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Roi Isaac

Title(s)Assistant Project Scientist, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CCL26 and CXCL12 preserve insulin-sensitizing macrophages in subcutaneous adipose tissue in obesity. Cell Rep. 2025 Oct 28; 44(10):116450. Jeelani I, Franco da Cunha F, Rohm TV, Nasamran CA, Wang L, Moon JS, Prakash S, Oswari J, Isaac R, Murphy C, Glass CK, Olefsky JM, Lee YS. PMID: 41100258; PMCID: PMC12587491.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Adipose Tissue Macrophages in Metabolic Dysfunction-Associated Steatohepatitis Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice. Gastroenterology. 2025 Sep; 169(4):691-704.e9. Rohm TV, Dos Reis FCG, Cunha E Rocha K, Isaac R, Strayer S, Murphy C, Bandyopadhyay G, Gao H, Ganguly S, Nguyen T, Wang J, Youhanna JE, Pack D, Liu X, Kim HY, Jeelani I, Dhar D, Kisseleva T, Ying W, Olefsky JM. PMID: 40204101.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    3. Metabolic Dysfunction-Associated Steatohepatitis Adipose Tissue Macrophages Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice. Gastroenterology. 2025 Apr 09. Rohm TV, Dos Reis FCG, Cunha E Rocha K, Isaac R, Strayer S, Murphy C, Bandyopadhyay G, Gao H, Ganguly S, Nguyen T, Wang J, Youhanna JE, Pack D, Liu X, Kim HY, Jeelani I, Dhar D, Kisseleva T, Ying W, Olefsky JM. PMID: 40204101.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 Aug; 6(8):1646. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38969830.
      View in: PubMed   Mentions: 1     Fields:    
    5. TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metab. 2024 May 07; 36(5):1030-1043.e7. Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. PMID: 38670107; PMCID: PMC11113091.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    6. Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 May; 6(5):880-898. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38605183; PMCID: PMC11430498.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    7. Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins. Cell Genom. 2023 Jul 12; 3(7):100339. DeForest N, Kavitha B, Hu S, Isaac R, Krohn L, Wang M, Du X, De Arruda Saldanha C, Gylys J, Merli E, Abagyan R, Najmi L, Mohan V, Alnylam Human Genetics, AMP-T2D Consortium, Flannick J, Peloso GM, Gordts PLSM, Heinz S, Deaton AM, Khera AV, Olefsky J, Radha V, Majithia AR. PMID: 37492105; PMCID: PMC10363808.
      View in: PubMed   Mentions: 12     Fields:    
    8. A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing. iScience. 2022 Nov 18; 25(11):105270. Isaac R, Vinik Y, Mikl M, Nadav-Eliyahu S, Shatz-Azoulay H, Yaakobi A, DeForest N, Majithia AR, Webster NJG, Shav-Tal Y, Elhanany E, Zick Y. PMID: 36304109; PMCID: PMC9593240.
      View in: PubMed   Mentions:
    9. HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity. Diabetes. 2022 07 01; 71(7):1508-1524. Moon JS, Riopel M, Seo JB, Herrero-Aguayo V, Isaac R, Lee YS. PMID: 35472707; PMCID: PMC9233300.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    10. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 06; 24(6):954-967. Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. PMID: 35637408; PMCID: PMC9233030.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    11. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021 09 07; 33(9):1744-1762. Isaac R, Reis FCG, Ying W, Olefsky JM. PMID: 34496230; PMCID: PMC8428804.
      View in: PubMed   Mentions: 370     Fields:    Translation:HumansCells
    12. Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nat Metab. 2021 09; 3(9):1163-1174. Ji Y, Luo Z, Gao H, Dos Reis FCG, Bandyopadhyay G, Jin Z, Manda KA, Isaac R, Yang M, Fu W, Ying W, Olefsky JM. PMID: 34489604; PMCID: PMC8460610.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    13. TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Cell Metab. 2020 01 07; 31(1):162-173.e5. El Ouarrat D, Isaac R, Lee YS, Oh DY, Wollam J, Lackey D, Riopel M, Bandyopadhyay G, Seo JB, Sampath-Kumar R, Olefsky JM. PMID: 31708444; PMCID: PMC7784082.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    14. Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice. Sci Rep. 2019 10 14; 9(1):14779. Lackey DE, Reis FCG, Isaac R, Zapata RC, El Ouarrat D, Lee YS, Bandyopadhyay G, Ofrecio JM, Oh DY, Osborn O. PMID: 31611602; PMCID: PMC6791934.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 02 05; 29(2):457-474.e5. Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. PMID: 30595478; PMCID: PMC6701710.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    16. Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo. Diabetes. 2017 07; 66(7):1879-1889. Isaac R, Vinik Y, Boura-Halfon S, Farack L, Streim S, Elhanany E, Kam Z, Zick Y. PMID: 28424159.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells. Biochem Biophys Res Commun. 2015 Oct 02; 465(4):851-6. Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y. PMID: 26319551.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells. J Biol Chem. 2013 Feb 22; 288(8):5682-93. Isaac R, Boura-Halfon S, Gurevitch D, Shainskaya A, Levkovitz Y, Zick Y. PMID: 23275337; PMCID: PMC3581374.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    19. Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress. Diabetes. 2010 Sep; 59(9):2188-97. Gurevitch D, Boura-Halfon S, Isaac R, Shahaf G, Alberstein M, Ronen D, Lewis EC, Zick Y. PMID: 20547979; PMCID: PMC2927941.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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