Xanthogranulomatous pyelonephritis (XGP) is a chronic pyelonephritis subtype in which destruction... more Xanthogranulomatous pyelonephritis (XGP) is a chronic pyelonephritis subtype in which destruction of the renal parenchymal occurs, resulting in progressive loss of kidney functions. Although middle age is the predominant age group affected, but it can be spotted at any age. There is accumulation of macrophages (lipid-laden), leading to renal parenchymal destruction and fibrosis. In this study, we present our data of 15 patients who had undergone nephrectomy and had biopsy-proven XGP. XGP constituted 4.53% of the 331 nephrectomies performed for infective causes over a period of 8 years. All our patients had undergone unilateral total nephrectomy. Demographic and clinical data were analyzed after taking consent from all the patients. The age range of patients in our study was 18–65 years with a mean age of 43.93 ± 13.86 years. Ten (66.6%) of our patients were females. Diabetes was present in 40% of the patients. Three patients had imaging, suggestive of pyonephrosis, 3 had perinephric...
Nephrectomy is conducted either as an open or a laparoscopic procedure for a variety of clinical ... more Nephrectomy is conducted either as an open or a laparoscopic procedure for a variety of clinical indications. These include both neoplastic and non-neoplastic conditions, such as the non-functioning kidney. In many patients the final diagnosis is established on the histopathology of the retrieved kidney. In this study, retrospective analysis of data of last 14 years was studied pertaining to the number and indications of nephrec-tomy at the present study centre. Demographic and clinical details were assessed. Gross and microscopic histopathological details were recorded. Diagnosis was established on the basis of clinical features and histopathology. A total of 638 total nephrectomy specimens were received. Of these, 280 cases were of neoplastic and 358 of non-neoplastic lesions, with a male-to-female ratio of 1.21:1. The age range varied widely accord-ing to clinical manifestations. The age range in the present study was 5–84 years. Patients operated for non-neoplastic disorders wer...
Aim: The aim of this study is to evaluate the clinic-pathological spectrum of breast biopsies for... more Aim: The aim of this study is to evaluate the clinic-pathological spectrum of breast biopsies for a period of three years. Materials and Methods: This study includes 529 breast pathology cases received by histopathology laboratories of Department of pathology, Government Medical College, Srinagar between January 2017 to January December 2019. The samples included mastectomies, lumpectomies, core needle biopsy and tru cut biopsy specimens. Results: In the present study, out of 529 cases there were 56 (10.58%) inflammatory lesions, 287 (54.2%) benign lesions and 186 (35.16%) malignant lesions. Fibroadenoma was the most common benign breast lesion. Among the malignant breast lesions, infiltrating duct cell carcinoma was the most common. Conclusion: The pattern of breast lesions observed showed higher prevelance of non-malignant breast lesions over malignant lesions. Awareness and screening of these entities can facilitate early diagnosis and management.
Transactions of the Royal Society of Tropical Medicine and Hygiene, Jul 1, 1998
Diagnosis of pulmonary tuberculosis depends on the bacteriological examination of sputum. Sputum ... more Diagnosis of pulmonary tuberculosis depends on the bacteriological examination of sputum. Sputum smear microscopy is efficient and can confirm the disease. However, direct microscopy of sputum, though rapid, has low sensitivity. There is, therefore, an urgent need to develop rapid, much more sensitive and specific methods. In a field study we collected sputum samples from 488 tuberculosis suspects and compared the results of examining smears prepared after treatment with sodium hypochlorite (NaOCl) and concentration of bacteria by centrifugation and direct staining with Ziehl-Neelsen stain. Direct smears stained with auramine-phenol were the reference standard. The use of NaOCl increased the sensitivity from 43.4% to 76.3%, with a specificity of 100% for both methods.The method is simple and cheap. As a potent disinfectant, NaOCl also reduces the risk of laboratory-acquired infection. Its application would increase the efficiency of tuberculosis control programmes.
Xanthogranulomatous pyelonephritis (XGP) is a chronic pyelonephritis subtype in which destruction... more Xanthogranulomatous pyelonephritis (XGP) is a chronic pyelonephritis subtype in which destruction of the renal parenchymal occurs, resulting in progressive loss of kidney functions. Although middle age is the predominant age group affected, but it can be spotted at any age. There is accumulation of macrophages (lipid-laden), leading to renal parenchymal destruction and fibrosis. In this study, we present our data of 15 patients who had undergone nephrectomy and had biopsy-proven XGP. XGP constituted 4.53% of the 331 nephrectomies performed for infective causes over a period of 8 years. All our patients had undergone unilateral total nephrectomy. Demographic and clinical data were analyzed after taking consent from all the patients. The age range of patients in our study was 18–65 years with a mean age of 43.93 ± 13.86 years. Ten (66.6%) of our patients were females. Diabetes was present in 40% of the patients. Three patients had imaging, suggestive of pyonephrosis, 3 had perinephric...
Nephrectomy is conducted either as an open or a laparoscopic procedure for a variety of clinical ... more Nephrectomy is conducted either as an open or a laparoscopic procedure for a variety of clinical indications. These include both neoplastic and non-neoplastic conditions, such as the non-functioning kidney. In many patients the final diagnosis is established on the histopathology of the retrieved kidney. In this study, retrospective analysis of data of last 14 years was studied pertaining to the number and indications of nephrec-tomy at the present study centre. Demographic and clinical details were assessed. Gross and microscopic histopathological details were recorded. Diagnosis was established on the basis of clinical features and histopathology. A total of 638 total nephrectomy specimens were received. Of these, 280 cases were of neoplastic and 358 of non-neoplastic lesions, with a male-to-female ratio of 1.21:1. The age range varied widely accord-ing to clinical manifestations. The age range in the present study was 5–84 years. Patients operated for non-neoplastic disorders wer...
Aim: The aim of this study is to evaluate the clinic-pathological spectrum of breast biopsies for... more Aim: The aim of this study is to evaluate the clinic-pathological spectrum of breast biopsies for a period of three years. Materials and Methods: This study includes 529 breast pathology cases received by histopathology laboratories of Department of pathology, Government Medical College, Srinagar between January 2017 to January December 2019. The samples included mastectomies, lumpectomies, core needle biopsy and tru cut biopsy specimens. Results: In the present study, out of 529 cases there were 56 (10.58%) inflammatory lesions, 287 (54.2%) benign lesions and 186 (35.16%) malignant lesions. Fibroadenoma was the most common benign breast lesion. Among the malignant breast lesions, infiltrating duct cell carcinoma was the most common. Conclusion: The pattern of breast lesions observed showed higher prevelance of non-malignant breast lesions over malignant lesions. Awareness and screening of these entities can facilitate early diagnosis and management.
Transactions of the Royal Society of Tropical Medicine and Hygiene, Jul 1, 1998
Diagnosis of pulmonary tuberculosis depends on the bacteriological examination of sputum. Sputum ... more Diagnosis of pulmonary tuberculosis depends on the bacteriological examination of sputum. Sputum smear microscopy is efficient and can confirm the disease. However, direct microscopy of sputum, though rapid, has low sensitivity. There is, therefore, an urgent need to develop rapid, much more sensitive and specific methods. In a field study we collected sputum samples from 488 tuberculosis suspects and compared the results of examining smears prepared after treatment with sodium hypochlorite (NaOCl) and concentration of bacteria by centrifugation and direct staining with Ziehl-Neelsen stain. Direct smears stained with auramine-phenol were the reference standard. The use of NaOCl increased the sensitivity from 43.4% to 76.3%, with a specificity of 100% for both methods.The method is simple and cheap. As a potent disinfectant, NaOCl also reduces the risk of laboratory-acquired infection. Its application would increase the efficiency of tuberculosis control programmes.
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