Aspartame, low-calorie sweeteners and disease: regulatory safety and epidemiological issues
- PMID: 23891579
- DOI: 10.1016/j.fct.2013.07.040
Aspartame, low-calorie sweeteners and disease: regulatory safety and epidemiological issues
Abstract
Aspartame is a synthetic sweetener that has been used safely in food for more than 30 years. Its safety has been evaluated by various regulatory agencies in accordance with procedures internationally recognized, and decisions have been revised and updated regularly. The present review summarizes the most relevant conclusions of epidemiological studies concerning the use of low-calorie sweeteners (mainly aspartame), published between January 1990 and November 2012. In the Nurses' Health study and the Health Professionals Followup study some excess risk of Hodgkin lymphoma and multiple myeloma was found in men but not in women; no association was found with leukemia. In the NIH-AARP Diet and Health Study, there was no association between aspartame and haematopoietic neoplasms. US case-control studies of brain and haematopoietic neoplasms also showed no association. The NIH-AARP Diet and Health Study and case-control studies from California showed no association with pancreatic cancer, and a case-control study from Denmark found no relation with breast cancer risk. Italian case-control studies conducted in 1991-2008 reported no consistent association for cancers of the upper aerodigestive tract, digestive tract, breast, endometrium, ovary, prostate, and kidney. Low calorie sweeteners were not consistently related to vascular events and preterm deliveries.
Keywords: Aspartame; Cancer risk; Sweeteners; Toxicity.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Similar articles
-
Acceptable daily intake and the regulation of intense sweeteners.Food Addit Contam. 1990 Jul-Aug;7(4):463-75. doi: 10.1080/02652039009373909. Food Addit Contam. 1990. PMID: 1697543 Review.
-
Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies.Crit Rev Toxicol. 2007;37(8):629-727. doi: 10.1080/10408440701516184. Crit Rev Toxicol. 2007. PMID: 17828671 Review.
-
Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin.Drug Chem Toxicol. 2008;31(4):447-57. doi: 10.1080/01480540802390270. Drug Chem Toxicol. 2008. PMID: 18850355
-
Nephrotoxic Effect of Aspartame as an Artificial Sweetener: a Brief Review.Iran J Kidney Dis. 2017 Oct;11(5):339-343. Iran J Kidney Dis. 2017. PMID: 29038387 Review.
-
Aspartame and Risk of Cancer: A Meta-analytic Review.Arch Environ Occup Health. 2015;70(3):133-41. doi: 10.1080/19338244.2013.828674. Arch Environ Occup Health. 2015. PMID: 24965331
Cited by
-
Measuring Artificial Sweeteners Toxicity Using a Bioluminescent Bacterial Panel.Molecules. 2018 Sep 25;23(10):2454. doi: 10.3390/molecules23102454. Molecules. 2018. PMID: 30257473 Free PMC article.
-
Assessing developmental toxicity of caffeine and sweeteners in medaka (Oryzias latipes).Springerplus. 2015 Sep 8;4:486. doi: 10.1186/s40064-015-1284-0. eCollection 2015. Springerplus. 2015. PMID: 26380162 Free PMC article.
-
Long-term intake of aspartame-induced cardiovascular toxicity is reflected in altered histochemical parameters, evokes oxidative stress, and trigger P53-dependent apoptosis in a mouse model.Int J Exp Pathol. 2022 Dec;103(6):252-262. doi: 10.1111/iep.12458. Epub 2022 Oct 17. Int J Exp Pathol. 2022. PMID: 36251541 Free PMC article.
-
Aspartame Safety as a Food Sweetener and Related Health Hazards.Nutrients. 2023 Aug 18;15(16):3627. doi: 10.3390/nu15163627. Nutrients. 2023. PMID: 37630817 Free PMC article. Review.
-
Aspartame-True or False? Narrative Review of Safety Analysis of General Use in Products.Nutrients. 2021 Jun 7;13(6):1957. doi: 10.3390/nu13061957. Nutrients. 2021. PMID: 34200310 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
