Mobley, William
first name: William
last name: Mobley
workplace homepage: https://profiles.ucsd.edu/william.mobley
coauthor of: Chen, Xu Qiao
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Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease
end date: 2023-01-31
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 2018-05-01
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contributes to: Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease

Authorship 1040040
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linked author: Mobley, William
linked information resource: (H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling.

(H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling.
PubMed Identifier: 32281945
author list: Kaplan DR, Mobley WC
published in: The Journal of clinical investigation
information resource reference: (H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling. J Clin Invest. 2020 05 01; 130(5):2195-2198.
journal title abbreviation: J Clin Invest
publication date: 2020-05-01T00:00:00
year: 2020
type: Academic Article
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https://researcherprofiles.org/profile/111335
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address line 1: 9500 Gilman Drive #
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3 D Electron Microscopy of Macromolecules
end date: 2014-12-31
grant awarded by: NIH
principal investigator name: CHIU, WAH
start date: 1985-03-01
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sponsor award id: P41RR002250

NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION
end date: 2005-08-31
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 1900-01-01
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sponsor award id: R01AG016999

University of California San Diego Neuroscience Microscopy Imaging Core
end date: 2021-11-30
grant awarded by: NIH
principal investigator name: ZHENG, BINHAI
start date: 2003-09-30
type: Agreement
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sponsor award id: P30NS047101

Alzheimer's Disease Cooperative Study
end date: 2021-02-28
grant awarded by: NIH
principal investigator name: FELDMAN, HOWARD
start date: 1997-07-01
type: Agreement
type: Grant
sponsor award id: U19AG010483

Training in Translational Develomental Neuroscience
end date: 2010-06-30
grant awarded by: NIH
principal investigator name: FISHER, PAUL GRAHAM
start date: 2004-08-15
type: Agreement
type: Grant
sponsor award id: K12NS049648

Translating discoveries in neurological diseases of infancy and childhood
end date: 2019-06-30
grant awarded by: NIH
principal investigator name: FULLERTON, HEATHER J
start date: 1993-07-01
type: Agreement
type: Grant
sponsor award id: K12NS001692

Genetic Basis of Failed Cognition in Young and Aged Mouse Models of Trisomy 21
end date: 2017-07-31
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 2010-09-30
type: Agreement
type: Grant
sponsor award id: R01NS066072

Disrupted Transport of NGF-TrKA Signaling in Mouse Models of Down Syndrome
end date: 2012-04-30
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 2007-05-07
type: Agreement
type: Grant
sponsor award id: R01NS055371

Nerve Growth Factor-Mechanisms for Signal Transduction
end date: 2009-09-30
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 1986-07-01
type: Agreement
type: Grant
sponsor award id: R01NS024054

2009 Neurotrophic Factors Gordon Research Conference
end date: 2010-03-31
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 2009-04-01
type: Agreement
type: Grant
sponsor award id: R13NS065502

Scientific Review and Evaluation Award - NST Committee
end date: 2006-08-31
grant awarded by: NIH
principal investigator name: HALL, ALISON K
start date: 1991-07-01
type: Agreement
type: Grant
sponsor award id: U09NS030469

From Structure to Therapy: The TRiC Chaperonin Network in Huntington's Disease
end date: 2021-03-31
grant awarded by: NIH
principal investigator name: THOMPSON, LESLIE MICHELS
start date: 2016-04-01
type: Agreement
type: Grant
sponsor award id: P01NS092525

MAPPING DS RELATED CNS PHENOTYPES
end date: 2005-02-28
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 1999-03-01
type: Agreement
type: Grant
sponsor award id: R01NS038869

NERVE GROWTH FACTOR--EFFECTS ON DEVELOPING CNS NEURONS
end date: 1988-06-30
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 1985-07-01
type: Agreement
type: Grant
sponsor award id: K08NS001015

NEUROTROPHIC FACTOR THERAPY FOR ALZHEIMERS DISEASE
end date: 1997-06-30
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 1991-09-29
type: Agreement
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sponsor award id: R01AG010672

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.
PubMed Identifier: 22062771
author list: Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC
published in: Neurobiology of disease
information resource reference: Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2012 Feb; 45(2):683-91.
journal title abbreviation: Neurobiol Dis
publication date: 2011-10-17T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Changes in the localization of brain prion proteins during scrapie infection.
PubMed Identifier: 3112607
author list: DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner SB
published in: Neurology
information resource reference: Changes in the localization of brain prion proteins during scrapie infection. Neurology. 1987 Aug; 37(8):1271-80.
journal title abbreviation: Neurology
publication date: 1987-08-01T00:00:00
year: 1987
type: Academic Article
type: Article
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Authorship 1061748
type: Authorship
Person has claimed publications: 0
author rank in publication: 13
linked author: Mobley, William
linked information resource: Reversing a model of Parkinson's disease with in situ converted nigral neurons.

Authorship 1061383
type: Authorship
Person has claimed publications: 0
author rank in publication: 16
linked author: Mobley, William
linked information resource: Further understanding the connection between Alzheimer's disease and Down syndrome.

Further understanding the connection between Alzheimer's disease and Down syndrome.
PubMed Identifier: 32544310
author list: Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077.
journal title abbreviation: Alzheimers Dement
publication date: 2020-06-16T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Reversing a model of Parkinson's disease with in situ converted nigral neurons.
PubMed Identifier: 32581380
author list: Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD
published in: Nature
information resource reference: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556.
journal title abbreviation: Nature
publication date: 2020-06-24T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
PubMed Identifier: 25341459
author list: Alzheimer's Association National Plan Milestone Workgroup, Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimers Dement. 2014 Oct; 10(5 Suppl):S430-52.
journal title abbreviation: Alzheimers Dement
publication date: 2014-10-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
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Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome.
PubMed Identifier: 25753471
author list: Nosheny RL, Belichenko PV, Busse BL, Weissmiller AM, Dang V, Das D, Fahimi A, Salehi A, Smith SJ, Mobley WC
published in: Neurobiology of disease
information resource reference: Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome. Neurobiol Dis. 2015 May; 77:173-90.
journal title abbreviation: Neurobiol Dis
publication date: 2015-03-06T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.
PubMed Identifier: 27023444
author list: Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC
published in: PloS one
information resource reference: An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS One. 2016; 11(3):e0152471.
journal title abbreviation: PLoS One
publication date: 2016-03-29T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1063877
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Minocycline Topical Foam: A New Drug for the Treatment of Acne.

Authorship 1064106
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Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.

Minocycline Topical Foam: A New Drug for the Treatment of Acne.
PubMed Identifier: 32618475
author list: Onge ES, Mobley WC
published in: The Annals of pharmacotherapy
information resource reference: Minocycline Topical Foam: A New Drug for the Treatment of Acne. Ann Pharmacother. 2021 01; 55(1):105-110.
journal title abbreviation: Ann Pharmacother
publication date: 2020-07-03T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.
PubMed Identifier: 32601248
author list: Stupack J, Xiong XP, Jiang LL, Zhang T, Zhou L, Campos A, Ranscht B, Mobley W, Pasquale EB, Xu H, Huang TY
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis. J Neurosci. 2020 07 29; 40(31):5908-5921.
journal title abbreviation: J Neurosci
publication date: 2020-06-29T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA.
PubMed Identifier: 11150291
author list: Mischel PS, Smith SG, Vining ER, Valletta JS, Mobley WC, Reichardt LF
published in: The Journal of biological chemistry
information resource reference: The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. J Biol Chem. 2001 Apr 06; 276(14):11294-301.
journal title abbreviation: J Biol Chem
publication date: 2001-01-09T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
PubMed Identifier: 15371516
author list: Kleschevnikov AM, Belichenko PV, Villar AJ, Epstein CJ, Malenka RC, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci. 2004 Sep 15; 24(37):8153-60.
journal title abbreviation: J Neurosci
publication date: 2004-09-15T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.
PubMed Identifier: 15515178
author list: Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC
published in: The Journal of comparative neurology
information resource reference: Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol. 2004 Dec 13; 480(3):281-98.
journal title abbreviation: J Comp Neurol
publication date: 2004-12-13T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
PubMed Identifier: 16815330
author list: Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC
published in: Neuron
information resource reference: Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42.
journal title abbreviation: Neuron
publication date: 2006-07-06T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
PubMed Identifier: 17663443
author list: Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC
published in: The Journal of comparative neurology
information resource reference: Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol. 2007 Oct 01; 504(4):329-45.
journal title abbreviation: J Comp Neurol
publication date: 2007-10-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
PubMed Identifier: 19034952
author list: Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC
published in: The Journal of comparative neurology
information resource reference: Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol. 2009 Feb 01; 512(4):453-66.
journal title abbreviation: J Comp Neurol
publication date: 2009-02-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1072339
type: Authorship
Person has claimed publications: 0
author rank in publication: 13
linked author: Mobley, William
linked information resource: Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons.

Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons.
PubMed Identifier: 32724206
author list: Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD
published in: Nature
information resource reference: Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17.
journal title abbreviation: Nature
publication date: 2020-08-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks.
PubMed Identifier: 19296534
author list: Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC, Francke U
published in: The Journal of comparative neurology
information resource reference: Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. J Comp Neurol. 2009 May 20; 514(3):240-58.
journal title abbreviation: J Comp Neurol
publication date: 2009-05-20T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.
PubMed Identifier: 19420260
author list: Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci. 2009 May 06; 29(18):5938-48.
journal title abbreviation: J Neurosci
publication date: 2009-05-06T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.
PubMed Identifier: 20368182
author list: Salehi A, Faizi M, Colas D, Valletta J, Laguna J, Takimoto-Kimura R, Kleschevnikov A, Wagner SL, Aisen P, Shamloo M, Mobley WC
published in: Science translational medicine
information resource reference: Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med. 2009 Nov 18; 1(7):7ra17.
journal title abbreviation: Sci Transl Med
publication date: 2009-11-18T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
PubMed Identifier: 20826309
author list: Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL
published in: Neuron
information resource reference: Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80.
journal title abbreviation: Neuron
publication date: 2010-09-09T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.
PubMed Identifier: 20932954
author list: Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE
published in: Brain research
information resource reference: Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res. 2010 Dec 17; 1366:162-71.
journal title abbreviation: Brain Res
publication date: 2010-10-26T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease.
PubMed Identifier: 21388375
author list: Rissman RA, Mobley WC
published in: Journal of neurochemistry
information resource reference: Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem. 2011 May; 117(4):613-22.
journal title abbreviation: J Neurochem
publication date: 2011-03-28T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.
PubMed Identifier: 21527343
author list: Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M
published in: Neurobiology of disease
information resource reference: Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis. 2011 Aug; 43(2):397-413.
journal title abbreviation: Neurobiol Dis
publication date: 2011-04-17T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator.
PubMed Identifier: 21812392
author list: Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA
published in: Organic letters
information resource reference: Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Org Lett. 2011 Sep 02; 13(17):4554-7.
journal title abbreviation: Org Lett
publication date: 2011-08-03T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Mouse models for Down syndrome-associated developmental cognitive disabilities.
PubMed Identifier: 21865664
author list: Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE
published in: Developmental neuroscience
information resource reference: Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci. 2011; 33(5):404-13.
journal title abbreviation: Dev Neurosci
publication date: 2011-08-25T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.
PubMed Identifier: 22126738
author list: Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE
published in: Bioengineered bugs
information resource reference: Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs. 2012 Jan 01; 3(1):8-12.
journal title abbreviation: Bioeng Bugs
publication date: 2012-01-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome.
PubMed Identifier: 22658745
author list: Ruparelia A, Pearn ML, Mobley WC
published in: Current opinion in neurobiology
information resource reference: Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Curr Opin Neurobiol. 2012 Oct; 22(5):880-6.
journal title abbreviation: Curr Opin Neurobiol
publication date: 2012-05-30T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
PubMed Identifier: 22801784
author list: Wagner SL, Tanzi RE, Mobley WC, Galasko D
published in: Archives of neurology
information resource reference: Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Arch Neurol. 2012 Oct; 69(10):1255-8.
journal title abbreviation: Arch Neurol
publication date: 2012-10-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.
PubMed Identifier: 22764230
author list: Kleschevnikov AM, Belichenko PV, Faizi M, Jacobs LF, Htun K, Shamloo M, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci. 2012 Jul 04; 32(27):9217-27.
journal title abbreviation: J Neurosci
publication date: 2012-07-04T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.
PubMed Identifier: 23526661
author list: Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA
published in: Chemistry (Weinheim an der Bergstrasse, Germany)
information resource reference: Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry. 2013 May 10; 19(20):6398-408.
journal title abbreviation: Chemistry
publication date: 2013-03-22T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
PubMed Identifier: 23524343
author list: Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H
published in: Nature medicine
information resource reference: Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80.
journal title abbreviation: Nat Med
publication date: 2013-03-24T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Aging and intellectual disability: insights from mouse models of Down syndrome.
PubMed Identifier: 23949828
author list: Ruparelia A, Pearn ML, Mobley WC
published in: Developmental disabilities research reviews
information resource reference: Aging and intellectual disability: insights from mouse models of Down syndrome. Dev Disabil Res Rev. 2013; 18(1):43-50.
journal title abbreviation: Dev Disabil Res Rev
publication date: 2013-01-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

The challenge of connecting the dots in the B.R.A.I.N.
PubMed Identifier: 24139032
author list: Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG
published in: Neuron
information resource reference: The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4.
journal title abbreviation: Neuron
publication date: 2013-10-16T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.
PubMed Identifier: 24041763
author list: Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE
published in: Human molecular genetics
information resource reference: Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Hum Mol Genet. 2014 Feb 01; 23(3):578-89.
journal title abbreviation: Hum Mol Genet
publication date: 2013-09-16T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
PubMed Identifier: 24401146
author list: Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE
published in: Biochemistry
information resource reference: Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 2014 Feb 04; 53(4):702-13.
journal title abbreviation: Biochemistry
publication date: 2014-01-22T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons.
PubMed Identifier: 25286194
author list: Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C
published in: Journal of visualized experiments : JoVE
information resource reference: Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp. 2014 Sep 15; (91):51899.
journal title abbreviation: J Vis Exp
publication date: 2014-09-15T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
PubMed Identifier: 25710492
author list: Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C
published in: PloS one
information resource reference: A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379.
journal title abbreviation: PLoS One
publication date: 2015-02-24T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.
PubMed Identifier: 26230397
author list: Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC
published in: PloS one
information resource reference: Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. PLoS One. 2015; 10(7):e0134861.
journal title abbreviation: PLoS One
publication date: 2015-07-31T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy.
PubMed Identifier: 26157985
author list: Selfridge A, Hyun N, Chiang CC, Reyna SM, Weissmiller AM, Shi LZ, Preece D, Mobley WC, Berns MW
published in: Neurophotonics
information resource reference: Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy. Neurophotonics. 2015 Jan; 2(1):015006.
journal title abbreviation: Neurophotonics
publication date: 2015-02-13T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.
PubMed Identifier: 26335643
author list: Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H
published in: Neuron
information resource reference: Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 2015 Sep 02; 87(5):963-75.
journal title abbreviation: Neuron
publication date: 2015-09-02T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic dissection of the Down syndrome critical region.
PubMed Identifier: 26374847
author list: Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, Belichenko PV, Kleschevnikov AM, Pao A, Peresie J, Wie S, Mobley WC, Yu YE
published in: Human molecular genetics
information resource reference: Genetic dissection of the Down syndrome critical region. Hum Mol Genet. 2015 Nov 15; 24(22):6540-51.
journal title abbreviation: Hum Mol Genet
publication date: 2015-09-15T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome.
PubMed Identifier: 26441570
author list: Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA
published in: Frontiers in behavioral neuroscience
information resource reference: The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239.
journal title abbreviation: Front Behav Neurosci
publication date: 2015-09-14T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.
PubMed Identifier: 27064279
author list: Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C
published in: The Journal of clinical investigation
information resource reference: Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 05 02; 126(5):1815-33.
journal title abbreviation: J Clin Invest
publication date: 2016-04-11T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App.
PubMed Identifier: 27701794
author list: Mojabi FS, Fahimi A, Moghadam S, Moghadam S, Windy McNerneny M, Ponnusamy R, Kleschevnikov A, Mobley WC, Salehi A
published in: Hippocampus
information resource reference: GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App. Hippocampus. 2016 12; 26(12):1641-1654.
journal title abbreviation: Hippocampus
publication date: 2016-10-24T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
PubMed Identifier: 28342823
author list: Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zeng Z, Yu YE, Mobley WC
published in: Neurobiology of disease
information resource reference: Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2017 Jul; 103:1-10.
journal title abbreviation: Neurobiol Dis
publication date: 2017-03-22T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
PubMed Identifier: 28416568
author list: Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44.
journal title abbreviation: J Pharmacol Exp Ther
publication date: 2017-04-17T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Dissociation of Down syndrome and Alzheimer's disease effects with imaging.
PubMed Identifier: 28642933
author list: Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS
published in: Alzheimer's & dementia (New York, N. Y.)
information resource reference: Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81.
journal title abbreviation: Alzheimers Dement (N Y)
publication date: 2016-06-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Project Scientist
is primary position: true
position in department: Neurosciences
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Assistant Project Scientist
position in organization: University of California San Diego

Emeritus Professor
is primary position: true
position in department: Neurosciences
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Emeritus Professor
position in organization: University of California San Diego

Professor
is primary position: true
position in department: Neurosciences
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Professor
position in organization: University of California San Diego

Vc-health Sciences-schools
type: Division
type: Organization

PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI).
PubMed Identifier: 28946567
author list: Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC, Down Syndrome Biomarker Initiative and the Alzheimer’s Disease Neuroimaging Initiative
published in: Journal of Alzheimer's disease : JAD
information resource reference: PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450.
journal title abbreviation: J Alzheimers Dis
publication date: 2017-01-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes.
PubMed Identifier: 8987823
author list: Grimes ML, Zhou J, Beattie EC, Yuen EC, Hall DE, Valletta JS, Topp KS, LaVail JH, Bunnett NW, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci. 1996 Dec 15; 16(24):7950-64.
journal title abbreviation: J Neurosci
publication date: 1996-12-15T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1094698
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Local TrkB signaling: themes in development and neural plasticity.

Local TrkB signaling: themes in development and neural plasticity.
PubMed Identifier: 32936344
author list: Johnstone A, Mobley W
published in: Cell and tissue research
information resource reference: Local TrkB signaling: themes in development and neural plasticity. Cell Tissue Res. 2020 Oct; 382(1):101-111.
journal title abbreviation: Cell Tissue Res
publication date: 2020-09-16T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.
PubMed Identifier: 32975365
author list: Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2021 02; 17(2):271-292.
journal title abbreviation: Alzheimers Dement
publication date: 2020-09-25T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.
PubMed Identifier: 9343242
author list: Schätzl HM, Laszlo L, Holtzman DM, Tatzelt J, DeArmond SJ, Weiner RI, Mobley WC, Prusiner SB
published in: Journal of virology
information resource reference: A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. J Virol. 1997 Nov; 71(11):8821-31.
journal title abbreviation: J Virol
publication date: 1997-11-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1096636
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.

Authorship 1097939
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Editorial for the special issue neurotrophic factors.

Editorial for the special issue neurotrophic factors.
PubMed Identifier: 32974736
author list: Saarma M, Mobley W, Leßmann V
published in: Cell and tissue research
information resource reference: Editorial for the special issue neurotrophic factors. Cell Tissue Res. 2020 10; 382(1):1-4.
journal title abbreviation: Cell Tissue Res
publication date: 2020-10-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Changes in the localization of brain prion proteins during scrapie infection.
PubMed Identifier: 9443448
author list: DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner SB
published in: Neurology
information resource reference: Changes in the localization of brain prion proteins during scrapie infection. Neurology. 1998 Jan; 50(1):1271-80; discussion 2.
journal title abbreviation: Neurology
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Abnormal plasma membrane properties and functions in prion-infected cell lines.
PubMed Identifier: 9246479
author list: DeArmond SJ, Qiu Y, Wong K, Nixon R, Hyun W, Prusiner SB, Mobley WC
published in: Cold Spring Harbor symposia on quantitative biology
information resource reference: Abnormal plasma membrane properties and functions in prion-infected cell lines. Cold Spring Harb Symp Quant Biol. 1996; 61:531-40.
journal title abbreviation: Cold Spring Harb Symp Quant Biol
publication date: 1996-01-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Doxycycline control of prion protein transgene expression modulates prion disease in mice.
PubMed Identifier: 9770528
author list: Tremblay P, Meiner Z, Galou M, Heinrich C, Petromilli C, Lisse T, Cayetano J, Torchia M, Mobley W, Bujard H, DeArmond SJ, Prusiner SB
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12580-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1998-10-13T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.
PubMed Identifier: 9836577
author list: Butte MJ, Hwang PK, Mobley WC, Fletterick RJ
published in: Biochemistry
information resource reference: Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 1998 Dec 01; 37(48):16846-52.
journal title abbreviation: Biochemistry
publication date: 1998-12-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.
PubMed Identifier: 10089883
author list: Wilde A, Beattie EC, Lem L, Riethof DA, Liu SH, Mobley WC, Soriano P, Brodsky FM
published in: Cell
information resource reference: EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell. 1999 Mar 05; 96(5):677-87.
journal title abbreviation: Cell
publication date: 1999-03-05T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor.
PubMed Identifier: 1647026
author list: Taiwo YO, Levine JD, Burch RM, Woo JE, Mobley WC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5144-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1991-06-15T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1099624
type: Authorship
Person has claimed publications: 0
author rank in publication: 11
linked author: Mobley, William
linked information resource: Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.

Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
PubMed Identifier: 33007551
author list: Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL
published in: Bioorganic & medicinal chemistry
information resource reference: Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 11 15; 28(22):115734.
journal title abbreviation: Bioorg Med Chem
publication date: 2020-09-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected].
PubMed Identifier: 10527801
author list: Mitchison HM, Bernard DJ, Greene ND, Cooper JD, Junaid MA, Pullarkat RK, de Vos N, Breuning MH, Owens JW, Mobley WC, Gardiner RM, Lake BD, Taschner PE, Nussbaum RL
published in: Neurobiology of disease
information resource reference: Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]. Neurobiol Dis. 1999 Oct; 6(5):321-34.
journal title abbreviation: Neurobiol Dis
publication date: 1999-10-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system.
PubMed Identifier: 10811872
author list: Villoslada P, Hauser SL, Bartke I, Unger J, Heald N, Rosenberg D, Cheung SW, Mobley WC, Fisher S, Genain CP
published in: The Journal of experimental medicine
information resource reference: Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. J Exp Med. 2000 May 15; 191(10):1799-806.
journal title abbreviation: J Exp Med
publication date: 2000-05-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.
PubMed Identifier: 11007890
author list: Beattie EC, Howe CL, Wilde A, Brodsky FM, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. J Neurosci. 2000 Oct 01; 20(19):7325-33.
journal title abbreviation: J Neurosci
publication date: 2000-10-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Alzheimer Disease
MeSH DescriptorUI: D000544
MeSH semantic group name: Disorders
number of authors: 1815
number of publications: 15719
uniqueness weight: 0.167319
type: Concept

Authorship 668038
type: Authorship
Person has claimed publications: 0
author rank in publication: 13
linked author: Mobley, William
linked information resource: TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.
PubMed Identifier: 27601642
author list: Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5655-64.
journal title abbreviation: Proc Natl Acad Sci U S A
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year: 2016
type: Academic Article
type: Article
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Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system.
PubMed Identifier: 1982367
author list: McKinley MP, Longo FM, Valletta JS, Rahbar F, Neve RL, Prusiner SB, Mobley WC
published in: Progress in brain research
information resource reference: Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system. Prog Brain Res. 1990; 86:227-38.
journal title abbreviation: Prog Brain Res
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year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.
PubMed Identifier: 18726789
author list: Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS
published in: Critical reviews in toxicology
information resource reference: Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol. 2008; 38 Suppl 2:1-125.
journal title abbreviation: Crit Rev Toxicol
publication date: 2008-01-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Disease Models, Animal
MeSH DescriptorUI: D004195
MeSH semantic group name: Disorders
number of authors: 5513
number of publications: 25061
uniqueness weight: 0.21384
type: Concept

Down Syndrome
MeSH DescriptorUI: D004314
MeSH semantic group name: Disorders
number of authors: 404
number of publications: 1263
uniqueness weight: 0.477811
type: Concept

Acceleration of scrapie in neonatal Syrian hamsters.
PubMed Identifier: 2507957
author list: McKinley MP, DeArmond SJ, Torchia M, Mobley WC, Prusiner SB
published in: Neurology
information resource reference: Acceleration of scrapie in neonatal Syrian hamsters. Neurology. 1989 Oct; 39(10):1319-24.
journal title abbreviation: Neurology
publication date: 1989-10-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer.
PubMed Identifier: 2574872
author list: De Armond SJ, Gonzales M, Mobley WC, Kon AA, Stern A, Prusiner H, Prusiner SB
published in: Progress in clinical and biological research
information resource reference: PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer. Prog Clin Biol Res. 1989; 317:601-18.
journal title abbreviation: Prog Clin Biol Res
publication date: 1989-01-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.
PubMed Identifier: 2904679
author list: Mobley WC, Neve RL, Prusiner SB, McKinley MP
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9811-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1988-12-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Training in Translational Develomental Neuroscience

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Disrupted Transport of NGF-TrKA Signaling in Mouse Models of Down Syndrome

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: NERVE GROWTH FACTOR--EFFECTS ON DEVELOPING CNS NEURONS

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: MAPPING DS RELATED CNS PHENOTYPES

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: 2009 Neurotrophic Factors Gordon Research Conference

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Translating discoveries in neurological diseases of infancy and childhood

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: NEUROTROPHIC FACTOR THERAPY FOR ALZHEIMERS DISEASE

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Genetic Basis of Failed Cognition in Young and Aged Mouse Models of Trisomy 21

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: University of California San Diego Neuroscience Microscopy Imaging Core

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Alzheimer's Disease Cooperative Study

Co-Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: From Structure to Therapy: The TRiC Chaperonin Network in Huntington's Disease

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Scientific Review and Evaluation Award - NST Committee

Co-Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: 3 D Electron Microscopy of Macromolecules

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Nerve Growth Factor-Mechanisms for Signal Transduction

Nerve Growth Factors
MeSH DescriptorUI: D009414
MeSH semantic group name: Chemicals & Drugs
number of authors: 387
number of publications: 985
uniqueness weight: 0.697623
type: Concept

Endosomes
MeSH DescriptorUI: D011992
MeSH semantic group name: Anatomy
number of authors: 415
number of publications: 779
uniqueness weight: 0.688471
type: Concept

Trisomy
MeSH DescriptorUI: D014314
MeSH semantic group name: Disorders
number of authors: 173
number of publications: 280
uniqueness weight: 0.855699
type: Concept

Amyloid beta-Peptides
MeSH DescriptorUI: D016229
MeSH semantic group name: Chemicals & Drugs
number of authors: 904
number of publications: 4996
uniqueness weight: 0.349902
type: Concept

Amyloid beta-Protein Precursor
MeSH DescriptorUI: D016564
MeSH semantic group name: Chemicals & Drugs
number of authors: 388
number of publications: 1318
uniqueness weight: 0.629454
type: Concept

Authorship 1141436
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome.

Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome.
PubMed Identifier: 33288820
author list: Takahashi T, Sakai N, Iwasaki T, Doyle TC, Mobley WC, Nishino S
published in: Scientific reports
information resource reference: Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome. Sci Rep. 2020 12 07; 10(1):21323.
journal title abbreviation: Sci Rep
publication date: 2020-12-07T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Gene Dosage
MeSH DescriptorUI: D018628
MeSH semantic group name: Concepts & Ideas
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number of publications: 1092
uniqueness weight: 0.720728
type: Concept

rab GTP-Binding Proteins
MeSH DescriptorUI: D020691
MeSH semantic group name: Chemicals & Drugs
number of authors: 171
number of publications: 343
uniqueness weight: 0.78888
type: Concept

rab5 GTP-Binding Proteins
MeSH DescriptorUI: D020696
MeSH semantic group name: Chemicals & Drugs
number of authors: 54
number of publications: 85
uniqueness weight: 0.931509
type: Concept

Receptor, trkB
MeSH DescriptorUI: D020813
MeSH semantic group name: Chemicals & Drugs
number of authors: 152
number of publications: 233
uniqueness weight: 0.887304
type: Concept

Receptor, trkA
MeSH DescriptorUI: D020917
MeSH semantic group name: Chemicals & Drugs
number of authors: 173
number of publications: 272
uniqueness weight: 0.839256
type: Concept

Nerve Growth Factor
MeSH DescriptorUI: D020932
MeSH semantic group name: Chemicals & Drugs
number of authors: 187
number of publications: 361
uniqueness weight: 0.78481
type: Concept

Amyloid Precursor Protein Secretases
MeSH DescriptorUI: D053829
MeSH semantic group name: Chemicals & Drugs
number of authors: 205
number of publications: 460
uniqueness weight: 0.780059
type: Concept

Medicine
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Neurosciences
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type: Organization

Cellular and Molecular Medicine
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type: Organization

Anesthesiology
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type: Organization

Pathology
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type: Organization

Pediatrics
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type: Organization

Psychiatry
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type: Organization

Keck School of Medicine of Usc
type: Division
type: Organization

University of California San Diego
type: Organization

University of California, Irvine
type: Organization

University of Southern California
type: Organization

Multiplexed Single Nucleus RNA and ATAC-seq Sequencing and Cortical Organoids: Transformative Insights into Down Syndrome
end date: 2025-06-30
grant awarded by: NIH
principal investigator name: ROSENFELD, MICHAEL G
start date: 2020-09-15
type: Agreement
type: Grant
sponsor award id: R01AG070154

Co-Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Multiplexed Single Nucleus RNA and ATAC-seq Sequencing and Cortical Organoids: Transformative Insights into Down Syndrome

Rafii, Michael
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last name: Rafii
workplace homepage: https://profiles.sc-ctsi.org/michael.rafii
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person in primary position: Professor of Clinical Neurology
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Heinz, Sven
first name: Sven
last name: Heinz
workplace homepage: https://profiles.ucsd.edu/sven.heinz
full name: Sven Heinz
has faculty rank: Associate Professor
latitude: 32.88006040000000
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Person ID: 4797
person in primary position: Associate Professor
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Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
PubMed Identifier: 33691783
author list: Chen XQ, Das U, Park G, Mobley WC
published in: Alzheimer's research & therapy
information resource reference: Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. Alzheimers Res Ther. 2021 03 10; 13(1):59.
journal title abbreviation: Alzheimers Res Ther
publication date: 2021-03-10T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1169616
type: Authorship
Person has claimed publications: 0
author rank in publication: 21
linked author: Mobley, William
linked information resource: Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.

Authorship 1169466
type: Authorship
Person has claimed publications: 0
author rank in publication: 22
linked author: Mobley, William
linked information resource: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.

Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
PubMed Identifier: 33651103
author list: Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL
published in: The Journal of experimental medicine
information resource reference: Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4).
journal title abbreviation: J Exp Med
publication date: 2021-04-05T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Specific Susceptibility to COVID-19 in Adults with Down Syndrome.
PubMed Identifier: 33660221
author list: Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E
published in: Neuromolecular medicine
information resource reference: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 12; 23(4):561-571.
journal title abbreviation: Neuromolecular Med
publication date: 2021-03-04T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Chen, Xu Qiao
first name: Xu Qiao
last name: Chen
workplace homepage: https://profiles.ucsd.edu/xuqiao.chen
Featured Publications: https://researcherprofiles.org/profile/29814031
full name: Xu Qiao Chen
has faculty rank: Other Academic/Other
latitude: 32.88006040000000
longitude: -117.23620219999999
Person ID: 684
person in primary position: Assistant Project Scientist
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preferred title: Assistant Project Scientist

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Authorship 1170999
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.

Authorship 1173772
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Specialty clinics for adults with Down syndrome: A clinic survey.

Specialty clinics for adults with Down syndrome: A clinic survey.
PubMed Identifier: 33729670
author list: Santoro SL, Campbell A, Balasubramanian A, Haugen K, Schafer K, Mobley W
published in: American journal of medical genetics. Part A
information resource reference: Specialty clinics for adults with Down syndrome: A clinic survey. Am J Med Genet A. 2021 06; 185(6):1767-1775.
journal title abbreviation: Am J Med Genet A
publication date: 2021-03-17T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Kleschevnikov, Alexander
first name: Alexander
last name: Kleschevnikov
workplace homepage: https://profiles.ucsd.edu/alexander.kleschevnikov
full name: Alexander Kleschevnikov
has faculty rank: Other Academic/Other
latitude: 32.88006040000000
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Person ID: 5898
person in primary position: Assistant Researcher
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preferred title: Assistant Researcher

Authorship 1184164
type: Authorship
Person has claimed publications: 0
author rank in publication: 46
linked author: Mobley, William
linked information resource: Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study.

Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study.
PubMed Identifier: 33924960
author list: Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W
published in: Journal of clinical medicine
information resource reference: Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9).
journal title abbreviation: J Clin Med
publication date: 2021-04-28T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Masliah, Eliezer
first name: Eliezer
last name: Masliah
workplace homepage: https://profiles.ucsd.edu/eliezer.masliah
full name: Eliezer Masliah
has faculty rank: Professor
latitude: 32.88006040000000
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Person ID: 7092
person in primary position: Emeritus Professor
type: Agent
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Authorship 1186062
type: Authorship
Person has claimed publications: 0
author rank in publication: 22
linked author: Mobley, William
linked information resource: Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.

Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.
PubMed Identifier: 33948879
author list: Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E
published in: Neuromolecular medicine
information resource reference: Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec; 23(4):572-573.
journal title abbreviation: Neuromolecular Med
publication date: 2021-12-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Opportunities, barriers, and recommendations in down syndrome research.
PubMed Identifier: 34268067
author list: Hendrix JA, Amon A, Abbeduto L, Agiovlasitis S, Alsaied T, Anderson HA, Bain LJ, Baumer N, Bhattacharyya A, Bogunovic D, Botteron KN, Capone G, Chandan P, Chase I, Chicoine B, Cieuta-Walti C, DeRuisseau LR, Durand S, Esbensen A, Fortea J, Giménez S, Granholm AC, Hahn LJ, Head E, Hillerstrom H, Jacola LM, Janicki MP, Jasien JM, Kamer AR, Kent RD, Khor B, Lawrence JB, Lemonnier C, Lewanda AF, Mobley W, Moore PE, Nelson LP, Oreskovic NM, Osorio RS, Patterson D, Rasmussen SA, Reeves RH, Roizen N, Santoro S, Sherman SL, Talib N, Tapia IE, Walsh KM, Warren SF, White AN, Wong GW, Yi JS
published in: Translational science of rare diseases
information resource reference: Opportunities, barriers, and recommendations in down syndrome research. Transl Sci Rare Dis. 2021; 5(3-4):99-129.
journal title abbreviation: Transl Sci Rare Dis
publication date: 2021-04-15T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1215033
type: Authorship
Person has claimed publications: 0
author rank in publication: 35
linked author: Mobley, William
linked information resource: Opportunities, barriers, and recommendations in down syndrome research.

Authorship 1214976
type: Authorship
Person has claimed publications: 0
author rank in publication: 15
linked author: Mobley, William
linked information resource: Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.

Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.
PubMed Identifier: 34248930
author list: Illouz T, Biragyn A, Iulita MF, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, London J, Mobley W, Strydom A, Okun E
published in: Frontiers in immunology
information resource reference: Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome. Front Immunol. 2021; 12:621440.
journal title abbreviation: Front Immunol
publication date: 2021-06-25T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1218931
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome.

Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome.
PubMed Identifier: 34276349
author list: Chen XQ, Xing Z, Chen QD, Salvi RJ, Zhang X, Tycko B, Mobley WC, Yu YE
published in: Frontiers in aging neuroscience
information resource reference: Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome. Front Aging Neurosci. 2021; 13:700280.
journal title abbreviation: Front Aging Neurosci
publication date: 2021-07-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Yuan, Wei
first name: Wei
last name: Yuan
workplace homepage: https://profiles.ucsd.edu/wei.yuan
full name: Wei Yuan
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person in primary position: SRA 3
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Authorship 1230965
type: Authorship
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author rank in publication: 9
linked author: Mobley, William
linked information resource: Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.
PubMed Identifier: 34421499
author list: Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A
published in: Molecular syndromology
information resource reference: Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul; 12(4):202-218.
journal title abbreviation: Mol Syndromol
publication date: 2021-05-20T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Postdoctoral Scholar
is primary position: true
position in department: Neurosciences
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Postdoctoral Scholar
position in organization: University of California San Diego

Zuo, Xinxin
first name: Xinxin
last name: Zuo
workplace homepage: https://profiles.ucsd.edu/xinxin.zuo
full name: Xinxin Zuo
has faculty rank: Postdoctoral Scholar
latitude: 32.88006040000000
longitude: -117.23620219999999
photo: https://researcherprofiles.org/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 55188
person in primary position: Postdoctoral Scholar
type: Agent
type: Person
preferred title: Postdoctoral Scholar

Authorship 724380
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation.

T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation.
PubMed Identifier: 30120810
author list: Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C
published in: Traffic (Copenhagen, Denmark)
information resource reference: T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 11; 19(11):840-853.
journal title abbreviation: Traffic
publication date: 2018-09-12T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1252819
type: Authorship
Person has claimed publications: 0
author rank in publication: 12
linked author: Mobley, William
linked information resource: Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.

Authorship 1253732
type: Authorship
Person has claimed publications: 0
author rank in publication: 22
linked author: Mobley, William
linked information resource: Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.

Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.
PubMed Identifier: 34757693
author list: Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimers Dement. 2022 06; 18(6):1203-1234.
journal title abbreviation: Alzheimers Dement
publication date: 2021-11-10T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.
PubMed Identifier: 34797469
author list: Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E
published in: Neuromolecular medicine
information resource reference: Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec; 23(4):574-575.
journal title abbreviation: Neuromolecular Med
publication date: 2021-12-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1261810
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.

Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.
PubMed Identifier: 34990205
author list: Bartesaghi R, Vicari S, Mobley WC
published in: Annual review of pharmacology and toxicology
information resource reference: Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders. Annu Rev Pharmacol Toxicol. 2022 01 06; 62:211-233.
journal title abbreviation: Annu Rev Pharmacol Toxicol
publication date: 2022-01-06T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor
is primary position: true
position in department: Pathology
position in division: School of Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: University of California, Irvine

Authorship 1312590
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial.

Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial.
PubMed Identifier: 35532913
author list: Rafii MS, Sol O, Mobley WC, Delpretti S, Skotko BG, Burke AD, Sabbagh MN, Yuan SH, Rissman RA, Pulsifer M, Evans C, Evans AC, Beth G, Fournier N, Gray JA, Dos Santos AM, Hliva V, Vukicevic M, Kosco-Vilbois M, Streffer J, Pfeifer A, Feldman HH
published in: JAMA neurology
information resource reference: Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial. JAMA Neurol. 2022 06 01; 79(6):565-574.
journal title abbreviation: JAMA Neurol
publication date: 2022-06-01T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.
PubMed Identifier: 36370135
author list: Chen XQ, Zuo X, Becker A, Head E, Mobley WC
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. Alzheimers Dement. 2023 05; 19(5):2095-2116.
journal title abbreviation: Alzheimers Dement
publication date: 2022-11-12T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1373080
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Learning to Practice Compassionate Care: Medical Students Discuss Their Most Memorable Lessons.

Authorship 1390315
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling.

Authorship 1383514
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.

Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling.
PubMed Identifier: 36095039
author list: Riegner G, Posey G, Oliva V, Jung Y, Mobley W, Zeidan F
published in: Pain
information resource reference: Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling. Pain. 2023 02 01; 164(2):280-291.
journal title abbreviation: Pain
publication date: 2022-07-07T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Learning to Practice Compassionate Care: Medical Students Discuss Their Most Memorable Lessons.
PubMed Identifier: 35957650
author list: Schairer CE, Tutjer J, Cannavino C, Mobley WC, Eyler L, Bloss CS
published in: Journal of patient experience
information resource reference: Learning to Practice Compassionate Care: Medical Students Discuss Their Most Memorable Lessons. J Patient Exp. 2022; 9:23743735221117383.
journal title abbreviation: J Patient Exp
publication date: 2022-08-04T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1393580
type: Authorship
Person has claimed publications: 0
author rank in publication: 18
linked author: Mobley, William
linked information resource: CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons.

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons.
PubMed Identifier: 36754966
author list: Wu GH, Smith-Geater C, Galaz-Montoya JG, Gu Y, Gupte SR, Aviner R, Mitchell PG, Hsu J, Miramontes R, Wang KQ, Geller NR, Hou C, Danita C, Joubert LM, Schmid MF, Yeung S, Frydman J, Mobley W, Wu C, Thompson LM, Chiu W
published in: Nature communications
information resource reference: CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons. Nat Commun. 2023 02 08; 14(1):692.
journal title abbreviation: Nat Commun
publication date: 2023-02-08T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1397409
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons.

BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons.
PubMed Identifier: 36826992
author list: Moya-Alvarado G, Tiburcio-Felix R, Ibáñez MR, Aguirre-Soto AA, Guerra MV, Wu C, Mobley WC, Perlson E, Bronfman FC
published in: eLife
information resource reference: BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons. Elife. 2023 02 24; 12.
journal title abbreviation: Elife
publication date: 2023-02-24T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Researcher
is primary position: true
position in department: Neurosciences
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Assistant Researcher
position in organization: University of California San Diego

School of Medicine
type: Division
type: Organization

Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.
PubMed Identifier: 37042072
author list: Chen XQ, Sawa M, Becker A, Karachentsev D, Zuo X, Rynearson KD, Tanzi RE, Mobley WC
published in: Annals of neurology
information resource reference: Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator. Ann Neurol. 2023 08; 94(2):245-258.
journal title abbreviation: Ann Neurol
publication date: 2023-04-29T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1422349
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.

Authorship 1425189
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Editorial: Current advances in the study of Down Syndrome: From development to aging.

Editorial: Current advances in the study of Down Syndrome: From development to aging.
PubMed Identifier: 37021132
author list: Johnstone A, Mobley W
published in: Frontiers in neuroscience
information resource reference: Editorial: Current advances in the study of Down Syndrome: From development to aging. Front Neurosci. 2023; 17:1161147.
journal title abbreviation: Front Neurosci
publication date: 2023-03-20T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Zeidan, Fadel
first name: Fadel
last name: Zeidan
workplace homepage: https://profiles.ucsd.edu/fadel.zeidan
Clinical Trials: https://researcherprofiles.org/profile/761250196
full name: Fadel Zeidan
has faculty rank: Professor
latitude: 32.88006040000000
longitude: -117.23620219999999
photo: https://researcherprofiles.org/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 32806
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Postdoctoral Scholar
is primary position: true
position in department: Cellular and Molecular Medicine
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Postdoctoral Scholar
position in organization: University of California San Diego

Yano, Seiichi
first name: Seiichi
last name: Yano
workplace homepage: https://profiles.ucsd.edu/seiichi.yano
full name: Seiichi Yano
has faculty rank: Postdoctoral Scholar
latitude: 32.88006040000000
longitude: -117.23620219999999
Person ID: 64371
person in primary position: Postdoctoral Scholar
type: Agent
type: Person
preferred title: Postdoctoral Scholar

Authorship 1440194
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion.

Authorship 1443522
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain.

Authorship 1446731
type: Authorship
Person has claimed publications: 0
author rank in publication: 12
linked author: Mobley, William
linked information resource: Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior.

Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior.
PubMed Identifier: 37449271
author list: Overk C, Fiorini E, Babolin C, Vukicevic M, Morici C, Madani R, Eligert V, Kosco-Vilbois M, Roberts A, Becker A, Pfeifer A, Mobley WC
published in: Frontiers in neuroscience
information resource reference: Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior. Front Neurosci. 2023; 17:1202208.
journal title abbreviation: Front Neurosci
publication date: 2023-06-28T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion.
PubMed Identifier: 37286647
author list: Hao Y, Hu J, Xue Y, Dowdy SF, Mobley WC, Qian H, Fu XD
published in: Nature
information resource reference: Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion. Nature. 2023 06; 618(7964):E8-E13.
journal title abbreviation: Nature
publication date: 2023-06-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain.
PubMed Identifier: 37428606
author list: Fu XD, Mobley WC
published in: Annual review of neuroscience
information resource reference: Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain. Annu Rev Neurosci. 2023 07 10; 46:145-165.
journal title abbreviation: Annu Rev Neurosci
publication date: 2023-07-10T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor
is primary position: true
position in department: Medicine
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: University of California San Diego

WITHDRAWN: I feel your pain: Higher empathy is associated with higher posterior default mode network activity.
PubMed Identifier: 37645854
author list: Oliva V, Riegner G, Dean J, Khatib LA, Allen A, Barrows D, Chen C, Fuentes R, Jacobson A, Lopez C, Mosbey D, Reyes M, Ross J, Uvarova A, Liu T, Mobley W, Zeidan F
published in: bioRxiv : the preprint server for biology
information resource reference: WITHDRAWN: I feel your pain: Higher empathy is associated with higher posterior default mode network activity. bioRxiv. 2023 Dec 28.
journal title abbreviation: bioRxiv
publication date: 2023-12-28T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1479705
type: Authorship
Person has claimed publications: 0
author rank in publication: 15
linked author: Mobley, William
linked information resource: Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling.

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling.
PubMed Identifier: 37577527
author list: Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MC, Franco ML, Özcan B, Moreira DG, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L
published in: bioRxiv : the preprint server for biology
information resource reference: Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. bioRxiv. 2024 Apr 23.
journal title abbreviation: bioRxiv
publication date: 2024-04-23T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1482284
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease.

Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease.
PubMed Identifier: 37924159
author list: Valdes P, Henry KW, Fitzgerald MQ, Muralidharan K, Caldwell AB, Ramachandran S, Goldstein LSB, Mobley WC, Galasko DR, Subramaniam S
published in: Molecular brain
information resource reference: Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease. Mol Brain. 2023 11 03; 16(1):75.
journal title abbreviation: Mol Brain
publication date: 2023-11-03T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1496994
type: Authorship
Person has claimed publications: 0
author rank in publication: 16
linked author: Mobley, William
linked information resource: WITHDRAWN: I feel your pain: Higher empathy is associated with higher posterior default mode network activity.

Professor of Clinical Neurology
is primary position: true
position in department: Medicine
position in division: Keck School of Medicine of Usc
sort order: 1
type: Position
HR job title: Professor of Clinical Neurology
position in organization: University of Southern California

Authorship 1512136
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration.

Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration.
PubMed Identifier: 38429379
author list: de Luzy IR, Lee MK, Mobley WC, Studer L
published in: Nature aging
information resource reference: Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration. Nat Aging. 2024 Mar; 4(3):309-318.
journal title abbreviation: Nat Aging
publication date: 2024-03-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Antisense Oligonucleotides targeting APP to prevent neurodegeneration in models of Down Syndrome and Alzheimer's disease
end date: 2024-01-31
grant awarded by: NIH
principal investigator name: MOBLEY, WILLIAM C
start date: 2019-04-15
type: Agreement
type: Grant
sponsor award id: R01AG061151

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Mobley, William
contributes to: Antisense Oligonucleotides targeting APP to prevent neurodegeneration in models of Down Syndrome and Alzheimer's disease

Head, Elizabeth
first name: Elizabeth
last name: Head
workplace homepage: https://profiles.icts.uci.edu/elizabeth.head
full name: Elizabeth Head
has faculty rank: Professor
latitude: 33.64049520000000
longitude: -117.84648489999999
photo: https://researcherprofiles.org/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 33674
person in primary position: Professor
type: Agent
type: Person
ORCID id: 1115-6396
preferred title: Professor

Authorship 1524538
type: Authorship
Person has claimed publications: 0
author rank in publication: 14
linked author: Mobley, William
linked information resource: BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease.

BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease.
PubMed Identifier: 38608784
author list: Gu Y, Pope A, Smith C, Carmona C, Johnstone A, Shi L, Chen X, Santos S, Bacon-Brenes CC, Shoff T, Kleczko KM, Frydman J, Thompson LM, Mobley WC, Wu C
published in: Neurobiology of disease
information resource reference: BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease. Neurobiol Dis. 2024 06 01; 195:106502.
journal title abbreviation: Neurobiol Dis
publication date: 2024-04-10T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.
PubMed Identifier: 38747498
author list: Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC
published in: Annals of neurology
information resource reference: γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome. Ann Neurol. 2024 Aug; 96(2):390-404.
journal title abbreviation: Ann Neurol
publication date: 2024-05-15T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1542262
type: Authorship
Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.

Postdoctoral Scholar
is primary position: true
position in department: Psychiatry
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Postdoctoral Scholar
position in organization: University of California San Diego

Litif, Carl
first name: Carl
last name: Litif
workplace homepage: https://profiles.ucsd.edu/carl.litif
full name: Carl Litif
has faculty rank: Postdoctoral Scholar
latitude: 32.88006040000000
longitude: -117.23620219999999
Person ID: 70595
person in primary position: Postdoctoral Scholar
type: Agent
type: Person
preferred title: Postdoctoral Scholar

Professor
is primary position: true
position in department: Anesthesiology
position in division: Vc-health Sciences-schools
sort order: 1
type: Position
HR job title: Professor
position in organization: University of California San Diego

Authorship 1550169
type: Authorship
Person has claimed publications: 0
author rank in publication: 15
linked author: Mobley, William
linked information resource: Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling.

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling.
PubMed Identifier: 39027984
author list: Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MCQ, Franco ML, Özcan B, Gomes Moreira D, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L
published in: eLife
information resource reference: Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. Elife. 2024 Jul 19; 12.
journal title abbreviation: Elife
publication date: 2024-07-19T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Recall Hcomp
is primary position: true
position in department: Pediatrics
position in division: School of Medicine
sort order: 1
type: Position
HR job title: Recall Hcomp
position in organization: University of California, Irvine

Lott, Ira
first name: Ira
last name: Lott
workplace homepage: https://profiles.icts.uci.edu/ira.lott
Clinical Trials: https://researcherprofiles.org/profile/761253978
full name: Ira T Lott
has faculty rank: Other Academic/Other
latitude: 33.64049520000000
longitude: -117.84648489999999
Person ID: 71536
person in primary position: Recall Hcomp
type: Agent
type: Person
preferred title: Recall Hcomp

Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses.
PubMed Identifier: 31133787
author list: Chen XQ, Mobley WC
published in: Frontiers in neuroscience
information resource reference: Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Front Neurosci. 2019; 13:446.
journal title abbreviation: Front Neurosci
publication date: 2019-05-07T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 788066
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses.

Santoro, Jonathan
first name: Jonathan
last name: Santoro
workplace homepage: https://profiles.sc-ctsi.org/jonathan.santoro
Tag Editor: https://researcherprofiles.org/profile/64376499
full name: Jonathan Santoro
has faculty rank: Associate Professor
latitude: 34.02235190000000
longitude: -118.28730570000000
photo: https://researcherprofiles.org/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 34422
person in primary position: Associate Professor of Clinical Pediatrics and Neurology
type: Agent
type: Person
ORCID id: 0000-0002-8350-8234
preferred title: Associate Professor of Clinical Pediatrics and Neurology

Jones, Ying
first name: Ying
last name: Jones
workplace homepage: https://profiles.ucsd.edu/ying.jones
full name: Ying Jones
has faculty rank: Other Academic/Other
latitude: 32.88006040000000
longitude: -117.23620219999999
Person ID: 34444
person in primary position: Staff Res Assoc 4
type: Agent
type: Person
preferred title: Staff Res Assoc 4

Authorship 791313
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord.

Authorship 791323
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor.

Authorship 791063
type: Authorship
Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.

Authorship 793132
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves.

Authorship 795769
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Nerve growth factor (second of three parts).

Authorship 795677
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Potential use of nerve growth factor to treat Alzheimer's disease.

Authorship 799502
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Combination perineal cryosurgery and external radiation therapy for adenocarcinoma of prostate.

Authorship 803427
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

Authorship 808749
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway.

Authorship 808618
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.

Authorship 808386
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons.

Authorship 810001
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice.

Authorship 816103
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment.

Authorship 817378
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Preliminary characterization of the central nervous system in partial trisomy 16 mice.

Authorship 818920
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.

Authorship 789294
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat.

Authorship 788751
type: Authorship
Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.

Authorship 789195
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function.

Authorship 789147
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses.

Authorship 788777
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.

Authorship 789386
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease.

Authorship 790129
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system.

Authorship 790078
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins.

Authorship 790794
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer.

Authorship 792025
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.

Authorship 793474
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor.

Authorship 791933
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey.

Authorship 792822
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Infertility, chemical exposure, and farming in Iowa: absence of an association.

Authorship 795366
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes.

Authorship 788772
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain.

Authorship 795792
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.

Authorship 796672
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells.

Authorship 796067
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Nerve growth factor (third of three parts).

Authorship 796188
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth.

Authorship 796200
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Nerve growth factor in Alzheimer's disease: to treat or not to treat?

Authorship 797158
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome.

Authorship 797588
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Nerve growth factor and the neurotrophic factor hypothesis.

Authorship 799455
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Evidence for cholinergic neurites in senile plaques.

Authorship 797954
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

Authorship 800368
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Proteolytic modification of the beta nerve growth factor protein.

Authorship 798625
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Neurotrophic factors and neurologic disease.

Authorship 800286
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient.

Authorship 799357
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures.

Authorship 800569
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis.

Authorship 792311
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells.

Authorship 803063
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.

Authorship 801918
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: The effect of jet-milling on lyophilized liposomes.

Authorship 802158
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration.

Authorship 804074
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA.

Authorship 805333
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF.

Authorship 805898
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.

Authorship 805664
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Minimized hormones grow in stature.

Authorship 808417
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse.

Authorship 807612
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Therapeutic potential of neurotrophic factors for neurological disorders.

Authorship 807584
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C.

Authorship 808991
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections.

Authorship 814451
type: Authorship
Person has claimed publications: 0
author rank in publication: 15
linked author: Mobley, William
linked information resource: Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.

Authorship 808220
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Recent progress in developmental neurology: exploring the bench to bedside interface.

Authorship 808253
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain.

Authorship 811950
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Transgenic mouse brain histopathology resembles early Alzheimer's disease.

Authorship 794418
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome.

Authorship 812326
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.

Authorship 810224
type: Authorship
Person has claimed publications: 0
author rank in publication: 11
linked author: Mobley, William
linked information resource: Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

Authorship 811412
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Characterization and isolation of proteolytically modified nerve growth factor.

Authorship 813353
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides.

Authorship 814271
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Molecular studies in Alzheimer's disease.

Authorship 814062
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Rita Levi-Montalcini: the story of an uncommon intellect and spirit.

Authorship 817737
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.

Authorship 816494
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system.

Authorship 789144
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.

Authorship 817210
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.

Authorship 818147
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine.

Authorship 791699
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Use of intravesical cisplatin and mitomycin-C for recurrent transitional cell carcinoma of bladder refractory to thiotepa.

Authorship 793049
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: NGF effects on developing forebrain cholinergic neurons are regionally specific.

Authorship 793058
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration.

Authorship 797219
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor.

Authorship 797513
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor.

Authorship 795141
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Nerve growth factor (first of three parts).

Authorship 799321
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.

Authorship 800178
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates.

Authorship 804260
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Changes in the localization of brain prion proteins during scrapie infection.

Authorship 795248
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates.

Authorship 804843
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Acceleration of scrapie in neonatal Syrian hamsters.

Authorship 806260
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Abnormal plasma membrane properties and functions in prion-infected cell lines.

Authorship 796485
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Guillain-Barré syndrome: is there a role for plasmapheresis?

Authorship 798137
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.

Authorship 808129
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Nerve growth factor signaling, neuroprotection, and neural repair.

Authorship 798619
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Nerve growth factor signaling in caveolae-like domains at the plasma membrane.

Authorship 804094
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Comprehensive theory of Alzheimer's disease. The effects of cholesterol on membrane receptor trafficking.

Authorship 815568
type: Authorship
Person has claimed publications: 0
author rank in publication: 13
linked author: Mobley, William
linked information resource: Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.

Authorship 816339
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome.

Authorship 816750
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected].

Authorship 818137
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones.

Authorship 809511
type: Authorship
Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: Doxycycline control of prion protein transgene expression modulates prion disease in mice.

Authorship 818251
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Changes in the localization of brain prion proteins during scrapie infection.

Authorship 793000
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin.

Authorship 794657
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Early BDNF, NT-3, and NT-4 signaling events.

Authorship 799155
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.

Authorship 806668
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.

Authorship 812785
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Nerve growth factor activates persistent Rap1 signaling in endosomes.

Authorship 812966
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.

Authorship 817014
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.

Authorship 795519
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.

Authorship 796243
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum.

Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.
PubMed Identifier: 1741393
author list: Holtzman DM, Li YW, DeArmond SJ, McKinley MP, Gage FH, Epstein CJ, Mobley WC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1383-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1992-02-15T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular studies in Alzheimer's disease.
PubMed Identifier: 1877089
author list: Holtzman DM, Mobley WC
published in: Trends in biochemical sciences
information resource reference: Molecular studies in Alzheimer's disease. Trends Biochem Sci. 1991 Apr; 16(4):140-4.
journal title abbreviation: Trends Biochem Sci
publication date: 1991-04-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome.
PubMed Identifier: 1409747
author list: Holtzman DM, Li Y, Gage FH, Epstein CJ, Mobley WC
published in: Progress in clinical and biological research
information resource reference: Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome. Prog Clin Biol Res. 1992; 379:227-44.
journal title abbreviation: Prog Clin Biol Res
publication date: 1992-01-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse.
PubMed Identifier: 1148872
author list: Bjerre B, Björklund A, Mobley W, Rosengren E
published in: Brain research
information resource reference: Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse. Brain Res. 1975 Aug 29; 94(2):263-77.
journal title abbreviation: Brain Res
publication date: 1975-08-29T00:00:00
year: 1975
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor (second of three parts).
PubMed Identifier: 72356
author list: Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM
published in: The New England journal of medicine
information resource reference: Nerve growth factor (second of three parts). N Engl J Med. 1977 Nov 24; 297(21):1149-58.
journal title abbreviation: N Engl J Med
publication date: 1977-11-24T00:00:00
year: 1977
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization and isolation of proteolytically modified nerve growth factor.
PubMed Identifier: 999827
author list: Mobley WC, Schenker A, Shooter EM
published in: Biochemistry
information resource reference: Characterization and isolation of proteolytically modified nerve growth factor. Biochemistry. 1976 Dec 14; 15(25):5543-52.
journal title abbreviation: Biochemistry
publication date: 1976-12-14T00:00:00
year: 1976
type: Academic Article
type: Article
type: Document
type: Information Resource

Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat.
PubMed Identifier: 2037030
author list: Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL
published in: Experimental neurology
information resource reference: Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Exp Neurol. 1991 May; 112(2):161-73.
journal title abbreviation: Exp Neurol
publication date: 1991-05-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.
PubMed Identifier: 1524827
author list: Holtzman DM, Li Y, Parada LF, Kinsman S, Chen CK, Valletta JS, Zhou J, Long JB, Mobley WC
published in: Neuron
information resource reference: p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron. 1992 Sep; 9(3):465-78.
journal title abbreviation: Neuron
publication date: 1992-09-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.
PubMed Identifier: 2012805
author list: Fahnestock M, Woo JE, Lopez GA, Snow J, Walz DA, Arici MJ, Mobley WC
published in: Biochemistry
information resource reference: beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22. Biochemistry. 1991 Apr 09; 30(14):3443-50.
journal title abbreviation: Biochemistry
publication date: 1991-04-09T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey.
PubMed Identifier: 2269884
author list: Koliatsos VE, Nauta HJ, Clatterbuck RE, Holtzman DM, Mobley WC, Price DL
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey. J Neurosci. 1990 Dec; 10(12):3801-13.
journal title abbreviation: J Neurosci
publication date: 1990-12-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells.
PubMed Identifier: 2249737
author list: Knüsel B, Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F
published in: Experimental neurology
information resource reference: Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Exp Neurol. 1990 Dec; 110(3):274-83.
journal title abbreviation: Exp Neurol
publication date: 1990-12-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor.
PubMed Identifier: 2010817
author list: Gold BG, Mobley WC, Matheson SF
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor. J Neurosci. 1991 Apr; 11(4):943-55.
journal title abbreviation: J Neurosci
publication date: 1991-04-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates.
PubMed Identifier: 1789695
author list: Koliatsos VE, Clatterbuck RE, Nauta HJ, Knüsel B, Burton LE, Hefti FF, Mobley WC, Price DL
published in: Annals of neurology
information resource reference: Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Ann Neurol. 1991 Dec; 30(6):831-40.
journal title abbreviation: Ann Neurol
publication date: 1991-12-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor (first of three parts).
PubMed Identifier: 333290
author list: Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM
published in: The New England journal of medicine
information resource reference: Nerve growth factor (first of three parts). N Engl J Med. 1977 Nov 17; 297(20):1096-104.
journal title abbreviation: N Engl J Med
publication date: 1977-11-17T00:00:00
year: 1977
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor (third of three parts).
PubMed Identifier: 411033
author list: Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM
published in: The New England journal of medicine
information resource reference: Nerve growth factor (third of three parts). N Engl J Med. 1977 Dec 01; 297(22):1211-8.
journal title abbreviation: N Engl J Med
publication date: 1977-12-01T00:00:00
year: 1977
type: Academic Article
type: Article
type: Document
type: Information Resource

Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient.
PubMed Identifier: 206668
author list: Shapira R, Mobley WC, Thiele SB, Wilhelmi MR, Wallace A, Kibler RF
published in: Journal of neurochemistry
information resource reference: Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient. J Neurochem. 1978 Apr; 30(4):735-44.
journal title abbreviation: J Neurochem
publication date: 1978-04-01T00:00:00
year: 1978
type: Academic Article
type: Article
type: Document
type: Information Resource

Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease.
PubMed Identifier: 1838184
author list: Holtzman DM, Li YW, Gage FH, DeArmond SJ, Epstein CJ, McKinley MP, Mobley WC
published in: Progress in clinical and biological research
information resource reference: Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease. Prog Clin Biol Res. 1991; 373:189-202.
journal title abbreviation: Prog Clin Biol Res
publication date: 1991-01-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.
PubMed Identifier: 2111813
author list: Sinha S, Dovey HF, Seubert P, Ward PJ, Blacher RW, Blaber M, Bradshaw RA, Arici M, Mobley WC, Lieberburg I
published in: The Journal of biological chemistry
information resource reference: The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein. J Biol Chem. 1990 Jun 05; 265(16):8983-5.
journal title abbreviation: J Biol Chem
publication date: 1990-06-05T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.
PubMed Identifier: 2561975
author list: Mobley WC, Woo JE, Edwards RH, Riopelle RJ, Longo FM, Weskamp G, Otten U, Valletta JS, Johnston MV
published in: Neuron
information resource reference: Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen. Neuron. 1989 Nov; 3(5):655-64.
journal title abbreviation: Neuron
publication date: 1989-11-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth.
PubMed Identifier: 2752299
author list: Saffran BN, Woo JE, Mobley WC, Crutcher KA
published in: Brain research
information resource reference: Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth. Brain Res. 1989 Jul 17; 492(1-2):245-54.
journal title abbreviation: Brain Res
publication date: 1989-07-17T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides.
PubMed Identifier: 2100197
author list: Longo FM, Vu TK, Mobley WC
published in: Cell regulation
information resource reference: The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides. Cell Regul. 1990 Jan; 1(2):189-95.
journal title abbreviation: Cell Regul
publication date: 1990-01-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures.
PubMed Identifier: 2710345
author list: Hsiang J, Heller A, Hoffmann PC, Mobley WC, Wainer BH
published in: Neuroscience
information resource reference: The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures. Neuroscience. 1989; 29(1):209-23.
journal title abbreviation: Neuroscience
publication date: 1989-01-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Potential use of nerve growth factor to treat Alzheimer's disease.
PubMed Identifier: 2657468
author list: Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M
published in: Neurobiology of aging
information resource reference: Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiol Aging. 1989 Mar-Apr; 10(2):205-7.
journal title abbreviation: Neurobiol Aging
publication date: 1989-03-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor in Alzheimer's disease: to treat or not to treat?
PubMed Identifier: 2812231
author list: Mobley WC
published in: Neurobiology of aging
information resource reference: Nerve growth factor in Alzheimer's disease: to treat or not to treat? Neurobiol Aging. 1989 Sep-Oct; 10(5):578-80; discussion 588-90.
journal title abbreviation: Neurobiol Aging
publication date: 1989-09-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates.
PubMed Identifier: 2869445
author list: Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL
published in: Neuroscience
information resource reference: Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience. 1985 Nov; 16(3):691-9.
journal title abbreviation: Neuroscience
publication date: 1985-11-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.
PubMed Identifier: 2861660
author list: Mobley WC, Rutkowski JL, Tennekoon GI, Buchanan K, Johnston MV
published in: Science (New York, N.Y.)
information resource reference: Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science. 1985 Jul 19; 229(4710):284-7.
journal title abbreviation: Science
publication date: 1985-07-19T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Use of intravesical cisplatin and mitomycin-C for recurrent transitional cell carcinoma of bladder refractory to thiotepa.
PubMed Identifier: 3083555
author list: Mobley WC, Loening SA, Narayana AS, Culp DA
published in: Urology
information resource reference: Use of intravesical cisplatin and mitomycin-C for recurrent transitional cell carcinoma of bladder refractory to thiotepa. Urology. 1986 Apr; 27(4):335-9.
journal title abbreviation: Urology
publication date: 1986-04-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.
PubMed Identifier: 3742234
author list: Mobley WC, Rutkowski JL, Tennekoon GI, Gemski J, Buchanan K, Johnston MV
published in: Brain research
information resource reference: Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons. Brain Res. 1986 Jul; 387(1):53-62.
journal title abbreviation: Brain Res
publication date: 1986-07-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function.
PubMed Identifier: 2901487
author list: Long JB, Petras JM, Mobley WC, Holaday JW
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function. J Pharmacol Exp Ther. 1988 Sep; 246(3):1167-74.
journal title abbreviation: J Pharmacol Exp Ther
publication date: 1988-09-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Transgenic mouse brain histopathology resembles early Alzheimer's disease.
PubMed Identifier: 7513982
author list: Higgins LS, Holtzman DM, Rabin J, Mobley WC, Cordell B
published in: Annals of neurology
information resource reference: Transgenic mouse brain histopathology resembles early Alzheimer's disease. Ann Neurol. 1994 May; 35(5):598-607.
journal title abbreviation: Ann Neurol
publication date: 1994-05-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.
PubMed Identifier: 1371464
author list: Holtzman DM, Bayney RM, Li YW, Khosrovi H, Berger CN, Epstein CJ, Mobley WC
published in: The EMBO journal
information resource reference: Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. EMBO J. 1992 Feb; 11(2):619-27.
journal title abbreviation: EMBO J
publication date: 1992-02-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome.
PubMed Identifier: 6757937
author list: Mobley WC, Wolinsky JS
published in: Progress in clinical and biological research
information resource reference: Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome. Prog Clin Biol Res. 1982; 106:159-87.
journal title abbreviation: Prog Clin Biol Res
publication date: 1982-01-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for cholinergic neurites in senile plaques.
PubMed Identifier: 6505701
author list: Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC
published in: Science (New York, N.Y.)
information resource reference: Evidence for cholinergic neurites in senile plaques. Science. 1984 Dec 21; 226(4681):1443-5.
journal title abbreviation: Science
publication date: 1984-12-21T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones.
PubMed Identifier: 4406332
author list: Stenevi U, Bjerre B, Björklund A, Mobley W
published in: Brain research
information resource reference: Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones. Brain Res. 1974 Apr 05; 69(2):217-34.
journal title abbreviation: Brain Res
publication date: 1974-04-05T00:00:00
year: 1974
type: Academic Article
type: Article
type: Document
type: Information Resource

In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain.
PubMed Identifier: 2162385
author list: Burgin KE, Waxham MN, Rickling S, Westgate SA, Mobley WC, Kelly PT
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain. J Neurosci. 1990 Jun; 10(6):1788-98.
journal title abbreviation: J Neurosci
publication date: 1990-06-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord.
PubMed Identifier: 1851446
author list: Koliatsos VE, Shelton DL, Mobley WC, Price DL
published in: Brain research
information resource reference: A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord. Brain Res. 1991 Feb 08; 541(1):121-8.
journal title abbreviation: Brain Res
publication date: 1991-02-08T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses.
PubMed Identifier: 2901486
author list: Long JB, Mobley WC, Holaday JW
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses. J Pharmacol Exp Ther. 1988 Sep; 246(3):1158-66.
journal title abbreviation: J Pharmacol Exp Ther
publication date: 1988-09-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections.
PubMed Identifier: 2503789
author list: Sharp FR, Gonzalez MF, Hisanaga K, Mobley WC, Sagar SM
published in: Neuroscience letters
information resource reference: Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections. Neurosci Lett. 1989 May 22; 100(1-3):117-22.
journal title abbreviation: Neurosci Lett
publication date: 1989-05-22T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

NGF effects on developing forebrain cholinergic neurons are regionally specific.
PubMed Identifier: 3683745
author list: Johnston MV, Rutkowski JL, Wainer BH, Long JB, Mobley WC
published in: Neurochemical research
information resource reference: NGF effects on developing forebrain cholinergic neurons are regionally specific. Neurochem Res. 1987 Nov; 12(11):985-94.
journal title abbreviation: Neurochem Res
publication date: 1987-11-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Proteolytic modification of the beta nerve growth factor protein.
PubMed Identifier: 4811070
author list: Moore JB, Mobley WC, Shooter EM
published in: Biochemistry
information resource reference: Proteolytic modification of the beta nerve growth factor protein. Biochemistry. 1974 Feb 12; 13(4):833-40.
journal title abbreviation: Biochemistry
publication date: 1974-02-12T00:00:00
year: 1974
type: Academic Article
type: Article
type: Document
type: Information Resource

A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum.
PubMed Identifier: 7976482
author list: Chen CK, Kinsman SL, Holtzman DM, Mobley WC, Johnston MV
published in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
information resource reference: A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum. Int J Dev Neurosci. 1994 Jun; 12(4):255-62.
journal title abbreviation: Int J Dev Neurosci
publication date: 1994-06-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells.
PubMed Identifier: 8276812
author list: Taylor LK, Swanson KD, Kerigan J, Mobley W, Landreth GE
published in: The Journal of biological chemistry
information resource reference: Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells. J Biol Chem. 1994 Jan 07; 269(1):308-18.
journal title abbreviation: J Biol Chem
publication date: 1994-01-07T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins.
PubMed Identifier: 7867749
author list: Burke MA, Mobley WC, Cho J, Wiegand SJ, Lindsay RM, Mufson EJ, Kordower JH
published in: Experimental neurology
information resource reference: Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins. Exp Neurol. 1994 Dec; 130(2):178-95.
journal title abbreviation: Exp Neurol
publication date: 1994-12-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Infertility, chemical exposure, and farming in Iowa: absence of an association.
PubMed Identifier: 3336927
author list: Gerber WL, de la Pena VE, Mobley WC
published in: Urology
information resource reference: Infertility, chemical exposure, and farming in Iowa: absence of an association. Urology. 1988 Jan; 31(1):46-50.
journal title abbreviation: Urology
publication date: 1988-01-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.
PubMed Identifier: 3405211
author list: Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ
published in: Molecular and cellular biology
information resource reference: Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector. Mol Cell Biol. 1988 Jun; 8(6):2456-64.
journal title abbreviation: Mol Cell Biol
publication date: 1988-06-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Combination perineal cryosurgery and external radiation therapy for adenocarcinoma of prostate.
PubMed Identifier: 6539996
author list: Mobley WC, Loening SA, Narayana AS
published in: Urology
information resource reference: Combination perineal cryosurgery and external radiation therapy for adenocarcinoma of prostate. Urology. 1984 Jul; 24(1):11-4.
journal title abbreviation: Urology
publication date: 1984-07-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine.
PubMed Identifier: 4777497
author list: Bjerre B, Björklund A, Mobley W
published in: Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948)
information resource reference: A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine. Z Zellforsch Mikrosk Anat. 1973 Dec 31; 146(1):15-43.
journal title abbreviation: Z Zellforsch Mikrosk Anat
publication date: 1973-12-31T00:00:00
year: 1973
type: Academic Article
type: Article
type: Document
type: Information Resource

Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor.
PubMed Identifier: 7543930
author list: Zhou J, Valletta JS, Grimes ML, Mobley WC
published in: Journal of neurochemistry
information resource reference: Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor. J Neurochem. 1995 Sep; 65(3):1146-56.
journal title abbreviation: J Neurochem
publication date: 1995-09-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF.
PubMed Identifier: 8873091
author list: Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, Bredt DS, Mobley WC
published in: Neurochemical research
information resource reference: Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF. Neurochem Res. 1996 Jul; 21(7):861-8.
journal title abbreviation: Neurochem Res
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons.
PubMed Identifier: 7869118
author list: Holtzman DM, Kilbridge J, Li Y, Cunningham ET, Lenn NJ, Clary DO, Reichardt LF, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. J Neurosci. 1995 Feb; 15(2):1567-76.
journal title abbreviation: J Neurosci
publication date: 1995-02-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.
PubMed Identifier: 7536822
author list: Li Y, Holtzman DM, Kromer LF, Kaplan DR, Chua-Couzens J, Clary DO, Knüsel B, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J Neurosci. 1995 Apr; 15(4):2888-905.
journal title abbreviation: J Neurosci
publication date: 1995-04-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Guillain-Barré syndrome: is there a role for plasmapheresis?
PubMed Identifier: 7191502
author list: Asbury A, Fisher R, McKhann GM, Mobley W, Server A
published in: Neurology
information resource reference: Guillain-Barré syndrome: is there a role for plasmapheresis? Neurology. 1980 Oct; 30(10):1112.
journal title abbreviation: Neurology
publication date: 1980-10-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Neurotrophic factors and neurologic disease.
PubMed Identifier: 7975562
author list: Holtzman DM, Mobley WC
published in: The Western journal of medicine
information resource reference: Neurotrophic factors and neurologic disease. West J Med. 1994 Sep; 161(3):246-54.
journal title abbreviation: West J Med
publication date: 1994-09-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.
PubMed Identifier: 8170995
author list: Zhou J, Holtzman DM, Weiner RI, Mobley WC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3824-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1994-04-26T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration.
PubMed Identifier: 8255474
author list: Holtzman DM, Li Y, Chen K, Gage FH, Epstein CJ, Mobley WC
published in: Neurology
information resource reference: Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. 1993 Dec; 43(12):2668-73.
journal title abbreviation: Neurology
publication date: 1993-12-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Therapeutic potential of neurotrophic factors for neurological disorders.
PubMed Identifier: 8797524
author list: Yuen EC, Mobley WC
published in: Annals of neurology
information resource reference: Therapeutic potential of neurotrophic factors for neurological disorders. Ann Neurol. 1996 Sep; 40(3):346-54.
journal title abbreviation: Ann Neurol
publication date: 1996-09-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Preliminary characterization of the central nervous system in partial trisomy 16 mice.
PubMed Identifier: 8545453
author list: Holtzman DM, Kilbridge J, Chen KS, Rabin J, Luche R, Carlson E, Epstein CJ, Mobley WC
published in: Progress in clinical and biological research
information resource reference: Preliminary characterization of the central nervous system in partial trisomy 16 mice. Prog Clin Biol Res. 1995; 393:227-40.
journal title abbreviation: Prog Clin Biol Res
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor.
PubMed Identifier: 8804727
author list: Neve RL, Valletta JS, Li Y, Ventosa-Michelman M, Holtzman DM, Mobley WC
published in: Brain research. Molecular brain research
information resource reference: A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor. Brain Res Mol Brain Res. 1996 Jul; 39(1-2):185-97.
journal title abbreviation: Brain Res Mol Brain Res
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor and the neurotrophic factor hypothesis.
PubMed Identifier: 8891230
author list: Yuen EC, Howe CL, Li Y, Holtzman DM, Mobley WC
published in: Brain & development
information resource reference: Nerve growth factor and the neurotrophic factor hypothesis. Brain Dev. 1996 Sep-Oct; 18(5):362-8.
journal title abbreviation: Brain Dev
publication date: 1996-09-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.
PubMed Identifier: 9315882
author list: Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J Neurosci. 1997 Oct 15; 17(20):7594-605.
journal title abbreviation: J Neurosci
publication date: 1997-10-15T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration.
PubMed Identifier: 9246468
author list: Beattie EC, Zhou J, Grimes ML, Bunnett NW, Howe CL, Mobley WC
published in: Cold Spring Harbor symposia on quantitative biology
information resource reference: A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration. Cold Spring Harb Symp Quant Biol. 1996; 61:389-406.
journal title abbreviation: Cold Spring Harb Symp Quant Biol
publication date: 1996-01-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Early BDNF, NT-3, and NT-4 signaling events.
PubMed Identifier: 10486198
author list: Yuen EC, Mobley WC
published in: Experimental neurology
information resource reference: Early BDNF, NT-3, and NT-4 signaling events. Exp Neurol. 1999 Sep; 159(1):297-308.
journal title abbreviation: Exp Neurol
publication date: 1999-09-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

The effect of jet-milling on lyophilized liposomes.
PubMed Identifier: 9487563
author list: Mobley WC
published in: Pharmaceutical research
information resource reference: The effect of jet-milling on lyophilized liposomes. Pharm Res. 1998 Jan; 15(1):149-52.
journal title abbreviation: Pharm Res
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.
PubMed Identifier: 9628766
author list: Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM
published in: Experimental neurology
information resource reference: Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp Neurol. 1998 Jun; 151(2):314-25.
journal title abbreviation: Exp Neurol
publication date: 1998-06-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.
PubMed Identifier: 8917591
author list: Holtzman DM, Santucci D, Kilbridge J, Chua-Couzens J, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sun Y, Carlson E, Alleva E, Epstein CJ, Mobley WC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13333-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-11-12T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Recent progress in developmental neurology: exploring the bench to bedside interface.
PubMed Identifier: 8782977
author list: Mobley WC
published in: Current opinion in neurology
information resource reference: Recent progress in developmental neurology: exploring the bench to bedside interface. Curr Opin Neurol. 1996 Apr; 9(2):107-112.
journal title abbreviation: Curr Opin Neurol
publication date: 1996-04-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment.
PubMed Identifier: 10087069
author list: Cooper JD, Messer A, Feng AK, Chua-Couzens J, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment. J Neurosci. 1999 Apr 01; 19(7):2556-67.
journal title abbreviation: J Neurosci
publication date: 1999-04-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves.
PubMed Identifier: 9415162
author list: Yuen EC, Mobley WC
published in: Molecular medicine today
information resource reference: Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves. Mol Med Today. 1995 Sep; 1(6):278-86.
journal title abbreviation: Mol Med Today
publication date: 1995-09-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin.
PubMed Identifier: 9216986
author list: Holtzman DM, Kilbridge J, Bredt DS, Black SM, Li Y, Clary DO, Reichardt LF, Mobley WC
published in: Neurobiology of disease
information resource reference: NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin. Neurobiol Dis. 1994 Nov; 1(1-2):51-60.
journal title abbreviation: Neurobiol Dis
publication date: 1994-11-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Minimized hormones grow in stature.
PubMed Identifier: 9631056
author list: Longo FM, Mobley WC
published in: Nature biotechnology
information resource reference: Minimized hormones grow in stature. Nat Biotechnol. 1996 Sep; 14(9):1092.
journal title abbreviation: Nat Biotechnol
publication date: 1996-09-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.
PubMed Identifier: 9275225
author list: Grimes ML, Beattie E, Mobley WC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9909-14.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1997-09-02T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.
PubMed Identifier: 11504920
author list: Cooper JD, Salehi A, Delcroix JD, Howe CL, Belichenko PV, Chua-Couzens J, Kilbridge JF, Carlson EJ, Epstein CJ, Mobley WC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10439-44.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2001-08-14T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway.
PubMed Identifier: 11738027
author list: Howe CL, Valletta JS, Rusnak AS, Mobley WC
published in: Neuron
information resource reference: NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron. 2001 Dec 06; 32(5):801-14.
journal title abbreviation: Neuron
publication date: 2001-12-06T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis.
PubMed Identifier: 11332772
author list: Cooper JD, Mobley WC
published in: Advances in genetics
information resource reference: Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis. Adv Genet. 2001; 45:169-82.
journal title abbreviation: Adv Genet
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor signaling in caveolae-like domains at the plasma membrane.
PubMed Identifier: 10593976
author list: Huang CS, Zhou J, Feng AK, Lynch CC, Klumperman J, DeArmond SJ, Mobley WC
published in: The Journal of biological chemistry
information resource reference: Nerve growth factor signaling in caveolae-like domains at the plasma membrane. J Biol Chem. 1999 Dec 17; 274(51):36707-14.
journal title abbreviation: J Biol Chem
publication date: 1999-12-17T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.
PubMed Identifier: 9600952
author list: Sago H, Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6256-61.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1998-05-26T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Comprehensive theory of Alzheimer's disease. The effects of cholesterol on membrane receptor trafficking.
PubMed Identifier: 11193786
author list: Lynch C, Mobley W
published in: Annals of the New York Academy of Sciences
information resource reference: Comprehensive theory of Alzheimer's disease. The effects of cholesterol on membrane receptor trafficking. Ann N Y Acad Sci. 2000; 924:104-11.
journal title abbreviation: Ann N Y Acad Sci
publication date: 2000-01-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor activates persistent Rap1 signaling in endosomes.
PubMed Identifier: 11466412
author list: Wu C, Lai CF, Mobley WC
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci. 2001 Aug 01; 21(15):5406-16.
journal title abbreviation: J Neurosci
publication date: 2001-08-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Rita Levi-Montalcini: the story of an uncommon intellect and spirit.
PubMed Identifier: 24288807
author list: Chao M, Cattaneo A, Mobley W
published in: Neuroscience
information resource reference: Rita Levi-Montalcini: the story of an uncommon intellect and spirit. Neuroscience. 2013 Nov 12; 252:431-7.
journal title abbreviation: Neuroscience
publication date: 2013-11-12T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.
PubMed Identifier: 15464431
author list: Kakkis E, McEntee M, Vogler C, Le S, Levy B, Belichenko P, Mobley W, Dickson P, Hanson S, Passage M
published in: Molecular genetics and metabolism
information resource reference: Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I. Mol Genet Metab. 2004 Sep-Oct; 83(1-2):163-74.
journal title abbreviation: Mol Genet Metab
publication date: 2004-09-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain.
PubMed Identifier: 16006167
author list: Belichenko PV, Dickson PI, Passage M, Jungles S, Mobley WC, Kakkis ED
published in: Molecular genetics and metabolism
information resource reference: Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain. Mol Genet Metab. 2005 Sep-Oct; 86(1-2):141-9.
journal title abbreviation: Mol Genet Metab
publication date: 2005-07-11T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice.
PubMed Identifier: 16482204
author list: Watson G, Bastacky J, Belichenko P, Buddhikot M, Jungles S, Vellard M, Mobley WC, Kakkis E
published in: Gene therapy
information resource reference: Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice. Gene Ther. 2006 Jun; 13(11):917-25.
journal title abbreviation: Gene Ther
publication date: 2006-06-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C.
PubMed Identifier: 15627744
author list: Gardiner K, Davisson MT, Pritchard M, Patterson D, Groner Y, Crnic LS, Antonarakis S, Mobley W
published in: Cytogenetic and genome research
information resource reference: Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C. Cytogenet Genome Res. 2005; 108(4):269-77.
journal title abbreviation: Cytogenet Genome Res
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1581186
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: The Role of Biomedical and Pharmaceutical Sciences in Pharmacy Education and Practice.

The Role of Biomedical and Pharmaceutical Sciences in Pharmacy Education and Practice.
PubMed Identifier: 39433130
author list: Mobley WC, Harrold MW, Hall JM, Oliveira MA, Bloom TJ
published in: American journal of pharmaceutical education
information resource reference: The Role of Biomedical and Pharmaceutical Sciences in Pharmacy Education and Practice. Am J Pharm Educ. 2024 Dec; 88(12):101312.
journal title abbreviation: Am J Pharm Educ
publication date: 2024-10-19T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1587464
type: Authorship
Person has claimed publications: 0
author rank in publication: 14
linked author: Mobley, William
linked information resource: Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.
PubMed Identifier: 39520984
author list: Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H
published in: Neuron
information resource reference: Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 2024 Dec 04; 112(23):3984-3985.
journal title abbreviation: Neuron
publication date: 2024-11-08T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
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Authorship 1593175
type: Authorship
Person has claimed publications: 0
author rank in publication: 16
linked author: Mobley, William
linked information resource: I feel your pain: higher empathy is associated with higher posterior default mode network activity.

I feel your pain: higher empathy is associated with higher posterior default mode network activity.
PubMed Identifier: 39661395
author list: Oliva V, Riegner G, Dean J, Khatib LA, Allen A, Barrows D, Chen C, Fuentes R, Jacobson A, Lopez C, Mosbey D, Reyes M, Ross J, Uvarova A, Liu T, Mobley W, Zeidan F
published in: Pain
information resource reference: I feel your pain: higher empathy is associated with higher posterior default mode network activity. Pain. 2025 Apr 01; 166(4):e60-e67.
journal title abbreviation: Pain
publication date: 2024-10-01T00:00:00
year: 2024
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type: Article
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Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society.
PubMed Identifier: 39756004
author list: Flores-Aguilar L, Hamlett ED, Araya P, Barone E, Bhattacharyya A, Carmona-Iragui M, Chan L, Christian B, Costa ACS, Costanzo F, Del Hoyo Soriano L, Dierssen M, Eichler EE, Fisher E, Galbraith M, Ghosh S, Gimenez S, Guedj F, Guidi S, Iulita MF, Mobley W, Pelleri MC, Potier MC, Rabin KR, Rachubinski A, Rebillat AS, Rubenstein E, Saternos H, Sordo L, Strydom A, Valle-Tamayo N, Waugh KA, Yu E, Zeldich E, Busciglio J, Head E
published in: Neuromolecular medicine
information resource reference: Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society. Neuromolecular Med. 2025 01 05; 27(1):5.
journal title abbreviation: Neuromolecular Med
publication date: 2025-01-05T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 842077
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling.

c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling.
PubMed Identifier: 30988348
author list: Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC
published in: Scientific reports
information resource reference: c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Sci Rep. 2019 04 15; 9(1):6070.
journal title abbreviation: Sci Rep
publication date: 2019-04-15T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
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Authorship 1599969
type: Authorship
Person has claimed publications: 0
author rank in publication: 21
linked author: Mobley, William
linked information resource: Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society.

Authorship 853136
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species.

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species.
PubMed Identifier: 31293377
author list: Chen XQ, Mobley WC
published in: Frontiers in neuroscience
information resource reference: Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species. Front Neurosci. 2019; 13:659.
journal title abbreviation: Front Neurosci
publication date: 2019-06-21T00:00:00
year: 2019
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Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose.
PubMed Identifier: 40339170
author list: Chen XQ, Zuo X, Becker A, Mobley WC
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose. Alzheimers Dement. 2025 May; 21(5):e70046.
journal title abbreviation: Alzheimers Dement
publication date: 2025-05-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.
PubMed Identifier: 40339155
author list: Chen XQ, Zuo X, Becker A, Mante M, Florio JB, Jadhav SG, Albay R, Johnstone A, Karachentsev D, Rissman R, Zhao H, Dowdy SF, Mobley WC
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome. Alzheimers Dement. 2025 May; 21(5):e70022.
journal title abbreviation: Alzheimers Dement
publication date: 2025-05-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1624433
type: Authorship
Person has claimed publications: 0
author rank in publication: 26
linked author: Mobley, William
linked information resource: Correction: An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome.

Authorship 1629749
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose.

Authorship 1629746
type: Authorship
Person has claimed publications: 0
author rank in publication: 13
linked author: Mobley, William
linked information resource: Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.

Correction: An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome.
PubMed Identifier: 40354277
author list: Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SKS, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC
published in: PloS one
information resource reference: Correction: An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome. PLoS One. 2025; 20(5):e0324280.
journal title abbreviation: PLoS One
publication date: 2025-05-12T00:00:00
year: 2025
type: Academic Article
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type: Document
type: Information Resource

Authorship 1643351
type: Authorship
Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: The history of Down syndrome-associated Alzheimer's disease; past, present, and future.

The history of Down syndrome-associated Alzheimer's disease; past, present, and future.
PubMed Identifier: 40469048
author list: Maure-Blesa L, Carmona-Iragui M, Lott I, Head E, Wisniewski T, Rafii MS, Espinosa J, Flórez J, Mobley WC, Holland A, Strydom A, Zaman S, Fortea J
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: The history of Down syndrome-associated Alzheimer's disease; past, present, and future. Alzheimers Dement. 2025 Jun; 21(6):e70158.
journal title abbreviation: Alzheimers Dement
publication date: 2025-06-01T00:00:00
year: 2025
type: Academic Article
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type: Document
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Staff Res Assoc 4
is primary position: true
position in department: Cellular and Molecular Medicine
position in division: Vc-health Sciences-schools
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HR job title: Staff Res Assoc 4
position in organization: University of California San Diego

SRA 3
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position in department: Cellular and Molecular Medicine
position in division: Vc-health Sciences-schools
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Authorship 475380
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author rank in publication: 2
linked author: Mobley, William
linked information resource: Signaling endosome hypothesis: A cellular mechanism for long distance communication.

Authorship 476059
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Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: Trafficking the NGF signal: implications for normal and degenerating neurons.

Authorship 478598
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Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals.

Authorship 483024
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: An AUPN/ANA survey of department leader opinions on the health of US academic neurology.

Authorship 485247
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Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: BPAG1n4 is essential for retrograde axonal transport in sensory neurons.

Authorship 485565
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Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Long-distance retrograde neurotrophic signaling.

Authorship 487052
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author rank in publication: 6
linked author: Mobley, William
linked information resource: Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

Authorship 487091
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Traffic at the intersection of neurotrophic factor signaling and neurodegeneration.

Authorship 487562
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Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Going the distance, or not, with neurotrophin signals.

Authorship 488072
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation.

Authorship 492268
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Ethics and the practice of brain science.

Authorship 492638
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

Authorship 493233
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.

Authorship 496801
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.

Authorship 501942
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.

Authorship 504932
type: Authorship
Person has claimed publications: 0
author rank in publication: 15
linked author: Mobley, William
linked information resource: Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.

Authorship 507505
type: Authorship
Person has claimed publications: 0
author rank in publication: 20
linked author: Mobley, William
linked information resource: Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

Authorship 508238
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: One at a time, live tracking of NGF axonal transport using quantum dots.

Authorship 508459
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Using mouse models to explore genotype-phenotype relationship in Down syndrome.

Authorship 509989
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth.

Authorship 512933
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.

Authorship 515834
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: The coming of age of axonal neurotrophin signaling endosomes.

Authorship 516124
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome.

Authorship 517442
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway.

Authorship 518286
type: Authorship
Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.

Authorship 518467
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.

Authorship 522624
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome.

Authorship 524889
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Sleep and EEG features in genetic models of Down syndrome.

Authorship 526996
type: Authorship
Person has claimed publications: 0
author rank in publication: 11
linked author: Mobley, William
linked information resource: Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis.

Authorship 528881
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.

Authorship 530142
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation.

Authorship 539093
type: Authorship
Person has claimed publications: 0
author rank in publication: 18
linked author: Mobley, William
linked information resource: Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.

Authorship 539629
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.

Authorship 541199
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks.

Authorship 545170
type: Authorship
Person has claimed publications: 0
author rank in publication: 17
linked author: Mobley, William
linked information resource: Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Authorship 547934
type: Authorship
Person has claimed publications: 0
author rank in publication: 11
linked author: Mobley, William
linked information resource: Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.

Authorship 549651
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.

Authorship 551641
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease.

Authorship 1683095
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Strategies for innovation and interdisciplinary translational research: research and career benefits and barriers.

Authorship 1672729
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Supramolecular Enhancement of Protein Analysis via the Recognition of Phenylalanine with Cucurbit[7]uril.

Authorship 1682009
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: The Leicester empathy declaration: A model for implementing empathy in healthcare.

Supramolecular Enhancement of Protein Analysis via the Recognition of Phenylalanine with Cucurbit[7]uril.
PubMed Identifier: 26565603
author list: Lee JW, Shin MH, Mobley W, Urbach AR, Kim HI
published in: Journal of the American Chemical Society
information resource reference: Supramolecular Enhancement of Protein Analysis via the Recognition of Phenylalanine with Cucurbit[7]uril. J Am Chem Soc. 2015 Dec 09; 137(48):15322-9.
journal title abbreviation: J Am Chem Soc
publication date: 2015-11-24T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

The Leicester empathy declaration: A model for implementing empathy in healthcare.
PubMed Identifier: 39173478
author list: Howick J, Mercer S, Adams J, Levett-Jones T, Mobley W, Ward A, Winter R, Halpern J
published in: Patient education and counseling
information resource reference: The Leicester empathy declaration: A model for implementing empathy in healthcare. Patient Educ Couns. 2024 Dec; 129:108391.
journal title abbreviation: Patient Educ Couns
publication date: 2024-08-10T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 556386
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator.

Authorship 561187
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Potential use of γ-secretase modulators in the treatment of Alzheimer disease.

Authorship 562046
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome.

Authorship 564937
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Mouse models for Down syndrome-associated developmental cognitive disabilities.

Authorship 567501
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.

Authorship 567837
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.

Authorship 570338
type: Authorship
Person has claimed publications: 0
author rank in publication: 15
linked author: Mobley, William
linked information resource: Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.

Authorship 572167
type: Authorship
Person has claimed publications: 0
author rank in publication: 11
linked author: Mobley, William
linked information resource: Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.

Authorship 572498
type: Authorship
Person has claimed publications: 0
author rank in publication: 33
linked author: Mobley, William
linked information resource: The challenge of connecting the dots in the B.R.A.I.N.

Authorship 576253
type: Authorship
Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.

Authorship 578471
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.

Authorship 579256
type: Authorship
Person has claimed publications: 0
author rank in publication: 1
linked author: Mobley, William
linked information resource: The evolution of academic neurology: new information will bring new meaning.

Authorship 579566
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Aging and intellectual disability: insights from mouse models of Down syndrome.

Authorship 587099
type: Authorship
Person has claimed publications: 0
author rank in publication: 12
linked author: Mobley, William
linked information resource: Down syndrome and Alzheimer's disease: Common pathways, common goals.

Authorship 588299
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.

Authorship 588481
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography.

Authorship 589997
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome.

Authorship 592396
type: Authorship
Person has claimed publications: 0
author rank in publication: 11
linked author: Mobley, William
linked information resource: A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.

Authorship 600280
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy.

Authorship 600944
type: Authorship
Person has claimed publications: 0
author rank in publication: 14
linked author: Mobley, William
linked information resource: Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.

Authorship 601183
type: Authorship
Person has claimed publications: 0
author rank in publication: 12
linked author: Mobley, William
linked information resource: Genetic dissection of the Down syndrome critical region.

Authorship 603891
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

Authorship 605345
type: Authorship
Person has claimed publications: 0
author rank in publication: 5
linked author: Mobley, William
linked information resource: Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons.

Authorship 607151
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome.

Authorship 607471
type: Authorship
Person has claimed publications: 0
author rank in publication: 9
linked author: Mobley, William
linked information resource: PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI).

Authorship 607631
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease.

Authorship 608352
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome.

Authorship 610740
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.

Authorship 624815
type: Authorship
Person has claimed publications: 0
author rank in publication: 23
linked author: Mobley, William
linked information resource: A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

Authorship 629564
type: Authorship
Person has claimed publications: 0
author rank in publication: 26
linked author: Mobley, William
linked information resource: An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.

Authorship 629682
type: Authorship
Person has claimed publications: 0
author rank in publication: 13
linked author: Mobley, William
linked information resource: Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.

Authorship 632572
type: Authorship
Person has claimed publications: 0
author rank in publication: 12
linked author: Mobley, William
linked information resource: Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception.

Authorship 633398
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014.

Authorship 635440
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Single Figure Publications: Towards a novel alternative format for scholarly communication.

Authorship 636299
type: Authorship
Person has claimed publications: 0
author rank in publication: 23
linked author: Mobley, William
linked information resource: 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.

Authorship 638272
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Dementia in Down's syndrome.

Authorship 642232
type: Authorship
Person has claimed publications: 0
author rank in publication: 6
linked author: Mobley, William
linked information resource: Mouse-based genetic modeling and analysis of Down syndrome.

Authorship 648852
type: Authorship
Person has claimed publications: 0
author rank in publication: 10
linked author: Mobley, William
linked information resource: Dissociation of Down syndrome and Alzheimer's disease effects with imaging.

Authorship 648975
type: Authorship
Person has claimed publications: 0
author rank in publication: 17
linked author: Mobley, William
linked information resource: Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.

Authorship 649906
type: Authorship
Person has claimed publications: 0
author rank in publication: 8
linked author: Mobley, William
linked information resource: GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App.

Authorship 653157
type: Authorship
Person has claimed publications: 0
author rank in publication: 7
linked author: Mobley, William
linked information resource: Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.

Authorship 655451
type: Authorship
Person has claimed publications: 0
author rank in publication: 2
linked author: Mobley, William
linked information resource: Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series.

Tau pathology differs by sex in Alzheimer's disease in Down syndrome.
PubMed Identifier: 41126730
author list: Chen XQ, Zuo X, Mobley WC
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: Tau pathology differs by sex in Alzheimer's disease in Down syndrome. Alzheimers Dement. 2025 Oct; 21(10):e70838.
journal title abbreviation: Alzheimers Dement
publication date: 2025-10-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve growth factor signaling, neuroprotection, and neural repair.
PubMed Identifier: 11520933
author list: Sofroniew MV, Howe CL, Mobley WC
published in: Annual review of neuroscience
information resource reference: Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001; 24:1217-81.
journal title abbreviation: Annu Rev Neurosci
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Traffic at the intersection of neurotrophic factor signaling and neurodegeneration.
PubMed Identifier: 12536130
author list: Salehi A, Delcroix JD, Mobley WC
published in: Trends in neurosciences
information resource reference: Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci. 2003 Feb; 26(2):73-80.
journal title abbreviation: Trends Neurosci
publication date: 2003-02-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Trafficking the NGF signal: implications for normal and degenerating neurons.
PubMed Identifier: 14699953
author list: Delcroix JD, Valletta J, Wu C, Howe CL, Lai CF, Cooper JD, Belichenko PV, Salehi A, Mobley WC
published in: Progress in brain research
information resource reference: Trafficking the NGF signal: implications for normal and degenerating neurons. Prog Brain Res. 2004; 146:3-23.
journal title abbreviation: Prog Brain Res
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Signaling endosome hypothesis: A cellular mechanism for long distance communication.
PubMed Identifier: 14704953
author list: Howe CL, Mobley WC
published in: Journal of neurobiology
information resource reference: Signaling endosome hypothesis: A cellular mechanism for long distance communication. J Neurobiol. 2004 Feb 05; 58(2):207-16.
journal title abbreviation: J Neurobiol
publication date: 2004-02-05T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals.
PubMed Identifier: 12848933
author list: Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, Mobley WC
published in: Neuron
information resource reference: NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron. 2003 Jul 03; 39(1):69-84.
journal title abbreviation: Neuron
publication date: 2003-07-03T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

BPAG1n4 is essential for retrograde axonal transport in sensory neurons.
PubMed Identifier: 14581450
author list: Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E, Yang Y
published in: The Journal of cell biology
information resource reference: BPAG1n4 is essential for retrograde axonal transport in sensory neurons. J Cell Biol. 2003 Oct 27; 163(2):223-9.
journal title abbreviation: J Cell Biol
publication date: 2003-10-27T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation.
PubMed Identifier: 15374749
author list: Pontikis CC, Cella CV, Parihar N, Lim MJ, Chakrabarti S, Mitchison HM, Mobley WC, Rezaie P, Pearce DA, Cooper JD
published in: Brain research
information resource reference: Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain Res. 2004 Oct 15; 1023(2):231-42.
journal title abbreviation: Brain Res
publication date: 2004-10-15T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

An AUPN/ANA survey of department leader opinions on the health of US academic neurology.
PubMed Identifier: 15505148
author list: Rizzo M, Mobley WC
published in: Neurology
information resource reference: An AUPN/ANA survey of department leader opinions on the health of US academic neurology. Neurology. 2004 Oct 26; 63(8):1354-6.
journal title abbreviation: Neurology
publication date: 2004-10-26T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Going the distance, or not, with neurotrophin signals.
PubMed Identifier: 15260984
author list: Reichardt LF, Mobley WC
published in: Cell
information resource reference: Going the distance, or not, with neurotrophin signals. Cell. 2004 Jul 23; 118(2):141-3.
journal title abbreviation: Cell
publication date: 2004-07-23T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.
PubMed Identifier: 15859352
author list: Villar AJ, Belichenko PV, Gillespie AM, Kozy HM, Mobley WC, Epstein CJ
published in: Mammalian genome : official journal of the International Mammalian Genome Society
information resource reference: Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome. 2005 Feb; 16(2):79-90.
journal title abbreviation: Mamm Genome
publication date: 2005-02-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Long-distance retrograde neurotrophic signaling.
PubMed Identifier: 15721743
author list: Howe CL, Mobley WC
published in: Current opinion in neurobiology
information resource reference: Long-distance retrograde neurotrophic signaling. Curr Opin Neurobiol. 2005 Feb; 15(1):40-8.
journal title abbreviation: Curr Opin Neurobiol
publication date: 2005-02-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.
PubMed Identifier: 16565160
author list: Ding J, Allen E, Wang W, Valle A, Wu C, Nardine T, Cui B, Yi J, Taylor A, Jeon NL, Chu S, So Y, Vogel H, Tolwani R, Mobley W, Yang Y
published in: Human molecular genetics
information resource reference: Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Hum Mol Genet. 2006 May 01; 15(9):1451-63.
journal title abbreviation: Hum Mol Genet
publication date: 2006-03-24T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Ethics and the practice of brain science.
PubMed Identifier: 16619416
author list: Lo B, Albert MS, Hyman S, Parens E, Wolpe PR, Mobley W
published in: Cerebrum : the Dana forum on brain science
information resource reference: Ethics and the practice of brain science. Cerebrum. 2002; 4(3):64-6.
journal title abbreviation: Cerebrum
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.
PubMed Identifier: 16801538
author list: Miyamoto Y, Yamauchi J, Tanoue A, Wu C, Mobley WC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10444-10449.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2006-06-26T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.
PubMed Identifier: 17287360
author list: Liu JJ, Ding J, Wu C, Bhagavatula P, Cui B, Chu S, Mobley WC, Yang Y
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2223-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-02-07T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

One at a time, live tracking of NGF axonal transport using quantum dots.
PubMed Identifier: 17698956
author list: Cui B, Wu C, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13666-71.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-08-14T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway.
PubMed Identifier: 17822405
author list: Wu C, Ramirez A, Cui B, Ding J, Delcroix JD, Valletta JS, Liu JJ, Yang Y, Chu S, Mobley WC
published in: Traffic (Copenhagen, Denmark)
information resource reference: A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic. 2007 Nov; 8(11):1503-20.
journal title abbreviation: Traffic
publication date: 2007-09-06T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Using mouse models to explore genotype-phenotype relationship in Down syndrome.
PubMed Identifier: 17910089
author list: Salehi A, Faizi M, Belichenko PV, Mobley WC
published in: Mental retardation and developmental disabilities research reviews
information resource reference: Using mouse models to explore genotype-phenotype relationship in Down syndrome. Ment Retard Dev Disabil Res Rev. 2007; 13(3):207-14.
journal title abbreviation: Ment Retard Dev Disabil Res Rev
publication date: 2007-01-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
PubMed Identifier: 18034774
author list: Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ
published in: Traffic (Copenhagen, Denmark)
information resource reference: Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic. 2008 Feb; 9(2):215-29.
journal title abbreviation: Traffic
publication date: 2007-12-18T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome.
PubMed Identifier: 18306326
author list: Belichenko NP, Belichenko PV, Li HH, Mobley WC, Francke U
published in: The Journal of comparative neurology
information resource reference: Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. J Comp Neurol. 2008 May 01; 508(1):184-95.
journal title abbreviation: J Comp Neurol
publication date: 2008-05-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Sleep and EEG features in genetic models of Down syndrome.
PubMed Identifier: 18282758
author list: Colas D, Valletta JS, Takimoto-Kimura R, Nishino S, Fujiki N, Mobley WC, Mignot E
published in: Neurobiology of disease
information resource reference: Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis. 2008 Apr; 30(1):1-7.
journal title abbreviation: Neurobiol Dis
publication date: 2007-07-21T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth.
PubMed Identifier: 18768694
author list: Wan J, Cheung AY, Fu WY, Wu C, Zhang M, Mobley WC, Cheung ZH, Ip NY
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci. 2008 Sep 03; 28(36):9002-12.
journal title abbreviation: J Neurosci
publication date: 2008-09-03T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

The coming of age of axonal neurotrophin signaling endosomes.
PubMed Identifier: 19028611
author list: Wu C, Cui B, He L, Chen L, Mobley WC
published in: Journal of proteomics
information resource reference: The coming of age of axonal neurotrophin signaling endosomes. J Proteomics. 2009 Feb 15; 72(1):46-55.
journal title abbreviation: J Proteomics
publication date: 2008-11-06T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation.
PubMed Identifier: 19167498
author list: Belichenko NP, Belichenko PV, Mobley WC
published in: Neurobiology of disease
information resource reference: Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiol Dis. 2009 Apr; 34(1):71-7.
journal title abbreviation: Neurobiol Dis
publication date: 2009-01-08T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Strategies for innovation and interdisciplinary translational research: research and career benefits and barriers.
PubMed Identifier: 19174698
author list: Benedyk M, Berglund L, Facciotti M, Mobley W, Zucker D
published in: Journal of investigative medicine : the official publication of the American Federation for Clinical Research
information resource reference: Strategies for innovation and interdisciplinary translational research: research and career benefits and barriers. J Investig Med. 2009 Feb; 57(2):477-81.
journal title abbreviation: J Investig Med
publication date: 2009-02-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome.
PubMed Identifier: 19636252
author list: Mégarbané A, Ravel A, Mircher C, Sturtz F, Grattau Y, Rethoré MO, Delabar JM, Mobley WC
published in: Genetics in medicine : official journal of the American College of Medical Genetics
information resource reference: The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet Med. 2009 Sep; 11(9):611-6.
journal title abbreviation: Genet Med
publication date: 2009-09-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis.
PubMed Identifier: 19733542
author list: Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, Uchida N
published in: Cell stem cell
information resource reference: Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 04; 5(3):310-9.
journal title abbreviation: Cell Stem Cell
publication date: 2009-09-04T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.
PubMed Identifier: 20512340
author list: Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE
published in: Mammalian genome : official journal of the International Mammalian Genome Society
information resource reference: Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome. 2010 Jun; 21(5-6):258-67.
journal title abbreviation: Mamm Genome
publication date: 2010-05-29T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

The evolution of academic neurology: new information will bring new meaning.
PubMed Identifier: 22083800
author list: Mobley W, N Rosenberg R
published in: Archives of neurology
information resource reference: The evolution of academic neurology: new information will bring new meaning. Arch Neurol. 2012 Mar; 69(3):308-14.
journal title abbreviation: Arch Neurol
publication date: 2011-11-14T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography.
PubMed Identifier: 24561719
author list: Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W
published in: Journal of visualized experiments : JoVE
information resource reference: Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp. 2014 Feb 12; (84):e50783.
journal title abbreviation: J Vis Exp
publication date: 2014-02-12T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome.
PubMed Identifier: 24782952
author list: Decourt B, Mobley W, Reiman E, Shah RJ, Sabbagh MN
published in: Journal of Alzheimer's disease & Parkinsonism
information resource reference: Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome. J Alzheimers Dis Parkinsonism. 2013 Mar 20; Suppl 7:002.
journal title abbreviation: J Alzheimers Dis Parkinsonism
publication date: 2013-03-20T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease.
PubMed Identifier: 25063430
author list: Zhang H, Petit GH, Gaughwin PM, Hansen C, Ranganathan S, Zuo X, Smith R, Roybon L, Brundin P, Mobley WC, Li JY
published in: Journal of Huntington's disease
information resource reference: NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease. J Huntingtons Dis. 2013; 2(1):69-82.
journal title abbreviation: J Huntingtons Dis
publication date: 2013-01-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Down syndrome and Alzheimer's disease: Common pathways, common goals.
PubMed Identifier: 25510383
author list: Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T
published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
information resource reference: Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun; 11(6):700-9.
journal title abbreviation: Alzheimers Dement
publication date: 2014-12-12T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome.
PubMed Identifier: 26664707
author list: Do LH, Mobley WC, Singhal N
published in: F1000Research
information resource reference: Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome. F1000Res. 2015; 4:269.
journal title abbreviation: F1000Res
publication date: 2015-07-17T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.
PubMed Identifier: 27195491
author list: Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ
published in: PLoS genetics
information resource reference: A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet. 2016 05; 12(5):e1006033.
journal title abbreviation: PLoS Genet
publication date: 2016-05-19T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Dementia in Down's syndrome.
PubMed Identifier: 27302127
author list: Ballard C, Mobley W, Hardy J, Williams G, Corbett A
published in: The Lancet. Neurology
information resource reference: Dementia in Down's syndrome. Lancet Neurol. 2016 05; 15(6):622-36.
journal title abbreviation: Lancet Neurol
publication date: 2016-04-11T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Single Figure Publications: Towards a novel alternative format for scholarly communication.
PubMed Identifier: 27506233
author list: Do L, Mobley W
published in: F1000Research
information resource reference: Single Figure Publications: Towards a novel alternative format for scholarly communication. F1000Res. 2015; 4:268.
journal title abbreviation: F1000Res
publication date: 2015-07-17T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Mouse-based genetic modeling and analysis of Down syndrome.
PubMed Identifier: 27789459
author list: Xing Z, Li Y, Pao A, Bennett AS, Tycko B, Mobley WC, Yu YE
published in: British medical bulletin
information resource reference: Mouse-based genetic modeling and analysis of Down syndrome. Br Med Bull. 2016 12; 120(1):111-122.
journal title abbreviation: Br Med Bull
publication date: 2016-10-27T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series.
PubMed Identifier: 28587118
author list: Bradshaw RA, Mobley W, Rush RA
published in: International journal of molecular sciences
information resource reference: Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series. Int J Mol Sci. 2017 May 26; 18(6).
journal title abbreviation: Int J Mol Sci
publication date: 2017-05-26T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.
PubMed Identifier: 29031834
author list: Chen XQ, Sawa M, Mobley WC
published in: Free radical biology & medicine
information resource reference: Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome. Free Radic Biol Med. 2018 01; 114:52-61.
journal title abbreviation: Free Radic Biol Med
publication date: 2017-10-12T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception.
PubMed Identifier: 29483280
author list: Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 04 04; 38(14):3394-3413.
journal title abbreviation: J Neurosci
publication date: 2018-02-26T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014.
PubMed Identifier: 29609879
author list: Jiang X, Xiao H, Segal R, Mobley WC, Park H
published in: Clinical therapeutics
information resource reference: Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014. Clin Ther. 2018 04; 40(4):613-626.e1.
journal title abbreviation: Clin Ther
publication date: 2018-03-31T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.
PubMed Identifier: 29576115
author list: Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP
published in: British journal of anaesthesia
information resource reference: Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr; 120(4):745-760.
journal title abbreviation: Br J Anaesth
publication date: 2018-02-15T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor of Clinical Pediatrics and Neurology
is primary position: true
position in department: Medicine
position in division: Keck School of Medicine of Usc
sort order: 1
type: Position
HR job title: Associate Professor of Clinical Pediatrics and Neurology
position in organization: University of Southern California

Authorship 1762623
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Tau pathology differs by sex in Alzheimer's disease in Down syndrome.

Authorship 1749930
type: Authorship
Person has claimed publications: 0
author rank in publication: 3
linked author: Mobley, William
linked information resource: Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology.

Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology.
PubMed Identifier: 41305930
author list: Zeidan F, Stern JD, Mobley WC
published in: Annals of neurology
information resource reference: Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology. Ann Neurol. 2026 Jan; 99(1):35-48.
journal title abbreviation: Ann Neurol
publication date: 2025-11-26T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

https://researcherprofiles.org/profile/761250196
ProfilesRNS Plugin Searchable Data: Clinical Trials
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https://researcherprofiles.org/profile/761253978
ProfilesRNS Plugin Searchable Data: Clinical Trials
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Authorship 944262
type: Authorship
Person has claimed publications: 0
author rank in publication: 4
linked author: Mobley, William
linked information resource: Down syndrome.

Down syndrome.
PubMed Identifier: 31753140
author list: Rafii MS, Kleschevnikov AM, Sawa M, Mobley WC
published in: Handbook of clinical neurology
information resource reference: Down syndrome. Handb Clin Neurol. 2019; 167:321-336.
journal title abbreviation: Handb Clin Neurol
publication date: 2019-01-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor
sort order: 30
type: Faculty Rank

Postdoctoral Scholar
sort order: 70
type: Faculty Rank

Other Academic/Other
sort order: 90
type: Faculty Rank

Professor
sort order: 10
type: Faculty Rank

Authorship 957942
type: Authorship
Person has claimed publications: 0
author rank in publication: 11
linked author: Mobley, William
linked information resource: Enabling Technologies for Personalized and Precision Medicine.

Enabling Technologies for Personalized and Precision Medicine.
PubMed Identifier: 31980301
author list: Ho D, Quake SR, McCabe ERB, Chng WJ, Chow EK, Ding X, Gelb BD, Ginsburg GS, Hassenstab J, Ho CM, Mobley WC, Nolan GP, Rosen ST, Tan P, Yen Y, Zarrinpar A
published in: Trends in biotechnology
information resource reference: Enabling Technologies for Personalized and Precision Medicine. Trends Biotechnol. 2020 05; 38(5):497-518.
journal title abbreviation: Trends Biotechnol
publication date: 2020-01-21T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource