonly used QOL questionnaire, the Quality of Life Questionnaire--Cancer 30 (QLQ-C30; N. K. Aaronson et al., 1993), in multiethnic cancer patients. Content validation studies in patients and clinicians identified possible new items. Multiple-group confirmatory factor analysis supported equivalent structure across ethnic groups (Caucasians and Asian/Pacific Islanders [APIs]). A higher order QOL factor appeared to directly affect functioning scales and symptom count. Exploratory factor analysis examined effects of new items. Ten factors were extracted, 6 consistent with the original instrument and 4 reflecting potentially new aspects of QOL: Positive Social Support, Coping, Existential Well-Being, and Sexuality/Intimacy. The QLQ-C30 appears appropriate for use in API cancer patients. Further work needs to ensure that it includes all important domains.

Patient-Reported Outcomes In Cancer: a Review of Recent Research and Policy Initiatives

CA: A Cancer Journal for …, Jan 1, 2007

There is growing recognition that patient-reported outcome (PRO) measures--encompassing, for exam... more There is growing recognition that patient-reported outcome (PRO) measures--encompassing, for example, health-related quality of life--can complement traditional biomedical outcome measures (eg, survival, disease-free survival) in conveying important information for cancer care decision making. This paper provides an integrated review and interpretation of how PROs have been defined, measured, and used in a range of recent cancer research and policy initiatives. We focus, in turn, on the role of PRO measurement in the evaluation and approval of cancer therapies, the assessment of cancer care in the community, patient-provider decision making in clinical oncology practice, and population surveillance of cancer patients and survivors. The paper concludes with a discussion of future challenges and opportunities in PRO measure development and application, given the advancing state of the science in cancer outcomes measurement and the evolving needs of cancer decision makers at all levels.

by Nader Jahanmehr, Nataliya Foigt, Farshad Pourmalek, Carolyn Gotay, Walter Mendoza, and Ismael Campos-Nonato

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A qualitative focus group study to identify the needs of survivors of stage II and III colorectal cancer

Psycho-Oncology, 2015

Body mass index trajectories from ages 1 to 20: Results from two nationally representative canadian longitudinal cohorts

by Chris Richardson and Carolyn Gotay

Obesity, 2015

The Complementary Nature of Patient-Reported Outcomes (PROs) and Adverse Event Reporting in Cooperative Group Oncology Clinical Trials: A Pooled Analysis (NCCTG N0591)

Journal of pain and symptom management, Jan 29, 2015

The Global Burden of Cancer 2013

JAMA Oncology, 2015

Download

The Effectiveness of Exercise Interventions for Improving Health-Related Quality of Life From Diagnosis Through Active Cancer Treatment

Oncology Nursing Forum, 2014

Are exercise programs effective for improving health-related quality of life among cancer survivors? A systematic review and meta-analysis

Oncology nursing forum, 2014

To evaluate the effectiveness of exercise interventions on overall health-related quality of life... more To evaluate the effectiveness of exercise interventions on overall health-related quality of life (HRQOL) and its domains among cancer survivors who have completed primary treatment. 11 electronic databases were searched from inception (dates varied) to October 2011. The authors also identified eligible trials through a search of additional sources. 40 trials with 3,694 participants met the inclusion criteria. At 12 weeks, cancer survivors exposed to exercise interventions had greater positive improvement in overall HRQOL (standardized mean difference [SMD] 0.48; 95% confidence interval [CI] [0.16, 0.81]), emotional well-being (SMD 0.33; 95% CI [0.05, 0.61]), and social functioning (SMD 0.45; 95% CI [0.02, 0.87]); and had a significant reduction in anxiety (SMD -0.26; 95% CI [-0.44, -0.07]) and fatigue (SMD -0.82; 95% CI [-1.5, -0.14]). Exercise programs have a beneficial effect on HRQOL and most of its domains and can be integrated into the management plans for cancer survivors who...

Asbestos in Canada: time to change our legacy

Canadian Medical Association Journal, 2015

Hawaii's comprehensive cancer control program

Hawaii medical journal, 2005

Knowledge, attitudes, and behaviours towards cancer screening in indigenous populations: a systematic review

The Lancet Oncology, 2014

Download

Adaptation and Quality of Life among Long-Term Cervical Cancer Survivors in the Military Health Care System

Military Medicine, 2008

CVD prevention in 2014: Advances in the prevention of cardiovascular disease

Nature Reviews Cardiology, 2014

Patient-Reported Outcomes

International Journal of Gynecological Cancer, 2011

Examining the relationship between personality and affect-related attributes and adolescents' intentions to try smoking using the Substance Use Risk Profile Scale

by Jasmina Memetovic and Carolyn Gotay

Addictive Behaviors, 2016