Multivitamin tablets containing various substances of varying characteristics may have a problem ... more Multivitamin tablets containing various substances of varying characteristics may have a problem in quantitative analysis. This research has developed HPLC method for simultaneous determination of three vitamin components that is thiamine (Vit. B1), riboflavin (Vit. B2) and pyridoxine (Vit. B3) in tablet formulation. The chromatographic separation was achieved by using a C-18 column with dimension of 4.6 mm I.D.X 250 mm and particle size of 5μm. A mixture of methanol: water (22:78) was used as mobile phase. The aqueous mobile phase contained O- phosphoric acid adjusted to pH 2.5, with flow rate of 1mL/min. The effluent was monitored at 290 nm at ambient temperature. Effective separation and quantification was achieved in less than 10 min. The method was simple, accurate, precise, and could be successfully applied for the analysis of thiamine, riboflavin, and pyridoxine multivitamin tablets. The HPLC results revealed that % vitamins were found to be for B1, B2 and B6 respectively in ...
International Journal of Applied Pharmaceutics, 2015
The present study is very expectant towards the development of co-encapsulated liposomal formulat... more The present study is very expectant towards the development of co-encapsulated liposomal formulation. The assay method for artesunate has a challenge because it doesnot have a readily recognisable absorption chromophore needed for UV spectroscopy. Curcumin, a lipid soluble antioxidant, exhibits solvent and medium sensitive absorption and fluorescence properties. A simple and rapid method involving two reaction steps has been developed for assay of artesunate and curcumin combination in liposomal formulation. Stock solution of artesunate and curcumin were diluted to final concentration of 10 µg/ml. The UV scan of 10 µg/ml solution of artesunate and curcumin combinations showed the absorbtion maxima at 240 nm and 425 nm respectively. The coloured complex obeyed the Beer’s law in the concentration range of 2-20 µg/ml. The above methods is rapid tool for routine analysis of artesunate and curcumin in novel carrier system. The recovery studies confirmed the accuracy and precision of the ...
Autophagy is a widely conserved catabolic process that is essential for maintaining cellular home... more Autophagy is a widely conserved catabolic process that is essential for maintaining cellular homeostasis under normal physiological conditions and driving the cell to switch back to this condition under times of starvation, hypoxia, and oxidative stress. The potential similarities and differences between basal autophagy and stimulus-induced autophagy are still largely unknown. Both act by clearing unusual or unnecessary cytoplasmic material, such as misfolded proteins, supernumerary and defective organelles. The relationship between reactive oxygen species (ROS) and autophagy is complex. Cellular ROS is predominantly derived from mitochondria. Autophagy is triggered by this event, and by clearing the defective organelles effectively, it lowers cellular ROS thereby restoring cellular homeostasis. However, if cellular homeostasis cannot be reached, the cells can switch back and choose a regulated cell death response. Intriguingly, the autophagic and cell death machines both respond to...
In this review, the formation, characterization, properties and applications of nano-emulsions ar... more In this review, the formation, characterization, properties and applications of nano-emulsions are reviewed and summarized. Nanoemulsions are submicron sized emulsions that are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Nanoemulsions are the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase by means of an appropriate surfactants. Due to their small droplet size nano-emulsions possess stability against sedimentation or creaming with Ostwald ripening forming the main mechanism of nanoemulsion breakdown. Nanoemulsion droplet sizes fall typically in the range of 20200nm. Diameter and surface properties of droplets of nanoemulsion plays an important role in the biological behavior of the formulation. Nanoemulsion show great promise for the future of cosmetics, diagnostics, drug therapies, and biotechnologies. The main application of nanoemulsions is the preparatio...
"Magic Rock" Zeolites are microporous crystalline aluminosilicates resulting from the reaction of... more "Magic Rock" Zeolites are microporous crystalline aluminosilicates resulting from the reaction of volcanic rocks, ash layers and an alkaline groundwater. Zeolites are incorporated the group contain natural silica similarly diatomaceous earth. Zeolites situate apart among the many families of porous materials. They have a number of significant practical properties such as a high adsorption capacity and the ability to cation exchange because of their structure. The present reviews focus on the application of natural zeolites as they were naturally available and abundant, low cost and stable.
Aim: The aim of the study was to conduct a preand post-intervention analysis of knowledge, attitu... more Aim: The aim of the study was to conduct a preand post-intervention analysis of knowledge, attitude, and practices regarding coronavirus disease 2019 (COVID-19) protocols among doctor’s nurses, technicians. Materials and Methods: Study was carried on the doctors, staff nurse, technicians, and working in hospital. A scientifically designed questionnaire was distributed to the doctors, nurses, and technicians, they were explained about the questions and responses were marked. Results: The results of questionnaire analysis before intervention session show that doctors, nurses, and technicians had least knowledge about the various COVID-19 protocols, that is, 10%, 7.5%, and 5%, respectively. In addition, knowledge about practices regarding COVID-19 protocols at institute level was 32.5%, 27.5%, and 30% in doctors, nurses, and technicians, respectively. Knowledge about fundamentals of COVID-19 was found good in doctors (64%), nurses (41%), and technicians (46%). The results of questionna...
Formulation and Evaluation Os Sustained Release Matrix Tablets of Glibenclamide
The present work is aimed to design, develop and evaluate sustained release matrix tablets of gli... more The present work is aimed to design, develop and evaluate sustained release matrix tablets of glibenclamide capable of delivering drug at nearly constant rate, suitable for once a day administration. Glibenclamide is an oral hypoglycaemic agent, which is a drug for the treatment of patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM) and given in insulin resistance condition. . The relatively small daily dose, short half life, undesirable side effects and rapid absorption from the GIT make GBD a good candidate for formulation in a sustained release dosage form. GBD was incorporated in 5 formulae containing hydroxypropylmethylcellulose (HPMC) as a matrix former in variable quantity. Microcrystalline Cellulose (MCC) was added to formulae in different amounts in order to disintegrate the tablets and magnesium stearate was added as a lubricant. Direct compression techniques was used to prepare the tablets. The physical properties were found to be satisfactory for all the formul...
Context: The present work is to perform a docking analysis by AutoDock version 4.2 for artemether... more Context: The present work is to perform a docking analysis by AutoDock version 4.2 for artemether (ARM) and curcumin (CUR) with few validated protein targets (cyclooxygenase [COX-2] and tumor necrosis factor [TNF-α]) for anticancer therapy. Aims: The object of this work was to analyze inhibitory action of one artemisinin derivative ARM and a natural coloring pigment CUR against pro-inflammatory (a chemical substance that became inflammatory only after it is altered by metabolic process) by computational docking parameters and simulate these effects on the adjuvant arthritic rats were compared with that of drug combination and indomethacin. Materials and Methods: Two-dimensional (2-D) Structure of ARM and CUR was drawn using ChemSketch, the 2-D structure of ligands as well as receptor were converted into the three-dimensional (3-D) structure and optimized with 3-D geometry. The regions of interest used by AUTODOCK version 4.2 were defined by considering grid area by making a grid box...
Severe acute respiratory syndrome related coronavirus (sars-cov). So far again, we see the emerge... more Severe acute respiratory syndrome related coronavirus (sars-cov). So far again, we see the emergence of another outbreak due to a new strain called the sars-cov-2 virus. Sars-cov-2 is extremely contagious and has resulted in a speedy pandemic of covid-19. As the number of cases continues to rise, it is clear that these viruses pose a threat to public health. Swarna bhasma is an efficient dosage form in the ayurvedic treatment. In the conventional system of medicine some molecules of gold are skillful for management of various disorders. The renovation of metallic gold to medicinal gold is an ideal model of promising potentials of pharmaceutical branches of both systems of medicines. Therapeutically gold salts used for the decline in serum immunoglobulin levels and rheumatoid factor titers in rheumatoid arthritis. Gold inhibits stimulation of immunoglobulin-secreting cells. They can inhibit the activation of the classical and alternate complement pathways. Gold compounds reduce frequ...
Himesh Soni & Sarvesh Sharma; Sch Int J Anat Physiol, Nov., 2020; 3(11): 95-98, 2020
"Magic Rock" Zeolites are microporous crystalline aluminosilicates resulting from the reaction of... more "Magic Rock" Zeolites are microporous crystalline aluminosilicates resulting from the reaction of volcanic rocks, ash layers and an alkaline groundwater. Zeolites are incorporated the group contain natural silica similarly diatomaceous earth. Zeolites situate apart among the many families of porous materials. They have a number of significant practical properties such as a high adsorption capacity and the ability to cation exchange because of their structure. The present reviews focus on the application of natural zeolites as they were naturally available and abundant, low cost and stable.
Saudi Journal of Medical and Pharmaceutical Sciences
Corona virus (COVID-19) is an enveloped RNA virus that is diversely initiates in humans and wildl... more Corona virus (COVID-19) is an enveloped RNA virus that is diversely initiates in humans and wildlife. A total of 6 species have been identified to cause disease in humans. Viral infections play a critical role in human diseases, and recent outbreaks is the influx worldwide in form of novel corona .The SS-RNA virus from the enveloped corona virus family caused SARS (Severe acute respiratory syndrome) which is life threatening viral infection. The spreading of infection is quick in many countries of the world. The World Health Organization (WHO) called COVID-19 a pandemic on March 11, 2020. There are numerous drug trials going on with some positive results. Though, since no vaccine is available, the best way to fight the virus is by preventive measures. In the present research an attempt had been made to find new COVID-19 main protease inhibitor by molecular docking approach. The present study reveals that rifampicin has good binding affinity with COVID-19 protease and thus can be used as prophylaxis and therapeutic treatment for corona patient.
Review Article Tuberculosis is an omnipresent, highly contagious chronic granulamatous communicab... more Review Article Tuberculosis is an omnipresent, highly contagious chronic granulamatous communicable bacterial infectious disease caused by Mycobacterium tuberculosis and other species of same genera. Tuberculosis usually affects the lungs, but can also affect other parts of the body. The aim of the present review to illustrate the various sites and co-morbidities associated with extra-pulmonary tuberculosis along with their diagnosis and treatment approaches.
Review Article COVID-19 (Coronaviruses) was recently identified in saliva of infected patients. I... more Review Article COVID-19 (Coronaviruses) was recently identified in saliva of infected patients. In this article, we discuss the transmission of infection via the saliva of this virus. The members in dental practice expose to huge risk of COVID-19 infection due to the face-to-face communication and the exposure to blood, saliva, and other body fluids, and the handling of sharp instruments. Dental professionals play significant roles in preventing the transmission of COVID-19. Here we suggested the infection control count during dental practice to stop the person-to-person transmission way in dental hospitals and clinics. There is a required to increase investigations to the detection of Coronavirus in oral fluids and its effect on the transmission of this virus, which is critical to improve effective plan for prevention, especially for dentists and healthcare professionals. Saliva can play a important role in the person-to-person transmission, and noninvasive salivary analysis may provide a beneficial and cost-effective care platform for the fast and early detection of Coronavirus infection.
Review Article Corona virus (COVID-19) is an enveloped RNA virus that is diversely found in human... more Review Article Corona virus (COVID-19) is an enveloped RNA virus that is diversely found in humans and wildlife. A total of six species have been identified to cause disease in humans. They are known to infect the neurological, respiratory, enteric, and hepatic systems. The past few decades have seen endemic outbreaks in the form of Middle East Respiratory Syndrome coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome related coronavirus (SARS-CoV). Yet again, we see the emergence of another outbreak due to a new strain called the SARS-CoV-2 virus. The most recent outbreak initially presented as pneumonia of unknown etiology in a cluster of patients in Wuhan, China. The epicenter of infection was linked to seafood and exotic animal wholesale markets in the city. SARS-CoV-2 is highly contagious and has resulted in a rapid pandemic of COVID-19. As the number of cases continues to rise, it is clear that these viruses pose a threat to public health. This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. It will also provide a means to raise awareness among primary and secondary healthcare providers during the current pandemic. Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling of patients worldwide. In December 2019, several patients from Wuhan, China were admitted with symptoms of pneumonia. As the number of patients presenting with similar symptoms started to rise, the causative agent was eventually isolated from samples. It was initially called the 2019 novel coronavirus (2019-nCoV) and has been recently relabelled as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the disease it causes has been named coronavirus disease 2019 (COVID-19). Over the next few weeks, the virus spread from Wuhan to affect different provinces in China and, after a few months, it is now present in 109 countries. As of March 26, 2020, there have been 462,684 confirmed cases globally, and 20,834 deaths have been registered. The World Health Organization (WHO) called COVID-19 a pandemic on March 11, 2020. There are multiple drug trials going on with some positive results. However, since no vaccine is available, the best way to combat the virus is by preventive methods. In this review article, we provide a basic understanding of CoV infections and their potentially detrimental involvement to society.
International Journal of Pharmacy and Pharmaceutical Sciences, 2017
Objective: Cancer drug delivery has focused using novel carrier system due to their high drug loa... more Objective: Cancer drug delivery has focused using novel carrier system due to their high drug loading and release controlled property and minimum side effect. Artesunate (ART) and curcumin (CUR) are proved natural herbal lead chemotherapeutics used as Chinese and Indian food. But due to its low absorption and the poor bioavailability limits its clinical efficacy. The object of the present work was to investigate the cytotoxic vs apoptotic effect of these herbal lead molecules in the co-encapsulated liposome formulation.Methods: ART and CUR liposome were prepared by thin film hydration method. Because of their opposite solubility nature, ART loaded in the aqueous phase at pH 7.4 while CUR is present in the central core through lipophilic interaction. In vitro cytotoxicity action of the free and liposomal formulation was performed by MTT assay.Results: Physiochemical parameters were evaluated and compared to the co-encapsulated formulation of containing both molecules. The mean diamet...
International Journal of Applied Pharmaceutics, 2015
The present study is very expectant towards the development of co-encapsulated liposomal formulat... more The present study is very expectant towards the development of co-encapsulated liposomal formulation. The assay method for artesunate has a challenge because it doesnot have a readily recognisable absorption chromophore needed for UV spectroscopy. Curcumin, a lipid soluble antioxidant, exhibits solvent and medium sensitive absorption and fluorescence properties. A simple and rapid method involving two reaction steps has been developed for assay of artesunate and curcumin combination in liposomal formulation. Stock solution of artesunate and curcumin were diluted to final concentration of 10 µg/ml. The UV scan of 10 µg/ml solution of artesunate and curcumin combinations showed the absorbtion maxima at 240 nm and 425 nm respectively. The coloured complex obeyed the Beer's law in the concentration range of 2-20 µg/ml. The above methods is rapid tool for routine analysis of artesunate and curcumin in novel carrier system. The recovery studies confirmed the accuracy and precision of the methods.
Qualitative and Quantitative Profile of Tannic Acid Isolated from Terminalia Chebula
... mythology, this plant originated from the drops of ambrosa (Amrita) which fell on the earth w... more ... mythology, this plant originated from the drops of ambrosa (Amrita) which fell on the earth when Indra was drinking it [2]. T. Chebula possesses a wide variety of activities like antimicrobial [3], antioxidant [4], antiviral[5], anticarcinogenic[6 ... 7. Thakur CP, Thakur B, Singh S, et al. ...
Multivitamin tablets containing various substances of varying characteristics may have a problem ... more Multivitamin tablets containing various substances of varying characteristics may have a problem in quantitative analysis. This research has developed HPLC method for simultaneous determination of three vitamin components that is thiamine (Vit. B1), riboflavin (Vit. B2) and pyridoxine (Vit. B3) in tablet formulation. The chromatographic separation was achieved by using a C-18 column with dimension of 4.6 mm I.D.X 250 mm and particle size of 5μm. A mixture of methanol: water (22:78) was used as mobile phase. The aqueous mobile phase contained O- phosphoric acid adjusted to pH 2.5, with flow rate of 1mL/min. The effluent was monitored at 290 nm at ambient temperature. Effective separation and quantification was achieved in less than 10 min. The method was simple, accurate, precise, and could be successfully applied for the analysis of thiamine, riboflavin, and pyridoxine multivitamin tablets. The HPLC results revealed that % vitamins were found to be for B1, B2 and B6 respectively in ...
International Journal of Applied Pharmaceutics, 2015
The present study is very expectant towards the development of co-encapsulated liposomal formulat... more The present study is very expectant towards the development of co-encapsulated liposomal formulation. The assay method for artesunate has a challenge because it doesnot have a readily recognisable absorption chromophore needed for UV spectroscopy. Curcumin, a lipid soluble antioxidant, exhibits solvent and medium sensitive absorption and fluorescence properties. A simple and rapid method involving two reaction steps has been developed for assay of artesunate and curcumin combination in liposomal formulation. Stock solution of artesunate and curcumin were diluted to final concentration of 10 µg/ml. The UV scan of 10 µg/ml solution of artesunate and curcumin combinations showed the absorbtion maxima at 240 nm and 425 nm respectively. The coloured complex obeyed the Beer’s law in the concentration range of 2-20 µg/ml. The above methods is rapid tool for routine analysis of artesunate and curcumin in novel carrier system. The recovery studies confirmed the accuracy and precision of the ...
Autophagy is a widely conserved catabolic process that is essential for maintaining cellular home... more Autophagy is a widely conserved catabolic process that is essential for maintaining cellular homeostasis under normal physiological conditions and driving the cell to switch back to this condition under times of starvation, hypoxia, and oxidative stress. The potential similarities and differences between basal autophagy and stimulus-induced autophagy are still largely unknown. Both act by clearing unusual or unnecessary cytoplasmic material, such as misfolded proteins, supernumerary and defective organelles. The relationship between reactive oxygen species (ROS) and autophagy is complex. Cellular ROS is predominantly derived from mitochondria. Autophagy is triggered by this event, and by clearing the defective organelles effectively, it lowers cellular ROS thereby restoring cellular homeostasis. However, if cellular homeostasis cannot be reached, the cells can switch back and choose a regulated cell death response. Intriguingly, the autophagic and cell death machines both respond to...
In this review, the formation, characterization, properties and applications of nano-emulsions ar... more In this review, the formation, characterization, properties and applications of nano-emulsions are reviewed and summarized. Nanoemulsions are submicron sized emulsions that are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Nanoemulsions are the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase by means of an appropriate surfactants. Due to their small droplet size nano-emulsions possess stability against sedimentation or creaming with Ostwald ripening forming the main mechanism of nanoemulsion breakdown. Nanoemulsion droplet sizes fall typically in the range of 20200nm. Diameter and surface properties of droplets of nanoemulsion plays an important role in the biological behavior of the formulation. Nanoemulsion show great promise for the future of cosmetics, diagnostics, drug therapies, and biotechnologies. The main application of nanoemulsions is the preparatio...
"Magic Rock" Zeolites are microporous crystalline aluminosilicates resulting from the reaction of... more "Magic Rock" Zeolites are microporous crystalline aluminosilicates resulting from the reaction of volcanic rocks, ash layers and an alkaline groundwater. Zeolites are incorporated the group contain natural silica similarly diatomaceous earth. Zeolites situate apart among the many families of porous materials. They have a number of significant practical properties such as a high adsorption capacity and the ability to cation exchange because of their structure. The present reviews focus on the application of natural zeolites as they were naturally available and abundant, low cost and stable.
Aim: The aim of the study was to conduct a preand post-intervention analysis of knowledge, attitu... more Aim: The aim of the study was to conduct a preand post-intervention analysis of knowledge, attitude, and practices regarding coronavirus disease 2019 (COVID-19) protocols among doctor’s nurses, technicians. Materials and Methods: Study was carried on the doctors, staff nurse, technicians, and working in hospital. A scientifically designed questionnaire was distributed to the doctors, nurses, and technicians, they were explained about the questions and responses were marked. Results: The results of questionnaire analysis before intervention session show that doctors, nurses, and technicians had least knowledge about the various COVID-19 protocols, that is, 10%, 7.5%, and 5%, respectively. In addition, knowledge about practices regarding COVID-19 protocols at institute level was 32.5%, 27.5%, and 30% in doctors, nurses, and technicians, respectively. Knowledge about fundamentals of COVID-19 was found good in doctors (64%), nurses (41%), and technicians (46%). The results of questionna...
Formulation and Evaluation Os Sustained Release Matrix Tablets of Glibenclamide
The present work is aimed to design, develop and evaluate sustained release matrix tablets of gli... more The present work is aimed to design, develop and evaluate sustained release matrix tablets of glibenclamide capable of delivering drug at nearly constant rate, suitable for once a day administration. Glibenclamide is an oral hypoglycaemic agent, which is a drug for the treatment of patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM) and given in insulin resistance condition. . The relatively small daily dose, short half life, undesirable side effects and rapid absorption from the GIT make GBD a good candidate for formulation in a sustained release dosage form. GBD was incorporated in 5 formulae containing hydroxypropylmethylcellulose (HPMC) as a matrix former in variable quantity. Microcrystalline Cellulose (MCC) was added to formulae in different amounts in order to disintegrate the tablets and magnesium stearate was added as a lubricant. Direct compression techniques was used to prepare the tablets. The physical properties were found to be satisfactory for all the formul...
Context: The present work is to perform a docking analysis by AutoDock version 4.2 for artemether... more Context: The present work is to perform a docking analysis by AutoDock version 4.2 for artemether (ARM) and curcumin (CUR) with few validated protein targets (cyclooxygenase [COX-2] and tumor necrosis factor [TNF-α]) for anticancer therapy. Aims: The object of this work was to analyze inhibitory action of one artemisinin derivative ARM and a natural coloring pigment CUR against pro-inflammatory (a chemical substance that became inflammatory only after it is altered by metabolic process) by computational docking parameters and simulate these effects on the adjuvant arthritic rats were compared with that of drug combination and indomethacin. Materials and Methods: Two-dimensional (2-D) Structure of ARM and CUR was drawn using ChemSketch, the 2-D structure of ligands as well as receptor were converted into the three-dimensional (3-D) structure and optimized with 3-D geometry. The regions of interest used by AUTODOCK version 4.2 were defined by considering grid area by making a grid box...
Severe acute respiratory syndrome related coronavirus (sars-cov). So far again, we see the emerge... more Severe acute respiratory syndrome related coronavirus (sars-cov). So far again, we see the emergence of another outbreak due to a new strain called the sars-cov-2 virus. Sars-cov-2 is extremely contagious and has resulted in a speedy pandemic of covid-19. As the number of cases continues to rise, it is clear that these viruses pose a threat to public health. Swarna bhasma is an efficient dosage form in the ayurvedic treatment. In the conventional system of medicine some molecules of gold are skillful for management of various disorders. The renovation of metallic gold to medicinal gold is an ideal model of promising potentials of pharmaceutical branches of both systems of medicines. Therapeutically gold salts used for the decline in serum immunoglobulin levels and rheumatoid factor titers in rheumatoid arthritis. Gold inhibits stimulation of immunoglobulin-secreting cells. They can inhibit the activation of the classical and alternate complement pathways. Gold compounds reduce frequ...
Himesh Soni & Sarvesh Sharma; Sch Int J Anat Physiol, Nov., 2020; 3(11): 95-98, 2020
"Magic Rock" Zeolites are microporous crystalline aluminosilicates resulting from the reaction of... more "Magic Rock" Zeolites are microporous crystalline aluminosilicates resulting from the reaction of volcanic rocks, ash layers and an alkaline groundwater. Zeolites are incorporated the group contain natural silica similarly diatomaceous earth. Zeolites situate apart among the many families of porous materials. They have a number of significant practical properties such as a high adsorption capacity and the ability to cation exchange because of their structure. The present reviews focus on the application of natural zeolites as they were naturally available and abundant, low cost and stable.
Saudi Journal of Medical and Pharmaceutical Sciences
Corona virus (COVID-19) is an enveloped RNA virus that is diversely initiates in humans and wildl... more Corona virus (COVID-19) is an enveloped RNA virus that is diversely initiates in humans and wildlife. A total of 6 species have been identified to cause disease in humans. Viral infections play a critical role in human diseases, and recent outbreaks is the influx worldwide in form of novel corona .The SS-RNA virus from the enveloped corona virus family caused SARS (Severe acute respiratory syndrome) which is life threatening viral infection. The spreading of infection is quick in many countries of the world. The World Health Organization (WHO) called COVID-19 a pandemic on March 11, 2020. There are numerous drug trials going on with some positive results. Though, since no vaccine is available, the best way to fight the virus is by preventive measures. In the present research an attempt had been made to find new COVID-19 main protease inhibitor by molecular docking approach. The present study reveals that rifampicin has good binding affinity with COVID-19 protease and thus can be used as prophylaxis and therapeutic treatment for corona patient.
Review Article Tuberculosis is an omnipresent, highly contagious chronic granulamatous communicab... more Review Article Tuberculosis is an omnipresent, highly contagious chronic granulamatous communicable bacterial infectious disease caused by Mycobacterium tuberculosis and other species of same genera. Tuberculosis usually affects the lungs, but can also affect other parts of the body. The aim of the present review to illustrate the various sites and co-morbidities associated with extra-pulmonary tuberculosis along with their diagnosis and treatment approaches.
Review Article COVID-19 (Coronaviruses) was recently identified in saliva of infected patients. I... more Review Article COVID-19 (Coronaviruses) was recently identified in saliva of infected patients. In this article, we discuss the transmission of infection via the saliva of this virus. The members in dental practice expose to huge risk of COVID-19 infection due to the face-to-face communication and the exposure to blood, saliva, and other body fluids, and the handling of sharp instruments. Dental professionals play significant roles in preventing the transmission of COVID-19. Here we suggested the infection control count during dental practice to stop the person-to-person transmission way in dental hospitals and clinics. There is a required to increase investigations to the detection of Coronavirus in oral fluids and its effect on the transmission of this virus, which is critical to improve effective plan for prevention, especially for dentists and healthcare professionals. Saliva can play a important role in the person-to-person transmission, and noninvasive salivary analysis may provide a beneficial and cost-effective care platform for the fast and early detection of Coronavirus infection.
Review Article Corona virus (COVID-19) is an enveloped RNA virus that is diversely found in human... more Review Article Corona virus (COVID-19) is an enveloped RNA virus that is diversely found in humans and wildlife. A total of six species have been identified to cause disease in humans. They are known to infect the neurological, respiratory, enteric, and hepatic systems. The past few decades have seen endemic outbreaks in the form of Middle East Respiratory Syndrome coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome related coronavirus (SARS-CoV). Yet again, we see the emergence of another outbreak due to a new strain called the SARS-CoV-2 virus. The most recent outbreak initially presented as pneumonia of unknown etiology in a cluster of patients in Wuhan, China. The epicenter of infection was linked to seafood and exotic animal wholesale markets in the city. SARS-CoV-2 is highly contagious and has resulted in a rapid pandemic of COVID-19. As the number of cases continues to rise, it is clear that these viruses pose a threat to public health. This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. It will also provide a means to raise awareness among primary and secondary healthcare providers during the current pandemic. Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling of patients worldwide. In December 2019, several patients from Wuhan, China were admitted with symptoms of pneumonia. As the number of patients presenting with similar symptoms started to rise, the causative agent was eventually isolated from samples. It was initially called the 2019 novel coronavirus (2019-nCoV) and has been recently relabelled as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the disease it causes has been named coronavirus disease 2019 (COVID-19). Over the next few weeks, the virus spread from Wuhan to affect different provinces in China and, after a few months, it is now present in 109 countries. As of March 26, 2020, there have been 462,684 confirmed cases globally, and 20,834 deaths have been registered. The World Health Organization (WHO) called COVID-19 a pandemic on March 11, 2020. There are multiple drug trials going on with some positive results. However, since no vaccine is available, the best way to combat the virus is by preventive methods. In this review article, we provide a basic understanding of CoV infections and their potentially detrimental involvement to society.
International Journal of Pharmacy and Pharmaceutical Sciences, 2017
Objective: Cancer drug delivery has focused using novel carrier system due to their high drug loa... more Objective: Cancer drug delivery has focused using novel carrier system due to their high drug loading and release controlled property and minimum side effect. Artesunate (ART) and curcumin (CUR) are proved natural herbal lead chemotherapeutics used as Chinese and Indian food. But due to its low absorption and the poor bioavailability limits its clinical efficacy. The object of the present work was to investigate the cytotoxic vs apoptotic effect of these herbal lead molecules in the co-encapsulated liposome formulation.Methods: ART and CUR liposome were prepared by thin film hydration method. Because of their opposite solubility nature, ART loaded in the aqueous phase at pH 7.4 while CUR is present in the central core through lipophilic interaction. In vitro cytotoxicity action of the free and liposomal formulation was performed by MTT assay.Results: Physiochemical parameters were evaluated and compared to the co-encapsulated formulation of containing both molecules. The mean diamet...
International Journal of Applied Pharmaceutics, 2015
The present study is very expectant towards the development of co-encapsulated liposomal formulat... more The present study is very expectant towards the development of co-encapsulated liposomal formulation. The assay method for artesunate has a challenge because it doesnot have a readily recognisable absorption chromophore needed for UV spectroscopy. Curcumin, a lipid soluble antioxidant, exhibits solvent and medium sensitive absorption and fluorescence properties. A simple and rapid method involving two reaction steps has been developed for assay of artesunate and curcumin combination in liposomal formulation. Stock solution of artesunate and curcumin were diluted to final concentration of 10 µg/ml. The UV scan of 10 µg/ml solution of artesunate and curcumin combinations showed the absorbtion maxima at 240 nm and 425 nm respectively. The coloured complex obeyed the Beer's law in the concentration range of 2-20 µg/ml. The above methods is rapid tool for routine analysis of artesunate and curcumin in novel carrier system. The recovery studies confirmed the accuracy and precision of the methods.
Qualitative and Quantitative Profile of Tannic Acid Isolated from Terminalia Chebula
... mythology, this plant originated from the drops of ambrosa (Amrita) which fell on the earth w... more ... mythology, this plant originated from the drops of ambrosa (Amrita) which fell on the earth when Indra was drinking it [2]. T. Chebula possesses a wide variety of activities like antimicrobial [3], antioxidant [4], antiviral[5], anticarcinogenic[6 ... 7. Thakur CP, Thakur B, Singh S, et al. ...
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