Bruno Buchholz
Know-how and research interests:
Neurocardiology, basic mechanisms and clinical aspects. Cardiovascular physiology and pathophysiology. Mechanisms of myocardial ischemia and ischemia/reperfusion injury. Endogenous adaptation of the heart against ischemic and reperfusion injury. Post-myocardial infarction (MI) remodeling and heart failure. Autonomic nervous regulation of the normal heart and the ischemic and failing heart. Cardiac autonomic neuromodulation with special interest in the protective role of vagus stimulation on diseased heart. Reflex regulation of brain-heart interaction. Visceral modulation of behavior.
General human anatomy, with special interest in the structure and function of the autonomic nervous system. Intrinsic cardiac nervous system (epicardial plexuses) and extrinsic cardiac nervous system (cardiac nerves, mediastinal cardiac plexus). Higher centers of autonomic regulation.
Techniques and methods:
Experience in animal models of the aforementioned items: acute and chronic ischemia and ischemia/reperfusion experimental models of rabbits, rats and mice. Isolated heart preparation (Langendorff's system) in rabbit, rat and mouse. Preconditioning and postconditioning, vagal electro stimulation techniques. Mouse model of ventricular hypertrophy (aortic banding). Study of left ventricular function (acute hemodynamic monitoring). Experimental models of behavior study in mice. Anatomical knowledge and experience in dissection of structures of the human autonomic nervous system and experimental animals.
Neurocardiology, basic mechanisms and clinical aspects. Cardiovascular physiology and pathophysiology. Mechanisms of myocardial ischemia and ischemia/reperfusion injury. Endogenous adaptation of the heart against ischemic and reperfusion injury. Post-myocardial infarction (MI) remodeling and heart failure. Autonomic nervous regulation of the normal heart and the ischemic and failing heart. Cardiac autonomic neuromodulation with special interest in the protective role of vagus stimulation on diseased heart. Reflex regulation of brain-heart interaction. Visceral modulation of behavior.
General human anatomy, with special interest in the structure and function of the autonomic nervous system. Intrinsic cardiac nervous system (epicardial plexuses) and extrinsic cardiac nervous system (cardiac nerves, mediastinal cardiac plexus). Higher centers of autonomic regulation.
Techniques and methods:
Experience in animal models of the aforementioned items: acute and chronic ischemia and ischemia/reperfusion experimental models of rabbits, rats and mice. Isolated heart preparation (Langendorff's system) in rabbit, rat and mouse. Preconditioning and postconditioning, vagal electro stimulation techniques. Mouse model of ventricular hypertrophy (aortic banding). Study of left ventricular function (acute hemodynamic monitoring). Experimental models of behavior study in mice. Anatomical knowledge and experience in dissection of structures of the human autonomic nervous system and experimental animals.
less
Related Authors
InterestsView All (9)
Uploads
Papers by Bruno Buchholz