Papers by Mitashree Mitra
Journal of Psychological Research, XI (2), 259-270, 2016
In the present paper the findings of a pilot study to determine the Digital Awareness and Interne... more In the present paper the findings of a pilot study to determine the Digital Awareness and Internet usage among the school students of age-group 14 to 19 years in Raipur city of Chhattisgarh are presented. The random sample survey method is used to collect the data from randomly selected private and government schools. The questionnaire was designed to know the use of digital gadgets by the students and also the usage of Internet by them. This study reveals that the students of selected age-group in Raipur city are digitally aware and most of them use Internet for various purposes. The pattern of their Internet surfing is also studied. This study also reveals that majority of the students of this age-group are members of Social Networking sites and/or Social Apps.
International journal of social science review , 2018
The aim of the present piece of research work is to examine the predicting effects of personality... more The aim of the present piece of research work is to examine the predicting effects of personality dimensions, viz., extraversion and neuroticism on career maturity. Employing the correlational design 100 male students of Oraon tribe studying in class 10th within the age range 14-16 years were drawn randomly from different schools of Surguja District of the state of Chhattisgarh to serve as Ss. For assessing the criterion variable, i.e., career maturity, Career Maturity Inventory (CMI) by Gupta (1989) and for assessing the predicting variable viz., personality dimensions Junior Eysenck Personality Inventory by Helode (1985) were used. Multiple regression analysis was used to examine for predicting effects of personality dimensions. Extraversion and Neuroticism have emerged as significant predictors of career maturity. The theoretical implications have been discussed.
Malaria Journal
Background Reticulocyte binding protein-like homologs (RHs) are currently being evaluated as anti... more Background Reticulocyte binding protein-like homologs (RHs) are currently being evaluated as anti-erythrocytic stage vaccine targets against Plasmodium falciparum malaria. Present study explores the possible evolutionary drivers shaping the genetic organization of Pfrhs in Indian parasite population. It simultaneously evaluates a putative gain-of-function variant of PfRH5, a keystone member of PfRH family. Methods Receptor binding regions of Pfrh1, Pfrh2a/b, Pfrh4 and whole Pfrh5 were amplified using blood samples of P. falciparum malaria patients from Chhattisgarh and West Bengal and sequenced. Assembled sequences were analysed using MEGA7 and DnaSPv6. Binding affinities of recombinant PfRH5 proteins with basigin (BSG) were compared using in silico (CHARMM and AUTODOCK) and in vitro (Circular dichroism, fluorescence spectroscopy and isothermal titration calorimetry) methods. Results Pfrh1 (0.5), Pfrh2a/b (0.875), Pfrh4 (0.667) and Pfrh5 (0.778) sequence changes corresponded to low ...
Asian Man (The) - An International Journal
Malaria Journal
Background: Despite its immunogenicity, the polymorphic nature of merozoite surface protein 1, an... more Background: Despite its immunogenicity, the polymorphic nature of merozoite surface protein 1, an important vaccine candidate for Plasmodium falciparum malaria, remains a concern. This study analyses the impact of genetic variability and parasite population structure on epitope organization of different MSP1 segments. Methods: Altogether 98 blood samples collected from P. falciparum infected mild and severe malaria patients of Chhattisgarh and West Bengal were used to sequence regions encoding block 2 and MSP1-19 of msp1. Sequences were analysed using MEGA7, DnaSPv5, Arlequin3.5 and BepiPred. Results: All three major MSP1 block 2 allele families namely K1, MAD20 and RO33 were detected in the samples and they together resulted in 41 indel variants. Chhattisgarh samples displayed an average MOI of 2.07 ± 1.59 which was higher in mild malaria and in age group < 18 years. Ultra-structure of block 2 alleles revealed that mutation and repeat expansion were two major mechanisms responsible for allelic variability of K1 and MAD20. Regions flanking block 2 were highly variable in Chhattisgarh with average mismatch differences (k) ranging from 1.198 to 5.156 for three families. In contrast, region encompassing MSP1-19 exhibited limited heterogeneity (k Chhattisgarh = 1.45, k West Bengal = 1.363). Of the 50 possible B cell linear epitopes predicted from block 2 variants, 94.9% (131 of 138) of the parasites could be represented by three conserved antigens. Conclusions: Present data indicates that natural selection and transmission intensity jointly play a role in controlling allelic diversity of MSP1 in Indian parasite isolates. Despite remarkable genetic variability, a limited number of predominant and conserved epitopes are present in Indian parasite isolates reinstating the importance of MSP1 as a promising malaria vaccine candidate.
EBioMedicine, Jan 15, 2018
Plasmodium falciparum and Plasmodium vivax are two major parasites responsible for malaria which ... more Plasmodium falciparum and Plasmodium vivax are two major parasites responsible for malaria which remains a threat to almost 50% of world's population despite decade-long eradication program. One possible reason behind this conundrum is that the bases of clinical variability in malaria caused by either species are complex and poorly understood. Whole-genome transcriptome was analyzed to identify the active and predominant pathways in the PBMC of P. falciparum and P. vivax infected malaria patients. Deregulated genes were identified and annotated using R Bioconductor and DAVID/KEGG respectively. Genetic and functional regulation of CD14, a prioritized candidate, were established by quantitative RT-PCR, genotyping using RFLP and resequencing, mapping of transcription factor binding using CONSITE and TFBIND, dual luciferase assay, western blot analysis, RNAi- mediated gene knockdown and chromatin-immunoprecipation. The study highlighted that deregulation of host immune and inflammat...
Asian Man (The) - An International Journal, 2015
Anthropometric somatotype of women players of Chhattisgarh, India has been studied during 2006-20... more Anthropometric somatotype of women players of Chhattisgarh, India has been studied during 2006-2008 to evaluate the somatotype status following modified Heath and Carter method (1990). A cross-sectional study on sample of 366 women aged 18 to 25 years was considered for the present study. Out of them 123 were inter-university level player (IUP) (National level players) and 129 were inter- college level players (ICP) (State level players). These women players participated in various sports category and represented their educational institutes at state and national level. Remaining 114 were age –sex matched healthy control subjects (CS) from various colleges who never participated in any sports activity and physical training program. National level players are more mesomorphic then state level players whereas control subjects are more endomorphic. Key Words: Cross-sectional study, Somatotype, Women player, Chhattisgarh.
Asian Man (The) - An International Journal, 2014
Research Journal of Pharmacy and Technology, 2012
Asian Man (The) - An International Journal, 2016
Research Journal of Pharmacy and Technology
Research Journal of Humanities and Social Sciences, 2012
Anthropometric somatotype of women players from Chhattisgarh, India was studied to evaluate somat... more Anthropometric somatotype of women players from Chhattisgarh, India was studied to evaluate somatotype status. A cross-sectional sample of 366 women (18 to 25 years) was considered for the present study. Out of them, 123 were inter-university level players and 129 were inter-college level players (ICP). These women participated in various sports category and represented their educational institutes at inter-college level and inter-university level competitions. The remaining 114 were age –sex matched healthy control subjects (CS). Results of somatotype rating were calculated for each subject using Heath-Carter method of somatotypes. The somatotype rating shows that inter-university level players are more mesomorphic than inter-college level players whereas control subjects are more endomorphic. The ANOVA indicates that in height and weight all the groups were same however, height-weight ratio and somatotype (endomorphy, mesomorphy and ectomorphy) did show a significant difference (p...
... Page 2. RICHA CHANDRAKER, SUMAN CHAKRABARTY, MITASHREE MITRA ET AL. 98 ... A study in Banglad... more ... Page 2. RICHA CHANDRAKER, SUMAN CHAKRABARTY, MITASHREE MITRA ET AL. 98 ... A study in Bangladesh reveals that high infant and child mortality is influenced by limited use of health care services by mothers (Kabir and Amin 1993). ...
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Papers by Mitashree Mitra