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Dechen Lin, PhD

Photo of Dechen Lin, PhD
Title(s)Assistant Professor
SchoolHerman Ostrow School of Dentistry of Usc
Address2250 Alcazar St.
Health Sciences Campus
Los Angeles CA 90033
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    Collapse Biography 
    Collapse awards and honors
    Sigma Xi2024Elected full member
    Ming Hsieh Institute2023Ming Hsieh Research Award
    Springer Nature Publishing Group (Oncogene)2020Readers' Choice: The best of Oncogene 2019
    American Association for Cancer Research (AACR)2019Best of AACR Award: most-cited research article in Cancer Research
    American Society of Hematology2015ASH Fellow Scholar Award
    American Association for Cancer Research (AACR)2014Incorporated Scholar-in-Training Award
    NIH/NCI2020NCI R37 MERIT Award

    Collapse Overview 
    Collapse overview
    Dr. Dechen Lin is an Assistant Professor at the Herman Ostrow School of Dentistry of the USC and serves as the Associate Director of Research for the USC Head and Neck Center at the Keck School of Medicine. At the USC Center for Craniofacial Molecular Biology, he leads a research program focused on cancer genomics, transcriptional regulation, and epigenomics, particularly in head and neck squamous cell carcinoma (HNSCC) and esophageal cancers.

    Dr. Lin earned his B.S. in Biology from Nanjing University in 2005 and his Ph.D. in Cell Biology from the Chinese Academy of Medical Sciences in 2010. He completed postdoctoral training at the Cancer Science Institute of Singapore and Cedars-Sinai Medical Center. Prior to joining USC in 2022, he held faculty positions at Cedars-Sinai and served as an Adjunct Associate Professor at UCLA.

    His research employs advanced genomic and organoid-based models to investigate the molecular mechanisms driving cancer progression and immune evasion. Notably, his recent work identified the gene KMT2C as a key regulator of tumor-infiltrating lymphocytes, enhancing the efficacy of immune checkpoint blockade therapies in HNSCC.

    Dr. Lin's contributions have been recognized with several awards, including the NIH/NCI R37 MERIT Award (2020), the Ming Hsieh Research Award (2023), and he has authored over 100 peer-reviewed publications.
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    Collapse Research 
    Collapse research activities and funding
    Modeling Pathways of Early Growth Dysregulation at the GEJ
    NIH/NIDDK 1R01DK135562May 1, 2024 - May 1, 2029
    Role: MPI
    Pharmacological and dietary inhibition of a novel metabolic-epigenetic crosstalk in head and neck cancer
    NIH R01DE033648Mar 1, 2024 - Jan 31, 2029
    Role: Principal Investigator
    Master regulator transcription factors promote esophageal neoplastic evolution
    NIH R37CA237022Jun 1, 2020 - May 31, 2025
    Role: MPI

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Precision Epigenetic Reprogramming: CoREST Inhibition Sensitizes STK11-Mutant Tumors to Immune Checkpoint Blockade Therapy. Cancer Res. 2025 Oct 15; 85(20):3821-3822. Lin DC, Shen K. PMID: 41088878.
      View in: PubMed   Mentions:
    2. Unmasking cancer's hidden nerve route with patient-derived organoids. Cell Stem Cell. 2025 Oct 02; 32(10):1481-1482. Waters KM, Merchant A, Lin DC. PMID: 41043399.
      View in: PubMed   Mentions:
    3. A high-power spatial, single-cell view of pericytes in esophageal cancer metastasis. Nat Genet. 2025 Oct; 57(10):2350-2351. Sinha UK, Park YM, Lin DC. PMID: 41073784.
      View in: PubMed   Mentions:
    4. Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma. Cancer Res. 2025 Jul 15; 85(14):2726-2742. Um JH, Zheng Y, Mao Q, Nam C, Zhao H, Koh YW, Shin SJ, Park YM, Lin DC. PMID: 40261963; PMCID: PMC12263324.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer. J Exp Med. 2025 Apr 07; 222(4). Nam C, Huang G, Zheng Y, Zhao H, Pan Y, Hu B, Wenger T, Van HT, Xu LY, Li EM, Koeffler HP, Ge K, Dou Y, Sinha UK, Park YM, Lin DC. PMID: 39964485; PMCID: PMC11834937.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities. bioRxiv. 2025 Jan 22. Zhao H, Park YM, Zheng Y, Mao Q, Collet C, Hu B, Zhou T, Lin L, Wong S, Pan Y, Monreal AV, Sinha UK, Sedghizadeh P, Soragni A, Lin DC. PMID: 39896470; PMCID: PMC11785044.
      View in: PubMed   Mentions:
    7. Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis. Epigenetics Chromatin. 2025 Jan 20; 18(1):6. Liang Y, Liu M, Liu B, Ziman B, Peng G, Mao Q, Wang X, Jiang L, Lin DC, Zheng Y. PMID: 39833880; PMCID: PMC11748335.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Patient-derived tumor organoids to model drug response in gastric cancer. Cell Rep Med. 2024 Jul 16; 5(7):101650. Vistoso Monreal A, Zhao H, Sedghizadeh PP, Lin DC. PMID: 39019014; PMCID: PMC11293348.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma. bioRxiv. 2024 Jul 02. Um JH, Zheng Y, Mao Q, Nam C, Zhao H, Koh YW, Shin SJ, Park YM, Lin DC. PMID: 39005427; PMCID: PMC11244938.
      View in: PubMed   Mentions:
    10. A druggable cascade links methionine metabolism to epigenomic reprogramming in squamous cell carcinoma. Proc Natl Acad Sci U S A. 2024 Jun 25; 121(26):e2320835121. Nam C, Li LY, Yang Q, Ziman B, Zhao H, Hu B, Collet C, Jing P, Lei Q, Xu LY, Li EM, Koeffler HP, Sinha UK, Lin DC. PMID: 38900797; PMCID: PMC11214090.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer. Nat Commun. 2024 Mar 20; 15(1):2484. Jiang Y, Zheng Y, Zhang YW, Kong S, Dong J, Wang F, Ziman B, Gery S, Hao JJ, Zhou D, Zhou J, Ho AS, Sinha UK, Chen J, Zhang S, Yin C, Wei DD, Hazawa M, Pan H, Lu Z, Wei WQ, Wang MR, Koeffler HP, Lin DC, Jiang YY. PMID: 38509096; PMCID: PMC10954759.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    12. Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma. Cell Death Dis. 2024 02 19; 15(2):152. Ziman B, Yang Q, Zheng Y, Sheth M, Nam C, Zhao H, Zhang L, Hu B, Bhowmick NA, Sinha UK, Lin DC. PMID: 38373993; PMCID: PMC10876663.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response. Dis Model Mech. 2024 Jan 01; 17(1). Jiang Y, Zhao H, Kong S, Zhou D, Dong J, Cheng Y, Zhang S, Wang F, Kalra A, Yang N, Wei DD, Chen J, Zhang YW, Lin DC, Meltzer SJ, Jiang YY. PMID: 38258518; PMCID: PMC10846528.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    14. ARID1A Deficiency Regulates Anti-Tumor Immune Response in Esophageal Adenocarcinoma. Cancers (Basel). 2023 Nov 12; 15(22). Zhang L, Zheng Y, Chien W, Ziman B, Billet S, Koeffler HP, Lin DC, Bhowmick NA. PMID: 38001638; PMCID: PMC10670331.
      View in: PubMed   Mentions: 1  
    15. Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells. Cell Chem Biol. 2024 Apr 18; 31(4):792-804.e7. Hazawa M, Ikliptikawati DK, Iwashima Y, Lin DC, Jiang Y, Qiu Y, Makiyama K, Matsumoto K, Kobayashi A, Nishide G, Keesiang L, Yoshino H, Minamoto T, Suzuki T, Kobayashi I, Meguro-Horike M, Jiang YY, Nishiuchi T, Konno H, Koeffler HP, Hosomichi K, Tajima A, Horike SI, Wong RW. PMID: 37924814.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    16. Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics. Nat Commun. 2023 11 02; 14(1):7017. Park YM, Lin DC. PMID: 37919364; PMCID: PMC10622517.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation. Genome Biol. 2023 08 24; 24(1):193. Zheng Y, Ziman B, Ho AS, Sinha UK, Xu LY, Li EM, Koeffler HP, Berman BP, Lin DC. PMID: 37620896; PMCID: PMC10463844.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    18. Comparative impact of grade on mortality across salivary cancers: A novel, unifying staging system. Head Neck. 2023 08; 45(8):2028-2039. Ho AS, Luu M, Balzer BL, Aro K, Jang JK, Mita AC, Scher KS, Mallen-St Clair J, Vasquez M, Bastien AJ, Epstein JB, Lin DC, Chen MM, Zumsteg ZS. PMID: 37345665.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR. J Ovarian Res. 2023 Apr 22; 16(1):80. Chien W, Tyner JW, Gery S, Zheng Y, Li LY, Gopinatha Pillai MS, Nam C, Bhowmick NA, Lin DC, Koeffler HP. PMID: 37087441; PMCID: PMC10122390.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics. 2023; 13(6):1823-1825. Sinha UK, Lin DC. PMID: 37064876; PMCID: PMC10091883.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy. Cancer Res. 2023 03 15; 83(6):922-938. Ran XB, Ding LW, Sun QY, Yang H, Said JW, Zhentang L, Madan V, Dakle P, Xiao JF, Loh X, Li Y, Xu L, Xiang XQ, Wang LZ, Goh BC, Lin DC, Chng WJ, Tan SY, Jha S, Koeffler HP. PMID: 36638333.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    22. Large-scale genomic analyses reveal alterations and mechanisms underlying clonal evolution and immune evasion in esophageal cancer. Nat Commun. 2023 02 17; 14(1):893. Lin DC. PMID: 36807265; PMCID: PMC9938131.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Single-cell genomics identifies immune response to neoadjuvant chemoradiotherapy. EBioMedicine. 2022 12; 86:104389. Sinha UK, Kast WM, Lin DC. PMID: 36463779; PMCID: PMC9718959.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model. Sci Transl Med. 2022 11 30; 14(673):eabq6146. Zhao H, Cheng Y, Kalra A, Ma K, Zheng Y, Ziman B, Tressler C, Glunde K, Shin EJ, Ngamruengphong S, Khashab M, Singh V, Anders RA, Jit S, Wyhs N, Chen W, Li X, Lin DC, Meltzer SJ. PMID: 36449602; PMCID: PMC10026384.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    25. Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models. Comput Struct Biotechnol J. 2022; 20:5309-5315. Zhao H, Collet C, Peng D, Sinha UK, Lin DC. PMID: 36212534; PMCID: PMC9513696.
      View in: PubMed   Mentions: 5  
    26. Genomic and Epigenomic Characterization of Tumor Organoid Models. Cancers (Basel). 2022 Aug 24; 14(17). Nam C, Ziman B, Sheth M, Zhao H, Lin DC. PMID: 36077628; PMCID: PMC9454968.
      View in: PubMed   Mentions: 11  
    27. Quantitative Nodal Burden and Mortality Across Solid Cancers. J Natl Cancer Inst. 2022 07 11; 114(7):1003-1011. Nguyen AT, Luu M, Nguyen VP, Lu DJ, Shiao SL, Kamrava M, Atkins KM, Mita AC, Scher KS, Spratt DE, Faries MB, Daskivich TJ, Lin DC, Chen MM, Clair JM, Sandler HM, Ho AS, Zumsteg ZS. PMID: 35311991; PMCID: PMC9275768.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Chemotherapy predictors and a time-dependent chemotherapy effect in metastatic esophageal cancer. World J Gastrointest Oncol. 2022 Feb 15; 14(2):511-524. Midthun L, Kim S, Hendifar A, Osipov A, Klempner SJ, Chao J, Cho M, Guan M, Placencio-Hickok VR, Gangi A, Burch M, Lin DC, Waters K, Atkins K, Kamrava M, Gong J. PMID: 35317320; PMCID: PMC8919005.
      View in: PubMed   Mentions: 1  
    29. Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment. Nat Commun. 2021 12 17; 12(1):7335. Dinh HQ, Pan F, Wang G, Huang QF, Olingy CE, Wu ZY, Wang SH, Xu X, Xu XE, He JZ, Yang Q, Orsulic S, Haro M, Li LY, Huang GW, Breunig JJ, Koeffler HP, Hedrick CC, Xu LY, Lin DC, Li EM. PMID: 34921160; PMCID: PMC8683407.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    30. Comparative Proteomic Analysis of HPV(+) Oropharyngeal Squamous Cell Carcinoma Recurrence. J Proteome Res. 2022 01 07; 21(1):200-208. Ho AS, Robinson A, Shon W, Laury A, Raedschelders K, Venkatraman V, Holewinski R, Zhang Y, Shiao SL, Chen MM, Mallen-St Clair J, Lin DC, Zumsteg ZS, Van Eyk JE. PMID: 34846153.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Predicting master transcription factors from pan-cancer expression data. Sci Adv. 2021 Nov 26; 7(48):eabf6123. Reddy J, Fonseca MAS, Corona RI, Nameki R, Segato Dezem F, Klein IA, Chang H, Chaves-Moreira D, Afeyan LK, Malta TM, Lin X, Abbasi F, Font-Tello A, Sabedot T, Cejas P, Rodríguez-Malavé N, Seo JH, Lin DC, Matulonis U, Karlan BY, Gayther SA, Pasaniuc B, Gusev A, Noushmehr H, Long H, Freedman ML, Drapkin R, Young RA, Abraham BJ, Lawrenson K. PMID: 34818047; PMCID: PMC8612691.
      View in: PubMed   Mentions: 42     Fields:    
    32. Predictive Impact of Metastatic Lymph Node Burden on Distant Metastasis Across Papillary Thyroid Cancer Variants. Thyroid. 2021 10; 31(10):1549-1557. Ho AS, Luu M, Shafqat I, Mallen-St Clair J, Chen MM, Chen Y, Jain M, Ali N, Patio C, Filarski CF, Lin DC, Bankston H, Braunstein GD, Sacks WL, Zumsteg ZS. PMID: 34470466.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    33. A closer look at esophageal cancer through different lenses. EBioMedicine. 2021 09; 71:103545. Lin DC. PMID: 34419929; PMCID: PMC8385164.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Complete response to neoadjuvant pembrolizumab and capecitabine in microsatellite stable, Epstein-Barr virus-positive, locally advanced gastric adenocarcinoma: case report. AME Case Rep. 2021; 5:30. Lin CY, Mehta P, Waters KM, Chang E, Hendifar A, Osipov A, Burch M, Lin DC, Gangi A, Cho M, Gong J. PMID: 34312609; PMCID: PMC8256116.
      View in: PubMed   Mentions: 3  
    35. Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nat Commun. 2021 07 16; 12(1):4362. Li LY, Yang Q, Jiang YY, Yang W, Jiang Y, Li X, Hazawa M, Zhou B, Huang GW, Xu XE, Gery S, Zhang Y, Ding LW, Ho AS, Zumsteg ZS, Wang MR, Fullwood MJ, Freedland SJ, Meltzer SJ, Xu LY, Li EM, Koeffler HP, Lin DC. PMID: 34272396; PMCID: PMC8285542.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    36. Publisher Correction: A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes. Nat Commun. 2021 Jun 28; 12(1):4106. Zheng Y, Huang G, Silva TC, Yang Q, Jiang YY, Koeffler HP, Lin DC, Berman BP. PMID: 34183671; PMCID: PMC8238980.
      View in: PubMed   Mentions:    Fields:    
    37. Exercise impacts the epigenome of cancer. Prostate Cancer Prostatic Dis. 2022 09; 25(3):379-380. Lin DC. PMID: 34045658.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    38. Super-enhancer-mediated core regulatory circuitry in human cancer. Comput Struct Biotechnol J. 2021; 19:2790-2795. Jiang Y, Jiang YY, Lin DC. PMID: 34093993; PMCID: PMC8138668.
      View in: PubMed   Mentions: 21  
    39. A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes. Nat Commun. 2021 04 30; 12(1):2485. Zheng Y, Huang G, Silva TC, Yang Q, Jiang YY, Koeffler HP, Lin DC, Berman BP. PMID: 33931649; PMCID: PMC8087678.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    40. Nodal staging convergence for HPV- and HPV+ oropharyngeal carcinoma. Cancer. 2021 05 15; 127(10):1590-1597. Ho AS, Luu M, Kim S, Tighiouart M, Mita AC, Scher KS, Mallen-St Clair J, Walgama ES, Lin DC, Nguyen AT, Zumsteg ZS. PMID: 33595897.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    41. Systematic Proteome and Lysine Succinylome Analysis Reveals Enhanced Cell Migration by Hyposuccinylation in Esophageal Squamous Cell Carcinoma. Mol Cell Proteomics. 2021; 20:100053. Guo Z, Pan F, Peng L, Tian S, Jiao J, Liao L, Lu C, Zhai G, Wu Z, Dong H, Xu X, Wu J, Chen P, Bai X, Lin D, Xu L, Li E, Zhang K. PMID: 33561546; PMCID: PMC7970140.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    42. A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma. Cancer Res. 2021 03 01; 81(5):1216-1229. Ma S, Zhou B, Yang Q, Pan Y, Yang W, Freedland SJ, Ding LW, Freeman MR, Breunig JJ, Bhowmick NA, Pan J, Koeffler HP, Lin DC. PMID: 33402390; PMCID: PMC8026506.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    43. EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma. Nucleic Acids Res. 2020 11 18; 48(20):11434-11451. Shi X, Zheng Y, Jiang L, Zhou B, Yang W, Li L, Ding L, Huang M, Gery S, Lin DC, Koeffler HP. PMID: 33080033; PMCID: PMC7672457.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    44. Prognostic Impact of Histologic Grade for Papillary Thyroid Carcinoma. Ann Surg Oncol. 2021 Mar; 28(3):1731-1739. Ho AS, Luu M, Barrios L, Balzer BL, Bose S, Fan X, Walgama E, Mallen-St Clair J, Alam U, Shafqat I, Lin DC, Chen Y, Van Eyk JE, Maghami EG, Braunstein GD, Sacks WL, Zumsteg ZS. PMID: 32808161.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    45. TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines. Gastroenterology. 2020 10; 159(4):1311-1327.e19. Jiang YY, Jiang Y, Li CQ, Zhang Y, Dakle P, Kaur H, Deng JW, Lin RY, Han L, Xie JJ, Yan Y, Doan N, Zheng Y, Mayakonda A, Hazawa M, Xu L, Li Y, Aswad L, Jeitany M, Kanojia D, Guan XY, Said JW, Yang W, Fullwood MJ, Lin DC, Koeffler HP. PMID: 32619460.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    46. Characterization of super-enhancer-associated functional lncRNAs acting as ceRNAs in ESCC. Mol Oncol. 2020 09; 14(9):2203-2230. Wang QY, Peng L, Chen Y, Liao LD, Chen JX, Li M, Li YY, Qian FC, Zhang YX, Wang F, Li CQ, Lin DC, Xu LY, Li EM. PMID: 32460441; PMCID: PMC7463357.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    47. Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade. Cell Rep. 2020 06 09; 31(10):107753. Lin X, Dinglin X, Cao S, Zheng S, Wu C, Chen W, Li Q, Hu Q, Zheng F, Wu Z, Lin DC, Yao Y, Xu X, Xie Z, Liu Q, Yao H, Hu H. PMID: 32521278.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    48. Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas. Cancer Res. 2020 07 01; 80(13):2722-2736. Pan J, Silva TC, Gull N, Yang Q, Plummer JT, Chen S, Daigo K, Hamakubo T, Gery S, Ding LW, Jiang YY, Hu S, Xu LY, Li EM, Ding Y, Klempner SJ, Gayther SA, Berman BP, Koeffler HP, Lin DC. PMID: 32332020.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    49. dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27ac ChIP-Seq. Bioinformatics. 2020 03 01; 36(5):1649-1651. Huang M, Wang Y, Yang M, Yan J, Yang H, Zhuang W, Xu Y, Koeffler HP, Lin DC, Chen X. PMID: 31603498; PMCID: PMC7703781.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    50. Identification of key genes by integrating DNA methylation and next-generation transcriptome sequencing for esophageal squamous cell carcinoma. Aging (Albany NY). 2020 01 21; 12(2):1332-1365. Chen Y, Liao LD, Wu ZY, Yang Q, Guo JC, He JZ, Wang SH, Xu XE, Wu JY, Pan F, Lin DC, Xu LY, Li EM. PMID: 31962291; PMCID: PMC7053602.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    51. lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter. iScience. 2020 Feb 21; 23(2):100835. Fan S, Tian T, Lv X, Lei X, Yang Z, Liu M, Liang F, Li S, Lin X, Lin Z, Xie S, Li B, Chen W, Pan G, Lin X, Ou Z, Zhang Y, Peng Y, Xiao L, Zhang L, Sun S, Zhang H, Lin S, Li Q, Zeng B, Kontos F, Ruan Y, Ferrone S, Lin D, Tannous BA, Li J. PMID: 32000125; PMCID: PMC7033639.
      View in: PubMed   Mentions: 17  
    52. EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs). Nucleic Acids Res. 2020 01 08; 48(D1):D307-D313. Liao JY, Yang B, Zhang YC, Wang XJ, Ye Y, Peng JW, Yang ZZ, He JH, Zhang Y, Hu K, Lin DC, Yin D. PMID: 31598693; PMCID: PMC6943034.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    53. Validation of a genomic classifier for prediction of metastasis and prostate cancer-specific mortality in African-American men following radical prostatectomy in an equal access healthcare setting. Prostate Cancer Prostatic Dis. 2020 09; 23(3):419-428. Howard LE, Zhang J, Fishbane N, Hoedt AM, Klaassen Z, Spratt DE, Vidal AC, Lin D, Hitchins MP, You S, Freeman MR, Yamoah K, Davicioni E, Freedland SJ. PMID: 31844180.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    54. Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma. Oncogene. 2020 03; 39(10):2212-2223. Hazawa M, Sakai K, Kobayashi A, Yoshino H, Iga Y, Iwashima Y, Lim KS, Chih-Cheng Voon D, Jiang YY, Horike SI, Lin DC, Wong RW. PMID: 31822798; PMCID: PMC7056645.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    55. RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling. Cancer Res. 2020 01 15; 80(2):219-233. Loh XY, Sun QY, Ding LW, Mayakonda A, Venkatachalam N, Yeo MS, Silva TC, Xiao JF, Doan NB, Said JW, Ran XB, Zhou SQ, Dakle P, Shyamsunder P, Koh AP, Huang RY, Berman BP, Tan SY, Yang H, Lin DC, Koeffler HP. PMID: 31551365.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    56. Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma. Cancer Res. 2019 Dec 01; 79(23):5930-5943. You R, Liu YP, Lin DC, Li Q, Yu T, Zou X, Lin M, Zhang XL, He GP, Yang Q, Zhang YN, Xie YL, Jiang R, Wu CY, Zhang C, Cui C, Wang JQ, Wang Y, Zhuang AH, Guo GF, Hua YJ, Sun R, Yun JP, Zuo ZX, Liu ZX, Zhu XF, Kang TB, Qian CN, Mai HQ, Sun Y, Zeng MS, Feng L, Zeng YX, Chen MY. PMID: 31484669.
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    57. Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma. Gut. 2020 04; 69(4):630-640. Chen L, Huang M, Plummer J, Pan J, Jiang YY, Yang Q, Silva TC, Gull N, Chen S, Ding LW, An O, Yang H, Cheng Y, Said JW, Doan N, Dinjens WN, Waters KM, Tuli R, Gayther SA, Klempner SJ, Berman BP, Meltzer SJ, Lin DC, Koeffler HP. PMID: 31409603; PMCID: PMC8108390.
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    58. Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma. Cancers (Basel). 2019 Aug 12; 11(8). Lin L, Lin DC. PMID: 31409002; PMCID: PMC6721624.
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    60. SEanalysis: a web tool for super-enhancer associated regulatory analysis. Nucleic Acids Res. 2019 07 02; 47(W1):W248-W255. Qian FC, Li XC, Guo JC, Zhao JM, Li YY, Tang ZD, Zhou LW, Zhang J, Bai XF, Jiang Y, Pan Q, Wang QY, Li EM, Li CQ, Xu LY, Lin DC. PMID: 31028388; PMCID: PMC6602466.
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    61. ELMER v.2: an R/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles. Bioinformatics. 2019 06 01; 35(11):1974-1977. Silva TC, Coetzee SG, Gull N, Yao L, Hazelett DJ, Noushmehr H, Lin DC, Berman BP. PMID: 30364927; PMCID: PMC6546131.
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    62. LNK suppresses interferon signaling in melanoma. Nat Commun. 2019 05 20; 10(1):2230. Ding LW, Sun QY, Edwards JJ, Fernández LT, Ran XB, Zhou SQ, Scolyer RA, Wilmott JS, Thompson JF, Doan N, Said JW, Venkatachalam N, Xiao JF, Loh XY, Pein M, Xu L, Mullins DW, Yang H, Lin DC, Koeffler HP. PMID: 31110180; PMCID: PMC6527565.
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    63. Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Nat Cell Biol. 2019 04; 21(4):498-510. Chen F, Chen J, Yang L, Liu J, Zhang X, Zhang Y, Tu Q, Yin D, Lin D, Wong PP, Huang D, Xing Y, Zhao J, Li M, Liu Q, Su F, Su S, Song E. PMID: 30936474.
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    64. Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. Nucleic Acids Res. 2019 02 20; 47(3):1255-1267. Lin L, Huang M, Shi X, Mayakonda A, Hu K, Jiang YY, Guo X, Chen L, Pang B, Doan N, Said JW, Xie J, Gery S, Cheng X, Lin Z, Li J, Berman BP, Yin D, Lin DC, Koeffler HP. PMID: 30496486; PMCID: PMC6379679.
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    65. Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias. Haematologica. 2019 05; 104(5):e200-e203. Lao ZT, Ding LW, An O, Hattori N, Sun QY, Tan KT, Mayakonda A, Chuan WG, Madan V, Lin DC, Yang H, Koeffler HP. PMID: 30514800; PMCID: PMC6518916.
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    66. Super-Enhancer-Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma. Cancer Res. 2019 02 01; 79(3):572-584. Peng L, Jiang B, Yuan X, Qiu Y, Peng J, Huang Y, Zhang C, Zhang Y, Lin Z, Li J, Yao W, Deng W, Zhang Y, Meng M, Pan X, Li C, Yin D, Bi X, Li G, Lin DC. PMID: 30482773.
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    67. Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 2018 11; 28(11):1747-1756. Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP. PMID: 30341162; PMCID: PMC6211645.
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    68. Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines. BMC Cancer. 2018 Oct 01; 18(1):940. Tan KT, Ding LW, Sun QY, Lao ZT, Chien W, Ren X, Xiao JF, Loh XY, Xu L, Lill M, Mayakonda A, Lin DC, Yang H, Koeffler HP. PMID: 30285677; PMCID: PMC6167786.
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    69. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018 09 06; 9(1):3619. Jiang Y, Jiang YY, Xie JJ, Mayakonda A, Hazawa M, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC, Koeffler HP. PMID: 30190462; PMCID: PMC6127298.
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    73. Clonality and clonal evolution analysis of paediatric ALL based on B-cell receptor/T-cell receptor rearrangement. Br J Haematol. 2019 03; 184(5):829-833. Ding LW, Tan KT, Sun QY, Lao ZT, Yang H, Jiang N, Chien W, Xiao JF, Loh XY, Huang ML, Lill M, Lin DC, Yeoh AEJ, Koeffler HP. PMID: 29532914.
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    74. Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma. Gastroenterology. 2018 06; 154(8):2137-2151.e1. Xie JJ, Jiang YY, Jiang Y, Li CQ, Lim MC, An O, Mayakonda A, Ding LW, Long L, Sun C, Lin LH, Chen L, Wu JY, Wu ZY, Cao Q, Fang WK, Yang W, Soukiasian H, Meltzer SJ, Yang H, Fullwood M, Xu LY, Li EM, Lin DC, Koeffler HP. PMID: 29454790.
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    76. Non-malignant epithelial cells preferentially proliferate from nasopharyngeal carcinoma biopsy cultured under conditionally reprogrammed conditions. Sci Rep. 2017 12 12; 7(1):17359. Yu F, Lu Y, Tao L, Jiang YY, Lin DC, Wang L, Petersson F, Yoshiyama H, Koeffler PH, Goh BC, Loh KS. PMID: 29234119; PMCID: PMC5727117.
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    77. ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. EMBO Rep. 2018 01; 19(1):73-88. Hazawa M, Lin DC, Kobayashi A, Jiang YY, Xu L, Dewi FRP, Mohamed MS, Nakada M, Meguro-Horike M, Horike SI, Koeffler HP, Wong RW. PMID: 29217659; PMCID: PMC5757218.
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    78. Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):12548-12553. Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP. PMID: 29109286; PMCID: PMC5703267.
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    79. Genomic lesions drive the metastasis of esophageal squamous cell carcinoma. J Thorac Dis. 2017 Oct; 9(10):3523-3524. Lin DC, Koeffler HP. PMID: 29268331; PMCID: PMC5723768.
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    80. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018 01 01; 24(1):130-144. Zhao Z, Jia Q, Wu MS, Xie X, Wang Y, Song G, Zou CY, Tang Q, Lu J, Huang G, Wang J, Lin DC, Koeffler HP, Yin JQ, Shen J. PMID: 28951519.
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    81. Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017 12 01; 77(23):6614-6626. Yuan J, Jiang YY, Mayakonda A, Huang M, Ding LW, Lin H, Yu F, Lu Y, Loh TKS, Chow M, Savage S, Tyner JW, Lin DC, Koeffler HP. PMID: 28951465; PMCID: PMC6637769.
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    82. Correction: Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2017 Sep 08; 8(38):64651. Sun H, Lin DC, Guo X, Masouleh BK, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP. PMID: 28969101; PMCID: PMC5610033.
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    84. Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia. Neoplasia. 2017 Oct; 19(10):750-761. Gugliotta G, Sudo M, Cao Q, Lin DC, Sun H, Takao S, Le Moigne R, Rolfe M, Gery S, Müschen M, Cavo M, Koeffler HP. PMID: 28843399; PMCID: PMC5576979.
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    85. Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology. 2018 01; 154(2):374-389. Lin DC, Wang MR, Koeffler HP. PMID: 28757263; PMCID: PMC5951382.
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    86. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):3981-3986. Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. PMID: 28356518; PMCID: PMC5393201.
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    87. Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma. Clin Cancer Res. 2017 Aug 01; 23(15):4376-4387. Sun H, Lin DC, Cao Q, Pang B, Gae DD, Lee VKM, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP. PMID: 28336564.
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    88. Mutational profiling of acute lymphoblastic leukemia with testicular relapse. J Hematol Oncol. 2017 03 02; 10(1):65. Ding LW, Sun QY, Mayakonda A, Tan KT, Chien W, Lin DC, Jiang YY, Xu L, Garg M, Lao ZT, Lill M, Yang H, Yeoh AE, Koeffler HP. PMID: 28253933; PMCID: PMC5335697.
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    89. Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. Cancer Res. 2017 05 01; 77(9):2255-2265. Lin DC, Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, Ding LW, Wang J, Berman BP, Song EW, Yin D, Koeffler HP. PMID: 28302680; PMCID: PMC5413372.
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    90. Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma. Int J Oncol. 2017 Mar; 50(3):863-872. Xie J, Lin D, Lee DH, Akunowicz J, Hansen M, Miller C, Sanada M, Kato M, Akagi T, Kawamata N, Ogawa S, Koeffler HP. PMID: 28197627.
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    92. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016 12; 48(12):1500-1507. Hao JJ, Lin DC, Dinh HQ, Mayakonda A, Jiang YY, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ, Berman BP, Wang MR, Koeffler HP. PMID: 27749841; PMCID: PMC5127772.
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    94. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2016 Apr 05; 7(14):18736-49. Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP. PMID: 26934650; PMCID: PMC4951325.
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    95. CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling. Cancer Res. 2016 05 01; 76(9):2687-97. Sun H, Lin DC, Cao Q, Guo X, Marijon H, Zhao Z, Gery S, Xu L, Yang H, Pang B, Lee VK, Lim HJ, Doan N, Said JW, Chu P, Mayakonda A, Thomas T, Forscher C, Baloglu E, Shacham S, Rajalingam R, Koeffler HP. PMID: 26956669.
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    96. Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse. Blood. 2015 Nov 26; 126(22):2491-501. Garg M, Nagata Y, Kanojia D, Mayakonda A, Yoshida K, Haridas Keloth S, Zang ZJ, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ding LW, Alpermann T, Sun QY, Lin DC, Chien W, Madan V, Liu LZ, Tan KT, Sampath A, Venkatesan S, Inokuchi K, Wakita S, Yamaguchi H, Chng WJ, Kham SK, Yeoh AE, Sanada M, Schiller J, Kreuzer KA, Kornblau SM, Kantarjian HM, Haferlach T, Lill M, Kuo MC, Shih LY, Blau IW, Blau O, Yang H, Ogawa S, Koeffler HP. PMID: 26438511; PMCID: PMC4661172.
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    97. Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma. Cancer Res. 2015 May 01; 75(9):1815-27. Lin DC, Xu L, Chen Y, Yan H, Hazawa M, Doan N, Said JW, Ding LW, Liu LZ, Yang H, Yu S, Kahn M, Yin D, Koeffler HP. PMID: 25877876; PMCID: PMC4417379.
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    98. Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma. Oncol Rep. 2015 Mar; 33(3):1481-92. Zhang H, Li W, Huang P, Lin L, Ye H, Lin D, Koeffler HP, Wang J, Yin D. PMID: 25571929.
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    99. SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway. J Pathol. 2015 Mar; 235(4):559-70. Sun QY, Ding LW, Xiao JF, Chien W, Lim SL, Hattori N, Goodglick L, Chia D, Mah V, Alavi M, Kim SR, Doan NB, Said JW, Loh XY, Xu L, Liu LZ, Yang H, Hayano T, Shi S, Xie D, Lin DC, Koeffler HP. PMID: 25404354; PMCID: PMC4333197.
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    108. Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood. 2012 Oct 18; 120(16):3310-7. Lin DC, Yin T, Koren-Michowitz M, Ding LW, Gueller S, Gery S, Tabayashi T, Bergholz U, Kazi JU, Rönnstrand L, Stocking C, Koeffler HP. PMID: 22942183; PMCID: PMC3476541.
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