Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease
(H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling. J Clin Invest. 2020 05 01; 130(5):2195-2198.
(H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling.
3 D Electron Microscopy of Macromolecules
NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION
University of California San Diego Neuroscience Microscopy Imaging Core
Training in Translational Develomental Neuroscience
Translating discoveries in neurological diseases of infancy and childhood
Genetic Basis of Failed Cognition in Young and Aged Mouse Models of Trisomy 21
Disrupted Transport of NGF-TrKA Signaling in Mouse Models of Down Syndrome
Nerve Growth Factor-Mechanisms for Signal Transduction
2009 Neurotrophic Factors Gordon Research Conference
Scientific Review and Evaluation Award - NST Committee
From Structure to Therapy: The TRiC Chaperonin Network in Huntington's Disease
NERVE GROWTH FACTOR--EFFECTS ON DEVELOPING CNS NEURONS
NEUROTROPHIC FACTOR THERAPY FOR ALZHEIMERS DISEASE
Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2012 Feb; 45(2):683-91.
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.
DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner SB
Changes in the localization of brain prion proteins during scrapie infection. Neurology. 1987 Aug; 37(8):1271-80.
Changes in the localization of brain prion proteins during scrapie infection.
Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS
Alzheimer's & dementia : the journal of the Alzheimer's Association
Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077.
Further understanding the connection between Alzheimer's disease and Down syndrome.
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD
Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556.
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
Alzheimer's Association National Plan Milestone Workgroup, Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimers Dement. 2014 Oct; 10(5 Suppl):S430-52.
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
Nosheny RL, Belichenko PV, Busse BL, Weissmiller AM, Dang V, Das D, Fahimi A, Salehi A, Smith SJ, Mobley WC
Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome. Neurobiol Dis. 2015 May; 77:173-90.
Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome.
Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC
An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS One. 2016; 11(3):e0152471.
An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.
Minocycline Topical Foam: A New Drug for the Treatment of Acne. Ann Pharmacother. 2021 01; 55(1):105-110.
Minocycline Topical Foam: A New Drug for the Treatment of Acne.
Stupack J, Xiong XP, Jiang LL, Zhang T, Zhou L, Campos A, Ranscht B, Mobley W, Pasquale EB, Xu H, Huang TY
The Journal of neuroscience : the official journal of the Society for Neuroscience
Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis. J Neurosci. 2020 07 29; 40(31):5908-5921.
Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.
Mischel PS, Smith SG, Vining ER, Valletta JS, Mobley WC, Reichardt LF
The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. J Biol Chem. 2001 Apr 06; 276(14):11294-301.
The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA.
Kleschevnikov AM, Belichenko PV, Villar AJ, Epstein CJ, Malenka RC, Mobley WC
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci. 2004 Sep 15; 24(37):8153-60.
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol. 2004 Dec 13; 480(3):281-98.
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42.
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol. 2007 Oct 01; 504(4):329-45.
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol. 2009 Feb 01; 512(4):453-66.
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17.
Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons.
Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC, Francke U
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. J Comp Neurol. 2009 May 20; 514(3):240-58.
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks.
Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci. 2009 May 06; 29(18):5938-48.
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.
Salehi A, Faizi M, Colas D, Valletta J, Laguna J, Takimoto-Kimura R, Kleschevnikov A, Wagner SL, Aisen P, Shamloo M, Mobley WC
Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med. 2009 Nov 18; 1(7):7ra17.
Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80.
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res. 2010 Dec 17; 1366:162-71.
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem. 2011 May; 117(4):613-22.
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease.
Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis. 2011 Aug; 43(2):397-413.
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.
Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA
Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Org Lett. 2011 Sep 02; 13(17):4554-7.
Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator.
Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE
Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci. 2011; 33(5):404-13.
Mouse models for Down syndrome-associated developmental cognitive disabilities.
Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs. 2012 Jan 01; 3(1):8-12.
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Curr Opin Neurobiol. 2012 Oct; 22(5):880-6.
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome.
Wagner SL, Tanzi RE, Mobley WC, Galasko D
Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Arch Neurol. 2012 Oct; 69(10):1255-8.
Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
Kleschevnikov AM, Belichenko PV, Faizi M, Jacobs LF, Htun K, Shamloo M, Mobley WC
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci. 2012 Jul 04; 32(27):9217-27.
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.
Chemistry (Weinheim an der Bergstrasse, Germany)
Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry. 2013 May 10; 19(20):6398-408.
Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80.
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Developmental disabilities research reviews
Aging and intellectual disability: insights from mouse models of Down syndrome. Dev Disabil Res Rev. 2013; 18(1):43-50.
Aging and intellectual disability: insights from mouse models of Down syndrome.
Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG
The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4.
The challenge of connecting the dots in the B.R.A.I.N.
Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Hum Mol Genet. 2014 Feb 01; 23(3):578-89.
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.
Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 2014 Feb 04; 53(4):702-13.
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C
Journal of visualized experiments : JoVE
Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp. 2014 Sep 15; (91):51899.
Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons.
Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C
A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379.
A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC
Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. PLoS One. 2015; 10(7):e0134861.
Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.
Selfridge A, Hyun N, Chiang CC, Reyna SM, Weissmiller AM, Shi LZ, Preece D, Mobley WC, Berns MW
Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy. Neurophotonics. 2015 Jan; 2(1):015006.
Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy.
Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 2015 Sep 02; 87(5):963-75.
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.
Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, Belichenko PV, Kleschevnikov AM, Pao A, Peresie J, Wie S, Mobley WC, Yu YE
Genetic dissection of the Down syndrome critical region. Hum Mol Genet. 2015 Nov 15; 24(22):6540-51.
Genetic dissection of the Down syndrome critical region.
Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA
The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239.
The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome.
Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C
Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 05 02; 126(5):1815-33.
Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.
Mojabi FS, Fahimi A, Moghadam S, Moghadam S, Windy McNerneny M, Ponnusamy R, Kleschevnikov A, Mobley WC, Salehi A
GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App. Hippocampus. 2016 12; 26(12):1641-1654.
GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App.
Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zeng Z, Yu YE, Mobley WC
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2017 Jul; 103:1-10.
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE
The Journal of pharmacology and experimental therapeutics
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44.
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS
Alzheimer's & dementia (New York, N. Y.)
Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81.
Dissociation of Down syndrome and Alzheimer's disease effects with imaging.
Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC, Down Syndrome Biomarker Initiative and the Alzheimer’s Disease Neuroimaging Initiative
PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450.
PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI).
Grimes ML, Zhou J, Beattie EC, Yuen EC, Hall DE, Valletta JS, Topp KS, LaVail JH, Bunnett NW, Mobley WC
Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci. 1996 Dec 15; 16(24):7950-64.
Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes.
Local TrkB signaling: themes in development and neural plasticity. Cell Tissue Res. 2020 Oct; 382(1):101-111.
Local TrkB signaling: themes in development and neural plasticity.
Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC
Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2021 02; 17(2):271-292.
Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.
Schätzl HM, Laszlo L, Holtzman DM, Tatzelt J, DeArmond SJ, Weiner RI, Mobley WC, Prusiner SB
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. J Virol. 1997 Nov; 71(11):8821-31.
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.
Editorial for the special issue neurotrophic factors. Cell Tissue Res. 2020 10; 382(1):1-4.
Editorial for the special issue neurotrophic factors.
Changes in the localization of brain prion proteins during scrapie infection. Neurology. 1998 Jan; 50(1):1271-80; discussion 2.
DeArmond SJ, Qiu Y, Wong K, Nixon R, Hyun W, Prusiner SB, Mobley WC
Cold Spring Harbor symposia on quantitative biology
Abnormal plasma membrane properties and functions in prion-infected cell lines. Cold Spring Harb Symp Quant Biol. 1996; 61:531-40.
Abnormal plasma membrane properties and functions in prion-infected cell lines.
Tremblay P, Meiner Z, Galou M, Heinrich C, Petromilli C, Lisse T, Cayetano J, Torchia M, Mobley W, Bujard H, DeArmond SJ, Prusiner SB
Proceedings of the National Academy of Sciences of the United States of America
Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12580-5.
Doxycycline control of prion protein transgene expression modulates prion disease in mice.
Butte MJ, Hwang PK, Mobley WC, Fletterick RJ
Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 1998 Dec 01; 37(48):16846-52.
Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.
Wilde A, Beattie EC, Lem L, Riethof DA, Liu SH, Mobley WC, Soriano P, Brodsky FM
EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell. 1999 Mar 05; 96(5):677-87.
EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.
Taiwo YO, Levine JD, Burch RM, Woo JE, Mobley WC
Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5144-8.
Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor.
Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 11 15; 28(22):115734.
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
Mitchison HM, Bernard DJ, Greene ND, Cooper JD, Junaid MA, Pullarkat RK, de Vos N, Breuning MH, Owens JW, Mobley WC, Gardiner RM, Lake BD, Taschner PE, Nussbaum RL
Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]. Neurobiol Dis. 1999 Oct; 6(5):321-34.
Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected].
Villoslada P, Hauser SL, Bartke I, Unger J, Heald N, Rosenberg D, Cheung SW, Mobley WC, Fisher S, Genain CP
Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. J Exp Med. 2000 May 15; 191(10):1799-806.
Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system.
Beattie EC, Howe CL, Wilde A, Brodsky FM, Mobley WC
NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. J Neurosci. 2000 Oct 01; 20(19):7325-33.
NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.
Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5655-64.
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.
McKinley MP, Longo FM, Valletta JS, Rahbar F, Neve RL, Prusiner SB, Mobley WC
Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system. Prog Brain Res. 1990; 86:227-38.
Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system.
Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol. 2008; 38 Suppl 2:1-125.
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.
McKinley MP, DeArmond SJ, Torchia M, Mobley WC, Prusiner SB
Acceleration of scrapie in neonatal Syrian hamsters. Neurology. 1989 Oct; 39(10):1319-24.
Acceleration of scrapie in neonatal Syrian hamsters.
De Armond SJ, Gonzales M, Mobley WC, Kon AA, Stern A, Prusiner H, Prusiner SB
Progress in clinical and biological research
PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer. Prog Clin Biol Res. 1989; 317:601-18.
PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer.
Mobley WC, Neve RL, Prusiner SB, McKinley MP
Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9811-5.
Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.
Takahashi T, Sakai N, Iwasaki T, Doyle TC, Mobley WC, Nishino S
Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome. Sci Rep. 2020 12 07; 10(1):21323.
Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome.
Multiplexed Single Nucleus RNA and ATAC-seq Sequencing and Cortical Organoids: Transformative Insights into Down Syndrome
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. Alzheimers Res Ther. 2021 03 10; 13(1):59.
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4).
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E
Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 12; 23(4):561-571.
Specific Susceptibility to COVID-19 in Adults with Down Syndrome.
Santoro SL, Campbell A, Balasubramanian A, Haugen K, Schafer K, Mobley W
American journal of medical genetics. Part A
Specialty clinics for adults with Down syndrome: A clinic survey. Am J Med Genet A. 2021 06; 185(6):1767-1775.
Specialty clinics for adults with Down syndrome: A clinic survey.
Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W
Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9).
Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study.
Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec; 23(4):572-573.
Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.
Hendrix JA, Amon A, Abbeduto L, Agiovlasitis S, Alsaied T, Anderson HA, Bain LJ, Baumer N, Bhattacharyya A, Bogunovic D, Botteron KN, Capone G, Chandan P, Chase I, Chicoine B, Cieuta-Walti C, DeRuisseau LR, Durand S, Esbensen A, Fortea J, Giménez S, Granholm AC, Hahn LJ, Head E, Hillerstrom H, Jacola LM, Janicki MP, Jasien JM, Kamer AR, Kent RD, Khor B, Lawrence JB, Lemonnier C, Lewanda AF, Mobley W, Moore PE, Nelson LP, Oreskovic NM, Osorio RS, Patterson D, Rasmussen SA, Reeves RH, Roizen N, Santoro S, Sherman SL, Talib N, Tapia IE, Walsh KM, Warren SF, White AN, Wong GW, Yi JS
Opportunities, barriers, and recommendations in down syndrome research. Transl Sci Rare Dis. 2021; 5(3-4):99-129.
Opportunities, barriers, and recommendations in down syndrome research.
Illouz T, Biragyn A, Iulita MF, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, London J, Mobley W, Strydom A, Okun E
Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome. Front Immunol. 2021; 12:621440.
Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.
Chen XQ, Xing Z, Chen QD, Salvi RJ, Zhang X, Tycko B, Mobley WC, Yu YE
Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome. Front Aging Neurosci. 2021; 13:700280.
Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome.
Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A
Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul; 12(4):202-218.
Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.
Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C
T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 11; 19(11):840-853.
T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation.
Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC
Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimers Dement. 2022 06; 18(6):1203-1234.
Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.
Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec; 23(4):574-575.
Annual review of pharmacology and toxicology
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders. Annu Rev Pharmacol Toxicol. 2022 01 06; 62:211-233.
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.
Rafii MS, Sol O, Mobley WC, Delpretti S, Skotko BG, Burke AD, Sabbagh MN, Yuan SH, Rissman RA, Pulsifer M, Evans C, Evans AC, Beth G, Fournier N, Gray JA, Dos Santos AM, Hliva V, Vukicevic M, Kosco-Vilbois M, Streffer J, Pfeifer A, Feldman HH
Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial. JAMA Neurol. 2022 06 01; 79(6):565-574.
Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial.
Chen XQ, Zuo X, Becker A, Head E, Mobley WC
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. Alzheimers Dement. 2023 05; 19(5):2095-2116.
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.
Riegner G, Posey G, Oliva V, Jung Y, Mobley W, Zeidan F
Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling. Pain. 2023 02 01; 164(2):280-291.
Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling.
Schairer CE, Tutjer J, Cannavino C, Mobley WC, Eyler L, Bloss CS
Learning to Practice Compassionate Care: Medical Students Discuss Their Most Memorable Lessons. J Patient Exp. 2022; 9:23743735221117383.
Learning to Practice Compassionate Care: Medical Students Discuss Their Most Memorable Lessons.
Wu GH, Smith-Geater C, Galaz-Montoya JG, Gu Y, Gupte SR, Aviner R, Mitchell PG, Hsu J, Miramontes R, Wang KQ, Geller NR, Hou C, Danita C, Joubert LM, Schmid MF, Yeung S, Frydman J, Mobley W, Wu C, Thompson LM, Chiu W
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons. Nat Commun. 2023 02 08; 14(1):692.
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons.
Moya-Alvarado G, Tiburcio-Felix R, Ibáñez MR, Aguirre-Soto AA, Guerra MV, Wu C, Mobley WC, Perlson E, Bronfman FC
BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons. Elife. 2023 02 24; 12.
BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons.
Chen XQ, Sawa M, Becker A, Karachentsev D, Zuo X, Rynearson KD, Tanzi RE, Mobley WC
Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator. Ann Neurol. 2023 08; 94(2):245-258.
Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.
Editorial: Current advances in the study of Down Syndrome: From development to aging. Front Neurosci. 2023; 17:1161147.
Editorial: Current advances in the study of Down Syndrome: From development to aging.
Overk C, Fiorini E, Babolin C, Vukicevic M, Morici C, Madani R, Eligert V, Kosco-Vilbois M, Roberts A, Becker A, Pfeifer A, Mobley WC
Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior. Front Neurosci. 2023; 17:1202208.
Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior.
Hao Y, Hu J, Xue Y, Dowdy SF, Mobley WC, Qian H, Fu XD
Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion. Nature. 2023 06; 618(7964):E8-E13.
Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion.
Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain. Annu Rev Neurosci. 2023 07 10; 46:145-165.
Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain.
Oliva V, Riegner G, Dean J, Khatib LA, Allen A, Barrows D, Chen C, Fuentes R, Jacobson A, Lopez C, Mosbey D, Reyes M, Ross J, Uvarova A, Liu T, Mobley W, Zeidan F
bioRxiv : the preprint server for biology
WITHDRAWN: I feel your pain: Higher empathy is associated with higher posterior default mode network activity. bioRxiv. 2023 Dec 28.
WITHDRAWN: I feel your pain: Higher empathy is associated with higher posterior default mode network activity.
Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MC, Franco ML, Özcan B, Moreira DG, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L
Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. bioRxiv. 2024 Apr 23.
Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling.
Valdes P, Henry KW, Fitzgerald MQ, Muralidharan K, Caldwell AB, Ramachandran S, Goldstein LSB, Mobley WC, Galasko DR, Subramaniam S
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease. Mol Brain. 2023 11 03; 16(1):75.
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease.
Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration. Nat Aging. 2024 Mar; 4(3):309-318.
Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration.
Antisense Oligonucleotides targeting APP to prevent neurodegeneration in models of Down Syndrome and Alzheimer's disease
Gu Y, Pope A, Smith C, Carmona C, Johnstone A, Shi L, Chen X, Santos S, Bacon-Brenes CC, Shoff T, Kleczko KM, Frydman J, Thompson LM, Mobley WC, Wu C
BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease. Neurobiol Dis. 2024 06 01; 195:106502.
BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease.
Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC
γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome. Ann Neurol. 2024 Aug; 96(2):390-404.
γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.
Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MCQ, Franco ML, Özcan B, Gomes Moreira D, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L
Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. Elife. 2024 Jul 19; 12.
Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Front Neurosci. 2019; 13:446.
Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses.
Associate Professor of Clinical Pediatrics and Neurology
Holtzman DM, Li YW, DeArmond SJ, McKinley MP, Gage FH, Epstein CJ, Mobley WC
Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1383-7.
Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.
Molecular studies in Alzheimer's disease. Trends Biochem Sci. 1991 Apr; 16(4):140-4.
Molecular studies in Alzheimer's disease.
Holtzman DM, Li Y, Gage FH, Epstein CJ, Mobley WC
Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome. Prog Clin Biol Res. 1992; 379:227-44.
Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome.
Bjerre B, Björklund A, Mobley W, Rosengren E
Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse. Brain Res. 1975 Aug 29; 94(2):263-77.
Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse.
Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM
Nerve growth factor (second of three parts). N Engl J Med. 1977 Nov 24; 297(21):1149-58.
Nerve growth factor (second of three parts).
Characterization and isolation of proteolytically modified nerve growth factor. Biochemistry. 1976 Dec 14; 15(25):5543-52.
Characterization and isolation of proteolytically modified nerve growth factor.
Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL
Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Exp Neurol. 1991 May; 112(2):161-73.
Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat.
Holtzman DM, Li Y, Parada LF, Kinsman S, Chen CK, Valletta JS, Zhou J, Long JB, Mobley WC
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron. 1992 Sep; 9(3):465-78.
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.
Fahnestock M, Woo JE, Lopez GA, Snow J, Walz DA, Arici MJ, Mobley WC
beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22. Biochemistry. 1991 Apr 09; 30(14):3443-50.
beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.
Koliatsos VE, Nauta HJ, Clatterbuck RE, Holtzman DM, Mobley WC, Price DL
Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey. J Neurosci. 1990 Dec; 10(12):3801-13.
Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey.
Knüsel B, Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F
Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Exp Neurol. 1990 Dec; 110(3):274-83.
Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells.
Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor. J Neurosci. 1991 Apr; 11(4):943-55.
Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor.
Koliatsos VE, Clatterbuck RE, Nauta HJ, Knüsel B, Burton LE, Hefti FF, Mobley WC, Price DL
Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Ann Neurol. 1991 Dec; 30(6):831-40.
Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates.
Nerve growth factor (first of three parts). N Engl J Med. 1977 Nov 17; 297(20):1096-104.
Nerve growth factor (first of three parts).
Nerve growth factor (third of three parts). N Engl J Med. 1977 Dec 01; 297(22):1211-8.
Nerve growth factor (third of three parts).
Shapira R, Mobley WC, Thiele SB, Wilhelmi MR, Wallace A, Kibler RF
Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient. J Neurochem. 1978 Apr; 30(4):735-44.
Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient.
Holtzman DM, Li YW, Gage FH, DeArmond SJ, Epstein CJ, McKinley MP, Mobley WC
Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease. Prog Clin Biol Res. 1991; 373:189-202.
Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease.
Sinha S, Dovey HF, Seubert P, Ward PJ, Blacher RW, Blaber M, Bradshaw RA, Arici M, Mobley WC, Lieberburg I
The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein. J Biol Chem. 1990 Jun 05; 265(16):8983-5.
The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.
Mobley WC, Woo JE, Edwards RH, Riopelle RJ, Longo FM, Weskamp G, Otten U, Valletta JS, Johnston MV
Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen. Neuron. 1989 Nov; 3(5):655-64.
Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.
Saffran BN, Woo JE, Mobley WC, Crutcher KA
Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth. Brain Res. 1989 Jul 17; 492(1-2):245-54.
Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth.
The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides. Cell Regul. 1990 Jan; 1(2):189-95.
The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides.
Hsiang J, Heller A, Hoffmann PC, Mobley WC, Wainer BH
The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures. Neuroscience. 1989; 29(1):209-23.
The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures.
Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M
Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiol Aging. 1989 Mar-Apr; 10(2):205-7.
Potential use of nerve growth factor to treat Alzheimer's disease.
Nerve growth factor in Alzheimer's disease: to treat or not to treat? Neurobiol Aging. 1989 Sep-Oct; 10(5):578-80; discussion 588-90.
Nerve growth factor in Alzheimer's disease: to treat or not to treat?
Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL
Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience. 1985 Nov; 16(3):691-9.
Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates.
Mobley WC, Rutkowski JL, Tennekoon GI, Buchanan K, Johnston MV
Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science. 1985 Jul 19; 229(4710):284-7.
Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.
Mobley WC, Loening SA, Narayana AS, Culp DA
Use of intravesical cisplatin and mitomycin-C for recurrent transitional cell carcinoma of bladder refractory to thiotepa. Urology. 1986 Apr; 27(4):335-9.
Use of intravesical cisplatin and mitomycin-C for recurrent transitional cell carcinoma of bladder refractory to thiotepa.
Mobley WC, Rutkowski JL, Tennekoon GI, Gemski J, Buchanan K, Johnston MV
Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons. Brain Res. 1986 Jul; 387(1):53-62.
Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.
Long JB, Petras JM, Mobley WC, Holaday JW
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function. J Pharmacol Exp Ther. 1988 Sep; 246(3):1167-74.
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function.
Higgins LS, Holtzman DM, Rabin J, Mobley WC, Cordell B
Transgenic mouse brain histopathology resembles early Alzheimer's disease. Ann Neurol. 1994 May; 35(5):598-607.
Transgenic mouse brain histopathology resembles early Alzheimer's disease.
Holtzman DM, Bayney RM, Li YW, Khosrovi H, Berger CN, Epstein CJ, Mobley WC
Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. EMBO J. 1992 Feb; 11(2):619-27.
Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.
Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome. Prog Clin Biol Res. 1982; 106:159-87.
Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome.
Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC
Evidence for cholinergic neurites in senile plaques. Science. 1984 Dec 21; 226(4681):1443-5.
Evidence for cholinergic neurites in senile plaques.
Stenevi U, Bjerre B, Björklund A, Mobley W
Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones. Brain Res. 1974 Apr 05; 69(2):217-34.
Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones.
Burgin KE, Waxham MN, Rickling S, Westgate SA, Mobley WC, Kelly PT
In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain. J Neurosci. 1990 Jun; 10(6):1788-98.
In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain.
Koliatsos VE, Shelton DL, Mobley WC, Price DL
A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord. Brain Res. 1991 Feb 08; 541(1):121-8.
A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord.
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses. J Pharmacol Exp Ther. 1988 Sep; 246(3):1158-66.
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses.
Sharp FR, Gonzalez MF, Hisanaga K, Mobley WC, Sagar SM
Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections. Neurosci Lett. 1989 May 22; 100(1-3):117-22.
Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections.
Johnston MV, Rutkowski JL, Wainer BH, Long JB, Mobley WC
NGF effects on developing forebrain cholinergic neurons are regionally specific. Neurochem Res. 1987 Nov; 12(11):985-94.
NGF effects on developing forebrain cholinergic neurons are regionally specific.
Proteolytic modification of the beta nerve growth factor protein. Biochemistry. 1974 Feb 12; 13(4):833-40.
Proteolytic modification of the beta nerve growth factor protein.
Chen CK, Kinsman SL, Holtzman DM, Mobley WC, Johnston MV
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum. Int J Dev Neurosci. 1994 Jun; 12(4):255-62.
A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum.
Taylor LK, Swanson KD, Kerigan J, Mobley W, Landreth GE
Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells. J Biol Chem. 1994 Jan 07; 269(1):308-18.
Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells.
Burke MA, Mobley WC, Cho J, Wiegand SJ, Lindsay RM, Mufson EJ, Kordower JH
Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins. Exp Neurol. 1994 Dec; 130(2):178-95.
Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins.
Infertility, chemical exposure, and farming in Iowa: absence of an association. Urology. 1988 Jan; 31(1):46-50.
Infertility, chemical exposure, and farming in Iowa: absence of an association.
Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ
Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector. Mol Cell Biol. 1988 Jun; 8(6):2456-64.
Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.
Combination perineal cryosurgery and external radiation therapy for adenocarcinoma of prostate. Urology. 1984 Jul; 24(1):11-4.
Combination perineal cryosurgery and external radiation therapy for adenocarcinoma of prostate.
Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948)
A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine. Z Zellforsch Mikrosk Anat. 1973 Dec 31; 146(1):15-43.
A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine.
Zhou J, Valletta JS, Grimes ML, Mobley WC
Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor. J Neurochem. 1995 Sep; 65(3):1146-56.
Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor.
Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, Bredt DS, Mobley WC
Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF. Neurochem Res. 1996 Jul; 21(7):861-8.
Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF.
Holtzman DM, Kilbridge J, Li Y, Cunningham ET, Lenn NJ, Clary DO, Reichardt LF, Mobley WC
TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. J Neurosci. 1995 Feb; 15(2):1567-76.
TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons.
Li Y, Holtzman DM, Kromer LF, Kaplan DR, Chua-Couzens J, Clary DO, Knüsel B, Mobley WC
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J Neurosci. 1995 Apr; 15(4):2888-905.
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.
Asbury A, Fisher R, McKhann GM, Mobley W, Server A
Guillain-Barré syndrome: is there a role for plasmapheresis? Neurology. 1980 Oct; 30(10):1112.
Guillain-Barré syndrome: is there a role for plasmapheresis?
Neurotrophic factors and neurologic disease. West J Med. 1994 Sep; 161(3):246-54.
Neurotrophic factors and neurologic disease.
Zhou J, Holtzman DM, Weiner RI, Mobley WC
Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3824-8.
Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.
Holtzman DM, Li Y, Chen K, Gage FH, Epstein CJ, Mobley WC
Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. 1993 Dec; 43(12):2668-73.
Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration.
Therapeutic potential of neurotrophic factors for neurological disorders. Ann Neurol. 1996 Sep; 40(3):346-54.
Therapeutic potential of neurotrophic factors for neurological disorders.
Holtzman DM, Kilbridge J, Chen KS, Rabin J, Luche R, Carlson E, Epstein CJ, Mobley WC
Preliminary characterization of the central nervous system in partial trisomy 16 mice. Prog Clin Biol Res. 1995; 393:227-40.
Preliminary characterization of the central nervous system in partial trisomy 16 mice.
Neve RL, Valletta JS, Li Y, Ventosa-Michelman M, Holtzman DM, Mobley WC
Brain research. Molecular brain research
A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor. Brain Res Mol Brain Res. 1996 Jul; 39(1-2):185-97.
A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor.
Yuen EC, Howe CL, Li Y, Holtzman DM, Mobley WC
Nerve growth factor and the neurotrophic factor hypothesis. Brain Dev. 1996 Sep-Oct; 18(5):362-8.
Nerve growth factor and the neurotrophic factor hypothesis.
Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM
Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J Neurosci. 1997 Oct 15; 17(20):7594-605.
Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.
Beattie EC, Zhou J, Grimes ML, Bunnett NW, Howe CL, Mobley WC
A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration. Cold Spring Harb Symp Quant Biol. 1996; 61:389-406.
A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration.
Early BDNF, NT-3, and NT-4 signaling events. Exp Neurol. 1999 Sep; 159(1):297-308.
Early BDNF, NT-3, and NT-4 signaling events.
The effect of jet-milling on lyophilized liposomes. Pharm Res. 1998 Jan; 15(1):149-52.
The effect of jet-milling on lyophilized liposomes.
Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM
Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp Neurol. 1998 Jun; 151(2):314-25.
Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.
Holtzman DM, Santucci D, Kilbridge J, Chua-Couzens J, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sun Y, Carlson E, Alleva E, Epstein CJ, Mobley WC
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13333-8.
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.
Recent progress in developmental neurology: exploring the bench to bedside interface. Curr Opin Neurol. 1996 Apr; 9(2):107-112.
Recent progress in developmental neurology: exploring the bench to bedside interface.
Cooper JD, Messer A, Feng AK, Chua-Couzens J, Mobley WC
Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment. J Neurosci. 1999 Apr 01; 19(7):2556-67.
Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment.
Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves. Mol Med Today. 1995 Sep; 1(6):278-86.
Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves.
Holtzman DM, Kilbridge J, Bredt DS, Black SM, Li Y, Clary DO, Reichardt LF, Mobley WC
NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin. Neurobiol Dis. 1994 Nov; 1(1-2):51-60.
NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin.
Minimized hormones grow in stature. Nat Biotechnol. 1996 Sep; 14(9):1092.
A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9909-14.
A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.
Cooper JD, Salehi A, Delcroix JD, Howe CL, Belichenko PV, Chua-Couzens J, Kilbridge JF, Carlson EJ, Epstein CJ, Mobley WC
Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10439-44.
Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.
Howe CL, Valletta JS, Rusnak AS, Mobley WC
NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron. 2001 Dec 06; 32(5):801-14.
NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway.
Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis. Adv Genet. 2001; 45:169-82.
Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis.
Huang CS, Zhou J, Feng AK, Lynch CC, Klumperman J, DeArmond SJ, Mobley WC
Nerve growth factor signaling in caveolae-like domains at the plasma membrane. J Biol Chem. 1999 Dec 17; 274(51):36707-14.
Nerve growth factor signaling in caveolae-like domains at the plasma membrane.
Sago H, Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT
Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6256-61.
Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.
Annals of the New York Academy of Sciences
Comprehensive theory of Alzheimer's disease. The effects of cholesterol on membrane receptor trafficking. Ann N Y Acad Sci. 2000; 924:104-11.
Comprehensive theory of Alzheimer's disease. The effects of cholesterol on membrane receptor trafficking.
Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci. 2001 Aug 01; 21(15):5406-16.
Nerve growth factor activates persistent Rap1 signaling in endosomes.
Rita Levi-Montalcini: the story of an uncommon intellect and spirit. Neuroscience. 2013 Nov 12; 252:431-7.
Rita Levi-Montalcini: the story of an uncommon intellect and spirit.
Kakkis E, McEntee M, Vogler C, Le S, Levy B, Belichenko P, Mobley W, Dickson P, Hanson S, Passage M
Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I. Mol Genet Metab. 2004 Sep-Oct; 83(1-2):163-74.
Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.
Belichenko PV, Dickson PI, Passage M, Jungles S, Mobley WC, Kakkis ED
Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain. Mol Genet Metab. 2005 Sep-Oct; 86(1-2):141-9.
Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain.
Watson G, Bastacky J, Belichenko P, Buddhikot M, Jungles S, Vellard M, Mobley WC, Kakkis E
Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice. Gene Ther. 2006 Jun; 13(11):917-25.
Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice.
Gardiner K, Davisson MT, Pritchard M, Patterson D, Groner Y, Crnic LS, Antonarakis S, Mobley W
Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C. Cytogenet Genome Res. 2005; 108(4):269-77.
Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C.
Mobley WC, Harrold MW, Hall JM, Oliveira MA, Bloom TJ
American journal of pharmaceutical education
The Role of Biomedical and Pharmaceutical Sciences in Pharmacy Education and Practice. Am J Pharm Educ. 2024 Dec; 88(12):101312.
The Role of Biomedical and Pharmaceutical Sciences in Pharmacy Education and Practice.
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 2024 Dec 04; 112(23):3984-3985.
I feel your pain: higher empathy is associated with higher posterior default mode network activity. Pain. 2025 Apr 01; 166(4):e60-e67.
I feel your pain: higher empathy is associated with higher posterior default mode network activity.
Flores-Aguilar L, Hamlett ED, Araya P, Barone E, Bhattacharyya A, Carmona-Iragui M, Chan L, Christian B, Costa ACS, Costanzo F, Del Hoyo Soriano L, Dierssen M, Eichler EE, Fisher E, Galbraith M, Ghosh S, Gimenez S, Guedj F, Guidi S, Iulita MF, Mobley W, Pelleri MC, Potier MC, Rabin KR, Rachubinski A, Rebillat AS, Rubenstein E, Saternos H, Sordo L, Strydom A, Valle-Tamayo N, Waugh KA, Yu E, Zeldich E, Busciglio J, Head E
Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society. Neuromolecular Med. 2025 01 05; 27(1):5.
Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society.
Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Sci Rep. 2019 04 15; 9(1):6070.
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling.
Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species. Front Neurosci. 2019; 13:659.
Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species.
Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose. Alzheimers Dement. 2025 May; 21(5):e70046.
Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose.
Chen XQ, Zuo X, Becker A, Mante M, Florio JB, Jadhav SG, Albay R, Johnstone A, Karachentsev D, Rissman R, Zhao H, Dowdy SF, Mobley WC
Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome. Alzheimers Dement. 2025 May; 21(5):e70022.
Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.
Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SKS, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC
Correction: An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome. PLoS One. 2025; 20(5):e0324280.
Correction: An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome.
Maure-Blesa L, Carmona-Iragui M, Lott I, Head E, Wisniewski T, Rafii MS, Espinosa J, Flórez J, Mobley WC, Holland A, Strydom A, Zaman S, Fortea J
The history of Down syndrome-associated Alzheimer's disease; past, present, and future. Alzheimers Dement. 2025 Jun; 21(6):e70158.
The history of Down syndrome-associated Alzheimer's disease; past, present, and future.
Lee JW, Shin MH, Mobley W, Urbach AR, Kim HI
Journal of the American Chemical Society
Supramolecular Enhancement of Protein Analysis via the Recognition of Phenylalanine with Cucurbit[7]uril. J Am Chem Soc. 2015 Dec 09; 137(48):15322-9.
Supramolecular Enhancement of Protein Analysis via the Recognition of Phenylalanine with Cucurbit[7]uril.
Howick J, Mercer S, Adams J, Levett-Jones T, Mobley W, Ward A, Winter R, Halpern J
The Leicester empathy declaration: A model for implementing empathy in healthcare. Patient Educ Couns. 2024 Dec; 129:108391.
The Leicester empathy declaration: A model for implementing empathy in healthcare.
Tau pathology differs by sex in Alzheimer's disease in Down syndrome. Alzheimers Dement. 2025 Oct; 21(10):e70838.
Tau pathology differs by sex in Alzheimer's disease in Down syndrome.
Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001; 24:1217-81.
Nerve growth factor signaling, neuroprotection, and neural repair.
Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci. 2003 Feb; 26(2):73-80.
Traffic at the intersection of neurotrophic factor signaling and neurodegeneration.
Delcroix JD, Valletta J, Wu C, Howe CL, Lai CF, Cooper JD, Belichenko PV, Salehi A, Mobley WC
Trafficking the NGF signal: implications for normal and degenerating neurons. Prog Brain Res. 2004; 146:3-23.
Trafficking the NGF signal: implications for normal and degenerating neurons.
Signaling endosome hypothesis: A cellular mechanism for long distance communication. J Neurobiol. 2004 Feb 05; 58(2):207-16.
Signaling endosome hypothesis: A cellular mechanism for long distance communication.
Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, Mobley WC
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron. 2003 Jul 03; 39(1):69-84.
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals.
Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E, Yang Y
BPAG1n4 is essential for retrograde axonal transport in sensory neurons. J Cell Biol. 2003 Oct 27; 163(2):223-9.
BPAG1n4 is essential for retrograde axonal transport in sensory neurons.
Pontikis CC, Cella CV, Parihar N, Lim MJ, Chakrabarti S, Mitchison HM, Mobley WC, Rezaie P, Pearce DA, Cooper JD
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain Res. 2004 Oct 15; 1023(2):231-42.
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation.
An AUPN/ANA survey of department leader opinions on the health of US academic neurology. Neurology. 2004 Oct 26; 63(8):1354-6.
An AUPN/ANA survey of department leader opinions on the health of US academic neurology.
Going the distance, or not, with neurotrophin signals. Cell. 2004 Jul 23; 118(2):141-3.
Going the distance, or not, with neurotrophin signals.
Villar AJ, Belichenko PV, Gillespie AM, Kozy HM, Mobley WC, Epstein CJ
Mammalian genome : official journal of the International Mammalian Genome Society
Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome. 2005 Feb; 16(2):79-90.
Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.
Long-distance retrograde neurotrophic signaling. Curr Opin Neurobiol. 2005 Feb; 15(1):40-8.
Long-distance retrograde neurotrophic signaling.
Ding J, Allen E, Wang W, Valle A, Wu C, Nardine T, Cui B, Yi J, Taylor A, Jeon NL, Chu S, So Y, Vogel H, Tolwani R, Mobley W, Yang Y
Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Hum Mol Genet. 2006 May 01; 15(9):1451-63.
Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.
Lo B, Albert MS, Hyman S, Parens E, Wolpe PR, Mobley W
Cerebrum : the Dana forum on brain science
Ethics and the practice of brain science. Cerebrum. 2002; 4(3):64-6.
Ethics and the practice of brain science.
Miyamoto Y, Yamauchi J, Tanoue A, Wu C, Mobley WC
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10444-10449.
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.
Liu JJ, Ding J, Wu C, Bhagavatula P, Cui B, Chu S, Mobley WC, Yang Y
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2223-8.
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.
Cui B, Wu C, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S
One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13666-71.
One at a time, live tracking of NGF axonal transport using quantum dots.
Wu C, Ramirez A, Cui B, Ding J, Delcroix JD, Valletta JS, Liu JJ, Yang Y, Chu S, Mobley WC
A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic. 2007 Nov; 8(11):1503-20.
A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway.
Salehi A, Faizi M, Belichenko PV, Mobley WC
Mental retardation and developmental disabilities research reviews
Using mouse models to explore genotype-phenotype relationship in Down syndrome. Ment Retard Dev Disabil Res Rev. 2007; 13(3):207-14.
Using mouse models to explore genotype-phenotype relationship in Down syndrome.
Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic. 2008 Feb; 9(2):215-29.
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
Belichenko NP, Belichenko PV, Li HH, Mobley WC, Francke U
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. J Comp Neurol. 2008 May 01; 508(1):184-95.
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome.
Colas D, Valletta JS, Takimoto-Kimura R, Nishino S, Fujiki N, Mobley WC, Mignot E
Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis. 2008 Apr; 30(1):1-7.
Sleep and EEG features in genetic models of Down syndrome.
Wan J, Cheung AY, Fu WY, Wu C, Zhang M, Mobley WC, Cheung ZH, Ip NY
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci. 2008 Sep 03; 28(36):9002-12.
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth.
The coming of age of axonal neurotrophin signaling endosomes. J Proteomics. 2009 Feb 15; 72(1):46-55.
The coming of age of axonal neurotrophin signaling endosomes.
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiol Dis. 2009 Apr; 34(1):71-7.
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation.
Benedyk M, Berglund L, Facciotti M, Mobley W, Zucker D
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Strategies for innovation and interdisciplinary translational research: research and career benefits and barriers. J Investig Med. 2009 Feb; 57(2):477-81.
Strategies for innovation and interdisciplinary translational research: research and career benefits and barriers.
Mégarbané A, Ravel A, Mircher C, Sturtz F, Grattau Y, Rethoré MO, Delabar JM, Mobley WC
Genetics in medicine : official journal of the American College of Medical Genetics
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet Med. 2009 Sep; 11(9):611-6.
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome.
Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, Uchida N
Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 04; 5(3):310-9.
Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis.
Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome. 2010 Jun; 21(5-6):258-67.
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.
The evolution of academic neurology: new information will bring new meaning. Arch Neurol. 2012 Mar; 69(3):308-14.
The evolution of academic neurology: new information will bring new meaning.
Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W
Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp. 2014 Feb 12; (84):e50783.
Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography.
Decourt B, Mobley W, Reiman E, Shah RJ, Sabbagh MN
Journal of Alzheimer's disease & Parkinsonism
Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome. J Alzheimers Dis Parkinsonism. 2013 Mar 20; Suppl 7:002.
Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome.
Zhang H, Petit GH, Gaughwin PM, Hansen C, Ranganathan S, Zuo X, Smith R, Roybon L, Brundin P, Mobley WC, Li JY
NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease. J Huntingtons Dis. 2013; 2(1):69-82.
NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease.
Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T
Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun; 11(6):700-9.
Down syndrome and Alzheimer's disease: Common pathways, common goals.
Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome. F1000Res. 2015; 4:269.
Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome.
Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet. 2016 05; 12(5):e1006033.
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.
Ballard C, Mobley W, Hardy J, Williams G, Corbett A
Dementia in Down's syndrome. Lancet Neurol. 2016 05; 15(6):622-36.
Single Figure Publications: Towards a novel alternative format for scholarly communication. F1000Res. 2015; 4:268.
Single Figure Publications: Towards a novel alternative format for scholarly communication.
Xing Z, Li Y, Pao A, Bennett AS, Tycko B, Mobley WC, Yu YE
Mouse-based genetic modeling and analysis of Down syndrome. Br Med Bull. 2016 12; 120(1):111-122.
Mouse-based genetic modeling and analysis of Down syndrome.
International journal of molecular sciences
Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series. Int J Mol Sci. 2017 May 26; 18(6).
Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series.
Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome. Free Radic Biol Med. 2018 01; 114:52-61.
Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.
Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C
Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 04 04; 38(14):3394-3413.
Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception.
Jiang X, Xiao H, Segal R, Mobley WC, Park H
Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014. Clin Ther. 2018 04; 40(4):613-626.e1.
Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014.
Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP
Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr; 120(4):745-760.
Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.
Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology. Ann Neurol. 2026 Jan; 99(1):35-48.
Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology.
[{"Id":"NCT06080464","Title":"Clinician Satisfaction With the VERABAND™","StartDate":"2025-06-09T00:00:00","EstimatedCompletionDate":"2027-06-30T00:00:00","CompletionDate":null,"Conditions":"Back Pain,Lower Back Pain,Pain","Status":"Recruiting","IsMultiSite":false,"SourceUrl":"https://clinicaltrials.ucsd.edu/trial/NCT06080464"},{"Id":"NCT06393101","Title":"The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome","StartDate":"2024-06-01T00:00:00","EstimatedCompletionDate":"2029-06-01T00:00:00","CompletionDate":null,"Conditions":"Complex Regional Pain Syndrome,Cannabis,Pain","Status":"Recruiting","IsMultiSite":false,"SourceUrl":"https://clinicaltrials.ucsd.edu/trial/NCT06393101"},{"Id":"NCT05607381","Title":"Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain","StartDate":"2022-11-30T00:00:00","EstimatedCompletionDate":"2027-06-30T00:00:00","CompletionDate":null,"Conditions":"Back Pain,Lower Back Pain,Opioid Use,Meditation,Pain","Status":"Recruiting","IsMultiSite":false,"SourceUrl":"https://clinicaltrials.ucsd.edu/trial/NCT05607381"},{"Id":"NCT05224336","Title":"Psilocybin-assisted Therapy for Phantom Limb Pain","StartDate":"2022-10-03T00:00:00","EstimatedCompletionDate":null,"CompletionDate":"2024-03-07T00:00:00","Conditions":"Amputation,Phantom Limb,Psilocybin,Pain","Status":"Completed","IsMultiSite":false,"SourceUrl":"https://clinicaltrials.gov/ct2/show/NCT05224336"},{"Id":"NCT04982965","Title":"Brain Mechanisms Supporting Cannabis-induced Pain Relief","StartDate":"2021-05-07T00:00:00","EstimatedCompletionDate":"2027-03-15T00:00:00","CompletionDate":null,"Conditions":"Pain,Cannabis","Status":"Recruiting","IsMultiSite":false,"SourceUrl":"https://clinicaltrials.ucsd.edu/trial/NCT04982965"},{"Id":"NCT04034004","Title":"Chronic Low Back Pain and Meditation","StartDate":"2021-01-01T00:00:00","EstimatedCompletionDate":null,"CompletionDate":"2022-12-22T00:00:00","Conditions":"Pain,Back Pain,Lower Back Pain,Meditation,Mindfulness","Status":"Completed","IsMultiSite":false,"SourceUrl":"https://clinicaltrials.gov/ct2/show/NCT04034004"},{"Id":"NCT03354585","Title":"Mindfulness and Chronic Low Back Pain","StartDate":"2020-01-02T00:00:00","EstimatedCompletionDate":null,"CompletionDate":"2024-02-05T00:00:00","Conditions":"Back Pain,Lower Back Pain,Pain,Mindfulness","Status":"Completed","IsMultiSite":false,"SourceUrl":"https://clinicaltrials.gov/ct2/show/NCT03354585"}]
[{"Id":"NCT04165109","Title":"Trial-Ready Cohort-Down Syndrome (TRC-DS)","StartDate":"2021-06-07T00:00:00","EstimatedCompletionDate":"2027-12-31T00:00:00","CompletionDate":null,"Conditions":"Down Syndrome,Alzheimer's Disease,Dementia","Status":"Recruiting","IsMultiSite":false,"SourceUrl":"https://clinicaltrials.icts.uci.edu/trial/NCT04165109"}]
Rafii MS, Kleschevnikov AM, Sawa M, Mobley WC
Down syndrome. Handb Clin Neurol. 2019; 167:321-336.
Ho D, Quake SR, McCabe ERB, Chng WJ, Chow EK, Ding X, Gelb BD, Ginsburg GS, Hassenstab J, Ho CM, Mobley WC, Nolan GP, Rosen ST, Tan P, Yen Y, Zarrinpar A
Enabling Technologies for Personalized and Precision Medicine. Trends Biotechnol. 2020 05; 38(5):497-518.
Enabling Technologies for Personalized and Precision Medicine.