Food components and ocular pathophysiology: a critical appraisal of the role of oxidative mechanisms
- PMID: 28582804
- DOI: 10.6133/apjcn.082016.01
Food components and ocular pathophysiology: a critical appraisal of the role of oxidative mechanisms
Abstract
Background and objectives: Three of the major ocular diseases, namely cataracts, age-related macular degeneration and glaucoma are associated with oxidative damage. Disease risk and progression may be reduced through consumption of dietary components. To critically examine the literature on dietary and supplemental intakes of fruit and vegetables, meat, antioxidants (vitamins C, E and A), calcium, folate, iron, and their association with ocular disease.
Methods and study design: Google Scholar and key references from texts and publications were searched using search terms (eye disease, antioxidants), (vision, nutrition), no date restriction, only articles in English were included.
Results: We found probable evidence that dietary intake of fruits and vegetables, and vitamin C lowered incidence of cataracts and age-related macular degeneration. In high supplemental doses, vitamin C increases macular degeneration risk. Vitamin A from food was protective for cataracts and glaucoma, but not in supplemental form. Vitamin A was associated with lower incidence of macular degeneration. We also found probable evidence that higher intakes of meat increased the risk of cataracts and macular degeneration. Dietary calcium and iron appeared protective against glaucoma, but not in supplemental form.
Conclusions: While a nutrient rich diet high in fruit and vegetables, and associated antioxidants appeared to be protective, we would caution intake of supplementary antioxidants for those with ocular disease.
Similar articles
-
The Association between Dietary Intake of Antioxidants and Ocular Disease.Diseases. 2017 Jan 30;5(1):3. doi: 10.3390/diseases5010003. Diseases. 2017. PMID: 28933356 Free PMC article.
-
The importance of nutrition in the prevention of ocular disease with special reference to cataract.Ophthalmic Res. 2010;44(3):166-72. doi: 10.1159/000316477. Epub 2010 Sep 9. Ophthalmic Res. 2010. PMID: 20829640 Review.
-
Phytochemicals and age-related eye diseases.Nutr Rev. 2008 Aug;66(8):465-72. doi: 10.1111/j.1753-4887.2008.00078.x. Nutr Rev. 2008. PMID: 18667008 Review.
-
Zeaxanthin and ocular health, from bench to bedside.Fitoterapia. 2016 Mar;109:58-66. doi: 10.1016/j.fitote.2015.12.009. Epub 2015 Dec 17. Fitoterapia. 2016. PMID: 26705841 Review.
-
Review of nutrient actions on age-related macular degeneration.Nutr Res. 2014 Feb;34(2):95-105. doi: 10.1016/j.nutres.2013.10.011. Epub 2013 Nov 4. Nutr Res. 2014. PMID: 24461310 Review.
Cited by
-
A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations.Int J Mol Sci. 2017 Nov 1;18(11):2302. doi: 10.3390/ijms18112302. Int J Mol Sci. 2017. PMID: 29104244 Free PMC article.
-
The Association between Dietary Intake of Antioxidants and Ocular Disease.Diseases. 2017 Jan 30;5(1):3. doi: 10.3390/diseases5010003. Diseases. 2017. PMID: 28933356 Free PMC article.
-
Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies.Nutrients. 2019 May 27;11(5):1186. doi: 10.3390/nu11051186. Nutrients. 2019. PMID: 31137834 Free PMC article. Review.
-
Scavenging of Retinoid Cation Radicals by Urate, Trolox, and α-, β-, γ-, and δ-Tocopherols.Int J Mol Sci. 2019 Jun 7;20(11):2799. doi: 10.3390/ijms20112799. Int J Mol Sci. 2019. PMID: 31181693 Free PMC article.
-
Association of serum retinol concentration with normal-tension glaucoma.Eye (Lond). 2022 Sep;36(9):1820-1825. doi: 10.1038/s41433-021-01740-6. Epub 2021 Aug 12. Eye (Lond). 2022. PMID: 34385698 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
