Find Reactions, Proteins and Pathways
Pathway Browser
Visualize and interact with Reactome biological pathways
Analysis Tools
Merges pathway identifier mapping,
over-representation, and expression analysis
AI Chatbot
Meet the React-to-Me AI Chatbot! Designed to answer your questions about Reactome Pathways.
ReactomeFIViz
Designed to find pathways and network patterns related to cancer and other types of diseases
Documentation
Information to browse the database and use its principal tools for data analysis
Reactome Research Spotlight
[Jan 8, 2026] In their December 2025 Journal of Virology article "Inhibition of type I interferon signaling is a conserved function of gamma-herpesvirus-encoded microRNAs", Fachko et al. examine how gamma-herpesviruses from non-human primates utilize viral microRNAs to suppress type I interferon signaling, a crucial antiviral defense pathway, thereby facilitating the establishment and maintenance of lifelong infections. Using functional assays and mutant viruses, the authors demonstrate that these microRNAs directly target interferon receptors and core JAK/STAT signaling components, reducing antiviral gene activation during both early and latent infection. Reactome pathway analysis identified interferon signaling as a primary target of viral microRNA activity and linked specific host genes to the biologically relevant immune pathways.
Why Reactome
Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education.
The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.
Version 95 released on December 9, 2025
Human Pathways
Reactions
Proteins
Small Molecules
Drugs
Literature References
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