Papers by Minarda De la O Arciniega
Pharmacology Biochemistry and Behavior, 2009
In order to detect an anti-nociceptive interaction between morphine and gabapentin, the anti-allo... more In order to detect an anti-nociceptive interaction between morphine and gabapentin, the anti-allodynic and anti-hyperalgesic effects of these drugs, administered either separately or in combination, were determined using the von Frey and acetone tests in a rat model of neuropathic pain (Bennett model). Morphine and gabapentin individually induced moderate attenuation of mechanical hyperalgesia, whereas the morphine and gabapentin combination completely decreased hyperalgesia. Morphine showed its maximal effect at 30 min post-injection in the acetone test; however, this effect gradually returned to the baseline value. Gabapentin did not produce an anti-allodynic effect, whereas the morphine and gabapentin combination completely decreased allodynia behavior at 30 min post-injection, an effect that persisted until 120 min. The area under the curve (AUC) of the anti-allodynic or anti-hyperalgesic effects produced by the combinations were significantly greater than the theoretical sum of effects produced by each drug alone or similar to the theoretical sum. The analysis of the effect, expressed as the AUC of the time course, supports the hypothesis that the combination of these drugs is useful in neuropathic pain therapy.
Efectos antinociceptivos de la combinación metamizol + morfina en ratas con dolor intenso Volumen... more Efectos antinociceptivos de la combinación metamizol + morfina en ratas con dolor intenso Volumen 75, No. 5, septiembre-octubre 2007 medigraphic.com Cir Ciruj 2007;75:371-376 Efectos antinociceptivos de la combinación metamizol + morfina en ratas con dolor intenso (artritis tipo "gota" producida por ácido úrico)
Phytochemistry, 1999
The roots and aerial parts of Tephrosia crassifolia afforded an isopropenyldihydrofuran biflavano... more The roots and aerial parts of Tephrosia crassifolia afforded an isopropenyldihydrofuran biflavanol and a new chalcone. The structures and relative configuration were established by spectroscopic and chemical methods, and confirmed by X-ray diffraction. Crassifolin is the second 3,4″ ether-linked biflavan-4-ol to be isolated from the genus Tephrosia.
Raphanus sativus L. var niger (black radish) is a plant of the cruciferous family with important ... more Raphanus sativus L. var niger (black radish) is a plant of the cruciferous family with important ethnobotanical uses for the treatment of gallstones in Mexican traditional medicine. It has been established that the juice of black radish decreases cholesterol levels in plasma and dissolves gallstones in mice. Glucosinolates, the main secondary metabolites of black radish, can hydrolyze into its respective isothiocyanates and have already demonstrated antioxidant properties as well as their ability to diminish hepatic cholesterol levels; such therapeutic effects can prevent the formation of cholesterol gallstones. This disease is considered a current problem of public health. In the present review, we analyze and discuss the therapeutic effects of the main glucosinolates of black radish, as well as the effects that this plant has on cholesterol gallstones disease.
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Papers by Minarda De la O Arciniega