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Review
. 2014 Dec;23(12):2716-36.
doi: 10.1158/1055-9965.EPI-14-0207. Epub 2014 Sep 5.

Childhood brain tumor epidemiology: a brain tumor epidemiology consortium review

Kimberly J Johnson  1 , Jennifer Cullen  2 , Jill S Barnholtz-Sloan  3 , Quinn T Ostrom  3 , Chelsea E Langer  4 , Michelle C Turner  5 , Roberta McKean-Cowdin  6 , James L Fisher  7 , Philip J Lupo  8 , Sonia Partap  9 , Judith A Schwartzbaum  7 , Michael E Scheurer  10
Affiliations
Review

Childhood brain tumor epidemiology: a brain tumor epidemiology consortium review

Kimberly J Johnson et al. Cancer Epidemiol Biomarkers Prev. 2014 Dec.

Abstract

Childhood brain tumors are the most common pediatric solid tumor and include several histologic subtypes. Although progress has been made in improving survival rates for some subtypes, understanding of risk factors for childhood brain tumors remains limited to a few genetic syndromes and ionizing radiation to the head and neck. In this report, we review descriptive and analytical epidemiology childhood brain tumor studies from the past decade and highlight priority areas for future epidemiology investigations and methodological work that is needed to advance our understanding of childhood brain tumor causes. Specifically, we summarize the results of a review of studies published since 2004 that have analyzed incidence and survival in different international regions and that have examined potential genetic, immune system, developmental and birth characteristics, and environmental risk factors. Cancer Epidemiol Biomarkers Prev; 23(12); 2716-36. ©2014 AACR.

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Conflict of interest statement

Conflict of Interest Statement: The authors have no conflicts of interest to disclose

Figures

Figure 1
Figure 1. Summary of established and suspected risk factors related to childhood brain tumors
More established risk factors are listed in bold type. Suggested risk factors that are high-priority for validation are listed in non-bold type.
See this image and copyright information in PMC

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