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Gen-sheng Feng

Title(s)Emeritus Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    A new mechanism of hepatocyte proliferation under stress
    NIH R01DK128320Mar 1, 2021 - Feb 28, 2025
    Role: Principal Investigator
    Tumor-promoting liver injuries and mechanisms
    NIH R01CA239629Feb 20, 2020 - Jan 31, 2025
    Role: Principal Investigator
    Intra- and inter-cellular signals that drive hepato-oncogenesis
    NIH R01CA236074Feb 10, 2020 - Jan 31, 2025
    Role: Principal Investigator
    Shp2 and Pten in Leukemia and Anemia
    NIH R01HL129763Sep 1, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Dissection of Pten-regulated signals in hepatopathogenesis
    NIH R01CA188506Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Molecular and cellular communications in liver tumorigenesis
    NIH R01CA176012Mar 1, 2014 - Feb 29, 2020
    Role: Principal Investigator
    Tyrosine Dephosphorylation and Blood Cell Development
    NIH R01HL096125Aug 17, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Coordinated regulation of signaling events for insulin biosynthesis and secretion
    NIH R01DK075916Jan 15, 2009 - Nov 30, 2013
    Role: Principal Investigator
    Regulation of Leptin Signaling
    NIH R01DK073945Jul 1, 2007 - Jun 30, 2011
    Role: Principal Investigator
    Signaling Interactions in Cell Survival and Invasion
    NIH P01CA102583Sep 22, 2004 - Aug 31, 2010
    Role: Co-Investigator
    GAB2 AND A NOVEL CYTOPLASMIC NUCLEAR SIGNALING MECHANISM
    NIH R01HL066208Jan 1, 2001 - Nov 30, 2005
    Role: Principal Investigator
    Tyrosine dephosphorylation and blood cell development
    NIH R01CA078606May 1, 1999 - Feb 28, 2009
    Role: Principal Investigator
    Role of the Shp-2 tyrosine phosphatase in signal transdu
    NIH R01GM053660Mar 1, 1996 - Jun 30, 2006
    Role: Principal Investigator
    SYP PHOSPHATASE AND SIGNAL TRANSDUCTION
    NIH R29GM053660Mar 1, 1996 - Feb 28, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by Aging. Aging Cell. 2026 Feb; 25(2):e70395. Havas A, Rajesh A, Lei X, Proulx J, Miller KN, Field A, Davis A, Teneche MG, Gandhi A, Lee J, Feng GS, Adams PD. PMID: 41653162; PMCID: PMC12882742.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles. Hepatology. 2025 Sep 10. Liu Y, Wang X, Krishnan N, Hsiao T, Ji Y, Kaneko K, Teneche MG, Adams PD, Zuniga E, Kaech SM, Zhang L, Feng GS. PMID: 40928035.
      View in: PubMed   Mentions:    Fields:    
    3. Author Correction: ImAge quantitates aging and rejuvenation. Nat Aging. 2025 Sep; 5(9):1914. Alvarez-Kuglen M, Ninomiya K, Qin H, Rodriguez D, Fiengo L, Farhy C, Hsu WM, Kirk B, Havas A, Kaufman C, Feng GS, Roberts AJ, Anderson RM, Serrano M, Adams PD, Sharpee TO, Terskikh AV. PMID: 40764433.
      View in: PubMed   Mentions:    Fields:    
    4. CD133 + Vesicles Mediate Resistance to RAS-ERK Inhibition Regulated by YAP Activation in Liver Cancer Cells. bioRxiv. 2025 Aug 02. Zhang S, Feng X, Quan E, Kaneko K, Feng GS. PMID: 40766665; PMCID: PMC12324482.
      View in: PubMed   Mentions:
    5. Bioprinted high cell density liver model with improved hepatic metabolic functions. Biomaterials. 2025 Sep; 320:123256. Lu TY, Ji Y, Lyu C, Shen EN, Sun Y, Xiang Y, Meng-Saccoccio T, Feng GS, Chen S. PMID: 40101310.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Author Correction: Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis. Nat Commun. 2025 Feb 07; 16(1):1455. Shao F, Liu Q, Zhu Y, Fan Z, Chen W, Liu S, Li X, Guo W, Feng GS, Yu H, Xu Q, Sun Y. PMID: 39920151; PMCID: PMC11805986.
      View in: PubMed   Mentions:    Fields:    
    7. Bile acid synthesis impedes tumor-specific T cell responses during liver cancer. Science. 2025 01 10; 387(6730):192-201. Varanasi SK, Chen D, Liu Y, Johnson MA, Miller CM, Ganguly S, Lande K, LaPorta MA, Hoffmann FA, Mann TH, Teneche MG, Casillas E, Mangalhara KC, Mathew V, Sun M, Jensen IJ, Farsakoglu Y, Chen T, Parisi B, Deota S, Havas A, Lee J, Chung HK, Schietinger A, Panda S, Williams AE, Farber DL, Dhar D, Adams PD, Feng GS, Shadel GS, Sundrud MS, Kaech SM. PMID: 39787217; PMCID: PMC12166762.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    8. ImAge quantitates aging and rejuvenation. Nat Aging. 2024 Sep; 4(9):1308-1327. Alvarez-Kuglen M, Ninomiya K, Qin H, Rodriguez D, Fiengo L, Farhy C, Hsu WM, Kirk B, Havas A, Kaufman C, Feng GS, Roberts AJ, Anderson RM, Serrano M, Adams PD, Sharpee TO, Terskikh AV. PMID: 39210148; PMCID: PMC12699518.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. Genomic and transcriptomic analyses of chemical hepatocarcinogenesis aggravated by oncoprotein loss. Hepatology. 2025 Apr 01; 81(4):1181-1196. Wang X, Liu Y, Zhang S, Zhang J, Lin X, Liang Y, Zong M, Hanley KL, Lee J, Karin M, Feng GS. PMID: 39397357.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. The most impactful findings on liver cancer in 2023. Hepatol Commun. 2024 04 01; 8(4). Lee J, Hanley KL, Feng GS. PMID: 38466874; PMCID: PMC10932523.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Complex Roles of PTPN11/SHP2 in Carcinogenesis and Prospect of Targeting SHP2 in Cancer Therapy. Annu Rev Cancer Biol. 2024 Jun; 8(1):15-33. Scheiter A, Lu LC, Gao LH, Feng GS. PMID: 39959686; PMCID: PMC11824402.
      View in: PubMed   Mentions: 4  
    12. Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution. Nat Commun. 2023 11 14; 14(1):7356. Liu M, Ji M, Cheng J, Li Y, Tian Y, Zhao H, Wang Y, Zhu S, Zhang L, Xu X, Feng GS, Liang X, Bao H, Tang Y, Kong S, Lu J, Wang H, Lu Z, Deng W. PMID: 37963860; PMCID: PMC10646072.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Imaging-based chromatin and epigenetic age, ImAge, quantitates aging and rejuvenation. Res Sq. 2023 Nov 07. Alvarez-Kuglen M, Rodriguez D, Qin H, Ninomiya K, Fiengo L, Farhy C, Hsu WM, Havas A, Feng GS, Roberts AJ, Anderson RM, Serrano M, Adams PD, Sharpee TO, Terskikh AV. PMID: 37986947; PMCID: PMC10659560.
      View in: PubMed   Mentions:
    14. NCOA5 Deficiency in Macrophages Provokes NASH and HCC. Cell Mol Gastroenterol Hepatol. 2024; 17(1):171-172. Liu Y, Feng GS. PMID: 37935378; PMCID: PMC10791592.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit. Elife. 2023 10 17; 12. Kaneko K, Liang Y, Liu Q, Zhang S, Scheiter A, Song D, Feng GS. PMID: 37846866; PMCID: PMC10581692.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Pharmaceutical SH2 domain-containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity. Hepatology. 2023 05 01; 77(5):1512-1526. Liu JJ, Xin B, Du L, Chen L, Long Y, Feng GS. PMID: 35503714; PMCID: PMC9948275.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    17. Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages. Cell Mol Gastroenterol Hepatol. 2023; 15(6):1351-1369. Du L, Ji Y, Xin B, Zhang J, Lu LC, Glass CK, Feng GS. PMID: 36828281; PMCID: PMC10140795.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    18. Osr1 Is a Critical Regulator of Macrophage Polarization in NASH Progression. Cell Mol Gastroenterol Hepatol. 2023; 15(5):1249-1250. Lee J, Feng GS. PMID: 36801205; PMCID: PMC10140276.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. Mol Cancer Res. 2022 Mar 01; 20(3):337-349. Hanley KL, Liang Y, Wang G, Lin X, Yang M, Karin M, Fu W, Feng GS. PMID: 34810213; PMCID: PMC8898265.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    20. Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics. Dev Cell. 2022 02 07; 57(3):398-414.e5. Liang Y, Kaneko K, Xin B, Lee J, Sun X, Zhang K, Feng GS. PMID: 35134346; PMCID: PMC8842999.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    21. Enhancing the therapeutic efficacy of programmed death ligand 1 antibody for metastasized liver cancer by overcoming hepatic immunotolerance in mice. Hepatology. 2022 09; 76(3):630-645. Xin B, Yang M, Wu P, Du L, Deng X, Hui E, Feng GS. PMID: 34860431; PMCID: PMC9163212.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis. Nat Commun. 2021 11 11; 12(1):6540. Shao F, Liu Q, Zhu Y, Fan Z, Chen W, Liu S, Li X, Guo W, Feng GS, Yu H, Xu Q, Sun Y. PMID: 34764263; PMCID: PMC8585952.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    23. Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment. Cell Rep. 2021 11 09; 37(6):109974. Chen WS, Liang Y, Zong M, Liu JJ, Kaneko K, Hanley KL, Zhang K, Feng GS. PMID: 34758313; PMCID: PMC8656042.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    24. Androgen receptor, neovascularization and liver cancer metastasis. J Hepatol. 2021 10; 75(4):768-769. Feng MW, Hanley KL, Feng GS. PMID: 34233845; PMCID: PMC9948677.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Human-specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression. FASEB Bioadv. 2021 Feb; 3(2):69-82. Siddiqui SS, Vaill M, Do R, Khan N, Verhagen AL, Zhang W, Lenz HJ, Johnson-Pais TL, Leach RJ, Fraser G, Wang C, Feng GS, Varki N, Varki A. PMID: 33615152; PMCID: PMC7876704.
      View in: PubMed   Mentions: 14  
    26. Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies. Hepatology. 2021 01; 73 Suppl 1:104-114. Feng GS, Hanley KL, Liang Y, Lin X. PMID: 32715491; PMCID: PMC7854886.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    27. Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels. J Biol Chem. 2020 07 31; 295(31):10842-10856. Liu W, Yin Y, Wang M, Fan T, Zhu Y, Shen L, Peng S, Gao J, Deng G, Meng X, Kong L, Feng GS, Guo W, Xu Q, Sun Y. PMID: 32546483; PMCID: PMC7397102.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis. Asian J Androl. 2020 Jan-Feb; 22(1):79-87. Li Y, Liu WS, Yi J, Kong SB, Ding JC, Zhao YN, Tian YP, Feng GS, Li CJ, Liu W, Wang HB, Lu ZX. PMID: 31210146; PMCID: PMC6958991.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    29. A tumorigenic index for quantitative analysis of liver cancer initiation and progression. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26873-26880. Wang G, Luo X, Liang Y, Kaneko K, Li H, Fu XD, Feng GS. PMID: 31843886; PMCID: PMC6936392.
      View in: PubMed   Mentions: 7     Fields:    
    30. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019 06 18; 27(12):3629-3645.e6. Yang BH, Wang K, Wan S, Liang Y, Yuan X, Dong Y, Cho S, Xu W, Jepsen K, Feng GS, Lu LF, Xue HH, Fu W. PMID: 31216480; PMCID: PMC6701704.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    31. Stress Conditions Induced by Locoregional Therapies Stimulate Enrichment and Proliferation of Liver Cancer Stem Cells. J Vasc Interv Radiol. 2019 Dec; 30(12):2016-2025.e5. Huo Y, Chen WS, Lee J, Feng GS, Newton IG. PMID: 31208945.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    32. Tumor immunology and immunotherapy: a journey I started from Hangzhou. J Zhejiang Univ Sci B. 2019 May; 20(5):373-380. Feng GS. PMID: 31090263; PMCID: PMC6568228.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    33. An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice. Hepatology. 2019 06; 69(6):2518-2532. Wen L, Xin B, Wu P, Lin CH, Peng C, Wang G, Lee J, Lu LF, Feng GS. PMID: 30693544; PMCID: PMC6541536.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    34. Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury. Hepatology. 2019 05; 69(5):2196-2213. Khambu B, Li T, Yan S, Yu C, Chen X, Goheen M, Li Y, Lin J, Cummings OW, Lee YA, Friedman S, Dong Z, Feng GS, Wu S, Yin XM. PMID: 30520052; PMCID: PMC6461497.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    35. Lens differentiation is controlled by the balance between PDGF and FGF signaling. PLoS Biol. 2019 02; 17(2):e3000133. Li H, Mao Y, Bouaziz M, Yu H, Qu X, Wang F, Feng GS, Shawber C, Zhang X. PMID: 30716082; PMCID: PMC6375662.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    36. High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice. Int J Obes (Lond). 2019 09; 43(9):1747-1758. Qiao L, Chu K, Wattez JS, Lee S, Gao H, Feng GS, Hay WW, Shao J. PMID: 30622311; PMCID: PMC6614019.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    37. β-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β-catenin and MET. Hepatology. 2018 05; 67(5):1807-1822. Liang Y, Feng Y, Zong M, Wei XF, Lee J, Feng Y, Li H, Yang GS, Wu ZJ, Fu XD, Feng GS. PMID: 29152756; PMCID: PMC5906147.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    38. Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET. J Hepatol. 2018 07; 69(1):79-88. Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. PMID: 29505847; PMCID: PMC6008184.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    39. Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 01 23; 7. Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X. PMID: 29360039; PMCID: PMC5818251.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    40. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017 12 18; 8(1):2168. Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, Shen Y, Wang X, Feng GS, Sun Y, Xu Q. PMID: 29255148; PMCID: PMC5735095.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    41. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Rep. 2017 Nov 14; 21(7):1870-1882. Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng GS. PMID: 29141219; PMCID: PMC5737819.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    42. Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis. PLoS Genet. 2017 Oct; 13(10):e1007047. Garg A, Bansal M, Gotoh N, Feng GS, Zhong J, Wang F, Kariminejad A, Brooks S, Zhang X. PMID: 29028795; PMCID: PMC5656309.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    43. Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. FASEB J. 2017 12; 31(12):5530-5542. Cheng J, Zhong Y, Chen S, Sun Y, Huang L, Kang Y, Chen B, Chen G, Wang F, Tian Y, Liu W, Feng GS, Lu Z. PMID: 28842424; PMCID: PMC5690380.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    44. Gel-seq: whole-genome and transcriptome sequencing by simultaneous low-input DNA and RNA library preparation using semi-permeable hydrogel barriers. Lab Chip. 2017 07 25; 17(15):2619-2630. Hoople GD, Richards A, Wu Y, Kaneko K, Luo X, Feng GS, Zhang K, Pisano AP. PMID: 28660979.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    45. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4816-4821. Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H. PMID: 28424251; PMCID: PMC5422785.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    46. Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in China. Oncotarget. 2017 Jan 03; 8(1):1774-1787. Liao R, Fu YP, Wang T, Deng ZG, Li DW, Fan J, Zhou J, Feng GS, Qiu SJ, Du CY. PMID: 27662665; PMCID: PMC5352096.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    47. Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. Cell Rep. 2016 12 13; 17(11):2979-2993. Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng GS. PMID: 27974211; PMCID: PMC5330282.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    48. Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13156-13161. Mathew G, Hannan A, Hertzler-Schaefer K, Wang F, Feng GS, Zhong J, Zhao JJ, Downward J, Zhang X. PMID: 27799550; PMCID: PMC5135310.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    49. SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development. Oncotarget. 2016 Oct 04; 7(40):65676-65695. Gagné-Sansfaçon J, Coulombe G, Langlois MJ, Langlois A, Paquet M, Carrier J, Feng GS, Qu CK, Rivard N. PMID: 27582544; PMCID: PMC5323184.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    50. Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease. J Mol Cell Biol. 2016 12; 8(6):492-504. Chen S, Kang Y, Sun Y, Zhong Y, Li Y, Deng L, Tao J, Li Y, Tian Y, Zhao Y, Cheng J, Liu W, Feng GS, Lu Z. PMID: 27282405.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    51. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. PMID: 27275015; PMCID: PMC4889026.
      View in: PubMed   Mentions: 31     Fields:    
    52. SHP-2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host-Microbiota Homeostasis. J Cell Physiol. 2016 11; 231(11):2529-40. Coulombe G, Langlois A, De Palma G, Langlois MJ, McCarville JL, Gagné-Sanfaçon J, Perreault N, Feng GS, Bercik P, Boudreau F, Verdu EF, Rivard N. PMID: 27100271; PMCID: PMC5330278.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    53. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. PMID: 26858399; PMCID: PMC4776497.
      View in: PubMed   Mentions: 344     Fields:    Translation:HumansCells
    54. Treating leukemia at the risk of inducing severe anemia. Exp Hematol. 2016 May; 44(5):329-31. Chen WS, Zhu HH, Feng GS. PMID: 26826310; PMCID: PMC5331859.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    55. Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proc Natl Acad Sci U S A. 2015 Oct 27; 112(43):13342-7. Zhu HH, Luo X, Zhang K, Cui J, Zhao H, Ji Z, Zhou Z, Yao J, Zeng L, Ji K, Gao WQ, Zhang ZY, Feng GS. PMID: 26460004; PMCID: PMC4629356.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12; 5:12982. Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z. PMID: 26265072; PMCID: PMC4533007.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    57. SHP2-Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice. J Bone Miner Res. 2015 Nov; 30(11):2028-32. Kamiya N, Shen J, Noda K, Kitami M, Feng GS, Chen D, Komatsu Y. PMID: 25919282.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    58. A new VETC in hepatocellular carcinoma metastasis. Hepatology. 2015 Aug; 62(2):343-5. Hanley KL, Feng GS. PMID: 25902918; PMCID: PMC5330284.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    59. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015 Jun; 16(6):642-52. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H. PMID: 25915733; PMCID: PMC4439382.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    60. PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients. J Hepatol. 2015 Sep; 63(3):651-60. Han T, Xiang DM, Sun W, Liu N, Sun HL, Wen W, Shen WF, Wang RY, Chen C, Wang X, Cheng Z, Li HY, Wu MC, Cong WM, Feng GS, Ding J, Wang HY. PMID: 25865556.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    61. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. J Biol Chem. 2015 Feb 13; 290(7):3894-909. Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng GS, Chan RJ. PMID: 25538234; PMCID: PMC4326800.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    62. Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis. Acta Pharmacol Sin. 2015 Jan; 36(1):113-8. Li S, Ni A, Feng GS. PMID: 25500873; PMCID: PMC4571317.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    63. Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. PLoS One. 2014; 9(7):e102847. Li J, Kang Y, Wei L, Liu W, Tian Y, Chen B, Lin X, Li Y, Feng GS, Lu Z. PMID: 25048202; PMCID: PMC4105620.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    64. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 2014 Aug 05; 20(2):320-32. Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS. PMID: 24981838; PMCID: PMC4365973.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    65. Grb2-associated binder 1 is essential for cardioprotection against ischemia/reperfusion injury. Basic Res Cardiol. 2014 Jul; 109(4):420. Sun L, Chen C, Jiang B, Li Y, Deng Q, Sun M, An X, Yang X, Yang Y, Zhang R, Lu Y, Zhu DS, Huo Y, Feng GS, Zhang Y, Luo J. PMID: 24951957.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    66. Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One. 2014; 9(6):e99575. Lee B, Qiao L, Kinney B, Feng GS, Shao J. PMID: 24911652; PMCID: PMC4049836.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    67. VEGFA genomic amplification tailors treatment of HCCs with sorafenib. Cancer Discov. 2014 Jun; 4(6):640-1. Luo X, Feng GS. PMID: 24891362; PMCID: PMC4633301.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    68. NCOA5, a molecular link between type 2 diabetes and liver cancer. Hepatobiliary Surg Nutr. 2014 Jun; 3(3):106-8. Liu CY, Feng GS. PMID: 25019069; PMCID: PMC4073315.
      View in: PubMed   Mentions: 8  
    69. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. PMID: 24789228; PMCID: PMC4008632.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    70. C/EBPα regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. PMID: 24691027; PMCID: PMC4025063.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    71. SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):E1374-82. Lajiness JD, Snider P, Wang J, Feng GS, Krenz M, Conway SJ. PMID: 24706815; PMCID: PMC3986121.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    72. Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions. J Bone Miner Res. 2014 Mar; 29(3):761-9. Kim HK, Feng GS, Chen D, King PD, Kamiya N. PMID: 23929766; PMCID: PMC4081537.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    73. The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase. Stem Cells. 2014 Mar; 32(3):741-53. Puri P, Phillips BT, Suzuki H, Orwig KE, Rajkovic A, Lapinski PE, King PD, Feng GS, Walker WH. PMID: 24123360.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    74. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. PMID: 24531262; PMCID: PMC4077285.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    75. Computation-guided discovery of influenza endonuclease inhibitors. ACS Med Chem Lett. 2014 Jan 09; 5(1):61-64. Chen E, Swift RV, Alderson N, Feher VA, Feng GS, Amaro RE. PMID: 24490002; PMCID: PMC3904387.
      View in: PubMed   Mentions: 12  
    76. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Invest Ophthalmol Vis Sci. 2013 Dec 03; 54(13):7933-42. Ng GY, Yeh LK, Zhang Y, Liu H, Feng GS, Kao WW, Liu CY. PMID: 24204042; PMCID: PMC3850669.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    77. Control of body weight versus tumorigenesis by concerted action of leptin and estrogen. Rev Endocr Metab Disord. 2013 Dec; 14(4):339-45. He Z, Feng GS. PMID: 24142297.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    78. Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 01; 127(Pt 3):571-82. Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X. PMID: 24284065; PMCID: PMC4007765.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    79. Induction of SHP2 deficiency in chondrocytes causes severe scoliosis and kyphosis in mice. Spine (Phila Pa 1976). 2013 Oct 01; 38(21):E1307-12. Kim HK, Aruwajoye O, Sucato D, Richards BS, Feng GS, Chen D, King PD, Kamiya N. PMID: 23873233; PMCID: PMC3864111.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    80. Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice. Dis Model Mech. 2013 Nov; 6(6):1448-58. Lapinski PE, Meyer MF, Feng GS, Kamiya N, King PD. PMID: 24077964; PMCID: PMC3820267.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    81. Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. Mol Cancer Ther. 2013 Sep; 12(9):1796-804. Wen W, Han T, Chen C, Huang L, Sun W, Wang X, Chen SZ, Xiang DM, Tang L, Cao D, Feng GS, Wu MC, Ding J, Wang HY. PMID: 23804702.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    82. Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development. 2013 Jul; 140(13):2711-23. Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F, Zhang X. PMID: 23720040; PMCID: PMC3678341.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    83. Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Mol Cell Biol. 2013 Jun; 33(11):2275-84. Coulombe G, Leblanc C, Cagnol S, Maloum F, Lemieux E, Perreault N, Feng GS, Boudreau F, Rivard N. PMID: 23530062; PMCID: PMC3648065.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    84. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3137-42. Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA. PMID: 23382182; PMCID: PMC3581884.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    85. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem. 2013 Feb 08; 288(6):3823-30. Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS. PMID: 23269672; PMCID: PMC3567637.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    86. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. Stem Cells Dev. 2013 Mar 15; 22(6):998-1006. Broxmeyer HE, Etienne-Julan M, Gotoh A, Braun SE, Lu L, Cooper S, Feng GS, Li XJ, Chan RJ. PMID: 23082805; PMCID: PMC3585482.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    87. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):E79-88. He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS. PMID: 23236157; PMCID: PMC3538237.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    88. Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology. 2012 Dec; 56(6):2255-67. Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. PMID: 22898879.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    89. The unique cysteine knot regulates the pleotropic hormone leptin. PLoS One. 2012; 7(9):e45654. Haglund E, Sulkowska JI, He Z, Feng GS, Jennings PA, Onuchic JN. PMID: 23029163; PMCID: PMC3454405.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    90. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis. Front Med. 2012 Sep; 6(3):275-9. Li S, Hsu DD, Wang H, Feng GS. PMID: 22869052.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    91. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 2012 Sep 27; 120(13):2669-78. Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, Kapur R. PMID: 22806893; PMCID: PMC3460688.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    92. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 2012 Jul 15; 26(14):1587-601. Huang H, Woo AJ, Waldon Z, Schindler Y, Moran TB, Zhu HH, Feng GS, Steen H, Cantor AB. PMID: 22759635; PMCID: PMC3404386.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    93. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun. 2012 Jun 19; 3:911. Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J. PMID: 22713753.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    94. OV6⁺ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J Hepatol. 2012 Sep; 57(3):613-20. Yang W, Wang C, Lin Y, Liu Q, Yu LX, Tang L, Yan HX, Fu J, Chen Y, Zhang HL, Tang L, Zheng LY, He YQ, Li YQ, Wu FQ, Zou SS, Li Z, Wu MC, Feng GS, Wang HY. PMID: 22612999.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    95. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol. 2012 Jul; 32(14):2653-63. Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng GS, Hartmann K, Roers A, Craig AW. PMID: 22566685; PMCID: PMC3416204.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    96. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol Cell Biol. 2012 May; 32(10):1867-78. He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS. PMID: 22431513; PMCID: PMC3347413.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    97. p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology. 2012 Jun; 142(7):1547-58.e14. Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, Wang HY. PMID: 22387393.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    98. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB J. 2012 Jun; 26(6):2338-50. Zhang X, Zhang Y, Tao B, Teng L, Li Y, Cao R, Gui Q, Ye M, Mou X, Cheng H, Hu H, Zhou R, Wu X, Xie Q, Ning W, Lai M, Shen H, Feng GS, Ke Y. PMID: 22362894.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    99. Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. Cancer Cell. 2012 Feb 14; 21(2):150-4. Feng GS. PMID: 22340589; PMCID: PMC3285429.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    100. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood. 2012 Mar 29; 119(13):3155-63. Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng GS, Zhang DE. PMID: 22223820; PMCID: PMC3321875.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    101. Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells. Hepatology. 2011 Oct; 54(4):1259-72. Sun W, Ding J, Wu K, Ning BF, Wen W, Sun HY, Han T, Huang L, Dong LW, Yang W, Deng X, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. PMID: 21735473.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    102. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology. 2011 Nov; 54(5):1620-30. Li L, Chen L, Hu L, Liu Y, Sun HY, Tang J, Hou YJ, Chang YX, Tu QQ, Feng GS, Shen F, Wu MC, Wang HY. PMID: 21809356.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    103. The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. Cell Cycle. 2011 Jul 15; 10(14):2241-2. Zhu HH, Feng GS. PMID: 21701261; PMCID: PMC3322470.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    104. G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Blood. 2011 Jul 28; 118(4):1077-86. Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng GS, Corey SJ. PMID: 21636860; PMCID: PMC3148159.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    105. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell. 2011 May 17; 19(5):629-39. Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng GS. PMID: 21575863; PMCID: PMC3098128.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    106. Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul; 31(14):2973-83. Cai Z, Simons DL, Fu XY, Feng GS, Wu SM, Zhang X. PMID: 21576358; PMCID: PMC3133408.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    107. Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat. J Cell Mol Med. 2011 Apr; 15(4):763-72. Ruan X, Li Z, Zhang Y, Yang L, Pan Y, Wang Z, Feng GS, Chen Y. PMID: 20193037; PMCID: PMC3922665.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    108. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood. 2011 May 19; 117(20):5350-61. Zhu HH, Ji K, Alderson N, He Z, Li S, Liu W, Zhang DE, Li L, Feng GS. PMID: 21450902; PMCID: PMC3109710.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    109. Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1016-23. Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM, Hamik A, Jain MK, Feng GS, Jin ZG. PMID: 21372298; PMCID: PMC3094153.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    110. Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2957-62. Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Hessling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, Feng GS, Luo J. PMID: 21282639; PMCID: PMC3041066.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    111. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways. Hepatology. 2011 Jan; 53(1):181-92. Fu J, Chen Y, Cao J, Luo T, Qian YW, Yang W, Ren YB, Su B, Cao GW, Yang Y, Yan YQ, Shen F, Wu MC, Feng GS, Wang HY. PMID: 21254169.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    112. Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations. Dis Model Mech. 2011 Mar; 4(2):228-39. Bauler TJ, Kamiya N, Lapinski PE, Langewisch E, Mishina Y, Wilkinson JE, Feng GS, King PD. PMID: 21068439; PMCID: PMC3046097.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    113. Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphatase. Glia. 2010 Sep; 58(12):1407-14. Zhu Y, Park J, Hu X, Zheng K, Li H, Cao Q, Feng GS, Qiu M. PMID: 20648636; PMCID: PMC3762492.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    114. Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development. 2010 Apr; 137(7):1085-93. Pan Y, Carbe C, Powers A, Feng GS, Zhang X. PMID: 20215346; PMCID: PMC2835324.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    115. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. J Neurosci. 2010 Mar 17; 30(11):4110-9. Cai Z, Feng GS, Zhang X. PMID: 20237281; PMCID: PMC2845916.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    116. Osteoblastic molecular scaffold Gab1 is required for maintaining bone homeostasis. J Cell Sci. 2010 Mar 01; 123(Pt 5):682-9. Weng T, Mao F, Wang Y, Sun Q, Li R, Yang G, Zhang X, Luo J, Feng GS, Yang X. PMID: 20124419.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    117. SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells. J Immunol. 2009 Oct 15; 183(8):4940-7. McPherson VA, Sharma N, Everingham S, Smith J, Zhu HH, Feng GS, Craig AW. PMID: 19786542.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    118. Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development. Dev Biol. 2009 Oct 01; 334(1):276-84. Hagihara K, Zhang EE, Ke YH, Liu G, Liu JJ, Rao Y, Feng GS. PMID: 19635473; PMCID: PMC2744846.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    119. Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway. Sci Signal. 2009 Apr 28; 2(68):ra17. Cao C, Huang X, Han Y, Wan Y, Birnbaumer L, Feng GS, Marshall J, Jiang M, Chu WM. PMID: 19401591; PMCID: PMC4138699.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    120. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7531-6. Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS. PMID: 19380737; PMCID: PMC2678606.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    121. A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. PLoS One. 2009; 4(3):e4914. Wu D, Pang Y, Ke Y, Yu J, He Z, Tautz L, Mustelin T, Ding S, Huang Z, Feng GS. PMID: 19290061; PMCID: PMC2655646.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    122. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 2009 Jan 07; 28(1):21-33. Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T. PMID: 19057511; PMCID: PMC2633077.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    123. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol. 2009 Jan; 29(2):378-88. Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS. PMID: 19001090; PMCID: PMC2612510.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    124. Characterization of the topology and functional domains of RKTG. Biochem J. 2008 Sep 15; 414(3):399-406. Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, Chen Y. PMID: 18547165.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    125. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity. J Med Chem. 2008 Sep 25; 51(18):5650-62. Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, Hobbs PD, Jong L, Waleh N, Chao WR, Feng GS, Pang Y, Su Y. PMID: 18759424; PMCID: PMC4097887.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    126. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol. 2008 May; 172(5):1312-24. Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. PMID: 18403587; PMCID: PMC2329840.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    127. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development. 2008 Jan; 135(2):301-10. Pan Y, Carbe C, Powers A, Zhang EE, Esko JD, Grobe K, Feng GS, Zhang X. PMID: 18077586.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    128. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol. 2007 Oct; 27(19):6706-17. Ke Y, Zhang EE, Hagihara K, Wu D, Pang Y, Klein R, Curran T, Ranscht B, Feng GS. PMID: 17646384; PMCID: PMC2099234.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    129. SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5419-24. Amin AR, Thakur VS, Paul RK, Feng GS, Qu CK, Mukhtar H, Agarwal ML. PMID: 17369354; PMCID: PMC1838507.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    130. A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection. Mol Cell Biol. 2007 May; 27(10):3708-15. Ni S, Zhao C, Feng GS, Paulson RF, Correll PH. PMID: 17353274; PMCID: PMC1899994.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    131. Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. Cell Res. 2007 Jan; 17(1):37-41. Feng GS. PMID: 17211446.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    132. Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. J Immunol. 2006 Nov 01; 177(9):5990-6. Nguyen TV, Ke Y, Zhang EE, Feng GS. PMID: 17056523.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    133. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood. 2007 Feb 01; 109(3):862-7. Chan RJ, Feng GS. PMID: 17053061; PMCID: PMC1785139.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCells
    134. Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J Biol Chem. 2006 Nov 10; 281(45):34374-80. Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS. PMID: 16959766; PMCID: PMC1761121.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    135. Shp2 is dispensable in the formation and maintenance of the neuromuscular junction. Neurosignals. 2006-2007; 15(2):53-63. Dong XP, Li XM, Gao TM, Zhang EE, Feng GS, Xiong WC, Mei L. PMID: 16837792.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    136. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol. 2006 Jun; 26(12):4664-74. Bard-Chapeau EA, Yuan J, Droin N, Long S, Zhang EE, Nguyen TV, Feng GS. PMID: 16738330; PMCID: PMC1489129.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    137. Shp2 as a therapeutic target for leptin resistance and obesity. Expert Opin Ther Targets. 2006 Feb; 10(1):135-42. Feng GS. PMID: 16441233.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    138. Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. Blood. 2005 Nov 01; 106(9):3142-9. Xu R, Yu Y, Zheng S, Zhao X, Dong Q, He Z, Liang Y, Lu Q, Fang Y, Gan X, Xu X, Zhang S, Dong Q, Zhang X, Feng GS. PMID: 16030196; PMCID: PMC1895328.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    139. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med. 2005 May; 11(5):567-71. Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS. PMID: 15821749.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    140. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A. 2004 Nov 09; 101(45):16064-9. Zhang EE, Chapeau E, Hagihara K, Feng GS. PMID: 15520383; PMCID: PMC528739.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    141. Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis. Mol Cell Biol. 2004 Feb; 24(4):1531-9. Sun Y, Yuan J, Liu H, Shi Z, Baker K, Vuori K, Wu J, Feng GS. PMID: 14749370; PMCID: PMC344197.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    142. Identification of trans-acting factors by electrophoretic mobility shift assay. Methods Mol Biol. 2004; 249:7-20. Chan RJ, You M, Feng GS. PMID: 14573887.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    143. SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix metalloproteinase 2 via the extracellular signal-regulated kinase and p38 pathways. Cancer Res. 2003 Oct 01; 63(19):6334-9. Ruhul Amin AR, Oo ML, Senga T, Suzuki N, Feng GS, Hamaguchi M. PMID: 14559821.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    144. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem. 2003 Sep 05; 278(36):34641-53. Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS. PMID: 12819203.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    145. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood. 2003 Sep 15; 102(6):2074-80. Chan RJ, Johnson SA, Li Y, Yoder MC, Feng GS. PMID: 12791646.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    146. The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts. J Biol Chem. 2003 Jul 18; 278(29):27190-8. MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP. PMID: 12721296.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    147. Identification of Shp-2 as a Stat5A phosphatase. J Biol Chem. 2003 May 09; 278(19):16520-7. Chen Y, Wen R, Yang S, Schuman J, Zhang EE, Yi T, Feng GS, Wang D. PMID: 12615921.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    148. SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J Biol Chem. 2002 Dec 06; 277(49):47572-80. Wu TR, Hong YK, Wang XD, Ling MY, Dragoi AM, Chung AS, Campbell AG, Han ZY, Feng GS, Chin YE. PMID: 12270932.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    149. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol Cell Biol. 2002 May; 22(10):3230-6. Shen R, Ouyang YB, Qu CK, Alonso A, Sperzel L, Mustelin T, Kaplan MH, Feng GS. PMID: 11971956; PMCID: PMC133801.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
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