EAS journal of biotechnology and genetics, Jul 15, 2023
Antimicrobial drug resistance is gradually increasing throughout the globe, and there is practica... more Antimicrobial drug resistance is gradually increasing throughout the globe, and there is practically no newer antimicrobial agent coming soon. Plant secondary metabolites are well known for their various biological activities, and there are few studies targeting mangrove plants. Thus, in this study, we aim to assess the effectiveness of the ethanolic extract of the flowers of Avicennia marina, a commonly found mangrove species in coastal regions, against multidrug resistant (MDR) microorganisms. The study focused on evaluating the extract's antibacterial activity against Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Escherichia coli (MDR), Klebsiella sp. (MDR), Acinetobacter sp. (MDR), Pseudomonas sp. (MDR). The results of the study demonstrated that the flower extracts of Avicennia marina exhibited noteworthy antimicrobial properties against all the tested MDR microorganisms. The plant contains several bioactive compounds, such as flavonoids, tannins, and alkaloids, which are believed to contribute to the observed antimicrobial effects. These findings indicate that Avicennia marina flowers could serve as a valuable natural source for developing antimicrobial agents that could combat drug-resistant bacterial infections. However, future studies should focus on evaluating the efficacy and safety of this extract in live organisms (in vivo) to determine its potential as a new drug for treating resistant infections.
Marine actinobacteriological investigation is still in its beginning in India. Earlier, in the 20... more Marine actinobacteriological investigation is still in its beginning in India. Earlier, in the 20th century, studies on Actinobacteria were started and highly concentrated on diversity, identification, and screening for enzymes, antibiotics, and enzyme inhibitors. With the spurge of infectious diseases requiring antibiotics, novel antibiotics are in search as the prevalent ones have declined uses, due to the antibiotic-resistant microbial growth. Unexploited ecosystems are studied for isolation of rare species such as Actinobacteria which are expected to yield newer metabolites. The marine actinobacterial isolation and enumeration were done from sediment samples. The marine Actinobacteria were identified by conventional methods. Further amylase enzyme production and their antibacterial activities are also done following the standard methods. The Micromonospora sp. was identified by chemotaxonomical characteristics and spore chain morphology. Further, the amylase enzyme production was done and quantification of enzyme also done. The potential antimicrobial activity from the amylase enzyme was done. Zone of inhibition and minimal inhibitory concentration were calculated. It concluded that potent antibacterial activity was obtained from Actinobacteria Micromonospora sp. producing amylase enzymes.
The development in nanotechnology, specifically the nanoparticulate system, has a great impact on... more The development in nanotechnology, specifically the nanoparticulate system, has a great impact on medicine, engineering and other scientific areas. Inorganic nanoparticles such as silver, gold, zinc oxide, selenium, iron, lead, platinum and copper, etc. were found to exhibit antimicrobial, antioxidant and other biological activities, used as biosensors and also used in different fields of engineering. In the 21st century, microorganisms and plant parts are playing a major role in the synthesis of inorganic nanoparticles. Green synthesis of inorganic nanoparticles becomes preferable to other approaches because of its eco-friendly and non-toxic approach. Additionally, the active molecules of plants (Tannins, flavonoids, terpenoids, saponins, proteins and glycosides) which act as capping and reducing agents in the synthesis of metal nanoparticles could make them most suitable for biomedical applications. This green approach fascinated researchers across the globe to explore the potential of different microorganisms and plants in the synthesis of inorganic nanoparticles. Selenium nanoparticles are one of the inorganic nanoparticles which are widely used in the area of medicine and engineering. In this chapter, we discussed the green synthesis using microorganism and Agri based products, characterisation and various applications of selenium nanoparticles.
The aim of the present study was to assess the anti bacterial activity of ethanolic extract of He... more The aim of the present study was to assess the anti bacterial activity of ethanolic extract of Heart wood of Acacia catechu willd, Aesculus hippocastanum, Glycyrrhiza glabra. These extracts are the oldest known herbal remedies famous for its vast variety of therapeutic properties. Ethanolic extract of these herbs were tested for antibacterial activity against multi drug resistant Staphylococus aureus [MRSA] Method: The screening of antibacterial activity of the three selected plant extracts was carried out using the agar well diffusion method. The wells were loaded with 100µl of the three herbal extracts at different concentrations [500ug/disc, 1000ug/disc and 2000µg/disc]. Positive controls used were standard antibiotic discs of amoxicillin (30mcg/disc) and Ciprofloxacin (30mcg/disc) Result : After incubation at 37 o C for 24 hours, the zone of Inhibition was measured . The extracts at different concentrations showed varying degree of antibacterial activity against the micro organisms tested compared to standard.
The use of medicinal plant either as a single drug or in combination is increasing in the health ... more The use of medicinal plant either as a single drug or in combination is increasing in the health care of human being. Medicinal plants can be important source of previously unknown chemical substances with potential therapeutic effect. The herbal remedies referred to as “ginseng” are derived from the roots of several plants.One of the most commonly used and researched of the ginseng is Panax ginseng, also called Asian or Korean ginseng. The main active components of Panax ginseng are ginsenosides,which have been shown to have a variety of beneficial effects, including anti‐inflammatory,antioxidant, and anticancer effects.Panax ginseng also improve psychologic function, immune function, and conditions associated with diabetes. This review gives a bird’s eye view mainly on the pharmacognostic characteristics, traditional uses, phytochemistry and pharmacological actions of the plant.
International Journal of Drug Development and Research, 2011
The aim of the present study is to evaluate the antibacterial activity of ethanolic and aqueous l... more The aim of the present study is to evaluate the antibacterial activity of ethanolic and aqueous leaf extract of Sesbania grandiflora Linn on selected bacterial species. Sesbania grandiflora (Linn) is a medicinal herb belongs to the family Leguminosae .The various parts of the plant like roots, bark, leaves, flower and fruit are known to possess different pharmacological properties. The leaf extract of
Asian Pacific Journal of Cancer Prevention, Feb 1, 2023
24 (2), 363-373 chemotherapeutic delivery molecules (Pardridge, 2012). Exosomes are involved in r... more 24 (2), 363-373 chemotherapeutic delivery molecules (Pardridge, 2012). Exosomes are involved in remodelling of the extracellular matrix (ECM) and mediates the intercellular transmission of signals and molecules (Xu et al., 2020). The major sources of exosomes include macrophages, B
The aim of the present study was to evaluate the anti bacterial activity of Acacia catechu willd ... more The aim of the present study was to evaluate the anti bacterial activity of Acacia catechu willd on selected enteric pathogens. Acacia catechu willd (AC) is a moderate thorny deciduous tree growing in tropical countries commonly known as Black cutch. It has a diverse pharmacological and phytochemical importance and is a potent medicinal plant in the traditional Indian medicinal systems. Antibacterial activity of ethanolic and aqueous extract of heart wood of Aacacia catechu was screened against Salmonella typhi, [Gram negative bacilli-GNB], Shigella flexneri [GNB], E.coli [GNB], Klebsiella pneumonia [GNB], Vibrio cholera [GNB], Pseudomonas aeruginosa [GNB] and Staphylococcus aureus, [Gram positive cocci], using agar well diffusion technique. The results of this study showed that both the extracts at different concentrations exhibited anti bacterial activity against the bacterial species tested. The ethanolic extract showed higher degree of activity than aqueous extract when compared with the standards.
EAS journal of biotechnology and genetics, Jul 15, 2023
Antimicrobial drug resistance is gradually increasing throughout the globe, and there is practica... more Antimicrobial drug resistance is gradually increasing throughout the globe, and there is practically no newer antimicrobial agent coming soon. Plant secondary metabolites are well known for their various biological activities, and there are few studies targeting mangrove plants. Thus, in this study, we aim to assess the effectiveness of the ethanolic extract of the flowers of Avicennia marina, a commonly found mangrove species in coastal regions, against multidrug resistant (MDR) microorganisms. The study focused on evaluating the extract's antibacterial activity against Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Escherichia coli (MDR), Klebsiella sp. (MDR), Acinetobacter sp. (MDR), Pseudomonas sp. (MDR). The results of the study demonstrated that the flower extracts of Avicennia marina exhibited noteworthy antimicrobial properties against all the tested MDR microorganisms. The plant contains several bioactive compounds, such as flavonoids, tannins, and alkaloids, which are believed to contribute to the observed antimicrobial effects. These findings indicate that Avicennia marina flowers could serve as a valuable natural source for developing antimicrobial agents that could combat drug-resistant bacterial infections. However, future studies should focus on evaluating the efficacy and safety of this extract in live organisms (in vivo) to determine its potential as a new drug for treating resistant infections.
Marine actinobacteriological investigation is still in its beginning in India. Earlier, in the 20... more Marine actinobacteriological investigation is still in its beginning in India. Earlier, in the 20th century, studies on Actinobacteria were started and highly concentrated on diversity, identification, and screening for enzymes, antibiotics, and enzyme inhibitors. With the spurge of infectious diseases requiring antibiotics, novel antibiotics are in search as the prevalent ones have declined uses, due to the antibiotic-resistant microbial growth. Unexploited ecosystems are studied for isolation of rare species such as Actinobacteria which are expected to yield newer metabolites. The marine actinobacterial isolation and enumeration were done from sediment samples. The marine Actinobacteria were identified by conventional methods. Further amylase enzyme production and their antibacterial activities are also done following the standard methods. The Micromonospora sp. was identified by chemotaxonomical characteristics and spore chain morphology. Further, the amylase enzyme production was done and quantification of enzyme also done. The potential antimicrobial activity from the amylase enzyme was done. Zone of inhibition and minimal inhibitory concentration were calculated. It concluded that potent antibacterial activity was obtained from Actinobacteria Micromonospora sp. producing amylase enzymes.
The development in nanotechnology, specifically the nanoparticulate system, has a great impact on... more The development in nanotechnology, specifically the nanoparticulate system, has a great impact on medicine, engineering and other scientific areas. Inorganic nanoparticles such as silver, gold, zinc oxide, selenium, iron, lead, platinum and copper, etc. were found to exhibit antimicrobial, antioxidant and other biological activities, used as biosensors and also used in different fields of engineering. In the 21st century, microorganisms and plant parts are playing a major role in the synthesis of inorganic nanoparticles. Green synthesis of inorganic nanoparticles becomes preferable to other approaches because of its eco-friendly and non-toxic approach. Additionally, the active molecules of plants (Tannins, flavonoids, terpenoids, saponins, proteins and glycosides) which act as capping and reducing agents in the synthesis of metal nanoparticles could make them most suitable for biomedical applications. This green approach fascinated researchers across the globe to explore the potential of different microorganisms and plants in the synthesis of inorganic nanoparticles. Selenium nanoparticles are one of the inorganic nanoparticles which are widely used in the area of medicine and engineering. In this chapter, we discussed the green synthesis using microorganism and Agri based products, characterisation and various applications of selenium nanoparticles.
The aim of the present study was to assess the anti bacterial activity of ethanolic extract of He... more The aim of the present study was to assess the anti bacterial activity of ethanolic extract of Heart wood of Acacia catechu willd, Aesculus hippocastanum, Glycyrrhiza glabra. These extracts are the oldest known herbal remedies famous for its vast variety of therapeutic properties. Ethanolic extract of these herbs were tested for antibacterial activity against multi drug resistant Staphylococus aureus [MRSA] Method: The screening of antibacterial activity of the three selected plant extracts was carried out using the agar well diffusion method. The wells were loaded with 100µl of the three herbal extracts at different concentrations [500ug/disc, 1000ug/disc and 2000µg/disc]. Positive controls used were standard antibiotic discs of amoxicillin (30mcg/disc) and Ciprofloxacin (30mcg/disc) Result : After incubation at 37 o C for 24 hours, the zone of Inhibition was measured . The extracts at different concentrations showed varying degree of antibacterial activity against the micro organisms tested compared to standard.
The use of medicinal plant either as a single drug or in combination is increasing in the health ... more The use of medicinal plant either as a single drug or in combination is increasing in the health care of human being. Medicinal plants can be important source of previously unknown chemical substances with potential therapeutic effect. The herbal remedies referred to as “ginseng” are derived from the roots of several plants.One of the most commonly used and researched of the ginseng is Panax ginseng, also called Asian or Korean ginseng. The main active components of Panax ginseng are ginsenosides,which have been shown to have a variety of beneficial effects, including anti‐inflammatory,antioxidant, and anticancer effects.Panax ginseng also improve psychologic function, immune function, and conditions associated with diabetes. This review gives a bird’s eye view mainly on the pharmacognostic characteristics, traditional uses, phytochemistry and pharmacological actions of the plant.
International Journal of Drug Development and Research, 2011
The aim of the present study is to evaluate the antibacterial activity of ethanolic and aqueous l... more The aim of the present study is to evaluate the antibacterial activity of ethanolic and aqueous leaf extract of Sesbania grandiflora Linn on selected bacterial species. Sesbania grandiflora (Linn) is a medicinal herb belongs to the family Leguminosae .The various parts of the plant like roots, bark, leaves, flower and fruit are known to possess different pharmacological properties. The leaf extract of
Asian Pacific Journal of Cancer Prevention, Feb 1, 2023
24 (2), 363-373 chemotherapeutic delivery molecules (Pardridge, 2012). Exosomes are involved in r... more 24 (2), 363-373 chemotherapeutic delivery molecules (Pardridge, 2012). Exosomes are involved in remodelling of the extracellular matrix (ECM) and mediates the intercellular transmission of signals and molecules (Xu et al., 2020). The major sources of exosomes include macrophages, B
The aim of the present study was to evaluate the anti bacterial activity of Acacia catechu willd ... more The aim of the present study was to evaluate the anti bacterial activity of Acacia catechu willd on selected enteric pathogens. Acacia catechu willd (AC) is a moderate thorny deciduous tree growing in tropical countries commonly known as Black cutch. It has a diverse pharmacological and phytochemical importance and is a potent medicinal plant in the traditional Indian medicinal systems. Antibacterial activity of ethanolic and aqueous extract of heart wood of Aacacia catechu was screened against Salmonella typhi, [Gram negative bacilli-GNB], Shigella flexneri [GNB], E.coli [GNB], Klebsiella pneumonia [GNB], Vibrio cholera [GNB], Pseudomonas aeruginosa [GNB] and Staphylococcus aureus, [Gram positive cocci], using agar well diffusion technique. The results of this study showed that both the extracts at different concentrations exhibited anti bacterial activity against the bacterial species tested. The ethanolic extract showed higher degree of activity than aqueous extract when compared with the standards.
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