Papers by Christine Moroni
NPG Neurologie - Psychiatrie - Gériatrie, 2007
HAL (Le Centre pour la Communication Scientifique Directe), 2019
HAL (Le Centre pour la Communication Scientifique Directe), Mar 1, 2022
NeuroImage, May 1, 1998
According to cognitive or neuropsychological studies. there is lillie evidence of hemispheric lat... more According to cognitive or neuropsychological studies. there is lillie evidence of hemispheric lateralizarion for processes involved in visual mcnral imagery (Cohen et al. 1996). Neuropsychological datas evidenced either a right or a left cerebral lateralization. As cercbral lateralizauon of a cognitive function is linked to ihe sex and the handeness of the subject, we designed an experiment which tested visual mental rotation. conducted. only in right-handed male subjects.
HAL (Le Centre pour la Communication Scientifique Directe), Oct 23, 2015
HAL (Le Centre pour la Communication Scientifique Directe), Aug 1, 2021
HAL (Le Centre pour la Communication Scientifique Directe), Jul 6, 2022
Annals of the Rheumatic Diseases, Jan 21, 2009
Objectives:To assess subclinical central nervous system (CNS) involvement in primary Sjögren synd... more Objectives:To assess subclinical central nervous system (CNS) involvement in primary Sjögren syndrome (pSS), by comparing standard brain MRI, in-depth neuropsychological testing and 99mTc-ECD brain single-photon emission computed tomography (SPECT) of patients with pSS with matched controls.Methods:10 women (&lt;55 years old), with pSS defined using European–American criteria, presence of anti-SSA and/or anti-SSB antibodies and no history of neurological involvement were prospectively investigated, and compared with 10 age- and sex-matched controls. All subjects underwent, within 1 month, brain MRI, neuropsychological testing, including overall evaluation and focal cognitive function assessment, and 99mTc-ECD brain SPECT.Results:99mTc-ECD brain SPECT abnormalities were significantly more common in patients with pSS (10/10) than controls (2/10; p&lt;0.05). Cognitive dysfunctions, mainly expressed as executive and visuospatial disorders, were also significantly more common in patients with pSS (8/10) than controls (0/10; p&lt;0.01). Notably, between-group comparisons enabled a significant correlation to be established between neuropsychological assessment and 99mTc-ECD brain SPECT abnormalities in patients with pSS (rs = 0.49, p&lt;0.01). MRI abnormalities in patients and controls did not differ significantly.Conclusions:Neuropsychological testing and 99mTc-ECD brain SPECT seem to be the most sensitive tools to detect subclinical CNS dysfunction in pSS. The strong correlation between cortical hypoperfusion in 99mTc-ECD brain SPECT and cognitive dysfunction suggests an organic aetiology of CNS dysfunction in pSS. These data should be confirmed in a larger study.
PubMed, Dec 1, 1999
Objective: To investigate the clinical, neuropsychological and imaging manifestations of Sjögren'... more Objective: To investigate the clinical, neuropsychological and imaging manifestations of Sjögren's syndrome (SS), a chronic auto-immune disease with peripheral and central nervous system (CNS) involvement. Design/methods: Fourteen female patients suffering from confirmed SS underwent within 2 weeks: neurological examination, immunological staging, brain MRI, brain 99m Tc-HMPAO SPECT, psychological evaluation and in-depth neuropsychological testing. Results: All patients showed neuropsychological abnormalities. The cognitive symptoms were of the same type in all patients, mostly frontal lobe syndrome and memory problems. The neuropsychological involvement was not associated with other kinds of CNS involvement or MRI abnormalities, but accurately reflected HMPAO imaging results. Conclusions: The results of this study indicate that cognitive evaluation is the most sensitive clinical test to diagnose CNS involvement in patients with SS, and that CNS involvement in SS seems to be more frequent when systematically assessed by neuropsychological tests.
HAL (Le Centre pour la Communication Scientifique Directe), Oct 7, 2021
Dunod eBooks, May 11, 2016
Annals of physical and rehabilitation medicine, Jul 1, 2018
Revue de neuropsychologie, neurosciences cognitives et cliniques, 2016
Resume L’amelioration des traitements neuro-oncologiques ces dernieres annees permettant une surv... more Resume L’amelioration des traitements neuro-oncologiques ces dernieres annees permettant une survie plus longue des patients atteints de tumeurs cerebrales fait emerger la problematique des effets secondaires a long terme. Parmi ces effets secondaires, les troubles cognitifs sont au premier plan et impactent lourdement la qualite de vie des patients. Leur prise en compte constitue actuellement un challenge majeur en neuro-oncologie et necessite un effort en recherche clinique ainsi que dans le suivi a moyen et a long terme des patients en pratique courante. Les troubles cognitifs peuvent etre causes par la progression tumorale et/ou par la recidive tumorale, mais sont souvent provoques par la neurotoxicite inherente aux traitements. L’objectif de cet article est de presenter les troubles cognitifs induits par les traitements anti-tumoraux ainsi que par les traitements concomitants les plus courants en neuro-oncologie. Nous exposons ensuite les principaux biais auxquels se heurte l’evaluation neuropsychologique dans ce contexte et presentons la batterie cognitive proposee par le Grec-Onco, actuellement utilisee dans differents protocoles de recherche clinique.
Neuro-oncology, Apr 2, 2021
Background. Chimeric antigen receptor-modified T (CAR T) cells are profoundly changing the standa... more Background. Chimeric antigen receptor-modified T (CAR T) cells are profoundly changing the standard of care in B-cell malignancies. This new therapeutic class induces a significant number of acute neurotoxicity, but data regarding mid-and long-term neurological safety are scarce. We evaluated mid-term neurological safety, with special emphasis on cognitive functions, in a series of adults treated with CAR T cells. Methods. Patients treated in a single center with CD19-targeted CAR T cells for a relapsing B-cell lymphoma were prospectively followed up by neurologists. Before CAR T-cell infusion, all patients underwent neurological examinations with neuropsychological testing and filled out questionnaires assessing anxiety, depression, and cognitive complaints. Patients surviving without tumor progression were re-evaluated similarly, 6-12 months later. Results. In this prospective cohort of 56 consecutive adult patients treated with CAR T cells, 27 were eligible for mid-term evaluation (median time 7.6 months). Twelve patients developed an acute and reversible neurotoxicity with median duration time of 5.5 days. In all patients, neurological examination on mid-term evaluation was similar to baseline. In self-assessment questionnaires, 63% of patients reported clinically meaningful anxiety, depression, or cognitive difficulties at baseline, a number reduced to 44% at the time of mid-term evaluation. On cognitive assessments, no significant deterioration was found when compared to baseline, in any cognitive functions assessed (verbal and visual memory, executive functions, language, and praxis), even in patients who developed acute neurotoxicity. Conclusion. In this cohort of patients treated with CD19-targeted CAR T cells, we found no evidence for neurological or cognitive toxicity, 6-12 months after treatment. Key Points • This study provides prospective data on mid-term neurotoxicity after CAR T-cell therapy. • No evidence for neurological deficits or cognitive disorders was found after 6-12 months.
HAL (Le Centre pour la Communication Scientifique Directe), Oct 14, 2021
Page 1. VISION, ESPACE ET COGNITION FONCTIONNEMENT NORMAL ET PATHOLOGIQUE us la direction psychol... more Page 1. VISION, ESPACE ET COGNITION FONCTIONNEMENT NORMAL ET PATHOLOGIQUE us la direction psychologie ptentnon PRESSES UNIVERSITAIRES Page 2. Page 3. Page 4. Page 5. VISION, ESPACE ET COGNITION ...
Age and Ageing
Although frailty is an important, well-characterized concept in the provision of medical care to ... more Although frailty is an important, well-characterized concept in the provision of medical care to older adults, it has not been linked to the concept of vulnerability developed in the humanities and social sciences. Here, we distinguish between the two main dimensions of vulnerability: a fundamental, anthropological dimension in which people are exposed to a risk of injury, and a relational dimension in which people depend on each other and on their environment. The relational notion of vulnerability might provide healthcare professionals with a better understanding of frailty (and its potential interaction with precarity). Precarity situates people in their relationship with a social environment that might threaten their living conditions. Frailty corresponds to individual-level changes in adaptation to a living environment and the loss of ability to evolve or react in that environment. Therefore, we suggest that by considering the geriatric notion of frailty as a particular form of...
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Papers by Christine Moroni