Papers by Afsaneh sharifian
Scientific Journal of Kurdistan University of Medical Sciences, Sep 15, 2007
Scientific Journal of Kurdistan University of Medical Sciences, Mar 15, 2001
Scientific Journal of Kurdistan University of Medical Sciences, Jun 15, 2009
Gastroenterology and Hepatology from Bed to Bench, Feb 7, 2014
Medical Science Journal of Islamic Azad Univesity Tehran Medical Branch, Jun 15, 2013
د وره 23 ﺷﻤﺎره ، 2 ، ﺗﺎﺑﺴﺘﺎن 92 ، ﺻﻔﺤﺎت 93 ﺗﺎ 99 ﭘﻠﻲ ﺑﺮرﺳﻲ ﻧﺎﺣﻴﻪ ﭘﺮوﻣﻮﺗﺮ ﻣﻮر... more د وره 23 ﺷﻤﺎره ، 2 ، ﺗﺎﺑﺴﺘﺎن 92 ، ﺻﻔﺤﺎت 93 ﺗﺎ 99 ﭘﻠﻲ ﺑﺮرﺳﻲ ﻧﺎﺣﻴﻪ ﭘﺮوﻣﻮﺗﺮ ﻣﻮرﻓﻴﺴﻢ 308 -ﻓﺎﻛﺘﻮر ﻧﻜﺮوز درﺗﻮﻣﻮر ) TNF-α ( در ﻫﭙﺎﺗﻴﺖ ﺑﻪ ﻣﺒﺘﻼء اﻳﺮاﻧﻲ ﺑﻴﻤﺎران C ﻣﺰﻣﻦ ﻗﻮاﻣﻲ ﺑﺮادران ﺷﻘﺎﻳﻖ 1 ، ﻣﺤﺒﻲ رﺿﺎ ﺳﻴﺪ 2 ، ﺳﭙﻬﻲ اﺧﻮان ﻋﺒﺎس 3 ﺣﺎﻣﺪ ، ﻧﺎﻗﻮﺳﻲ 4 اﺑﺮاﻫﻴﻢ ﻣﺤﻤﺪ ﺳﻴﺪ ، ﻃﺎﻫﺎﻳﻲ 5 زاده ﻋﻈﻴﻢ ﭘﺪرام ، 6 روﻣﺎﻧﻲ ﺳﺎرا ، 7 ﺷﺮﻳﻔﻴﺎن اﻓﺴﺎﻧﻪ ، 8 زاﻟﻲ رﺿﺎ ﻣﺤﻤﺪ ، 9 1 اﺳﻼﻣﻲ آزاد داﻧﺸﮕﺎه ﻣﻴﻜﺮوﺑﻴﻮﻟﻮژي، ارﺷﺪ ﻛﺎرﺷﻨﺎس ، ﺷﻤﺎل ﺗﻬﺮان واﺣﺪ 2 ﺑﻴﻤﺎري ﺗﺤﻘﻴﻘﺎت ﻣﺮﻛﺰ ﭘﺰﺷﻜﻲ، ﺷﻨﺎﺳﻲ وﻳﺮوس ﺗﺨﺼﺼﻲ دﻛﺘﺮي ﭘﺰﺷﻜﻲ ﻋﻠﻮم داﻧﺸﮕﺎه ﻛﺒﺪ، و ﮔﻮارش ﻫﺎي ﺑﻬﺸﺘﻲ ﺷﻬﻴﺪ 3 ﺗﺨﺼﺼ دﻛﺘﺮي ﻲ اﺳﻼﻣﻲ آزاد داﻧﺸﮕﺎه ﻣﻴﻜﺮوﺑﻴﻮﻟﻮژي، ، ﺷﻤﺎل ﺗﻬﺮان واﺣﺪ 4 ﺑﻴﻤﺎري ﺗﺤﻘﻴﻘﺎت ﻣﺮﻛﺰ ﻣﻴﻜﺮوﺑﻴﻮﻟﻮژي، ارﺷﺪ ﻛﺎرﺷﻨﺎس ﺑﻬﺸﺘﻲ ﺷﻬﻴﺪ ﭘﺰﺷﻜﻲ ﻋﻠﻮم داﻧﺸﮕﺎه ﻛﺒﺪ، و ﮔﻮارش ﻫﺎي 5 ﺑﻴﻤﺎري ﺗﺤﻘﻴﻘﺎت ﻣﺮﻛﺰ ﭘﺰﺷﻜﻲ، ﺷﻨﺎﺳﻲ وﻳﺮوس ارﺷﺪ ﻛﺎرﺷﻨﺎس ﻋﻠﻮم داﻧﺸﮕﺎه ﻛﺒﺪ، و ﮔﻮارش ﻫﺎي ﺑﻬﺸﺘﻲ ﺷﻬﻴﺪ ﭘﺰﺷﻜﻲ 6 و ﺳﻠﻮﻟﻲ ﺷﻨﺎﺳﻲ زﻳﺴﺖ ارﺷﺪ ﻛﺎرﺷﻨﺎس ﺑﻴﻤﺎري ﺗﺤﻘﻴﻘﺎت ﻣﺮﻛﺰ ﻣﻮﻟﻜﻮﻟﻲ، ﺑﻬﺸﺘﻲ ﺷﻬﻴﺪ ﭘﺰﺷﻜﻲ ﻋﻠﻮم داﻧﺸﮕﺎه ﻛﺒﺪ، و ﮔﻮارش ﻫﺎي 7 ﺑﻴﻤﺎري ﺗﺤﻘﻴﻘﺎت ﻣﺮﻛﺰ ﻣﻴﻜﺮوﺑﻴﻮﻟﻮژي، ارﺷﺪ ﻛﺎرﺷﻨﺎس ﺑﻬﺸﺘﻲ ﺷﻬﻴﺪ ﭘﺰﺷﻜﻲ ﻋﻠﻮم داﻧﺸﮕﺎه ﻛﺒﺪ، و ﮔﻮارش ﻫﺎي 8 اﺳﺘﺎدﻳﺎر، ﻛﺒﺪ و ﮔﻮارش ﺗﺨﺼﺺ ﻓﻮق ﺑﻴﻤﺎري ﺗﺤﻘﻴﻘﺎت ﻣﺮﻛﺰ ، ﺑﻬﺸﺘﻲ ﺷﻬﻴﺪ ﭘﺰﺷﻜﻲ ﻋﻠﻮم داﻧﺸﮕﺎه ﻛﺒﺪ، و ﮔﻮارش ﻫﺎي 9 / ﻣﺠﻠﻪ ﻋﻠﻮم ﭘﺰﺷﻜﻲ اﺳﻼﻣﻲ آزاد داﻧﺸﮕﺎه ﻧﺎﺣﻴﻪ ﭘﺮوﻣﻮﺗﺮ ﻣﻮرﻓﻴﺴﻢ ﭘﻠﻲ 308 در ﻫﭙﺎﺗﻴﺖ C ﻣﺰﻣﻦ دوره 23 ﺷﻤﺎره 2 ﺗﺎﺑﺴﺘﺎن 92 ﻗﻮاﻣﻲ ﺑﺮادران ﺷﻘﺎﻳﻖ ﻫﻤﻜﺎران و / 97 / ﻣﺠﻠﻪ ﻋﻠﻮم ﭘﺰﺷﻜﻲ اﺳﻼﻣﻲ آزاد داﻧﺸﮕﺎه ﻧﺎﺣﻴﻪ ﭘﺮوﻣﻮﺗﺮ ﻣﻮرﻓﻴﺴﻢ ﭘﻠﻲ 308 در ﻫﭙﺎﺗﻴﺖ C ﻣﺰﻣﻦ
Middle East journal of digestive diseases, 2015
BACKGROUND According to the reports of World Health Organization (WHO) and Centers for Disease Co... more BACKGROUND According to the reports of World Health Organization (WHO) and Centers for Disease Control and Prevention, the prevalence of chronic hepatitis B infection in Iran has decreased from 2-7% in 2001 to 1.3-0.8% in children aged 2-14 years. In 2010 the Institute of Medicine recommended more comprehensive screening by primary care physicians (PCPs) for evaluation, vaccination, and management of infected patients for further decrease in the prevalence of chronic HBV infection. Thus, with contribution of the Health Department, we developed a practical flowchart for PCPs to start active screening of hepatitis B virus (HBV) in all visited patients and refer the positive cases for further evaluation and management to Taleghani Hospital. METHODS With collaboration of Health Department of Shahid Beheshti University of Medical Sciences), physicians of health centers were asked to screen all their patients for HBsAg. Positive cases were referred to Taleghani Hospital. They were first r...
Jundishapur Journal of Microbiology, 2015
Interleukin-16 (IL-16) is an immunomodulatory cytokine, which plays an important role in some inf... more Interleukin-16 (IL-16) is an immunomodulatory cytokine, which plays an important role in some inflammatory and autoimmune diseases such as hepatitis B, which is a major health concern worldwide. In this study, we aimed to investigate the plausible association between IL-16 polymorphism and chronic HBV susceptibility in an Iranian population. In a case-control study, we analyzed rs1131445 polymorphism in the microRNA binding site of the IL-16 gene in 262 patients with chronic hepatitis B and 269 healthy controls, using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and DNA sequencing technology to confirm our results. Altogether, in this investigation, a significant association was observed between the IL-16 TC genotype compared with the TT genotype (OR = 0.696, 95% CI: 0.485 - 0.997, P = 0.048), after adjustments for confounders including age and gender. These findings show that immunogenetic factors, such as single nucleotide polymorphism in IL-16, could be a risk factor for susceptibility to chronic HBV infection. However, further investigations are needed to verify these results.
Gastroenterology and hepatology from bed to bench, 2015
This retrospective study is aimed to review demographic and clinical characteristics of IBD to el... more This retrospective study is aimed to review demographic and clinical characteristics of IBD to elucidate the probable factors associating with IBD development in Taleghani Hospital in Iran since 2001 during a 12-year-period. Ulcerative colitis (UC) and Crohn's disease (CD) are two major idiopathic entities of inflammatory bowel disease (IBD). Previous studies have reported an increased incidence of IBD in Middle East countries. In the present study 1914 patients with UC, 318 patients with CD and 25 with indeterminate colitis (IC) were included. Demographic information, clinical features, extraintestinal manifestations, complications and extension of disease were collected and interpreted for all participants. According to the time of registration, patients were divided into seven groups. Statistical analysis was performed using the chi-square test. In seven groups of IBD patients, disease registry was estimated for UC, CD, and total IBD during a 12-year-period. From 2001 to 2005...
World Journal of Hepatology, 2015
To review all of epidemiological and etiological aspects of hepatocellular carcinoma (HCC) and ex... more To review all of epidemiological and etiological aspects of hepatocellular carcinoma (HCC) and examined the prevention of this disease in Asia. We conducted a systematic review according to the PRISMA guidelines. We were chosen articles that published previously, from PubMed (MEDLINE), the Cochrane database and Scopus. The key words used in this research were as follows: HCC in Asia and the way of prevention of this disease, with no language limitations. We selected those papers published before 2014 that we considered to be most important and appropriate. All relevant articles were accessed in full text and all relevant materials was evaluated and reviewed. More than 70% of all new cases of liver cancer were diagnosed in Asia, a region that 75% of all those chronically infected with hepatitis B virus (HBV) in the world. Chronic HBV infection is the main cause of HCC in Asia, where the virus is endemic and vertical transmission is common. Japan, Saudi Arabia, Egypt and Pakistan are exception because of high prevalence of HCV infection in these regions. The prevalence of this cancer is high in Eastern and South-Eastern Asia, But Middle Eastern countries are characterized as moderate prevalence rate of HCC region and Central Asia and some part of Middle Eastern countries are known as low prevalence rate of HCC. In addition of HBV and HCV the other factors such as aflatoxin, alcohol, obesity, diabetes and non-alcoholic fatty liver disease (NAFLD) might be responsible for a low prevalence of HCC in Asian countries. Currently available HCC therapies, chemotherapy, surgical are inefficient, mainly due to usually late diagnosis and high recurrence rates after surgical resection, and usually end with treatment failure. Liver transplantation also remains as a difficult strategy in patients with HCC. Thus prevention of HCC by treating and prevention HBV and HCV infection, the major causative agents of HCC, and the other risk factors such as aflatoxin, alcohol, obesity, diabetes and NAFLD is of a great medical importance. The main challenge which still present in Asia, is the high prevalence of chronic hepatitis. So, prevention of HBV and HCV is the key strategy to reduce the incidence of HCC in Asia.
Gastroenterology and hepatology from bed to bench, 2014
The aim of this study was to determine the prevalence of HDV infection between HBV chronic patien... more The aim of this study was to determine the prevalence of HDV infection between HBV chronic patients referred to gastroenterology ward of Taleghani hospital Tehran, Iran and also investigating the risk factors in acquiring the HDV infection. Hepatitis B virus (HBV) and Hepatitis D virus (HDV) are major public health issues. Worldwide there are approximately 350 million individuals chronically infected with the HBV. A significant part of them, including 15 to 20 million coinfected with HDV. Hepatitis Delta virus is transferred mostly through blood and body fluids. HBV and HDV infections were evaluated by Enzyme-linked immunosorbent assay (ELISA). Liver functional tests were assessed through auto analyzer. Patients were interviewed and data along the test results were entered into SPSS program. We used chi-square, independent t-test and logistic regression for statistical analysis. 278 (54.6%) patients of the study group were male and 231 (45.4%) were female and the mean age of patient...
Gastroenterology and hepatology from bed to bench, 2012
This study was designed to evaluate the frequency of antibody against these viruses in individual... more This study was designed to evaluate the frequency of antibody against these viruses in individuals attending the endoscopy ward of Taleghani hospital Tehran, Iran. Blood-borne viruses such as hepatitis B and hepatitis C virus and HTLV-1 virus are among the world's public health problems. Hepatitis viruses cause liver problems and HTLV-1 infection can lead to adult T-Cell lymphoma (ATL). Blood samples of 219 individuals attending the endoscopy ward of Taleghani hospital between years 2009-2011 were collected. A questionnaire containing demographic data was completed for each subject. Blood samples were tested for antibody against HTLV-1, HCV and HBc by ELISA (Dia.pro Italy). In case of positive results for anti-HBc, samples were also tested for HBs Ag antigen. Ninety two subjects were male and 127 were female. Mean age of the population was 39.87 ± 16.47. None of the subjects had anti-HCV antibody, while 4 of them had anti-HTLV-1 antibody and 26 anti-HBc antibody; which only two ...
Iranian journal of allergy, asthma, and immunology, 2007
Baker's asthma is one of the most common forms of occupational asthma. This study was conduct... more Baker's asthma is one of the most common forms of occupational asthma. This study was conducted to determine prevalence of asthma and rhinitis among bakery workers in the city of Sanandaj, the provincial center of Kurdistan province in the west of Iran in the in Summer 2006. In this study 776 bread bakery workers were included. These subjects were selected randomly among 1620 bakery workers. The diagnosis of asthma was based on a medical history of episodic symptoms of cough, chest tightness, and dyspnea and spirometry. Airflow obstruction was determined with spirometry, the definition of airflow obstruction which was used in this study was an FEV1/FVC ratio < 0.8, and FEV1 or FVC increases of > or = 12 percent and at least 200 mL after using a short-acting inhaled beta2-agonist. Rhinitis was diagnosed by typical history of work related symptoms. Analyses were performed on 776 subjects (all were men) without missing data for asthma and rhinitis. All of subjects were male w...
World journal of gastroenterology : WJG, Jan 28, 2006
To evaluate the frequency, clinical and paraclinical features of hepatopulmonary syndrome (HPS) a... more To evaluate the frequency, clinical and paraclinical features of hepatopulmonary syndrome (HPS) and to determine their predictive values in diagnosis of this syndrome in patients in Iran. Fifty four cirrhotic patients underwent contrast enhanced echocardiography to detect intrapulmonary and intracardiac shunts by two cardiologists. Arterial blood oxygen, O(2) gradient (A-a) and orthodoxy were measured by arterial blood gas (ABG) test. The patients positive for diagnostic criteria of HPS were defined as clinical HPS cases and those manifesting the intrapulmonary arterial dilation but no other criteria (arterial blood hypoxemia) were defined as lHPS cases. HPS frequency, sensitivity, positive and negative predictive values of clinical and paraclinical features were studied. Ten (18.5%) and seven (13%) cases had clinical and subclinical HPS, respectively. The most common etiology was hepatitis B. Dyspnea (100%) and cyanosis (90%) were the most prevalent clinical features. Dyspnea and c...
Iranian Red Crescent Medical Journal, 2014
Background: Liver injury or dysfunction is considered as a serious health problem. The available ... more Background: Liver injury or dysfunction is considered as a serious health problem. The available synthetic drugs to treat liver disorders are expensive and cause further damage. Hence, hepatoprotective effects of some herbal drugs have been investigated, and one of the methods to choose herbs in order to study their biological effects is to search in ancient medical texts. Avicenna who is known as the prince of physicians had collected and classified Greek, Persian and Islamic medicine in the best possible way in the book of Canon in Arabic. Objectives: Avicenna's book of The Canon of Medicine was reviewed to find the hepatoprotective herbs. Patients and Methods: Three different versions of the Canon were prepared and utilized. To find scientific names of plants we took advantage of three botany references. All of the herbs were investigated on the basis of scientific data from hepatoprotective effects point of view. The searched term was "hepatoprotective" without narrowing and limiting. The searched databases included Cochrane library, Web of science, SID, Irandoc and IranMedex. Results: 18 plants were found. 85% of the presented species, genus or families of plants were reported to have hepatoprotective properties and in the remaining 15% there were no reports of hepatoprotective effect. Flowers and fruits were the most used part of the plants. Most of the plants had simultaneous protective effects on multiple organs but the protective effect on the liver was mostly accompanied by protective effect on the stomach (83%). The average temperament of these herbs is "hot" in the 2nd phase of the 2nd grade, and "dry" in the 3rd phase of the 2nd grade. Hepatoprotective herbs mostly prescribed as a part of hepatoprotective compound drugs formula or other formula for liver diseases are Crocus sativus, Pistacia lentiscus, and Cinnamomum spp. Conclusions: Maybe there is common mechanism for protecting both liver and stomach. Aquilaria agallocha, Aquilaria malaccensis, and Ruscus aculeatus whose hepatoprotective effects have not yet been reported are considered as good candidates for future investigations. Given that Crocus sativus, and Cinnamomum spp are used as flavors in most countries, they will be introduced for more investigation in order to produce hepatoprotective drugs.
Hepatitis Research and Treatment, 2014
Host genetic background is known as an important factor in patients' susceptibility to infectious... more Host genetic background is known as an important factor in patients' susceptibility to infectious diseases such as viral hepatitis. The aim of this study was to determine the effect of genetic polymorphisms of interleukin-16 (IL-16) cytokine on susceptibility of hepatitis B virus (HBV) infected patients to develop chronic HBV infection. Genotyping was conducted using PCR followed by enzymatic digestion and RFLP (restriction fragment length polymorphism) analysis. We genotyped three single nucleotide polymorphisms (SNPs) in the Il-16 gene (rs11556218 T>G, rs4778889 T>C, and rs4072111 C>T) to test for relationship between variation at these loci and patients' susceptibility to chronic HBV infection. Allele frequency of Il-16 gene rs4072111 and rs11556218 was significantly different between chronic HBV patients and healthy blood donors. Genotype frequency of rs4778889 polymorphism of Il-16 gene was significantly different when chronic HBV patients and HBV clearance subjects were compared. Our results showed that Il-16 gene polymorphisms are considerable host genetic factors when we chase biomarkers for prognosis of HBV infected patients.
Hepatitis Monthly, 2014
Chronic hepatitis B is one of the world&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;a... more Chronic hepatitis B is one of the world&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s major health concerns [corrected]. The etiological agent of this infection is hepatitis B virus (HBV), which can evade the immune system response. Transforming growth factor beta 1 (TGF-β1) can act against HBV by suppressing the viral replication. The TGF-β1 also plays an important role in preventing liver damage in chronically HBV infected patients. In this study, the association of TGF-β1 +915G/C and -509C/T gene polymorphisms with chronic hepatitis B was evaluated in Iranian patients. A population-based case-control study was conducted in Taleghani Hospital, Tehran. A number of 220 patients with chronic hepatitis B and the same number of healthy control subjects were designated the case and the control groups. The PCR-Restriction Fragment Length Polymorphism Method (PCR-RFLP) method was used for genotyping both polymorphisms. Ten percent of the control samples were sequenced to confirm the results. No statically significant differences in genotype distribution and allele frequency were observed for both polymorphisms between healthy controls and patients with chronic hepatitis B. There was no association between TGF-β1 -509C/T and +915G/C polymorphisms with chronic hepatitis B and it seems that these changes do not play a significant role in increasing the risk of chronic infection in Iranian patients [corrected].
Diabetes Care, Jan 1, 2009
OBJECTIVE -The purpose of this study was to provide the first national estimate on the prevalence... more OBJECTIVE -The purpose of this study was to provide the first national estimate on the prevalence of the metabolic syndrome and its components and the first ethnic-specific cutoff point for waist circumference in the Eastern Mediterranean Region.
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Papers by Afsaneh sharifian