Physiology and toxicity of fluoride
- PMID: 19884722
- DOI: 10.4103/0970-9290.57379
Physiology and toxicity of fluoride
Abstract
Fluoride has been described as an essential element needed for normal development and growth of animals and extremely useful for human beings. Fluoride is abundant in the environment and the main source of fluoride to humans is drinking water. It has been proved to be beneficial in recommended doses, and at the same time its toxicity at higher levels has also been well established. Fluoride gets accumulated in hard tissues of the body and has been know to play an important role in mineralization of bone and teeth. At high levels it has been known to cause dental and skeletal fluorosis. There are suggested effects of very high levels of fluoride on various body organs and genetic material. The purpose of this paper is to review the various aspects of fluoride and its importance in human life.
Similar articles
-
Position of the American Dietetic Association: the impact of fluoride on health.J Am Diet Assoc. 2005 Oct;105(10):1620-8. doi: 10.1016/j.jada.2005.08.017. J Am Diet Assoc. 2005. PMID: 16183366
-
Position of the American Dietetic Association: the impact of fluoride on health.J Am Diet Assoc. 2000 Oct;100(10):1208-13. doi: 10.1016/S0002-8223(00)00349-7. J Am Diet Assoc. 2000. PMID: 11043710 Review.
-
Fluorides in the new millennium.N Y State Dent J. 2001 Feb;67(2):34-8. N Y State Dent J. 2001. PMID: 11280144
-
Fluoride in Drinking Water and Skeletal Fluorosis: a Review of the Global Impact.Curr Environ Health Rep. 2020 Jun;7(2):140-146. doi: 10.1007/s40572-020-00270-9. Curr Environ Health Rep. 2020. PMID: 32207100 Review.
-
Fluoride metabolism and fluorosis.J Dent. 2005 Mar;33(3):177-86. doi: 10.1016/j.jdent.2004.10.003. Epub 2004 Dec 9. J Dent. 2005. PMID: 15725518 Review.
Cited by
-
Excessıve fluorıde ıntake alters the MMP-2, TIMP-1 and TGF-β levels of perıodontal soft tıssues: an experımental study ın rabbıts.Clin Oral Investig. 2012 Dec;16(6):1563-70. doi: 10.1007/s00784-011-0652-6. Epub 2011 Dec 7. Clin Oral Investig. 2012. PMID: 22143481
-
Mitigation of Fluorosis - A Review.J Clin Diagn Res. 2015 Jun;9(6):ZE05-9. doi: 10.7860/JCDR/2015/13261.6085. Epub 2015 Jun 1. J Clin Diagn Res. 2015. PMID: 26266235 Free PMC article. Review.
-
The use of hydroxyapatite toothpaste to prevent dental caries.Odontology. 2022 Apr;110(2):223-230. doi: 10.1007/s10266-021-00675-4. Epub 2021 Nov 22. Odontology. 2022. PMID: 34807345 Free PMC article. Review.
-
Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence.Pharmacogn Mag. 2014 Jan;10(37):61-5. doi: 10.4103/0973-1296.126663. Pharmacogn Mag. 2014. PMID: 24696547 Free PMC article.
-
Effects of Fluorine on Neutrophil Extracellular Trap Formation through Regulating AMPK/p38 Signaling Pathway.Oxid Med Cell Longev. 2021 Aug 2;2021:6693921. doi: 10.1155/2021/6693921. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34394830 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
