Papers by Mohamed Wael Mustafa
SVU-International Journal of Medical Sciences, 2021
Background: Sudden sensory neural hearing loss (SSNHL) is an ENT emergency which is defined as a ... more Background: Sudden sensory neural hearing loss (SSNHL) is an ENT emergency which is defined as a loss of hearing of 30 dB or more, over at least 3 successive frequencies, that develops within 3 days in most cases it is unilateral and the most age group to be affected are 40s and 50s in most cases the cause is not known and called idiopathic sensory neural hearing loss. pure tone audiometry is done to confirm the hearing loss, history, examination, MRI and blood tests to exclude serious underlying causes. Objective: to compare between the efficacy of four versus two intra tympanic injection of steroid for treatment of sudden idiopathic sensory neural hearing loss. Patients and Methods. During the time frame from February 2020 to January 2021 a thirty patients (15 males and 15 females) with ISSNHL who visited our otorhinolaryngology department, Qena university hospital. were merged with intra tympanic steroid injection for treatment of sudden sensory neural hearing loss. The ages rang was from 40 to 69. Results: According to our statistical analysis and data, hearing improvement after 4 intra tympanic injection is better than 2 injections with a p value is 0.000. Conclusion: Injection of 4 times intra tympanic injection of steroid appears to be more effective than two times of injection.
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Background: The tullio phenomenon consists of the production of vestibular signs or symptoms by a... more Background: The tullio phenomenon consists of the production of vestibular signs or symptoms by an acoustic stimulus. TP was found to be present in many inner ear pathologies such as superior semicircular canal dehiscence, perilymphatic fistula and endolymphatic hydrops. No previous study probed the value of tinnitus maskers in the alleviation of Tullio phenomenon associated with endolymphatic hydrops. Methods : Twenty one patients who had a confirmed unilateral endolymphatic hydrops associated with Tullio phenomenon were selected for the study. Their age ranged from 20 to 52 years old. Tinnitus masker±amplification was used according to the audiological findings of each patient. The device was used in the affected ear for a minimum of 6 months. Results: Ten patients reported marked improvement on a graded scale with a mean of 8.6±1.2 as regards the occurrence of tullio phenomenon. Six patients achieved an average amelioration (mean 5.9±0.12) while five patients reported failure of ...
SVU-International Journal of Medical Sciences, 2019
Idiopathic Sudden Sensorineural Hearing Loss(ISSNHL) is a an irritating problem that continues to... more Idiopathic Sudden Sensorineural Hearing Loss(ISSNHL) is a an irritating problem that continues to pose a diagnostic and therapeutic enigma for the otologist. It is most commonly defined as sensorineural hearing loss of 30dB or greater over at least three contiguous audiometric frequencies occurring within a 72-hr period. It is not one of the more common causes of HL, disproportionate interest in ISSNHL exists most likely because it is one of the few reversible (sensorineural) hearing losses encountered by clinicians. Intratympanic steroid injection is increasingly used in the management of ISSNHL as it offers the potential for directed therapy of a high concentration to the inner ear with avoidance of systemic side effects. It also can improve hearing function in patients with ISSNHL after the failure of systemic steroid treatment.
The Egyptian Journal of Otolaryngology, 2014
The internet has become a trustable and increasingly available source for medical information. Wh... more The internet has become a trustable and increasingly available source for medical information. When patients explore the internet, their attitude toward their selected physician and his medical decisions becomes distorted and biased by the medical information they get from the web. This study was designed to address the effect of medical data available on the web on tinnitus patients and their expectations for treatment. Design A total of 106 patients who had tinnitus, for variable periods and due to different causes, participated in the current study. At the end of the counseling session, half of the patients (53) were randomly selected and were advised to try Google search engine, using these keywords in Arabic language (tinnitus treatment fx1 fx2 fx3). The other half of the patients were not advised to use the internet. Each patient who came back after 2 weeks answered a questionnaire in Arabic that was designed to outline the patients' choice among available treatment options. Conclusion Use of the internet among Egyptian tinnitus patients is a complimentary rather than a basic source of medical information. Its impact on the physician-patient relationship could be both positive and negative. However, it did not hamper the physicians' credibility and/or reliability.
The Egyptian Journal of Otolaryngology, 2014
The internet has become a trustable and increasingly available source for medical information. Wh... more The internet has become a trustable and increasingly available source for medical information. When patients explore the internet, their attitude toward their selected physician and his medical decisions becomes distorted and biased by the medical information they get from the web. This study was designed to address the effect of medical data available on the web on tinnitus patients and their expectations for treatment. Design A total of 106 patients who had tinnitus, for variable periods and due to different causes, participated in the current study. At the end of the counseling session, half of the patients (53) were randomly selected and were advised to try Google search engine, using these keywords in Arabic language (tinnitus treatment fx1 fx2 fx3). The other half of the patients were not advised to use the internet. Each patient who came back after 2 weeks answered a questionnaire in Arabic that was designed to outline the patients' choice among available treatment options. Conclusion Use of the internet among Egyptian tinnitus patients is a complimentary rather than a basic source of medical information. Its impact on the physician-patient relationship could be both positive and negative. However, it did not hamper the physicians' credibility and/or reliability.
Sohag Medical Journal, 2017
Introduction: Vitiligo is an acquired hypomelanotic disorder characterized by circumscribed depig... more Introduction: Vitiligo is an acquired hypomelanotic disorder characterized by circumscribed depigmented macules or patches resulting from loss of functional melanocytes and of melanin from the epidermis. The affection of extracutaneous melanocytes in some vitiligo patients suggests that systemic immunological reactions directed at pigment cells might play a role in the development of the disease. Aim of the work: Evaluation of the cochlea and the auditory nerve in vitiligo patients. Patients and Methods: Cross sectional clinical study included total number of 60 subjects were examined. All subjects included were subjected to the following procedures: Full history taking, clinical examination, Basic audiologic evaluation, Transient Evoked otoacoustic emissions (TEOAEs), Distortion Product Otoacoustic Emission (DPOAE), Auditory Brainstem Response test (ABR). Results: The ABR finding concluded that melanin play a significant role in establishment and maintenance of structure and function of the auditory system and may modulate the transduction of auditory stimuli by the inner ear. Conclusion: TEOAE and DPOAE are sensitive tests for detecting cochlear dysfunction before symptoms become manifested as the TEOAE and DPOAE were impaired in 35% and 35%of the ears with normal hearing.
The Internet Journal of Otorhinolaryngology, 2005
Arabic is one of the youngest members of the Semitic Language Family. Arabic critically differs f... more Arabic is one of the youngest members of the Semitic Language Family. Arabic critically differs from most modern European languages, not only English, in being "diglossic". The International Outcome Inventory for Hearing Aids (IOI-HA) was developed as a product of an international workshop on Self Report Outcome Measures in Audiological Rehabilitation. The Arabic version of the IOI-HA emerged at the end of 2003. This work is designed to study the norms for the Arabic IOI-HA version. Out of 215 of our patients, who were asked to come to the Audiology Unit, only 106 came and completed the IOI-HA. Most of them had sensorineural hearing loss and were illiterate (does not understand formal Arabic). Measures to help illiterate people were taken. The results reflected a generalized impression that our patients were not happy with their hearing aids. The mean scores of each of the items of the IOI-HA ranged from 2.3 to 2.7. An immense need to develop a modified version of the IOI-HA in the informal form of Arabic was clearly noticed. The hearing aid delivery strategy of the Egyptian Health Insurance Authority has also to be revised.
The Internet Journal of Otorhinolaryngology, 2004
Hearing loss due to genetic defects is one of the most frequent causes of hearing impairment. Thi... more Hearing loss due to genetic defects is one of the most frequent causes of hearing impairment. This sensory loss affects approximately one in 1,000 children in most parts of the world. In Egypt, 8 out of 1000 children have a hearing impairment. Hereditary non-syndromic hearing loss (NSHL) is more prevalent due to the high rates of consanguineous marriages. Since connexin 26associated hearing loss has been discovered in many parts of the world, we examined the prevalence of mutations in this gene in thirty-one Egyptian families diagnosed with NSHL. Each nuclear family had between two to five cases of sensorineural hearing loss, with no symptoms or features suggestive of any other possible etiology. Control subjects were studied to determine the carrier rate of connexin 26 in the general population. All DNA samples were screened for the 35delG mutation using an allele-specific polymerase chain reaction (AS-PCR). We found that the 35delG mutation is much less common in Egypt (~10%) than in many other parts of the world, with a carrier rate of 2.7%.
Labyrinthine function is tightly coupled to proper homeostasis. Perturbations in labyrinthine mic... more Labyrinthine function is tightly coupled to proper homeostasis. Perturbations in labyrinthine microcirculation can lead to significant cochlear and/or vestibular dysfunction. Indeed, no studies were conducted to examine the effect of improvement in cardiac performance after coronary stent application on either hearing or vestibular function. This study included 30 patients presenting to the Catheterization Unit in Sohag University Hospitals. Their age ranged from 41 to 60 years. Those patients were suffering from ischemic heart disease and proved to be candidates for Percutaneous Coronary Intervention (PCI) and stenting through a list of pre-operative investigations that included: Electrocardiography (ECG), Echocardiography and Coronary angiography. A full battery of audiovestibular investigations was conducted both preoperatively and postoperatively. Significant differences were encountered between preoperative and postoperative auditory brainstem response (ABR) latency measures, t...
The Internet Journal of Otorhinolaryngology, 2004
Electrocochleography (ECochG) is a method of recording the stimulus related potentials of the coc... more Electrocochleography (ECochG) is a method of recording the stimulus related potentials of the cochlea and auditory nerve. The response that is measured in ECochG occurs within the first two or three milliseconds after an abrupt stimulus, and it includes the following components: the cochlear microphonic (CM), the summating potential (SP), and the whole nerve or compound action potential (AP). The amplitude ratio between the SP and the AP looked to be a more consistent within-subject feature of the overall response. Normal SP/AP ratios generally ranged from 0.1 to 0.4 across subjects with a mean value of 0.25. It is this particular measurement that appeared most sensitive to, or dependant on, the presence of endolymphatic hydrops. However, we were in need for a new measurement technique that integrates amplitude, latency and slope of the recorded waves. This technique was referred to as the Graphic Angle Measurement (GAM) Technique. It relies on the measurement of the angle between 2 intersecting lines: One connecting the peaks of the SP and the AP and the other one is dropped vertically from the peak of the SP. The normal values of our lab ranged from 102° to 158°.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2014
This study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and latencie... more This study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and latencies of vestibular evoked myogenic potentials (VEMPs) among non-smokers, cigarette smokers, water pipe smokers, mixed smokers and ex-smokers. A total of 50 non-smokers, 28 water pipe smokers, 34 pure cigarette smokers, 28 mixed cigarette-water pipe smokers, and 21 ex-smokers were evaluated in this study. Their age ranged from 20 to 40 years. All had normal hearing sensitivity and normal middle ear functions. TEOAEs amplitude and VEMPs were measured for all participants. Results of this study showed that smoking had deleterious effects on the hair cells in the labyrinth. Damage to the outer hair cells was evidenced by the reduced amplitude of the TEOAEs in smokers and ex-smokers when compared with control group. Harm to the saccular hair cells is detected by the increased latency of the VEMPs. Results also suggested that cessation of smoking could not change the profile of TEOAEs or VEMPs. Our results suggested that smoking could have irreversible hazardous effects on the labyrinthine hair cell functions. These effects could be attributed to the impact of nicotine on the microvascular dynamics.
Labyrinthine function is tightly coupled to proper homeostasis. Perturbations in labyrinthine mic... more Labyrinthine function is tightly coupled to proper homeostasis. Perturbations in labyrinthine microcirculation can lead to significant cochlear and/or vestibular dysfunction. Indeed, no studies were conducted to examine the effect of improvement in cardiac performance after coronary stent application on either hearing or vestibular function. This study included 30 patients presenting to the Catheterization Unit in Sohag University Hospitals. Their age ranged from 41 to 60 years. Those patients were suffering from ischemic heart disease and proved to be candidates for Percutaneous Coronary Intervention (PCI) and stenting through a list of pre-operative investigations that included: Electrocardiography (ECG), Echocardiography and Coronary angiography. A full battery of audiovestibular investigations was conducted both preoperatively and postoperatively. Significant differences were encountered between preoperative and postoperative auditory brainstem response (ABR) latency measures, transient evoked otoacoustic emission (TEOAE), vestibular evoked myogenic potentials (VEMP) and Computerized Dynamic Posturography (CDP) tests. Both TEOAE and VEMP proved to be reliable indicators of defective labyrinthine circulation. Severity of chest pain as well as its duration proved to be the best predictors of the degree of total stenosis of coronary arteries. It can be concluded that affection of the labyrinthine peripheral microcirculation is an intimate consequence of deterioration of cardiac output (COP) secondary to ischemic heart disease.
European Archives of Oto-Rhino-Laryngology, 2013
This study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and latencie... more This study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and latencies of vestibular evoked myogenic potentials (VEMPs) among non-smokers, cigarette smokers, water pipe smokers, mixed smokers and ex-smokers. A total of 50 non-smokers, 28 water pipe smokers, 34 pure cigarette smokers, 28 mixed cigarette-water pipe smokers, and 21 ex-smokers were evaluated in this study. Their age ranged from 20 to 40 years. All had normal hearing sensitivity and normal middle ear functions. TEOAEs amplitude and VEMPs were measured for all participants. Results of this study showed that smoking had deleterious effects on the hair cells in the labyrinth. Damage to the outer hair cells was evidenced by the reduced amplitude of the TEOAEs in smokers and ex-smokers when compared with control group. Harm to the saccular hair cells is detected by the increased latency of the VEMPs. Results also suggested that cessation of smoking could not change the profile of TEOAEs or VEMPs. Our results suggested that smoking could have irreversible hazardous effects on the labyrinthine hair cell functions. These effects could be attributed to the impact of nicotine on the microvascular dynamics.
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Papers by Mohamed Wael Mustafa