Papers by Rolando A. Spanevello
Organic Letters, Mar 1, 2006
[reaction: see text] A new chiral auxiliary derived from levoglucosenone is reported. The compoun... more [reaction: see text] A new chiral auxiliary derived from levoglucosenone is reported. The compound is obtained by a cycloaddition reaction with 9-methoxy methylanthracene followed by a diastereoselective reduction of the C-2 keto function. The auxiliary has been used as a chiral template in an asymmetric Diels-Alder reaction of the corresponding acrylic ester derivative with cyclopentadiene. The results showed excellent diastereomeric excess even at room temperature when the reaction was promoted by Et(2)AlCl as the Lewis acid.
Journal of Organic Chemistry, Feb 26, 2018
The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential an... more The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential anticancer agents is described. The discovery of base-catalyzed retro-aza-Michael//aza-Michael isomerizations allowed the exploration of the chemical space by affording novel types of triazoles, difficult to obtain otherwise. Following this strategy, 2,4-disubstituted-1,2,3-triazoles could be efficiently obtained from the corresponding 1,4-disubstituted analogues.
Chemischer Informationsdienst, Nov 4, 1986
Das ausgehend vom Ketoester (I) über den ogß‐ungesättigten Aldehyd (IIIc) gemäß Schema hergestell... more Das ausgehend vom Ketoester (I) über den ogß‐ungesättigten Aldehyd (IIIc) gemäß Schema hergestellte Enon (VII) liefert nach Etherspaltung mit Bortribromid über eine intramolekulare Michael‐Addition ein chromatographisch trennbares Gemisch der beiden isomeren Spirobenzofurane (VIII) und (IX) sowie des Enons (X).
Acs Symposium Series, 2018
ChemInform, Aug 1, 2016
Development of Polymer-Supported Chiral Aminoalcohols Derived from Biomass and Their Application ... more Development of Polymer-Supported Chiral Aminoalcohols Derived from Biomass and Their Application to Asymmetric Alkylation.-Novel polymer-supported chiral aminoalcohols are tested as chiral ligands for the asymmetric diethylzinc addition to aromatic aldehydes. The low to moderate enantioselectivities are comparable to those observed for non-immobilized analogs.-(BOTTA, M. C.; BIAVA, H. D.;
Investigational New Drugs, 2021
Bioorganic & Medicinal Chemistry Letters, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Industrial Crops and Products, 2017
The trend for material and energy recovery from residues along with the need to reduce greenhouse... more The trend for material and energy recovery from residues along with the need to reduce greenhouse gases has led to an increased interest in the thermal exploitation of biomass and/or their wastes. Due to the enormous quantity generated every year, agro-industrial byproducts have an attractive potential to be recycled. One way to do this is by means of pyrolysis, a thermal decomposition of high molecular weight polymers into simpler compounds. In this study, we applied an autographic assay to analyze the biological effect of bio-oils produced by pyrolysis of soybean hulls. The discovery of a compound with antimicrobial activity validated this novel approach as a tool for the generation of bioactive compounds.
Microbial Reagents in Organic Synthesis, 1992
A combination of microbial hydroxylation and lipase mediated hydrolysis insured access to chiral ... more A combination of microbial hydroxylation and lipase mediated hydrolysis insured access to chiral synthetic intermediates whose relative inaccessibility by conventional chemical means is obvious. Examples are given for allylic hydroxylations with Rhizopus arrhizus and ester hydrolysis with lipases.
The Journal of Organic Chemistry, 1989
... 81. 5335. - - - - 4) Wong, P. Y.-K.; Serhan, C. N. In Advances in Experimental Medicine and B... more ... 81. 5335. - - - - 4) Wong, P. Y.-K.; Serhan, C. N. In Advances in Experimental Medicine and Biology; Plenum Press: New York, 1988; Vol. ... Bromination of 10 by CBr,-PPh, (85%) followed by heating with PPh, gave the desired phosphonium salt 12 (97%) via bromide 11. ...
Ciencia hoy, 1989
El descubrimiento y la sintesis de una nueva sustancia, la FK-506, abren insospechadas perspectiv... more El descubrimiento y la sintesis de una nueva sustancia, la FK-506, abren insospechadas perspectivas para resolver los problemas originados por el rechazo de organos trasplantados.
ChemInform, Aug 18, 2010
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform, Mar 31, 1987
A spiro‐benzofuran unit, as shown in compounds (VI) and (VII), is common to several biologically ... more A spiro‐benzofuran unit, as shown in compounds (VI) and (VII), is common to several biologically active natural products.
Journal of Molecular Structure, Apr 1, 2022
Synthetic Communications, Jun 1, 1986
The regioselective construction of a spirocycle unit, common to several biologically active natur... more The regioselective construction of a spirocycle unit, common to several biologically active natural products, through an intramolecular Michael cyclization is described.
Chemischer Informationsdienst, May 29, 1984
Synthetic Communications, Jun 1, 1986
The regioselective construction of a spirocycle unit, common to several biologically active natur... more The regioselective construction of a spirocycle unit, common to several biologically active natural products, through an intramolecular Michael cyclization is described.
Electrochimica Acta, 2016
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service... more This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Electropolimerization of Functionalizaed Carbazole End-Capped Dendrimers.
RSC Adv., 2017
Structurally related triazolic dendrimers were efficiently synthesized applying CuAAC reaction.
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Papers by Rolando A. Spanevello