The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials

doi:10.1016/j.clnesp.2020.01.002

Meta-Analysis

. 2020 Apr:36:10-16.

doi: 10.1016/j.clnesp.2020.01.002. Epub 2020 Jan 20.

The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials

Amir Hadi¹, Marilyn S Campbell², Bahar Hassani³, Makan Pourmasoumi⁴, Ammar Salehi-Sahlabadi⁵, Seyed Ahmad Hosseini⁶

Affiliations

¹ Halal Research Center of IRI, FDA, Tehran, Iran.
² Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY, USA.
³ Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Health Safety and Environment (HSE), Razi Petrochemical Company, Mahshahr, Iran.
⁴ Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁵ Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: [email protected].

PMID: 32220351
DOI: 10.1016/j.clnesp.2020.01.002

Meta-Analysis

The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials

Amir Hadi et al. Clin Nutr ESPEN. 2020 Apr.

. 2020 Apr:36:10-16.

doi: 10.1016/j.clnesp.2020.01.002. Epub 2020 Jan 20.

Authors

Amir Hadi¹, Marilyn S Campbell², Bahar Hassani³, Makan Pourmasoumi⁴, Ammar Salehi-Sahlabadi⁵, Seyed Ahmad Hosseini⁶

Affiliations

¹ Halal Research Center of IRI, FDA, Tehran, Iran.
² Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY, USA.
³ Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Health Safety and Environment (HSE), Razi Petrochemical Company, Mahshahr, Iran.
⁴ Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁵ Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: [email protected].

PMID: 32220351
DOI: 10.1016/j.clnesp.2020.01.002

Abstract

Background & aims: Several clinical trials have shown that cinnamon can reduce blood pressure, but the results are controversial. Therefore, we conducted a systematic review and meta-analysis to provide a more precise estimate of the overall effects of cinnamon supplementation on blood pressure in adults.

Methods: We searched PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar databases through September 2019 to identify randomized clinical trials (RCTs) investigating the effect of cinnamon supplementation on blood pressure. Data were pooled by using the random-effects model, and weighted mean difference (WMD) was considered as the summary effect size. Sensitivity analysis was conducted using the leave-one-out method.

Results: Meta-analysis of 9 RCTs with 641 participants showed significant reductions in both systolic (WMD: -5.17 mmHg, 95% CI: -9.35 to -0.99, P = 0.01) and diastolic blood pressure (WMD: -3.36 mmHg, 95% CI: -5.67 to -1.04, P ≤ 0.001) after cinnamon supplementation. Subgroup analyses indicated that these results were significant only when cinnamon was administered at the dosages of ≤2 g/day, for a period longer than 8 weeks, and in participants with a baseline BMI of ≥30 kg/m².

Conclusion: The present meta-analysis suggests that cinnamon supplementation can improve blood pressure by a modest degree. However, due to limited availability of studies with hypertensive cases and relatively small sample sizes of available studies, well designed trials with adequate sample sizes aimed at hypertensive populations are recommended.

Keywords: Blood pressure; Cinnamon; Meta-analysis; Systematic review.

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Conflict of interest statement

Declaration of Competing Interest All authors confirm that they have no conflict of interests to declare.

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The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials

Affiliations

The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials

Authors

Affiliations

Abstract

Conflict of interest statement

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