Papers by Masoomeh Eghtedari
Iranian Journal of Pediatric Hematology & Oncology, 2021
Background: Retinoblastoma (RB) is the most common intraocular malignancy in childhood. The aim o... more Background: Retinoblastoma (RB) is the most common intraocular malignancy in childhood. The aim of this study was to investigate the epidemiological features and survival rates of patients with RB in southwestern Iran. Materials and Methods: This retrospective study was conducted on patients with RB referred to the only referral center of southwestern Iran from 2010 to 2018. Demographic characteristics at first symptom presentation, the time interval between the symptom presenting and the treatment, educational level, socioeconomic status, type of ocular symptoms, extra-ocular involvement, types of treatments, outcomes and follow-up, the treatment interval until death and the survival rate of the patient, and pathology reports were recorded and analyzed. Results: This study included 46 new patients with RB (25 boys and 21 girls) including 65.2% unilateral, 26.1% bilateral, and 8.7% trilateral involvements. The mean age at first symptom presentation was 18.98±16.16 months. The mean d...
Iranian Journal of Veterinary Research, 2010
Summary The purpose of this study was to evaluate the effects of different time combinations of d... more Summary The purpose of this study was to evaluate the effects of different time combinations of dexamethasone and acetylcysteine on experimentally induced corneal ulcers in dogs. Experimental corneal wounds were created surgically to the anterior one third of the cornea in the center of all eyes of 15 mixed breed dogs. The eyes were divided into five groups according to planned post-operative medications: group 1, one drop of N- acetylcysteine 3% and one drop of dexamethasone 0.1% immediately after surgery; group 2, two drops of N- acetylcysteine 3% from day 1, one drop of N-acetylcysteine 3% and one drop of dexamethasone 0.1% from day 15; group 3, two drops of N-acetylcysteine 3%; group 4, two drops of dexamethasone 0.1%; group 5 (control), two drops of normal saline. When applied immediately after corneal ulceration, dexamethasone 0.1% (group 4) decreased corneal haze significantly and did not delay corneal wound healing. Addition of dexamethasone 0.1% to N-acetylcysteine 3% from ...
Iranian journal of medical sciences, 2011
The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of ... more The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of this study was to evaluate the effects of combination therapy with dexamethasone and acetylcysteine at different times and durations on experimentally-induced corneal wounds and haze in rabbits. Eighteen adult New Zealand white rabbits were divided into three groups of six each. Under anesthesia corneal wounds were created surgically in the center of all eyes. The right eyes of rabbits in group 1 were treated topically with acetylcysteine and dexamethasone immediately after surgery, those in group 2 were treated with acetylcysteine from day 1 and with acetylcysteine and dexamethasone from day 8, and those in group 3 were treated with acetylcysteine from day 1 and with acetylcysteine and dexamethasone from day 15. The left eyes were assigned as controls and were treated with normal saline. All eyes were treated six times a day for 28 days. Corneal wounds were measured by fluorescein stain...
Purpose: Recession is the main surgical procedure in correction of eye deviation in Duane's s... more Purpose: Recession is the main surgical procedure in correction of eye deviation in Duane's syndrome. We evaluate the efficacy of botulinum toxin injection in the treatment of this type of strabismus instead of surgery or before it. Methods: Three patients with Duane's syndrome type I and one patient with Type II were selected at Poostchi eye clinic from patients who diagnosed primarily and had not any eye surgery before. Botulinum toxin (Dysport™, 10 IU) was injected into medial or lateral rectus muscles under general (2 patients) or local (2 others) anesthesia. Amount of deviation, leash phenomenon and limitation of movements were measured pre injection and 72 hours, 1, 4, 12 and 24 weeks postinjections and the results were compared. Results: The amount of deviation was decreased between 8-35 PD at 24 weeks postinjection. No significant change was observed in limitation of movement but leash phenomenon improved in 3 patients. Conclusion: Injection of botulinum toxin in Dua...
Research Article Expression of Maspin and Ezrin Proteins in Periocular Basal Cell Carcinoma
Copyright © 2014 Mansooreh Bagheri et al. This is an open access article distributed under the Cr... more Copyright © 2014 Mansooreh Bagheri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. The aim of this study was to investigate maspin and ezrin expression in different subtypes of periocular basal cell carcinoma (BCC).Methods. Tissue samples from 43 patients with periocular BCC. Our cases were comprised of 10 morpheaform, 25 nodular, and 8 adenoid type BCCs. Immunohistochemical staining for maspin and ezrin was performed by Envision detection system. Results.There was no difference between different subtypes of BCC inmaspin expression regarding positivity, intensity, and pattern of expression. Ezrin was expressed in all subtypes of BCC but the intensity was significantly higher in morpheaform BCC compared to nodular and adenoid types (
Autologous activated omental versus allogeneic adipose tissue-derived mesenchymal stem cells in corneal alkaline injury: An experimental study
Journal of Current Ophthalmology, 2021
Purpose: To compare the effects of two types of mesenchymal stem cells (MSCs), activated omental ... more Purpose: To compare the effects of two types of mesenchymal stem cells (MSCs), activated omental cells (AOCs), and adipose tissue-derived stem cells (ADSCs) in the healing process of animal model of ocular surface alkali injury. Methods: An alkaline burn was induced on the ocular surfaces of eighteen rats divided randomly into three groups. The first and second groups received subconjunctival AOCs and ADSCs, respectively. The control group received normal saline subconjunctival injection. On the 90th day after the injury, the eyes were examined using slit-lamp biomicroscopy. Corneal neovascularization and scarring were graded in a masked fashion. Histological evaluation of the corneal scar was performed, and the number of inflammatory cells was evaluated. Results: Corneal neovascularization scores revealed higher neovascularization in the control (0.49 ± 0.12) than the AOC (0.80 ± 0.20, P = 0.01) and ADSC groups (0.84 ± 0.24, P = 0.007). There were no statistically significant differences between the neovascularization score of the AOC and ADSC groups (P > 0.05). According to histologic evaluation, stromal infiltration was significantly more in the control group compared to AOC and ADSC groups (P < 0.05). Conclusions: Our results suggest that MSCs, even with different sources, can be used to promote wound healing after corneal chemical burns. However, the ease of harvesting ADSC from more superficial fat sources makes this method more clinically applicable.
Morphologic Changes of Corneal Epithelial Flap: Ethanol-mediated versus Mechanical Removal
Ultrastructural Pathology, 2012
To evaluate morphologic changes in human corneal epithelial flap removed mechanically or after et... more To evaluate morphologic changes in human corneal epithelial flap removed mechanically or after ethanol application. Epithelial corneal flap was removed after ethanol application (20 eyes) or mechanically (19 eyes). Any changes were studied by transmission electron microscopy. Thirty-nine eyes were enrolled in the study. The following changes were found in the alcohol-applied group: apoptotic cells, membrane-bound blebs with marked dilatation of endoplasmic reticulum, and short intercellular cleavage with approximately one-third of cell length depth. In mechanical debridement, cleavages extended more than half of the cell length by tearing hemidesmosomes. Alcohol application leads to cell damage in basal epithelial cells but cleavage plane remains smooth. Generally, none of the methods caused trauma to the basement membrane.
Iranian Journal of Pediatric Hematology & Oncology, 2021
Background: Retinoblastoma (RB) is the most common intraocular malignancy in childhood. The aim o... more Background: Retinoblastoma (RB) is the most common intraocular malignancy in childhood. The aim of this study was to investigate the epidemiological features and survival rates of patients with RB in southwestern Iran. Materials and Methods: This retrospective study was conducted on patients with RB referred to the only referral center of southwestern Iran from 2010 to 2018. Demographic characteristics at first symptom presentation, the time interval between the symptom presenting and the treatment, educational level, socioeconomic status, type of ocular symptoms, extra-ocular involvement, types of treatments, outcomes and follow-up, the treatment interval until death and the survival rate of the patient, and pathology reports were recorded and analyzed. Results: This study included 46 new patients with RB (25 boys and 21 girls) including 65.2% unilateral, 26.1% bilateral, and 8.7% trilateral involvements. The mean age at first symptom presentation was 18.98±16.16 months. The mean d...
Effect of Topical Phenytoin in Treatment of Corneal Epithelial Defect in Rabbits
Re-epithelialization of corneal epithelium is a major problem in delayed corneal wound healing. P... more Re-epithelialization of corneal epithelium is a major problem in delayed corneal wound healing. Phenytoin has been used topically for different type of cutaneous wounds and ulcers. The aim of this this study was to assess the efficacy of topical phenytoin eye drop and ointment 1% and on induced sterile corneal epithelial ulcer in rabbit eyes. Fifty eyes from 30 rabbits were evaluated for induction of corneal epithelial ulcer in this study. The right corneas of all rabbits underwent total epithelial debridement. Randomization was made. Odd labeled eyes as control group received artificial tear and even labeled eyes as case group received phenytoin 1% eye drop. Slit lamp examination was performed on day 1, 3, 5 &7. After healing of the right eyes, same procedure was performed on 20 corneas of left eyes. In the left eyes, phenytoin ointment 1% was used instead of phenytoin eye drop 1%.There was no statistically significant difference between corneas that received phenytoin 1% eye drop...
Purpose: To evaluate study of corneal the frequency of re-graft during 5 years at Khalili hospita... more Purpose: To evaluate study of corneal the frequency of re-graft during 5 years at Khalili hospital, Shiraz. Methods: In this retrospective observational study, all corneal re-grafts during 5 years (2009-2014) were assessed at Khalili Hospital, Shiraz. Demographic data of 76 cases, out of total of 1 190 transplants, were retrieved, including age, area of residence, primary disease, type of graft, cause of re-graft, and associated eye systemic diseases; then, the data were analyzed. Results: The number of re-grafts during 5 years was 76 cases (6.38%). The most common procedure was penetrating keratoplasty and the most successful ones were deep anterior lamellar keratoplasty. The shortest interval to the next procedure was observed in cases of fungal infections and, then, in failed endothelial keratoplasties. The main causes of graft failure were endothelial dysfunction, infection, immunologic rejection, and recurrence of primary disease (14 cases). Male gender, type of primary disease...
Iranian Journal of Veterinary Research, 2010
Summary The purpose of this study was to evaluate the effects of different time combinations of d... more Summary The purpose of this study was to evaluate the effects of different time combinations of dexamethasone and acetylcysteine on experimentally induced corneal ulcers in dogs. Experimental corneal wounds were created surgically to the anterior one third of the cornea in the center of all eyes of 15 mixed breed dogs. The eyes were divided into five groups according to planned post-operative medications: group 1, one drop of N- acetylcysteine 3% and one drop of dexamethasone 0.1% immediately after surgery; group 2, two drops of N- acetylcysteine 3% from day 1, one drop of N-acetylcysteine 3% and one drop of dexamethasone 0.1% from day 15; group 3, two drops of N-acetylcysteine 3%; group 4, two drops of dexamethasone 0.1%; group 5 (control), two drops of normal saline. When applied immediately after corneal ulceration, dexamethasone 0.1% (group 4) decreased corneal haze significantly and did not delay corneal wound healing. Addition of dexamethasone 0.1% to N-acetylcysteine 3% from ...
Chemistry & Biodiversity, 2019
The purpose of this study was to examine the neuroprotective effects of caffeic acid hexyl (CAF6)... more The purpose of this study was to examine the neuroprotective effects of caffeic acid hexyl (CAF6) and dodecyl (CAF12) amide derivatives on the early stage of retinopathy in streptozotocin-induced diabetic rats. Animals were divided in 5 groups (n = 8/group); One group consisted of control non-diabetic rats, while the other 4 were diabetic animals either non-treated or treated with CAF6, CAF12 or resveratrol intravitreally for 4 weeks. Retinal superoxide dismutase (SOD) activity and 8-iso prostaglandin F2α (iPF2α) levels were evaluated by an ELISA assay. Phosphorylation of ERK1/2 and AKT were determined by immunoblotting in retinal homogenates. Retinal morphology was also examined using light microscopy. Treatment with CAF6 and CAF12 increased retinal SOD activity, while it decreased iPF2α levels in diabetic rats. Phosphorylation of ERK1/2 was increased, while AKT phosphorylation was decreased in diabetic rats compared to normal control and these alterations were significantly reversed in diabetic rats treated with CAF6 and CAF12. Furthermore, thickness of the whole retinal layer, outer nuclear layer, and ganglion cell count were decreased in diabetic rats compared to control and CAF6 and CAF12 treatments prevented these changes. CAF6 and CAF12 seem to be effective agents for treatment of DR via attenuation of retinal oxidative stress, and improvement of neuronal survival signaling.
Iranian journal of medical sciences, 2011
The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of ... more The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of this study was to evaluate the effects of combination therapy with dexamethasone and acetylcysteine at different times and durations on experimentally-induced corneal wounds and haze in rabbits. Eighteen adult New Zealand white rabbits were divided into three groups of six each. Under anesthesia corneal wounds were created surgically in the center of all eyes. The right eyes of rabbits in group 1 were treated topically with acetylcysteine and dexamethasone immediately after surgery, those in group 2 were treated with acetylcysteine from day 1 and with acetylcysteine and dexamethasone from day 8, and those in group 3 were treated with acetylcysteine from day 1 and with acetylcysteine and dexamethasone from day 15. The left eyes were assigned as controls and were treated with normal saline. All eyes were treated six times a day for 28 days. Corneal wounds were measured by fluorescein stain...
Morphologic Changes of Corneal Epithelial Flap: Ethanol-mediated versus Mechanical Removal
Ultrastructural Pathology, 2012
To evaluate morphologic changes in human corneal epithelial flap removed mechanically or after et... more To evaluate morphologic changes in human corneal epithelial flap removed mechanically or after ethanol application. Epithelial corneal flap was removed after ethanol application (20 eyes) or mechanically (19 eyes). Any changes were studied by transmission electron microscopy. Thirty-nine eyes were enrolled in the study. The following changes were found in the alcohol-applied group: apoptotic cells, membrane-bound blebs with marked dilatation of endoplasmic reticulum, and short intercellular cleavage with approximately one-third of cell length depth. In mechanical debridement, cleavages extended more than half of the cell length by tearing hemidesmosomes. Alcohol application leads to cell damage in basal epithelial cells but cleavage plane remains smooth. Generally, none of the methods caused trauma to the basement membrane.
Effect of Honey inPseudomonas aeruginosaInduced Stromal Keratitis in Rabbits
Journal of Applied Animal Research, 2009
Nejabat, M., Astaneh, A., Eghtedari, M., Mosallaei, M., Ashraf, M.J. and Mehrabani, D. 2009. Effe... more Nejabat, M., Astaneh, A., Eghtedari, M., Mosallaei, M., Ashraf, M.J. and Mehrabani, D. 2009. Effect of honey in Pseudomonas aeruginosa induced stromal keratitis in rabbits. J. Appl. Anim. Res., 35: 101–104.To evaluate the healing effect of honey in Pseudomonas aeruginosa induced keratitis, 26 eyes of 26 white New Zealand Rabbits were experimentally infected with P. aeruginosa. Ten eyes were treated
The Prevalence of Exodeviation in Primary School Children in Shiraz
IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), Feb 1, 2002
Exodeviation (phoria & tropia) can cause visual suppression and amblyopia during childhood. In a ... more Exodeviation (phoria & tropia) can cause visual suppression and amblyopia during childhood. In a cross-sectional study, 1500 students (758 boys, 742 girls) in the first to fifth grades of primary schools in four regions of Shiraz were screened, based on alternate test. Then, visual acuity, amounts of deviation and central fusional ability were measured. In 24.06 percent of the students, exodeviation (96.57% exophoria, 3.43% exotropia) was detected. There was no significant difference between the sexes; but exodeviation was ...
Antrochoanal Polyp: A Three-Year Study in Shiraz
JOURNAL OF MEDICAL RESEARCH (JMR), 2003
Background: Antrochoanal polyp (ACP) is one of the rarest nasal polyps with an unknown etiology a... more Background: Antrochoanal polyp (ACP) is one of the rarest nasal polyps with an unknown etiology and without relation to allergy, sinusitis or lower respiratory tract diseases. Unilateral nasal stuffiness is the most common symptom and opacification of the antrum may be seen radiographically. Patients and Methods: In this retrospective study, patients with nasal polyps who underwent operation at Khalili hospital, Shiraz, during a three-year period (1995-1997) were selected. Data were collected and analyzed statistically for age, sex, ...
BINA, 2005
Purpose: To determine the correlation between hand dominancy and eye dominancy with visual acuity... more Purpose: To determine the correlation between hand dominancy and eye dominancy with visual acuity and refraction in subjects with refractive errors. Methods: This cross-sectional study includes 620 patients undergoing LASIK. Their refractive error (dry and cycloplegic), hand dominancy, eye dominancy (by hole-in-the-hand method) and visual acuity were determined. Exclusion criteria were monocularity, patient's inability to perform hole-inthe-hand test, and amblyopia.
BINA, 2005
To report a case of spinal cord tumor with visual symptoms and papilledema due to increased intra... more To report a case of spinal cord tumor with visual symptoms and papilledema due to increased intracranial pressure. Patient and findings: A 24-year-old woman was referred because of recent blurred vision in both eyes. Visual acuity was 20/25 and 20/20 in the right and left eyes, respectively. Fundoscopy revealed bilateral papilledema. Other ophthalmic examinations were normal. Visual fields showed blind spot enlargement and brain CT scan revealed dilated ventricles. Ventriculoperitoneal shunt was inserted for the patient with a diagnosis of hydrocephalus. Ten weeks later, she returned with low back pain and lower extremity weakness. Lumbosacral MRI revealed a tumor in the region of L1-L4. The patient underwent surgical removal of the tumor and histopathologic study showed mixopapillary ependymoma. Conclusion: Increased intracranial pressure and papilledema without evidence of a space occupying intracranial lesion may be the presenting sign of spinal cord tumors.
Histopathologic Changes of Extraocular Muscle Fibers After Injection of Botulinum Toxin
IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), Jun 1, 2007
Background: Use of botulinum toxin is becoming a popular way in treatment of some forms of strabi... more Background: Use of botulinum toxin is becoming a popular way in treatment of some forms of strabismus. To evaluate the morphological changes in the orbital surface layer muscles of the rabbit eye following a single injection of botulinum toxin. Methods: 10 white Dutch rabbits weighing 2–3 kg received either 10 units (group 1; n= 5) or 20 units (group 2; n= 5) of botulinum toxin into the superior rectus muscle of right eye. The superior rectus muscle of the left eye in each rabbit was considered as control. The diameter of at least 20 muscle ...
Uploads
Papers by Masoomeh Eghtedari