Autologous platelet-rich plasma therapy for pattern hair loss: A systematic review

doi:10.1111/jocd.13113

. 2020 Apr;19(4):827-835.

doi: 10.1111/jocd.13113. Epub 2019 Aug 26.

Autologous platelet-rich plasma therapy for pattern hair loss: A systematic review

Gezim Dervishi¹, Haibo Liu², Sandra Peternel^{3

4}, Alexander Labeit⁵, Frank Peinemann^{1

6}

Affiliations

¹ Children's Hospital, University Hospital Cologne, Cologne, Germany.
² Department of Dermatology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
³ Department of Dermatovenerology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
⁴ Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
⁵ Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
⁶ FOM University of Applied Science for Economics & Management, Essen, Germany.

PMID: 31452328
DOI: 10.1111/jocd.13113

Autologous platelet-rich plasma therapy for pattern hair loss: A systematic review

Gezim Dervishi et al. J Cosmet Dermatol. 2020 Apr.

. 2020 Apr;19(4):827-835.

doi: 10.1111/jocd.13113. Epub 2019 Aug 26.

Authors

Gezim Dervishi¹, Haibo Liu², Sandra Peternel^{3

4}, Alexander Labeit⁵, Frank Peinemann^{1

6}

Affiliations

¹ Children's Hospital, University Hospital Cologne, Cologne, Germany.
² Department of Dermatology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
³ Department of Dermatovenerology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
⁴ Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
⁵ Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
⁶ FOM University of Applied Science for Economics & Management, Essen, Germany.

PMID: 31452328
DOI: 10.1111/jocd.13113

Abstract

Background: Androgenetic alopecia (male pattern and female pattern hair loss) is characterized by thinning of the scalp hair. Intradermal injection of autologous platelet-rich plasma (PRP) might have an effect on hair regrowth.

Aims: The aim was to evaluate efficacy and safety of platelet-rich plasma compared to placebo or no treatment in people with pattern hair loss.

Patients/methods: We searched the databases CENTRAL and MEDLINE on December 24, 2018 and included randomized controlled trials (RCTs). Primary outcomes were mean change of hair density from baseline and serious treatment-related adverse events. Secondary outcome was mean change of hair thickness from baseline. Time point of outcome assessment was 6 months after start of treatment.

Results: We identified 13 relevant randomized controlled trials with 356 randomized (343 analyzed) people or half-head areas who received PRP in a simple parallel or half-head design. The pooled data of seven studies (171 analyzed people or half-head areas) were favorable in the PRP group on hair density. We estimated a mean difference from baseline of 30.35 associated with a wide 95% confidence interval (1.77-58.93), a considerable heterogeneity (I² = 100%), and unclear risk of bias in most of the studies. Regarding hair thickness, data were also favorable in the PRP group, but these data were limited to a single study. We did not identify serious treatment-related adverse events.

Conclusion: The results of seven RCTs indicated that autologous platelet-rich plasma was associated with an increase of hair density when compared to placebo.

Keywords: androgenetic alopecia; pattern hair loss; platelet-rich plasma; systematic review.

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References

REFERENCES

1. Vary JC Jr. Selected disorders of skin appendages-acne, alopecia, hyperhidrosis. Med Clin North Am. 2015;99(6):1195-1211.
1. Olsen EA. Androgenetic aopecia. In: Olsen EA, ed. Disorders of Hair Growth. New York, NY: McGraw-Hill; 1994:257-283.
1. Hamilton JB. Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci. 1951;53:708-728.
1. Gupta M, Mysore V. Classifications of patterned hair loss: a review. J Cutan Aesthet Surg. 2016;9(1):3-12.
1. Norwood OT. Male pattern baldness: classification and incidence. South Med J. 1975;68:1359-1365.

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[1] Vary JC Jr. Selected disorders of skin appendages-acne, alopecia, hyperhidrosis. Med Clin North Am. 2015;99(6):1195-1211.

[2] Vary JC Jr. Selected disorders of skin appendages-acne, alopecia, hyperhidrosis. Med Clin North Am. 2015;99(6):1195-1211.

[3] Olsen EA. Androgenetic aopecia. In: Olsen EA, ed. Disorders of Hair Growth. New York, NY: McGraw-Hill; 1994:257-283.

[4] Olsen EA. Androgenetic aopecia. In: Olsen EA, ed. Disorders of Hair Growth. New York, NY: McGraw-Hill; 1994:257-283.

[5] Hamilton JB. Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci. 1951;53:708-728.

[6] Hamilton JB. Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci. 1951;53:708-728.

[7] Gupta M, Mysore V. Classifications of patterned hair loss: a review. J Cutan Aesthet Surg. 2016;9(1):3-12.

[8] Gupta M, Mysore V. Classifications of patterned hair loss: a review. J Cutan Aesthet Surg. 2016;9(1):3-12.

[9] Norwood OT. Male pattern baldness: classification and incidence. South Med J. 1975;68:1359-1365.

[10] Norwood OT. Male pattern baldness: classification and incidence. South Med J. 1975;68:1359-1365.

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Autologous platelet-rich plasma therapy for pattern hair loss: A systematic review

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Autologous platelet-rich plasma therapy for pattern hair loss: A systematic review

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