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Comparative Study
. 2016 Jun 1;176(6):816-25.
doi: 10.1001/jamainternmed.2016.1548.

Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults

Steven C Moore  1 , I-Min Lee  2 , Elisabete Weiderpass  3 , Peter T Campbell  4 , Joshua N Sampson  1 , Cari M Kitahara  1 , Sarah K Keadle  1 , Hannah Arem  5 , Amy Berrington de Gonzalez  1 , Patricia Hartge  1 , Hans-Olov Adami  6 , Cindy K Blair  7 , Kristin B Borch  8 , Eric Boyd  9 , David P Check  1 , Agnès Fournier  10 , Neal D Freedman  1 , Marc Gunter  11 , Mattias Johannson  12 , Kay-Tee Khaw  13 , Martha S Linet  1 , Nicola Orsini  14 , Yikyung Park  15 , Elio Riboli  16 , Kim Robien  17 , Catherine Schairer  1 , Howard Sesso  2 , Michael Spriggs  9 , Roy Van Dusen  9 , Alicja Wolk  14 , Charles E Matthews  1 , Alpa V Patel  4
Affiliations
Comparative Study

Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults

Steven C Moore et al. JAMA Intern Med. .

Abstract

Importance: Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood.

Objective: To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking.

Design, setting, and participants: We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004). We used multivariable Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals for associations of leisure-time physical activity with incidence of 26 types of cancer. Leisure-time physical activity levels were modeled as cohort-specific percentiles on a continuous basis and cohort-specific results were synthesized by random-effects meta-analysis. Hazard ratios for high vs low levels of activity are based on a comparison of risk at the 90th vs 10th percentiles of activity. The data analysis was performed from January 1, 2014, to June 1, 2015.

Exposures: Leisure-time physical activity of a moderate to vigorous intensity.

Main outcomes and measures: Incident cancer during follow-up.

Results: A total of 1.44 million participants (median [range] age, 59 [19-98] years; 57% female) and 186 932 cancers were included. High vs low levels of leisure-time physical activity were associated with lower risks of 13 cancers: esophageal adenocarcinoma (HR, 0.58; 95% CI, 0.37-0.89), liver (HR, 0.73; 95% CI, 0.55-0.98), lung (HR, 0.74; 95% CI, 0.71-0.77), kidney (HR, 0.77; 95% CI, 0.70-0.85), gastric cardia (HR, 0.78; 95% CI, 0.64-0.95), endometrial (HR, 0.79; 95% CI, 0.68-0.92), myeloid leukemia (HR, 0.80; 95% CI, 0.70-0.92), myeloma (HR, 0.83; 95% CI, 0.72-0.95), colon (HR, 0.84; 95% CI, 0.77-0.91), head and neck (HR, 0.85; 95% CI, 0.78-0.93), rectal (HR, 0.87; 95% CI, 0.80-0.95), bladder (HR, 0.87; 95% CI, 0.82-0.92), and breast (HR, 0.90; 95% CI, 0.87-0.93). Body mass index adjustment modestly attenuated associations for several cancers, but 10 of 13 inverse associations remained statistically significant after this adjustment. Leisure-time physical activity was associated with higher risks of malignant melanoma (HR, 1.27; 95% CI, 1.16-1.40) and prostate cancer (HR, 1.05; 95% CI, 1.03-1.08). Associations were generally similar between overweight/obese and normal-weight individuals. Smoking status modified the association for lung cancer but not other smoking-related cancers.

Conclusions and relevance: Leisure-time physical activity was associated with lower risks of many cancer types. Health care professionals counseling inactive adults should emphasize that most of these associations were evident regardless of body size or smoking history, supporting broad generalizability of findings.

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Conflict of interest statement

Disclosure of potential conflicts of interest: The authors have no conflicts of interest to report.

Figures

Figure 1
Figure 1. Summary multivariable* hazard ratios (HR) and 95% confidence intervals (CI) for a higher (90th percentile) versus lower (10th percentile) level of leisure-time physical activity by cancer type†
* Multivariable models were adjusted for age, gender, smoking status (never, former, current), alcohol consumption (0, 0.1–14.9, 15.0–29.9 and 30.0+ g/day), education (did not complete high school, completed high school, post high-school training, some college, completed college), and race/ethnicity (white, black, other). Models for endometrial, breast, and ovarian cancers are additionally adjusted for hormone replacement therapy use (ever, never), oral contraceptive use (ever, never), age at menarche (<10 years, 10–11 years, 12–13 years, 14+ years), age at menopause (premenopausal, 40–44 years, 45–49 years, 50–54 years, 55+ years), and parity (0 children, 1 child, 2 children, 3+ children). † The Surveillance Epidemiology and End Results site recode and the International Classification of Diseases for Oncology, Third Edition code corresponding to each cancer type are shown in Supplementary Table 1. ‡ Pheterogeneity indicates the P-value for heterogeneity of hazard ratios across participating studies.
Figure 2
Figure 2. Summary multivariable* hazard ratios (HR) and 95% confidence intervals (CI) for a higher (90th percentile) versus lower (10th percentile) level of leisure-time physical activity by cancer type, stratified by body mass index of less than 25 kg/m2 or 25 kg/m2 or higher
* Multivariable models were adjusted for age, gender, smoking status (never, former, current), alcohol consumption (0, 0.1–14.9, 15.0–29.9 and 30.0+ g/day), education (did not complete high school, completed high school, post high-school training, some college, completed college), and race/ethnicity (white, black, other). Models for endometrial, breast, and ovarian cancers are additionally adjusted for hormone replacement therapy use (ever, never), oral contraceptive use (ever, never), age at menarche (<10 years, 10–11 years, 12–13 years, 14+ years), age at menopause (premenopausal, 40–44 years, 45–49 years, 50–54 years, 55+ years), and parity (0 children, 1 child, 2 children, 3+ children).
Figure 3
Figure 3. Summary multivariable* hazard ratios and 95% confidence intervals for a higher (90th percentile) versus lower (10th percentile) level of leisure-time physical activity by cancer type, stratified by current, former, and never smokers
* Multivariable models were adjusted for age, gender, alcohol consumption (0, 0.1–14.9, 15.0–29.9 and 30.0+ g/day), education (did not complete high school, completed high school, post high-school training, some college, completed college), and race/ethnicity (white, black, other). Models for endometrial, breast, and ovarian cancers are additionally adjusted for hormone replacement therapy use (ever, never), oral contraceptive use (ever, never), age at menarche (<10 years, 10–11 years, 12–13 years, 14+ years), age at menopause (premenopausal, 40–44 years, 45–49 years, 50–54 years, 55+ years), and parity (0 children, 1 child, 2 children, 3+ children). For gallbladder cancer among current smokers, case numbers were inadequate to provdie an estimate.
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References

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